Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis

References

• Miletta NR Donelan MB and Hivnor CM. Management of trauma and burn scars: the dermatologist’s role in expanding patient access to care. Cutis. 2017;100(1):18–20.
   PubMed Web of Science ®Google Scholar
• Van Der Veer WM, Bloemen MC, Ulrich MM, et al. Potential cellular and molecular causes of hypertrophic scar formation. Burns. 2009;35(1):15–29.
   PubMed Web of Science ®Google Scholar
• Zhang J, Li Y, Bai X, Shi J and Hu D et al. Recent advances in hypertrophic scar. Histol Histopathol. 2018;33(1):27–39.
   PubMed Web of Science ®Google Scholar
• Tang M, Wang W, Cheng L, et al. The inhibitory effects of 20(R)-ginsenoside Rg3 on the proliferation, angiogenesis, and collagen synthesis of hypertrophic scar derived fibroblasts in vitro. Iran J Basic Med Sci. 2018;21(3):309–317.
   PubMed Web of Science ®Google Scholar
• Liang X, Chai B, Duan R, Huang X and Li Q et al. Inhibition of FKBP10 attenuates hypertrophic scarring through suppressing fibroblast activity and extracellular matrix deposition. J Invest Dermatol. 2017;137(11):2326–2335.
   PubMed Web of Science ®Google Scholar
• Berman B. Maderal A and Raphael B: keloids and c Scars: Pathophysiology, Classification, and Treatment. Dermatol Surg. 2017;43(Suppl 1):S3–S18.
   PubMedGoogle Scholar
• Sidgwick GP, Bayat A. Extracellular matrix molecules implicated in hypertrophic and keloid scarring. J Eur Acad Dermatol Venereol. 2012;26(2):141–152.
   PubMed Web of Science ®Google Scholar
• Wang ZSong Q and Li H. Suppressive effects of human fetal keratinocytes on the proliferation, differentiation and extracellular matrix synthesis of human hypertrophic scar fibroblasts in vitro. Mol Med Rep. 2017;16(4):5377–5385.
   PubMed Web of Science ®Google Scholar
• Shi WWu Y and Bian D. P75NTR silencing inhibits proliferation, migration, and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting the PI3K/Akt/mTOR pathway. Can J Physiol Pharmacol. 2021;99(4):349–359.
   PubMed Web of Science ®Google Scholar
• Nong QW, Li ST, Wu YJ, et al. LncRNA COL1A2-AS1 inhibits the scar fibroblasts proliferation via regulating miR-21/Smad7 pathway. Biochem Biophys Res Commun. 2018;495(1):319–324.
   PubMed Web of Science ®Google Scholar
• Quinn JJ, Chang HY. Unique features of long non-coding RNA biogenesis and function. Nat Rev Genet. 2016;17(1):47–62.
   PubMed Web of Science ®Google Scholar
• Zhou X, Zhang W, Jin MC, et al. lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy. Cell Death Dis. 2017;8(7):8.
   Google Scholar
• Li WNotani D and Rosenfeld MG. Enhancers as non-coding RNA transcription units: recent insights and future perspectives. Nat Rev Genet. 2016;17(4):207–223.
   PubMed Web of Science ®Google Scholar
• Chen L, Li JY, Li Q, et al. Overexpression of LncRNA AC067945.2 down-regulates collagen expression in skin fibroblasts and possibly correlates with the VEGF and wnt signalling pathways. Cell Physiol Biochem. 2018;45(2):761–771.
   PubMedGoogle Scholar
• Ke D, Li HW, Zhang Y, et al. The combination of circulating long noncoding RNAs AK001058, INHBA-AS1, MIR4435-2HG, and CEBPA-AS1 fragments in plasma serve as diagnostic markers for gastric cancer. Oncotarget. 2017;8(13):21516–21525.
   PubMed Web of Science ®Google Scholar
• Lin H, Hong YG, Zhou JD, et al. LncRNA INHBA-AS1 promotes colorectal cancer cell proliferation by sponging miR-422a to increase AKT1 axis. Eur Rev Med Pharmacol Sci. 2020;24(19):9940–9948.
   PubMed Web of Science ®Google Scholar
• Ma WQ, Chen J, Fang W, et al. LncRNA INHBA-AS1 promotes cell growth, migration, and invasion of oral squamous cell carcinoma by sponging miR-143-3p. Eur Rev Med Pharmacol Sci. 2020;24(4):1821–1828.
   PubMed Web of Science ®Google Scholar
• Li M, Wang J, Liu D, et al. Highthroughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars. Mol Med Rep. 2018;18(6):5669–5682.
   PubMed Web of Science ®Google Scholar
• Shi Y, Wang L, Yu P, et al. MicroRNA4865p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression. Mol Med Rep. 2019;19(6):5203–5210.
