Advanced search
Publication Cover
Bioengineered Volume 7, 2016 - Issue 2
Submit an article Journal homepage
1,366
Views
10
CrossRef citations to date
0
Altmetric
Addenda

Heme metabolism in stress regulation and protein production: From Cinderella to a key player

J. L. MartínezNovo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden;Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden
,
D. PetranovicNovo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden;Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden
&
J. NielsenNovo Nordisk Foundation Center for Biosustainability, Chalmers University of Technology, Gothenburg, Sweden;Department of Biology and Biological Engineering, Chalmers University of Technology, Göteborg, Sweden;Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, DenmarkCorrespondence[email protected]
Pages 112-115 | Received 21 Oct 2015, Accepted 23 Nov 2015, Published online: 25 Mar 2016

References

  • Nielsen J, Larsson C, van Maris A, Pronk J. Metabolic engineering of yeast for production of fuels and chemicals. Curr Opin Biotechnol 2013; 24:398-404; PMID:23611565; http://dx.doi.org/10.1016/j.copbio.2013.03.023
  • Martinez JL, Liu L, Petranovic D, Nielsen J. Pharmaceutical protein production by yeast: towards production of human blood proteins by microbial fermentation. Curr Opin Biotechnol 2012; 23:965-71; PMID:22503236; http://dx.doi.org/10.1016/j.copbio.2012.03.011
  • Liu L, Martinez JL, Liu Z, Petranovic D, Nielsen J. Balanced globin protein expression and heme biosynthesis improve production of human hemoglobin in Saccharomyces cerevisiae. Metab Eng 2014; 21:9-16; PMID:24188961; http://dx.doi.org/10.1016/j.ymben.2013.10.010
  • Martinez JL, Liu L, Petranovic D, Nielsen J. Engineering the oxygen sensing regulation results in an enhanced recombinant human hemoglobin production by Saccharomyces cerevisiae. Biotechnol Bioeng 2015; 112:181-8; PMID:25082441; http://dx.doi.org/10.1002/bit.25347
  • Tiburzi F, Imperi F, Visca P. Is the host heme incorporated in microbial heme-proteins? IUBMB Life 2009; 61:80-3; PMID:18702108; http://dx.doi.org/10.1002/iub.123
  • Hardison R. Hemoglobins from bacteria to man: evolution of different patterns of gene expression. J Exp Biol 1998; 201:1099-117; PMID:9510523
  • Frankenberg N, Moser J, Jahn D. Bacterial heme biosynthesis and its biotechnological application. Appl Microbiol Biotechnol 2003; 63:115-27; PMID:13680202; http://dx.doi.org/10.1007/s00253-003-1432-2
  • Zitomer RS, Lowry CV. Regulation of gene expression by oxygen in Saccharomyces cerevisiae. Microbiol Rev 1992; 56:1-11; PMID:1579104
  • Anzaldi LL, Skaar EP. Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens. Infect Immun 2010; 78:4977-89; PMID:20679437; http://dx.doi.org/10.1128/IAI.00613-10
  • Wu JM, Fu WC. Intracellular co-expression of Vitreoscilla hemoglobin enhances cell performance and beta-galactosidase production in Pichia pastoris. J Biosci Bioeng 2012; 113:332-7; PMID:22099376; http://dx.doi.org/10.1016/j.jbiosc.2011.10.014
  • Wang X, Sun Y, Shen X, Ke F, Zhao H, Liu Y, et al. Intracellular expression of Vitreoscilla hemoglobin improves production of Yarrowia lipolytica lipase LIP2 in a recombinant Pichia pastoris. Enzyme Microb Technol 2012; 50:22-8; PMID:22133436; http://dx.doi.org/10.1016/j.enzmictec.2011.09.003
  • Yu J, Jiang J, Fang Z, Li Y, Lv H, Liu J. Enhanced expression of heterologous inulinase in Kluyveromyces lactis by disruption of hap1 gene. Biotechnol Lett 2010; 32:507-12; PMID:20013302; http://dx.doi.org/10.1007/s10529-009-0182-3
  • Tyo KE, Liu Z, Petranovic D, Nielsen J. Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress. BMC Biol 2012; 10:16; PMID:22380681; http://dx.doi.org/10.1186/1741-7007-10-16
  • Liu Z, Osterlund T, Hou J, Petranovic D, Nielsen J. Anaerobic alpha-amylase production and secretion with fumarate as the final electron acceptor in Saccharomyces cerevisiae. Appl Environ Microbiol 2013; 79:2962-7; PMID:23435897; http://dx.doi.org/10.1128/AEM.03207-12

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.