Design and evaluation of mRNA encoding recombinant neutralizing antibodies for botulinum neurotoxin type B intoxication prophylaxis

References

• Popoff MR, Bouvet P. Genetic characteristics of toxigenic Clostridia and toxin gene evolution. Toxicon 2013;75:63–8. doi:10.1016/j.toxicon.2013.05.003.
   PubMed Web of Science ®Google Scholar
• Hill KK, Smith TJ. Genetic diversity within Clostridium botulinum serotypes, botulinum neurotoxin gene clusters and toxin subtypes. Curr Top Microbiol Immunol. 2013;364:1–20. doi:10.1007/978-3-642-33570-9_1.
   PubMed Web of Science ®Google Scholar
• Pirazzini M, Rossetto O, Eleopra R, Montecucco C. Botulinum neurotoxins: biology, pharmacology, and toxicology. Pharmacol Rev. 2017;69(2):200–35. doi:10.1124/pr.116.012658.
   PubMed Web of Science ®Google Scholar
• Rossetto O, Montecucco C. Tables of toxicity of botulinum and tetanus neurotoxins. Toxins 2019;11(12):686. doi:10.3390/toxins11120686.
   PubMed Web of Science ®Google Scholar
• Dutta SR, Passi D, Singh M, Singh P, Sharma S, Sharma A. Botulinum toxin the poison that heals: a brief review. Natl J Maxillofac Surg. 2016;7(1):10–16. doi:10.4103/0975-5950.196133.
   PubMedGoogle Scholar
• Johnson EA, Montecucco C:. Botulism. Handb Clin Neurol. 2008;91:333–68. doi:10.1016/s0072-9752(07)01511-4.
   PubMedGoogle Scholar
• Cherington M. Clinical spectrum of botulism. Muscle Nerve. 1998;21(6):701–10. doi:10.1002/(sici)1097-4598(199806)21:6<701:aid-mus1>3.0.co;2-b.
   PubMed Web of Science ®Google Scholar
• Godakova SA, Noskov AN, Vinogradova ID, Ugriumova GA, Solovyev AI, Esmagambetov IB, Tukhvatulin AI, Logunov DY, Naroditsky BS, Shcheblyakov DV. et al. Camelid VHHs fused to human Fc fragments provide long term protection against botulinum neurotoxin a in mice. Toxins 2019;11(8):464. doi:10.3390/toxins11080464.
   PubMed Web of Science ®Google Scholar
• Thran M, Mukherjee J, Pönisch M, Fiedler K, Thess A, Mui BL, Hope MJ, Tam YK, Horscroft N, Heidenreich R. et al. mRNA mediates passive vaccination against infectious agents, toxins, and tumors. EMBO Mol Med. 2017;9(10):1434–47. doi:10.15252/emmm.201707678.
   PubMed Web of Science ®Google Scholar
• Dezfulian M, Hatheway CL, Yolken RH, Bartlett JG. Enzyme-linked immunosorbent assay for detection of Clostridium botulinum type a and type B toxins in stool samples of infants with botulism. J Clin Microbiol. 1984;20(3):379–83. doi:10.1128/jcm.20.3.379-383.1984.
   PubMed Web of Science ®Google Scholar
• Tacket CO, Shandera WX, Mann JM, Hargrett NT. Blake PA: equine antitoxin use and other factors that predict outcome in type a foodborne botulism. Am J Med. 1984;76(5):794–8. doi:10.1016/0002-9343(84)90988-4.
   PubMed Web of Science ®Google Scholar
• Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL. Direct gene transfer into mouse muscle in vivo. Science 1990;247(4949 Pt 1):1465–8. doi:10.1126/science.1690918.
   PubMed Web of Science ®Google Scholar
• Fiolet T, Kherabi Y, MacDonald CJ, Ghosn J, Peiffer-Smadja N. Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review. Clin Microbiol Infect. 2022;28(2):202–21. doi:10.1016/j.cmi.2021.10.005.
   PubMed Web of Science ®Google Scholar
• Schlake T, Thran M, Fiedler K, Heidenreich R, Petsch B, Fotin-Mleczek M. mRNA: a novel avenue to antibody therapy? Mol Ther. 2019;27(4):773–84. doi:10.1016/j.ymthe.2019.03.002.
   PubMed Web of Science ®Google Scholar
• Karikó K. In vitro-transcribed mRNA therapeutics: out of the shadows and into the spotlight. Mol Ther. 2019;27(4):691–2. doi:10.1016/j.ymthe.2019.03.009.
   PubMed Web of Science ®Google Scholar
• Mukherjee J, Ondeck CA, Tremblay JM, Archer J, Debatis M, Foss A, Awata J, Erasmus JH, McNutt PM, Shoemaker CB. Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three botulinum neurotoxin serotypes. Sci Rep. 2022;12(1):11664. doi:10.1038/s41598-022-15876-2.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Wang R, Guo J, Cheng K, Chen L, Wang X, Li Y, Du P, Gao C, Lu J. Isolation and characterization of Hc-targeting chimeric heavy chain antibodies neutralizing botulinum neurotoxin type B. Front Immunol. 2024;15:1380694. doi:10.3389/fimmu.2024.1380694.
   PubMed Web of Science ®Google Scholar
• Sample PJ, Wang B, Reid DW, Presnyak V, McFadyen IJ, Morris DR, Seelig G. Human 5′ UTR design and variant effect prediction from a massively parallel translation assay. Nat Biotechnol. 2019;37(7):803–9. doi:10.1038/s41587-019-0164-5.
   PubMed Web of Science ®Google Scholar
• Jackson LA, Anderson EJ, Rouphael NG, Roberts PC, Makhene M, Coler RN, McCullough MP, Chappell JD, Denison MR, Stevens LJ. et al. An mRNA vaccine against SARS-CoV-2 — preliminary report. N Engl J Med. 2020;383(20):1920–31. doi:10.1056/NEJMoa2022483.
   PubMed Web of Science ®Google Scholar
• Paunovska K, Loughrey D, Dahlman JE. Drug delivery systems for RNA therapeutics. Nat Rev Genet. 2022;23(5):265–80. doi:10.1038/s41576-021-00439-4.
   PubMed Web of Science ®Google Scholar
• Chaudhary N, Weissman D, Whitehead KA. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat Rev Drug Discov. 2021;20(11):817–38. doi:10.1038/s41573-021-00283-5.
   PubMed Web of Science ®Google Scholar
• Alfagih IM, Aldosari B, AlQuadeib B, Almurshedi A, Alfagih MM. Nanoparticles as adjuvants and nanodelivery systems for mRNA-based vaccines. Pharmaceutics 2020;13(1):45. doi:10.3390/pharmaceutics13010045.
   PubMed Web of Science ®Google Scholar
• Wesselhoeft RA, Kowalski PS, Anderson DG. Engineering circular RNA for potent and stable translation in eukaryotic cells. Nat Commun. 2018;9(1):2629. doi:10.1038/s41467-018-05096-6.
   PubMed Web of Science ®Google Scholar
• Erasmus JH, Archer J, Fuerte-Stone J, Khandhar AP, Voigt E, Granger B, Bombardi RG, Govero J, Tan Q, Durnell LA. et al. Intramuscular delivery of replicon RNA encoding ZIKV-117 human monoclonal antibody protects against Zika virus infection. Mol Ther Methods Clin Dev. 2020;18:402–14. doi:10.1016/j.omtm.2020.06.011.
   PubMed Web of Science ®Google Scholar