Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest

References

• Arbyn M, Weiderpass E, Bruni L, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. Lancet Glob Health. 2020;8(2):e191–191e203.
   PubMed Web of Science ®Google Scholar
• Li W, Liu P, Zhao W, et al. Effects of preoperative radiotherapy or chemoradiotherapy on postoperative pathological outcome of cervical cancer–from the large database of 46,313 cases of cervical cancer in China. Eur J Surg Oncol. 2020;46(1):148–154.
   PubMed Web of Science ®Google Scholar
• Jiang C, Zhao QQ, Gao Q, et al. Diagnostic potential of ionomic profile in the plasma of cervical cancer patients receiving neoadjuvant chemoradiotherapy. J Trace Elem Med Biol. 2020;57:68–74.
   PubMed Web of Science ®Google Scholar
• Pedone Anchora L, Turco LC, Bizzarri N, et al. How to select early-stage cervical cancer patients still suitable for laparoscopic radical hysterectomy: a propensity-matched study. Ann Surg Oncol. 2020;27(6):1947–1955.
   PubMed Web of Science ®Google Scholar
• Mérida I, Torres-Ayuso P, Ávila-Flores A, et al. Diacylglycerol kinases in cancer. Adv Biol Regul. 2017;63:22–31.
   PubMedGoogle Scholar
• Riese MJ, Moon EK, Johnson BD, et al. Diacylglycerol kinases (DGKs): novel targets for improving T cell activity in cancer. Front Cell Dev Biol. 2016;4:108.
   PubMed Web of Science ®Google Scholar
• Yamaki A, Akiyama R, Murakami C, et al. Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines. J Cell Biochem. 2019;120(6):10043–10056.
   PubMed Web of Science ®Google Scholar
• Guo Z, Jia J, Yao M, et al. Diacylglycerol kinase γ predicts prognosis and functions as a tumor suppressor by negatively regulating glucose transporter 1 in hepatocellular carcinoma. Exp Cell Res. 2018;373(1–2):211–220.
   PubMed Web of Science ®Google Scholar
• Li H, Dong C, Tian Y, et al. Knockdown of diacylglycerol kinase zeta (DGKZ) induces apoptosis and G2/M phase arrest in human acute myeloid leukemia HL-60 cells through MAPK/survivin/caspase pathway. Pharmazie. 2019;74(7):418–422.
   PubMed Web of Science ®Google Scholar
• Yu W, Tang L, Lin F, et al. DGKZ acts as a potential oncogene in osteosarcoma proliferation through its possible interaction with ERK1/2 and MYC pathway. Front Oncol. 2018;8:655.
   PubMed Web of Science ®Google Scholar
• Torres-Ayuso P, Tello-Lafoz M, Mérida I, et al. Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1. Oncogenesis. 2015;4:e164.
   PubMed Web of Science ®Google Scholar
• Huang Da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.
   PubMed Web of Science ®Google Scholar
• Huang Da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 2009;37(1):1–13.
   PubMed Web of Science ®Google Scholar
• Dong S, Wang R, Wang H, et al. HOXD-AS1 promotes the epithelial to mesenchymal transition of ovarian cancer cells by regulating miR-186-5p and PIK3R3. J Exp Clin Cancer Res. 2019;38(1):110.
   PubMedGoogle Scholar
• Gao W, Hu Y, Zhang Z, et al. Knockdown of EIF3C promotes human U-2OS cells apoptosis through increased CASP3/7 and Chk1/2 by upregulating SAPK/JNK. Onco Targets Ther. 2019;12:1225–1235.
   PubMed Web of Science ®Google Scholar
• Diao J, Wu C, Zhang J, et al. Loss of diacylglycerol kinase-Ζ inhibits cell proliferation and survival in human gliomas. Mol Neurobiol. 2016;53(8):5425–5435.
   PubMed Web of Science ®Google Scholar
• Topham MK, Bunting M, Zimmerman GA, et al. Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. Nature. 1998;394(6694):697–700.
   PubMed Web of Science ®Google Scholar
• Li Y, Luo X, Guo Q, et al. Discovery of N1-(4-((7-cyclopentyl-6-(dimethylcarbamoyl)-7 H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)phenyl)- N8-hydroxyoctanediamide as a novel inhibitor targeting cyclin-dependent kinase 4/9 (CDK4/9) and histone deacetlyase1 (HDAC1) against malignant cancer. J Med Chem. 2018;61(7):3166–3192.
   PubMed Web of Science ®Google Scholar
• Li Y, Dida F, Iwao A, et al. Cell cycle dependency of caspase activation in Fas-induced apoptosis in leukemia cells. Cancer Sci. 2007;98(8):1174–1183.
