Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway

References

• Molitch ME, DeFronzo RA, Franz MJ, et al. Nephropathy in diabetes. Diabetes Care. 2004;27:S79.
   PubMed Web of Science ®Google Scholar
• Collins AJ, Foley RN, Chavers B, et al. US renal data system 2013 annual data report. Am J Kidney Dis. 2014;63(1):A7.
   PubMed Web of Science ®Google Scholar
• Soldatos G, Cooper M. Diabetic nephropathy: important pathophysiologic mechanisms. Diabetes Res Clin Pract. 2008;82:S75–S79.
   PubMed Web of Science ®Google Scholar
• Remuzzi G, Schieppati A, Ruggenenti P. Nephropathy in patients with type 2 diabetes. N Engl J Med. 2002;346(15):1145–1151.
   PubMed Web of Science ®Google Scholar
• Park CW. Diabetic kidney disease: from epidemiology to clinical perspectives. Diabetes Metab J. 2014;38(4):252–260.
   PubMedGoogle Scholar
• Jefferson JA, Shankland SJ, Pichler RH. Proteinuria in diabetic kidney disease: a mechanistic viewpoint. Kidney Int. 2008;74(1):22–36.
   PubMed Web of Science ®Google Scholar
• Campbell KN, Wong JS, Gupta R, et al. Yes-associated protein (YAP) promotes cell survival by inhibiting proapoptotic dendrin signaling. J Biol Chem. 2013;288(24):17057–17062.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang L, Shi W, et al. Spironolactone inhibits podocyte motility via decreasing integrin β1 and increasing integrin β3 in podocytes under high-glucose conditions. Mol Med Rep. 2015;12(5):6849–6854.
   PubMed Web of Science ®Google Scholar
• Wu X, Wang J, Jiang H, et al. Wnt3a activates β1-integrin and regulates migration and adhesion of vascular smooth muscle cells. Mol Med Rep. 2014;9(4):1159–1164.
   PubMed Web of Science ®Google Scholar
• Zaidel-Bar R, Itzkovitz S, Ma’ayan A, et al. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007;9(8):858–867.
   PubMed Web of Science ®Google Scholar
• Kitsiou PV, Tzinia AK, Stetler-Stevenson WG, et al. Glucose-induced changes in integrins and matrix-related functions in cultured human glomerular epithelial cells. Am J Physiol Renal Physiol. 2003;284(4):F671–679.
   PubMed Web of Science ®Google Scholar
• Dai C, Stolz DB, Bastacky SI, et al. Essential role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diaphragm signaling. J Am Soc Nephrol. 2006;17(8):2164–2175.
   PubMed Web of Science ®Google Scholar
• Wei C, Möller CC, Altintas MM, et al. Modification of kidney barrier function by the urokinase receptor. Nat Med. 2008;14(1):55–63.
   PubMed Web of Science ®Google Scholar
• Wei C, El Hindi S, Li J, et al. Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis. Nat Med. 2011;17(8):952–960.
   PubMed Web of Science ®Google Scholar
• Huang J, Wu S, Barrera J, et al. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell. 2005;122(3):421–434.
   PubMed Web of Science ®Google Scholar
• Pan D. The hippo signaling pathway in development and cancer. Dev Cell. 2010;19(4):491–505.
   PubMed Web of Science ®Google Scholar
• Schwartzman M, Reginensi A, Wong JS, et al. Podocyte-specific deletion of Yes-associated protein causes FSGS and progressive renal failure. J Am Soc Nephrol. 2016;27(1):216–226.
   PubMed Web of Science ®Google Scholar
• Pavenstädt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev. 2003;83(1):253–307.
   PubMed Web of Science ®Google Scholar
• Scott RP, Hawley SP, Ruston J, et al. Podocyte-specific loss of Cdc42 leads to congenital nephropathy. J Am Soc Nephrol. 2012;23(7):1149–1154.
