1,665
Views
6
CrossRef citations to date
0
Altmetric
Research Paper

δ-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis

, , &
Pages 1861-1873 | Received 08 Feb 2021, Accepted 23 Apr 2021, Published online: 18 May 2021

References

  • Benny PA, Alakwaa FM, Schlueter RJ, et al. A review of omics approaches to study preeclampsia. Placenta. 2020;92:17–27.
  • Jeyabalan A. Epidemiology of preeclampsia: impact of obesity. Nutr Rev. 2013;71(SUPPL1). DOI:10.1111/nure.12055
  • Rahnemaei FA, Fashami MA, Abdi F, et al. Factors effective in the prevention of preeclampsia: asystematic review. Taiwan J Obstet Gynecol. 2020;59(2):173–182.
  • Jena MK, Sharma NR, Petitt M, et al. Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules. 2020;10(6):1–28.
  • Huppertz B. Traditional and new routes of trophoblast invasion and their implications for pregnancy diseases. Int J Mol Sci. 2020;21(1). DOI:10.3390/ijms21010289
  • Geusens N, Hering L, Verlohren S, et al. Changes in endovascular trophoblast invasion and spiral artery remodelling at term in a transgenic preeclamptic rat model. Placenta. 2010;31(4):320–326.
  • Yusuf AM, Kahane A, Ray JG. First and second trimester serum sFlt-1/PlGF ratio and subsequent preeclampsia: a systematic review. J Obstet Gynaecol Canada. 2018;40(5):618–626.
  • Ives CW, Sinkey R, Rajapreyar I, et al. Preeclampsia—pathophysiology and clinical presentations: JACC state-of-the-art review. J Am Coll Cardiol. 2020;76(14):1690–1702.
  • Kharb S. Vitamin E and C in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2000;93(1):37–39.
  • Taravati A, Tohidi F. Comprehensive analysis of oxidative stress markers and antioxidants status in preeclampsia. Taiwan J Obstet Gynecol. 2018;57(6):779–790.
  • Chiarello DI,  Abad C, Rojas D, et al. Oxidative stress: normal pregnancy versus preeclampsia. Vol. 1866. Elsevier B.V; 2020; 1866(2):165354.
  • Fu ZM, Ma ZZ, Liu GJ, et al. Vitamins supplementation affects the onset of preeclampsia. J Formos Med Assoc. 2018;117(1):6–13.
  • Tenório MB, Ferreira RC, Moura FA, et al. Oral antioxidant therapy for prevention and treatment of preeclampsia: meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2018;28(9):865–876.
  • Wilson RL, Gummow JA, McAninch D, et al. Vitamin and mineral supplementation in pregnancy: evidence to practice. J Pharm Pract Res. 2018;48(2):186–192.
  • Guan Z, Li HF, Guo LL, et al. Effects of vitamin C, vitamin E, and molecular hydrogen on the placental function in trophoblast cells. Arch Gynecol Obstet. 2015;292(2):337–342.
  • Park HA, Kubicki N, Gnyawali S, et al. Natural vitamin e α-tocotrienol protects against ischemic stroke by induction of multidrug resistance-associated protein 1. Stroke. 2011;42(8):2308–2314.
  • Idriss M, Hodroj MH, Fakhoury R, et al. Beta-tocotrienol exhibits more cytotoxic effects than gamma-tocotrienol on breast cancer cells by promoting apoptosis via a P53-independent PI3- kinase dependent pathway. Biomolecules. 2020;10(4):1–19.
  • Husain K, Francois RA, Yamauchi T, et al. Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancer. Mol Cancer Ther. 2011;10(12):2363–2372.
  • Husain K, Centeno BA, Coppola D, et al. δ-Tocotrienol, a natural form of vitamin E, inhibits pancreatic cancer stem-like cells and prevents pancreatic cancer metastasis. Oncotarget. 2017;8(19):31554–31567.
  • Pinto BI, Cruz ND, Lujan OR, et al. In vitro scratch assay to demonstrate effects of arsenic on skin cell migration. J Vis Exp. 2019;144:1–11. DOI:10.3791/58838
  • Justus CR, Leffler N, Ruiz-Echevarria M, et al. In vitro cell migration and invasion assays. J Vis Exp. 2014;88:1–8. DOI:10.3791/51046
