Dendritic cells in tumor microenvironment promoted the neuropathic pain via paracrine inflammatory and growth factors

References

• Neufeld NJ, Elnahal SM, Alvarez RH. Cancer pain: a review of epidemiology, clinical quality and value impact. Future Oncol. 2017;13(9):833–841.
   PubMed Web of Science ®Google Scholar
• van den Beuken-van Everdingen MH, Hochstenbach LM, Joosten EA, et al. Update on prevalence of pain in patients with cancer: systematic review and meta-analysis. J Pain Symptom Manage. 2016;51(6):1070–1090 e1079.
   PubMed Web of Science ®Google Scholar
• Lohse I, Brothers SP. Pathogenesis and treatment of pancreatic cancer related pain. Anticancer Res. 2020;40(4):1789–1796.
   PubMed Web of Science ®Google Scholar
• Pinho-Ribeiro FA, Verri WA Jr., Chiu IM. Nociceptor sensory neuron-immune interactions in pain and inflammation. Trends Immunol. 2017;38(1):5–19.
   PubMed Web of Science ®Google Scholar
• Kumar MP, Du J, Lagoudas G, et al. Analysis of single-cell RNA-seq identifies cell-cell communication associated with tumor characteristics. Cell Rep. 2018;25(6):1458–1468 e1454.
   PubMed Web of Science ®Google Scholar
• Singer M, Wang C, Cong L, et al. A distinct gene module for dysfunction uncoupled from activation in tumor-infiltrating T cells. Cell. 2016;166(6):1500–1511 e1509.
   PubMed Web of Science ®Google Scholar
• Wang M, Zhao J, Zhang L, et al. Role of tumor microenvironment in tumorigenesis. J Cancer. 2017;8(5):761–773.
   PubMed Web of Science ®Google Scholar
• Hinshaw DC, Shevde LA. The tumor microenvironment innately modulates cancer progression. Cancer Res. 2019;79(18):4557–4566.
   PubMed Web of Science ®Google Scholar
• Roma-Rodrigues C, Mendes R, Baptista PV, et al. Targeting tumor microenvironment for cancer therapy. Int J Mol Sci. 2019;20:4.
   Web of Science ®Google Scholar
• Lim B, Woodward WA, Wang X, et al. Inflammatory breast cancer biology: the tumour microenvironment is key. Nat Rev Cancer. 2018;18(8):485–499.
   PubMed Web of Science ®Google Scholar
• Spranger S, Gajewski TF. Impact of oncogenic pathways on evasion of antitumour immune responses. Nat Rev Cancer. 2018;18(3):139–147.
   PubMed Web of Science ®Google Scholar
• De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017;17(8):457–474.
   PubMed Web of Science ®Google Scholar
• Gotwals P, Cameron S, Cipolletta D, et al. Prospects for combining targeted and conventional cancer therapy with immunotherapy. Nat Rev Cancer. 2017;17(5):286–301.
   PubMed Web of Science ®Google Scholar
• Kerdidani D, Chouvardas P, Arjo AR, et al. Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma. Nat Commun. 2019;10(1):1405.
   PubMedGoogle Scholar
• Mi H, Muruganujan A, Ebert D, et al. PANTHER version 14: more genomes, a new PANTHER GO-slim and improvements in enrichment analysis tools. Nucleic Acids Res. 2019;47(D1):D419–D426.
   PubMed Web of Science ®Google Scholar
• Mi H, Muruganujan A, Huang X, et al. Protocol update for large-scale genome and gene function analysis with the PANTHER classification system (v.14.0). Nat Protoc. 2019;14(3):703–721.
   PubMed Web of Science ®Google Scholar
• Ray P, Torck A, Quigley L, et al. Comparative transcriptome profiling of the human and mouse dorsal root ganglia: an RNA-seq-based resource for pain and sensory neuroscience research. Pain. 2018;159(7):1325–1345.
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–2504.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):D607–D613.
   PubMed Web of Science ®Google Scholar
• Stuart T, Butler A, Hoffman P, et al. Comprehensive integration of single-cell data. Cell. 2019;177(7):1888–1902 e1821.
   PubMed Web of Science ®Google Scholar
• Janky R, Verfaillie A, Imrichova H, et al. iRegulon: from a gene list to a gene regulatory network using large motif and track collections. PLoS Comput Biol. 2014;10(7):e1003731.
   PubMed Web of Science ®Google Scholar
• Robinson JT, Thorvaldsdottir H, Winckler W, et al. Integrative genomics viewer. Nat Biotechnol. 2011;29(1):24–26.
   PubMed Web of Science ®Google Scholar
• Thorvaldsdottir H, Robinson JT, Mesirov JP. Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform. 2013;14(2):178–192.
   PubMed Web of Science ®Google Scholar
• Obara I, Telezhkin V, Alrashdi I, et al. Histamine, histamine receptors, and neuropathic pain relief. Br J Pharmacol. 2020;177(3):580–599.
   PubMed Web of Science ®Google Scholar
• Mobarakeh JI, Sakurada S, Katsuyama S, et al. Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice. Eur J Pharmacol. 2000;391(1–2):81–89.
   PubMed Web of Science ®Google Scholar
• Mobarakeh JI, Takahashi K, Sakurada S, et al. Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice. Neuropharmacology. 2006;51(3):612–622.
   PubMed Web of Science ®Google Scholar
• Khalilzadeh E, Azarpey F, Hazrati R, et al. Evaluation of different classes of histamine H1 and H2 receptor antagonist effects on neuropathic nociceptive behavior following tibial nerve transection in rats. Eur J Pharmacol. 2018;834:221–229.