   PubMed Web of Science ®Google Scholar
• Susztak K, Raff AC, Schiffer M, et al. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 2006;55(1):225–233.
   PubMed Web of Science ®Google Scholar
• Marshall CB, Krofft RD, Pippin JW, et al. CDK inhibitor p21 is prosurvival in adriamycin-induced podocyte injury, in vitro and in vivo. Am J Physiol Renal Physiol. 2010;298(5):F1140–1151.
   PubMed Web of Science ®Google Scholar
• Kistler AD, Altintas MM, Reiser J. Podocyte GTPases regulate kidney filter dynamics. Kidney Int. 2012;81(11):1053–1055.
   PubMed Web of Science ®Google Scholar
• Wang L, Luo JY, Li B, et al. Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow. Nature. 2016;540(7634):579–582.
   PubMed Web of Science ®Google Scholar
• Buvall L, Rashmi P, Lopez-Rivera E, et al. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nat Commun. 2013;4(1):2863.
   PubMed Web of Science ®Google Scholar
• Huang Z, Zhang L, Chen Y, et al. RhoA deficiency disrupts podocyte cytoskeleton and induces podocyte apoptosis by inhibiting YAP/dendrin signal. BMC Nephrol. 2016;17(1):66.
   PubMed Web of Science ®Google Scholar
• Ritz E, Rychlík I, Locatelli F, et al. End-stage renal failure in type 2 diabetes: a medical catastrophe of worldwide dimensions. Am J Kidney Dis. 1999;34(5):795–808.
   PubMed Web of Science ®Google Scholar
• Wolf G, Chen S, Ziyadeh FN. From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy. Diabetes. 2005;54(6):1626–1634.
   PubMed Web of Science ®Google Scholar
• Zhang L, Li R, Shi W, et al. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013;170(2):426–439.
   PubMed Web of Science ®Google Scholar
• Pagtalunan ME, Miller PL, Jumping-Eagle S, et al. Podocyte loss and progressive glomerular injury in type II diabetes. J Clin Invest. 1997;99(2):342–348.
   PubMed Web of Science ®Google Scholar
• White KE, Bilous RW, Marshall SM, et al. Podocyte number in normotensive type 1 diabetic patients with albuminuria. Diabetes. 2002;51(10):3083–3089.
   PubMed Web of Science ®Google Scholar
• Zhang B, Xie S, Shi W, et al. Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. Nephrol Dial Transplant. 2012;27(5):1746–1755.
   PubMed Web of Science ®Google Scholar
• Asanuma K, Yanagida-Asanuma E, Faul C, et al. Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling. Nat Cell Biol. 2006;8(5):485–491.
   PubMed Web of Science ®Google Scholar
• Yanagida-Asanuma E, Asanuma K, Kim K, et al. Synaptopodin protects against proteinuria by disrupting Cdc42: iRSp53: mena signaling complexes in kidney podocytes. Am J Pathol. 2007;171(2):415–427.
   PubMed Web of Science ®Google Scholar
• Mundel P, Reiser J. Proteinuria: an enzymatic disease of the podocyte? Kidney Int. 2010;77(7):571–580.
   PubMed Web of Science ®Google Scholar
• Sinha S, Yang W. Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal. 2008;20(11):1927–1934.
   PubMed Web of Science ®Google Scholar
• Dupont S, Morsut L, Aragona M, et al. Role of YAP/TAZ in mechanotransduction. Nature. 2011;474(7350):179–183.
   PubMed Web of Science ®Google Scholar
• Reginensi A, Scott RP, Gregorieff A, et al. Yap-and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013;9(3):e1003380.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Xia H, Ge X, et al. CD44 acts through RhoA to regulate YAP signaling. Cell Signal. 2014;26(11):2504–2513.
   PubMed Web of Science ®Google Scholar
• Carlier M-F, Ducruix A, Pantaloni D. Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection. Chem Biol. 1999;6(9):R235–R240.
   PubMedGoogle Scholar