  • Francescone RA, Faibish M, Shao R. A matrigel-based tube formation assay to assess the vasculogenic activity of tumor cells. J Vis Exp. 2011;55:1–4. DOI:10.3791/3040
  • Wang C, Ju H, Shen C, et al. miR-429 mediates δ-tocotrienol-induced apoptosis in triple-negative breast cancer cells by targeting XIAP. Int J Clin Exp Med. 2015;8(9):15648–15656.
  • Miller Iii ER, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality background: experimental models and observational studies. Ann Intern Med. 2005;142(1):37–46.
  • Rumbold A, Ota E, Hori H, et al. Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev. 2016;3:2015.
  • Fontana F, Moretti RM, Raimondi M, et al. δ-Tocotrienol induces apoptosis, involving endoplasmic reticulum stress and autophagy, and paraptosis in prostate cancer cells. Cell Prolif. 2019;52(3):1–15.
  • Wada S, Naito Y, Matsushita Y, et al. δ-Tocotrienol suppresses tumorigenesis by inducing apoptosis and blocking the COX-2/PGE2 pathway that stimulates tumor–stromal interactions in colon cancer. J Funct Foods. 2017;35:428–435.
  • Zhang P. Decidual vasculopathy and spiral artery remodeling revisited II: relations to trophoblastic dependent and independent vascular transformation. J Matern Neonatal Med. 2020;1–7. DOI:10.1080/14767058.2020.1718646
  • Zambuto SG, Clancy KBH, Harley BAC, A gelatin hydrogel to study endometrial angiogenesis and trophoblast invasion. bioRxiv, 2019, doi: 10.1101/548024.
  • Staff AC. The two-stage placental model of preeclampsia: an update. J Reprod Immunol. 2019;134–135(July):1–10.
  • Davies JE, Pollheimer J, Yong HE, et al. Epithelial-mesenchymal transition during extravillous trophoblast differentiation. Cell Adhes Migr. 2016;10(3):310–321.
  • Ridder A, Giorgione V, Khalil A, et al. Preeclampsia: the relationship between uterine artery blood flow and trophoblast function. Int J Mol Sci. 2019;20(13). DOI:10.3390/ijms20133263
  • Bin Ye Z, Ma G, Zhao Y-H, et al. MiR-429 inhibits migration and invasion of breast cancer cells in vitro. Int J Oncol. 2015;46(2):531–538.
  • Sun Y, Shen S, Liu X, et al. MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma. Mol Cell Biochem. 2014;390(1–2):19–30.
  • Wang D, Zheng J, Liu X, et al. Knockdown of USF1 inhibits the vasculogenic mimicry of glioma cells via stimulating SNHG16/miR-212-3p and linc00667/miR-429 axis. Mol Ther Nucleic Acids. 2019;14(March):465–482.
  • Morales-Prieto DM, Chaiwangyen W, Ospina-Prieto S, et al. MicroRNA expression profiles of trophoblastic cells. Placenta. 2012;33(9):725–734.
  • Shao Q, Wang Q, Wang J. LncRNA SCAMP1 regulates ZEB1/JUN and autophagy to promote pediatric renal cell carcinoma under oxidative stress via miR-429. Biomed Pharmacother. 2019;120(292):109460.
  • Zou J, Liu L, Wang Q, et al. Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1. Am J Transl Res. 2017;9(3):1357–1368.
  • Li N, Yang T, Yu WQ, et al. The role of Zeb1 in the pathogenesis of morbidly adherent placenta. Mol Med Rep. 2019;20(3):2812–2822.
  • Yang X, Meng T. MicroRNA-431 affects trophoblast migration and invasion by targeting ZEB1 in preeclampsia. Gene. 2019;683:225–232.
  • Gu Y, Zhao Y, Zhou Y, et al. Zeb1 is a potential regulator of Six2 in the proliferation, apoptosis and migration of metanephric mesenchyme cells. Int J Mol Sci. 2016;17(8). DOI:10.3390/ijms17081283
  • Magenta A, Cencioni C, Fasanaro P, et al. MiR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition. Cell Death Differ. 2011;18(10):1628–1639.
  • Liu L, Tong Q, Liu S, et al. ZEB1 upregulates VEGF expression and stimulates angiogenesis in breast cancer. Plos One. 2016;11(2):1–18.
  • Fu R, Lv W-C, Xu Y, et al. Endothelial ZEB1 promotes angiogenesis-dependent bone formation and reverses osteoporosis. Nat Commun. 2020;11(1):1–16.