   PubMed Web of Science ®Google Scholar
• Shi W, Wu Y, Bian D. p75NTR silencing inhibits proliferation, migration and extracellular matrix deposition of hypertrophic scar fibroblasts by activating autophagy through inhibiting PI3K/Akt/mTOR pathway. Can J Physiol Pharmacol. 2020;99(4):349–359.
   PubMed Web of Science ®Google Scholar
• Xie S, Yu X, Li Y, et al. Upregulation of lncRNA ADAMTS9-AS2 promotes salivary adenoid cystic carcinoma metastasis via PI3K/Akt and MEK/Erk Signaling. Mol Ther. 2018;26(12):2766–2778.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Zhao D, Wang Y, Du C, et al. Honokiol alleviates hypertrophic scar by targeting transforming growth Factor-beta/Smad2/3 signaling pathway. Front Pharmacol. 2017;8:206.
   PubMed Web of Science ®Google Scholar
• Tu L, Huang Q, Fu S, et al. Aberrantly expressed long noncoding RNAs in hypertrophic scar fibroblasts in vitro: a microarray study. Int J Mol Med. 2018;41(4):1917–1930.
   PubMed Web of Science ®Google Scholar
• Tang R, Wang YC, Mei XH, et al. LncRNA GAS5 attenuates fibroblast activation through inhibiting Smad3 signaling. Am. J. Physiol.-Cell Physiol. 2020;319(1):C105–C115.
   PubMed Web of Science ®Google Scholar
• Liu XH, Sun M, Nie FQ, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer. 2014;13(1):92.
   PubMed Web of Science ®Google Scholar
• Chen P, Zhao X, Wang H, et al. The down-regulation of lncRNA PCAT18 promotes the progression of gastric cancer via MiR-107/PTEN/PI3K/AKT signaling pathway. Onco Targets Ther. 2019;12:11017–11031.
   PubMed Web of Science ®Google Scholar
• Tang Y, Hu J, Zhong ZY, et al. Long noncoding RNA TUG1 Promotes the Function in ox-LDL-Treated HA-VSMCs via miR-141-3p/ROR2 Axis. Cardiovasc Ther. 2020;12:2020.
   Google Scholar
• Jiang X, Ru Q, Li P, et al. LncRNA SNHG16 induces proliferation and fibrogenesis via modulating miR-141-3p and CCND1 in diabetic nephropathy. Gene Ther. 2020;27(12):557–566.
   PubMed Web of Science ®Google Scholar
• Feng JJ, Xue SL, Pang QY, et al. miR-141-3p inhibits fibroblast proliferation and migration by targeting GAB1 in keloids. Biochem Biophys Res Commun. 2017;490(2):302–308.
   PubMed Web of Science ®Google Scholar
• Gras C, Ratuszny D, Hadamitzky C, et al. miR-145 contributes to hypertrophic scarring of the skin by inducing myofibroblast activity. Mol Med. 2015;21(1):296–304.
   PubMedGoogle Scholar
• Volk SW, Wang Y, Mauldin EALiechty KW and Adams SL. Diminished type III collagen promotes myofibroblast differentiation and increases scar deposition in cutaneous wound healing. Cells Tissues Organs. 2011;194(1):25–37.
   PubMed Web of Science ®Google Scholar
• Satish L, Gallo PH, Baratz MEJohnson S and Kathju S. Reversal of TGF-beta1 stimulation of alpha-smooth muscle actin and extracellular matrix components by cyclic AMP in dupuytren’s-derived fibroblasts. BMC Musculoskelet Disord. 2011;12(1):113.
   PubMedGoogle Scholar
• Zhou R, Zhang Q, Zhang Y, et al. Aberrant miR-21 and miR-200b expression and its pro-fibrotic potential in hypertrophic scars. Exp Cell Res. 2015;339(2):360–366.
   PubMed Web of Science ®Google Scholar
• Mukherjee N, Skees J, Todd KJ, et al. MCL1 inhibitors S63845/MIK665 plus navitoclax synergistically kill difficult-to-treat melanoma cells. Cell Death Dis. 2020;11(6):14.
   PubMed Web of Science ®Google Scholar
• Jimbo H, Nagai H, Fujiwara S. Shimoura N and nishigori C: fas-FasL interaction in cytotoxic T cell-mediated vitiligo: the role of lesional expression of tumor necrosis factor-alpha and interferon-gamma in Fas-mediated melanocyte apoptosis. Exp Dermatol. 2020;29(1):61–70.
   PubMed Web of Science ®Google Scholar
• Wu WY, Zhang LT, Zheng ZF, et al. [Expression and significance of mRNA and protein of eIF4E, p-eIF4E and MCl-1 in pathological scar]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2012;28(5):360–365.
   PubMedGoogle Scholar