   PubMed Web of Science ®Google Scholar
• Leung L, Cahill CM. TNF-alpha and neuropathic pain–a review. J Neuroinflammation. 2010;7:27.
   PubMed Web of Science ®Google Scholar
• Wagner R, Myers RR. Endoneurial injection of TNF-alpha produces neuropathic pain behaviors. Neuroreport. 1996;7(18):2897–2901.
   PubMed Web of Science ®Google Scholar
• Sorkin LS, Doom CM. Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J Peripher Nerv Syst. 2000;5(2):96–100.
   PubMed Web of Science ®Google Scholar
• Jin X. Gereau RWt: acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha. J Neurosci. 2006;26(1):246–255.
   PubMed Web of Science ®Google Scholar
• Pareek TK, Zipp L, Letterio JJ. Cdk5: an emerging kinase in pain signaling. Brain Disord Ther. 2013;2013(Suppl 1):003.
   PubMedGoogle Scholar
• Wang CH, Chou WY, Hung KS, et al. Intrathecal administration of roscovitine inhibits Cdk5 activity and attenuates formalin-induced nociceptive response in rats. Acta Pharmacol Sin. 2005;26(1):46–50.
   PubMed Web of Science ®Google Scholar
• Fu AK, Ip FC, Fu WY, et al. Aberrant motor axon projection, acetylcholine receptor clustering, and neurotransmission in cyclin-dependent kinase 5 null mice. Proc Natl Acad Sci U S A. 2005;102(42):15224–15229.
   PubMed Web of Science ®Google Scholar
• Pareek TK, Keller J, Kesavapany S, et al. Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1. Proc Natl Acad Sci U S A. 2007;104(2):660–665.
   PubMed Web of Science ®Google Scholar
• Pardridge WM. Biologic TNFalpha-inhibitors that cross the human blood-brain barrier. Bioeng Bugs. 2010;1(4):231–234.
   PubMedGoogle Scholar
• Zhao Y, Yang Z. Effect of Wnt signaling pathway on pathogenesis and intervention of neuropathic pain. Exp Ther Med. 2018;16(4):3082–3088.
   PubMed Web of Science ®Google Scholar
• Zhang YK, Huang ZJ, Liu S, et al. WNT signaling underlies the pathogenesis of neuropathic pain in rodents. J Clin Invest. 2013;123(5):2268–2286.
   PubMed Web of Science ®Google Scholar
• Chen G, Xie RG, Gao YJ, et al. beta-arrestin-2 regulates NMDA receptor function in spinal lamina II neurons and duration of persistent pain. Nat Commun. 2016;7:12531.
   PubMed Web of Science ®Google Scholar
• Nickho H, Younesi V, Aghebati-Maleki L, et al. Developing and characterization of single chain variable fragment (scFv) antibody against frizzled 7 (Fzd7) receptor. Bioengineered. 2017;8(5):501–510.
   PubMed Web of Science ®Google Scholar
• Narita M, Usui A, Narita M, et al. Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury. J Neurosci. 2005;25(43):10000–10009.
   PubMed Web of Science ®Google Scholar
• Inoue K, Tsuda M. Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci. 2018;19(3):138–152.
   PubMed Web of Science ®Google Scholar
• Welser-Alves JV, Milner R. Microglia are the major source of TNF-alpha and TGF-beta1 in postnatal glial cultures; regulation by cytokines, lipopolysaccharide, and vitronectin. Neurochem Int. 2013;63(1):47–53.
   PubMed Web of Science ®Google Scholar
• Syed N, Reddy K, Yang DP, et al. Soluble neuregulin-1 has bifunctional, concentration-dependent effects on Schwann cell myelination. J Neurosci. 2010;30(17):6122–6131.
   PubMed Web of Science ®Google Scholar
• Calvo M, Zhu N, Tsantoulas C, et al. Neuregulin-ErbB signaling promotes microglial proliferation and chemotaxis contributing to microgliosis and pain after peripheral nerve injury. J Neurosci. 2010;30(15):5437–5450.
   PubMed Web of Science ®Google Scholar
• White FA, Jung H, Miller RJ. Chemokines and the pathophysiology of neuropathic pain. Proc Natl Acad Sci U S A. 2007;104(51):20151–20158.
   PubMed Web of Science ®Google Scholar
• White FA, Wilson NM. Chemokines as pain mediators and modulators. Curr Opin Anaesthesiol. 2008;21(5):580–585.
   PubMed Web of Science ®Google Scholar
• Hu XM, Zhang H, Xu H, et al. Chemokine receptor CXCR4 regulates CaMKII/CREB pathway in spinal neurons that underlies cancer-induced bone pain. Sci Rep. 2017;7(1):4005.
   PubMed Web of Science ®Google Scholar
• Kiguchi N, Kobayashi D, Saika F, et al. Pharmacological regulation of neuropathic pain driven by inflammatory macrophages. Int J Mol Sci. 2017;18:11.
   Web of Science ®Google Scholar
• Liou JT, Lee CM, Day YJ. The immune aspect in neuropathic pain: role of chemokines. Acta Anaesthesiol Taiwan. 2013;51(3):127–132.
   PubMedGoogle Scholar
• Colloca L, Ludman T, Bouhassira D, et al. Neuropathic pain. Nat Rev Dis Primers. 2017;3:17002.
   PubMed Web of Science ®Google Scholar