3,107
Views
9
CrossRef citations to date
0
Altmetric
Research Paper

A signature of 13 autophagy‑related gene pairs predicts prognosis in hepatocellular carcinoma

ORCID Icon, , , &
Pages 697-707 | Received 16 Nov 2020, Accepted 19 Jan 2021, Published online: 23 Feb 2021

References

  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
  • Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86.
  • Raoul JL, Forner A, Bolondi L, et al. Updated use of TACE for hepatocellular carcinoma treatment: how and when to use it based on clinical evidence. Cancer Treat Rev. 2019;72:28–36.
  • Liu CY, Chen KF, Chen PJ. Treatment of Liver Cancer. Cold Spring Harb Perspect Med. 2015;5:a021535.
  • Li X, Xu W, Kang W, et al. Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features. Theranostics. 2018;8:1740–1751.
  • Gu JX, Zhang X, Miao RC, et al. Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma. World J Gastroenterol. 2019;25:220–232.
  • Chen PF, Li QH, Zeng LR, et al. A 4-gene prognostic signature predicting survival in hepatocellular carcinoma. J Cell Biochem. 2019;120:9117–9124.
  • Zhu CQ, Tsao MS. Prognostic markers in lung cancer: is it ready for prime time? Transl Lung Cancer Res. 2014;3:149–158.
  • Goh WWB, Wang W, Wong L. Why batch effects matter in omics data, and how to avoid them. Trends Biotechnol. 2017;35:498–507.
  • Wu J, Zhao Y, Zhang J, et al. Development and validation of an immune-related gene pairs signature in colorectal cancer. Oncoimmunology. 2019;8:1596715.
  • Li B, Cui Y, Diehn M, et al. Development and validation of an individualized immune prognostic signature in early-stage nonsquamous non-small cell lung cancer. JAMA Oncol. 2017;3:1529–1537.
  • Wilde L, Tanson K, Curry J, et al. Autophagy in cancer: a complex relationship. Biochem J. 2018;475:1939–1954.
  • Yang Q, Wang R, Zhu L. Chaperone-mediated autophagy. Adv Exp Med Biol. 2019;1206:435–452.
  • Zhu XJ, Jin X, Dai L, et al. ATG4 promotes cell proliferation, migration and invasion in HCC and predicts a poor prognosis. Eur Rev Med Pharmacol Sci. 2020;24:12686–12693.
  • Gerada C, Ryan KM. Autophagy, the innate immune response and cancer. Mol Oncol. 2020;14:1913–1929.
  • Tomczak K, Czerwinska P, Wiznerowicz M. The cancer genome atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol (Pozn). 2015;19:A68–77.
  • Zhang J, Bajari R, Andric D, et al. The international cancer genome consortium data portal. Nat Biotechnol. 2019;37:367–369.
  • Wang NN, Dong J, Zhang L, et al. HAMdb: a database of human autophagy modulators with specific pathway and disease information. J Cheminform. 2018;10:34.
  • Guinney J, Dienstmann R, Wang X, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21:1350–1356.
  • Friedman J, Hastie T, Tibshirani R. Regularization paths for generalized linear models via coordinate descent. J Stat Softw. 2010;33:1–22.
  • Zhao E, Zhou C, Chen S. A signature of 14 immune-related gene pairs predicts overall survival in gastric cancer. Clin Transl Oncol. 2020. DOI:10.1007/s12094-020-02414-7
  • Kamarudin AN, Cox T, Kolamunnage-Dona R. Time-dependent ROC curve analysis in medical research: current methods and applications. BMC Med Res Methodol. 2017;17:53.
  • Liberzon A. A description of the molecular signatures database (MSigDB) web site. Methods Mol Biol. 2014;1150:153–160.
  • Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12:453–457.
  • Rebouissou S, Nault JC. Advances in molecular classification and precision oncology in hepatocellular carcinoma. J Hepatol. 2020;72:215–229.
  • Banaudha KK, Verma M. Epigenetic biomarkers in liver cancer. Methods Mol Biol. 2015;1238:65–76.
  • Liu GM, Zeng HD, Zhang CY, et al. Identification of a six-gene signature predicting overall survival for hepatocellular carcinoma. Cancer Cell Int. 2019;19:138.
  • Cancer Genome Atlas Research Network. Electronic address wbe, cancer genome atlas research N. Comprehensive and integrative genomic characterization of hepatocellular carcinoma. Cell. 2017;169:1327–41e23.
  • Schulze K, Imbeaud S, Letouze E, et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 2015;47:505–511.
  • Schneider JL, Cuervo AM. Liver autophagy: much more than just taking out the trash. Nat Rev Gastroenterol Hepatol. 2014;11:187–200.
  • Sun XY, Yu SZ, Zhang HP, et al. A signature of 33 immune-related gene pairs predicts clinical outcome in hepatocellular carcinoma. Cancer Med. 2020;9:2868–2878.
  • Guo XL, Hu F, Zhang SS, et al. Inhibition of p53 increases chemosensitivity to 5-FU in nutrient-deprived hepatocarcinoma cells by suppressing autophagy. Cancer Lett. 2014;346:278–284.
  • Yin Z, Xu W, Xu H, et al. Overexpression of HDAC6 suppresses tumor cell proliferation and metastasis by inhibition of the canonical Wnt/beta-catenin signaling pathway in hepatocellular carcinoma. Oncol Lett. 2018;16:7082–7090.
  • Germic N, Frangez Z, Yousefi S, et al. Regulation of the innate immune system by autophagy: neutrophils, eosinophils, mast cells, NK cells. Cell Death Differ. 2019;26:703–714.
  • Tano T, Okamoto M, Kan S, et al. Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma. Neoplasia. 2013;15:305–314.
  • Kondo Y, Kimura O, Tanaka Y, et al. Differential expression of CX3CL1 in Hepatitis B virus-replicating hepatoma cells can affect the migration activity of CX3CR1+ immune cells. J Virol. 2015;89:7016–7027.