   PubMed Web of Science ®Google Scholar
• Liu Z, Ren B, Wang Y, et al. Sesamol induces human hepatocellular carcinoma cells apoptosis by impairing mitochondrial function and suppressing autophagy. Sci Rep. 2017;7:45728.
   PubMed Web of Science ®Google Scholar
• Wang H, Wang F, Wu S, et al. Traditional herbal medicine-derived sulforaphene promotes mitophagic cell death in lymphoma cells through CRM1-mediated p62/SQSTM1 accumulation and AMPK activation. Chem Biol Interact. 2018;281:11–23.
   PubMed Web of Science ®Google Scholar
• Maranhão SS, Moura AF, Oliveira A, et al. Synthesis of PJOV56, a new quinoxalinyl-hydrazone derivative able to induce autophagy and apoptosis in colorectal cancer cells, and related compounds. Bioorg Med Chem Lett. 2020;30(2):126851.
   PubMed Web of Science ®Google Scholar
• Ammoun S, Schmid MC, Zhou L, et al. The p53/mouse double minute 2 homolog complex deregulation in merlin-deficient tumours. Mol Oncol. 2015;9(1):236–248.
   PubMed Web of Science ®Google Scholar
• Ghorbani A, Jeddi-Tehrani M, Saidpour A, et al. PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in human pre-B NALM-6 cells. Arch Biochem Biophys. 2015;566:58–66.
   PubMed Web of Science ®Google Scholar
• Trivedi R, Maurya R, Mishra DP. Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway. Cell Death Dis. 2014;5:e1465.
   PubMed Web of Science ®Google Scholar
• Malki A, El Ashry El S. Quinuclidinone derivative 6 induced apoptosis in human breast cancer cells via sphingomyelinase and JNK signaling. J Chemother. 2012;24(5):268–278.
   PubMed Web of Science ®Google Scholar
• Hu Z, Tao YG, Yang LF, et al. [Effect of JIP on the proliferation and apoptosis of nasopharyngeal carcinoma cells]. Ai Zheng. 2002;21(11):1182–1186.
   PubMedGoogle Scholar
• Amin AH, El-Missiry MA, Othman AI, et al. Ameliorative effects of melatonin against solid Ehrlich carcinoma progression in female mice. J Pineal Res. 2019;67(2):e12585.
   PubMed Web of Science ®Google Scholar
• Lindner AU, Lucantoni F, Varešlija D, et al. Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers. J Mol Med (Berl). 2018;96(10):1025–1037.
   PubMed Web of Science ®Google Scholar
• Xie C, Zhang LZ, Chen ZL, et al. A hMTR4-PDIA3P1-miR-125/124-TRAF6 regulatory axis and its function in NF kappa B signaling and chemoresistance. Hepatology. 2020;71(5):1660–1677.
   PubMed Web of Science ®Google Scholar
• Stuhldreier F, Kassel S, Schumacher L, et al. Pleiotropic effects of spongean alkaloids on mechanisms of cell death, cell cycle progression and DNA damage response (DDR) of acute myeloid leukemia (AML) cells. Cancer Lett. 2015;361(1):39–48.
   PubMed Web of Science ®Google Scholar
• Oya E, Ovrevik J, Arlt VM, et al. DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. Mutagenesis. 2011;26(6):697–708.
   PubMed Web of Science ®Google Scholar
• Zhang M, Zhang H, Yu Y, et al. Synergistic effects of a novel lipid-soluble extract from Pinellia pedatisecta Schott and cisplatin on human cervical carcinoma cell lines through the regulation of DNA damage response signaling pathway. Oncol Lett. 2017;13(4):2121–2128.
   PubMed Web of Science ®Google Scholar
• Mori N, Wildes F, Kakkad S, et al. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015;28(12):1697–1706.
   PubMed Web of Science ®Google Scholar
• Chen X, Wang J, Gao X, et al. Tauroursodeoxycholic acid prevents ER stress-induced apoptosis and improves cerebral and vascular function in mice subjected to subarachnoid hemorrhage. Brain Res. 2020;1727:146566.
   PubMed Web of Science ®Google Scholar
• Freudlsperger C, Bian Y, Contag Wise S, et al. TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers. Oncogene. 2013;32(12):1549–1559.
   PubMed Web of Science ®Google Scholar
• Chen X, Duan N, Zhang C, et al. Survivin and tumorigenesis: molecular mechanisms and therapeutic strategies. J Cancer. 2016;7(3):314–323.
   PubMed Web of Science ®Google Scholar
• Rubio N, Garcia-Segura LM, Arevalo MA. Survivin prevents apoptosis by binding to caspase-3 in astrocytes infected with the BeAn strain of Theiler’s murine encephalomyelitis virus. J Neurovirol. 2012;18(5):354–363.
   PubMed Web of Science ®Google Scholar