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Research Paper

Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway

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Pages 507-515 | Received 11 Nov 2020, Accepted 19 Jan 2021, Published online: 31 Jan 2021

References

  • He S, Stankowska DL, Elli DZ, et al. Targets of neuroprotection in glaucoma. J Ocul Pharmacol Ther. 2018;34(1–2):85–106.
  • McMonnies CW. Glaucoma history and risk factors. J Optom. 2017;10(2):71–78.
  • Wiggs JL, Pasquale LR. Genetics of glaucoma. Hum Mol Genet. 2017;26(R1):R21–r27.
  • Novack GD. Cannabinoids for treatment of glaucoma. Curr Opin Ophthalmol. 2016;27(2):146–150.
  • Conlon R, Saheb H, Ahmed IIK. Glaucoma treatment trends: a review. Can J Ophthalmol. 2017;52(1):114–124.
  • Williams PA, Harder JM, John SWM. Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma. J Glaucoma. 2017;26(12):1161–1168.
  • Hadanny A, Maliar A, Fishlev G, et al. Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. Clin Ophthalmol. 2017;11:115–125.
  • Tobalem S, Schutz JS, Chronopoulos A. Central retinal artery occlusion - rethinking retinal survival time. BMC Ophthalmol. 2018;18(1):101.
  • Minhas G, Sharma J, Khan N. Cellular stress response and immune signaling in retinal ischemia-reperfusion injury. Front Immunol. 2016;7:444.
  • Shabanzadeh AP, D’Onofrio PM, Monnier PP, et al. Neurosurgical modeling of retinal ischemia-reperfusion injury. J Stroke Cerebrovasc Dis. 2018;27(4):845–856.
  • Chen HY, Chou HC, Chang SJ, et al. Proteomic analysis of various rat ocular tissues after ischemia-reperfusion injury and possible relevance to acute glaucoma. Int J Mol Sci. 2017;18(2):334.
  • Hartsock MJ, Cho H, Wu L, et al. A mouse model of retinal ischemia-reperfusion injury through elevation of intraocular pressure. J Vis Exp. 2016;113:54065.
  • Chen Z, Zhang C, Gao F, et al. A systematic review on the rhizome of Ligusticum chuanxiong Hort. (Chuanxiong). Food Chem Toxicol. 2018;119:309–325.
  • Zhang Q, Wang M, Wang Q, et al. Characterization of the potential new phthalides in Ligusticum chuanxiong Hort. using ultra-performance liquid chromatography coupled with quadrupole time of flight tandem mass spectrometry. J Sep Sci. 2017;40(10):2123–2130.
  • Yan S, Yue YZ, Zong Y, et al. Tetramethylpyrazine improves postoperative tissue adhesion: a drug repurposing. Chin J Integr Med. 2019;25(7):554–560.
  • Chen L, Liu T, Wang Q, et al. Anti-inflammatory effect of combined tetramethylpyrazine, resveratrol and curcumin in vivo. BMC Complement Altern Med. 2017;17(1):233.
  • Wei Y, Liu J, Zhang H, et al. Ligustrazine attenuates inflammation and the associated chemokines and receptors in ovalbumine-induced mouse asthma model. Environ Toxicol Pharmacol. 2016;46:55–61.
  • Lu F, Li X, Li W, et al. Tetramethylpyrazine reverses intracerebroventricular streptozotocin-induced memory deficits by inhibiting GSK-3beta. Acta Biochim Biophys Sin. 2017;49(8):722–728.
  • Shao Z, Wang L, Liu S, et al. Tetramethylpyrazine protects neurons from oxygen-glucose deprivation-induced death. Med Sci Monit. 2017;23:5277–5282.
  • Gao HJ, Liu PF, Li PW, et al. Ligustrazine monomer against cerebral ischemia/reperfusion injury. Neural Regen Res. 2015;10(5):832–840.
  • Ravanan P, Srikumar IF, Talwar P. Autophagy: the spotlight for cellular stress responses. Life Sci. 2017;188:53–67.
  • Sirohi K, Swarup G. Defects in autophagy caused by glaucoma-associated mutations in optineurin. Exp Eye Res. 2016;144:54–63.
  • Wang Y, Huang C, Zhang H, et al. Autophagy in glaucoma: crosstalk with apoptosis and its implications. Brain Res Bull. 2015;117:1–9.
