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Human Vaccines & Immunotherapeutics Volume 18, 2022 - Issue 6
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Immunotherapeutics – Short Report

Omalizumab added to allergen immunotherapy increased the effect of therapy in patients with severe local allergic rhinitis

Andrzej Bozeka Clinical Department of Internal Diseases, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, PolandCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2263-2263View further author information
ORCID Icon,
Renata Kozłowskaa Clinical Department of Internal Diseases, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, PolandView further author information
,
Maciej Misiołekb Department of Otorhinolaryngology and Laryngological Oncology in Zabrze, Medical University of Silesia, Katowice, PolandView further author information
,
Wojciech Ścierskib Department of Otorhinolaryngology and Laryngological Oncology in Zabrze, Medical University of Silesia, Katowice, PolandView further author information
&
Radosław Gawlikc Clinical Department of Internal Diseases, Allergology and Clinical Immunology in Zabrze, Medical University of Silesia, Katowice, PolandView further author information
Article: 2097818 | Received 01 Mar 2022, Accepted 01 Jul 2022, Published online: 11 Jul 2022

References

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  • Rondon C, Blanca – Lopez N, Aranda A, Herrera R, Rodriguez BJ, Canto G, Mayorga C, Torres MJ, Campo P, Blanca M, et al. Local allergic rhinitis: allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen. J Allergy Clin Immunol. 2011;127(4):1069–3. doi: 10.1016/j.jaci.2010.12.013.
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  • Kopp MV, Hamelmann E, Zielen S, Kamin W, Bergmann KC, Sieder C, Stenglein S, Seyfried S, Wahn U. DUAL study group. Combination of omalizumab and specific immunotherapy is superior to immunotherapy in patients with seasonal allergic rhinoconjunctivitis and co-morbid seasonal allergic asthma. Clin Exp Allergy. 2009;39(2):271–279. doi: 10.1111/j.1365-2222.2008.03121.x.
  • Corren J, Diaz-Sanchez D, Saxon A, Deniz Y, Reimann J, Sinclair DS, Davancaze T, Adelman D. Effects of omalizumab, a humanized monoclonal anti-IgE antibody, on nasal reactivity to allergen and local IgE synthesis. Ann Allergy Asthma Immunol. 2004;93(3):243–248. doi: 10.1016/S1081-1206(10)61495-0.
  • Klunker S, Saggar LR, Seyfert-Margolis V, Asare AL, Casale TB, Durham SR, Francis JN; Immune Tolerance Network Group. Combination treatment with omalizumab and rush immunotherapy for ragweed-induced allergic rhinitis: inhibition of IgE-facilitated allergen binding. Allergy Clin Immunol. 2007;120(3):688–695. doi: 10.1016/j.jaci.2007.05.034.

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