Advanced search
Publication Cover
Bioengineered Volume 12, 2021 - Issue 1
Submit an article Journal homepage
1,507
Views
4
CrossRef citations to date
0
Altmetric
Research Paper

Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression

Danyan Chena Departments of Endocrinology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, ChinaView further author information
,
Zhaonan Shenb Departments of Nephrology, The Fifth People’s Hospital of Chongqing, ChongqingChinaView further author information
,
Xi Chengc Departments of Science & Education, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, ChinaView further author information
,
Qi Wangd Departments of Laboratory, Chengdu Sixth People’s Hospital, Chengdu, Sichuan ProvinceChinaView further author information
,
Junlin Zhoue Departments of Endocrinology, The First Affiliated Hospital of University of South China, Hengyang, Hunan ProvinceChinaView further author information
,
Fang Renf Departments of Emergency, Chongqing General Hospital, University of Chinese Academy of Sciences, ChongqingChinaView further author information
,
Yue Sung Departments of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, ChongqingChinaView further author information
,
Hongman Wanga Departments of Endocrinology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, ChinaView further author information
&
Rongxi Huanga Departments of Endocrinology, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-0005-8697View further author information
ORCID Icon show all
Pages 1964-1975 | Received 05 Mar 2021, Accepted 27 Apr 2021, Published online: 23 May 2021

References

  • Jain M, Zhang L, He M, et al. TOP2A is overexpressed and is a therapeutic target for adrenocortical carcinoma. Endocr Relat Cancer. 2013;20(3):361–370.
  • Terzolo M, Ardito A, Zaggia B, et al. Management of adjuvant mitotane therapy following resection of adrenal cancer. Endocrine. 2012;42(3):521–525.
  • Else T, Kim AC, Sabolch A, et al. Adrenocortical carcinoma. Endocr Rev. 2014;35:282–326.
  • Rubin B, Pilon C, Pezzani R, et al. The effects of mitotane and 1alpha,25-dihydroxyvitamin D3 on Wnt/beta-catenin signaling in human adrenocortical carcinoma cells. J Endocrinol Invest. 2020;43(3):357–367.
  • DiStefano JK, Davis B. Diagnostic and Prognostic Potential of AKR1B10 in Human Hepatocellular Carcinoma. Cancers (Basel). 2019;11(4):112019.
  • Namba R, Kaneko H, Suzumura A, et al. In vitro epiretinal membrane model and antibody permeability: relationship with anti-VEGF resistance in diabetic macular edema. Invest Ophthalmol Vis Sci. 2019;60(8):2942–2949.
  • He YC, Shen Y, Cao Y, et al. Overexpression of AKR1B10 in nasopharyngeal carcinoma as a potential biomarker. Cancer Biomarkers. 2016;16(1):127–135.
  • Liu W, Song J, Du X, et al. AKR1B10 (Aldo-keto reductase family 1 B10) promotes brain metastasis of lung cancer cells in a multi-organ microfluidic chip model. Acta Biomater. 2019;91:195–208.
  • Yao Y, Wang X, Zhou D, et al. Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway. Aging (Albany NY). 2020;12(13):13059–13075.
  • Yan W, Liu S, Xu E, et al. Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene. 2013;32(5):599–609.
  • Wang H, Wei H, Wang J, et al. MicroRNA-181d-5p-containing exosomes derived from CAFs promote EMT by regulating CDX2/HOXA5 in breast cancer. molecular therapy. Nucleic acids. 2020;19: 654–667.
  • Ordóñez-Morán P, Dafflon C, Imajo M, et al. HOXA5 counteracts stem cell traits by inhibiting wnt signaling in colorectal cancer. Cancer Cell. 2015;28(6):815–829.
  • Gendronneau G, Lemieux M, Morneau M, et al. Influence of Hoxa5 on p53 tumorigenic outcome in mice. Am J Pathol. 2010;176(2):995–1005.
  • Chang CJ, Chen YL, Hsieh CH, et al. HOXA5 and p53 cooperate to suppress lung cancer cell invasion and serve as good prognostic factors in non-small cell lung cancer. J Cancer. 2017;8(6):1071–1081.
  • Aji G, Li F, Chen J, et al. Upregulation of PCP4 in human aldosterone-producing adenomas fosters human adrenocortical tumor cell growth via AKT and AMPK pathway. Int J Clin Exp Pathol. 2018;11(3):1197–1207.
  • Savard S, Amar L, Plouin PF, et al. Cardiovascular complications associated with primary aldosteronism: a controlled cross-sectional study. Hypertension. 2013;62(2):331–336.
  • Mulatero P, Monticone S, Bertello C, et al. Long-term cardio- and cerebrovascular events in patients with primary aldosteronism. J Clin Endocrinol Metab. 2013;98(12):4826–4833.
  • Chou CH, Chen YH, Hung CS, et al. Aldosterone impairs vascular smooth muscle function: from clinical to bench research. J Clin Endocrinol Metab. 2015;100(11):4339–4347.
  • Zennaro MC, Fernandes-Rosa F, Boulkroun S, et al. Bilateral idiopathic adrenal hyperplasia: genetics and beyond. Horm Metab Res. 2015;47(13):947–952.
  • Jouinot A, Armignacco R, Assie G. Genomics of benign adrenocortical tumors. J Steroid Biochem Mol Biol. 2019;193:105414.
  • Kim EM, Jung CH, Kim J, et al. The p53/p21 complex regulates cancer cell invasion and apoptosis by targeting Bcl-2 family proteins. Cancer Res. 2017;77(11):3092–3100.
  • Ohashi T, Idogawa M, Sasaki Y, et al. AKR1B10, a transcriptional target of p53, is downregulated in colorectal cancers associated with poor prognosis. Mol Cancer Res. 2013;11(12):1554–1563.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.