  • Wang Z, Zhou L, Zheng X, et al. Autophagy protects against PI3K/Akt/mTOR-mediated apoptosis of spinal cord neurons after mechanical injury. Neurosci Lett. 2017;656:158–164.
  • Cierniak S, Koktysz R, Jesiotr M, et al. Expression of the PI3K_AKT_mTOR pathway as a prognostic factor in patients with advanced high grade serous ovarian carcinoma treated with neoadjuvant chemotherapy. Eur J Gynaecol Oncol. 2019;40(5):744–751.
  • Bao H, Sun D, Qi P, et al. Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5. Biomed Pharmacother. 2019;109:1826–1833.
  • Nakajima Y, Shimazawa M, Mishima S, et al. Neuroprotective effects of Brazilian green propolis and its main constituents against oxygen-glucose deprivation stress, with a gene-expression analysis. Phytother Res. 2010;23(10):1431–1438.
  • Mao K, Wu X. Salvianolic acid a protects optic nerve from ischemia–reperfusion injury via inhibiting astrocytes and ROCK activation. SSRN Electron J. 2019. DOI:10.2139/ssrn.3501022
  • Fresno Vara JA, Casado E, de Castro J, et al. PI3K/Akt signalling pathway and cancer. Cancer Treat Rev. 2004;30(2):193–204.
  • Risso G, Blaustein M, Pozzi B, et al. Akt/PKB: one kinase, many modifications. Biochem J. 2015;468(2):203–214.
  • Wang XM, Yao M, Liu SX, et al. Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis. Am J Physiol Renal Physiol. 2014;306(2):F205–213.
  • Xu YP, Han F, Tan J. Edaravone protects the retina against ischemia/reperfusioninduced oxidative injury through the PI3K/Akt/Nrf2 pathway. Mol Med Rep. 2017;16(6):9210–9216.
  • Wu J, Wang R, Yang D, et al. Hydrogen postconditioning promotes survival of rat retinal ganglion cells against ischemia/reperfusion injury through the PI3K/Akt pathway. Biochem Biophys Res Commun. 2018;495(4):2462–2468.
  • Kaur A, Sharma S. Mammalian target of rapamycin (mTOR) as a potential therapeutic target in various diseases. Inflammopharmacology. 2017;25(3):293–312.
  • Nikoletopoulou V, Markaki M, Palikaras K, et al. Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta. 2013;1833(12):3448–3459.
  • Aoki M, Fujishita T. Oncogenic roles of the PI3K/AKT/mTOR axis. Curr Top Microbiol Immunol. 2017;407:153–189.
  • Ersahin T, Tuncbag N, Cetin-Atalay R. The PI3K/AKT/mTOR interactive pathway. Mol Biosyst. 2015;11(7):1946–1954.
  • Lascaratos G, Chau KY, Zhu H, et al. Systemic PTEN-Akt1-mTOR pathway activity in patients with normal tension glaucoma and ocular hypertension: a case series. Mitochondrion. 2017;36:96–102.
  • Li R, Jin Y, Li Q, et al. MiR-93-5p targeting PTEN regulates the NMDA-induced autophagy of retinal ganglion cells via AKT/mTOR pathway in glaucoma. Biomed Pharmacother. 2018;100:1–7.
  • Wolosin JM, Ritch R, Bernstein AM. Is autophagy dysfunction a key to exfoliation glaucoma? J Glaucoma. 2018;27(3):197–201.
  • Sun W, Li YN, Ye JF, et al. MEG3 is involved in the development of glaucoma through promoting the autophagy of retinal ganglion cells. Eur Rev Med Pharmacol Sci. 2018;22(9):2534–2540.
  • Kara S, Gencer B, Karaca T, et al. Protective effect of hesperetin and naringenin against apoptosis in ischemia/reperfusion-induced retinal injury in rats. Sci World J. 2014;2014:797824.
  • Kaczanowski S. Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging. Phys Biol. 2016;13(3):031001.
  • Zhu D, Sun C, Qian X. MST1 suppresses viability and promotes apoptosis of glioma cells via upregulating SIRT6 expression. J Integr Neurosci. 2019;18(2):117–126.
  • Xu L, Shen J, Yu L, et al. Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells. Brain Res Bull. 2018;140:291–298.