MicroRNA miR-146a-5p inhibits the inflammatory response and injury of airway epithelial cells via targeting TNF receptor-associated factor 6

References

• Wu TD, Brigham EP, McCormack MC. Asthma in the primary care setting. Med Clin North Am. 2019 May;103(3):435–452.
   PubMed Web of Science ®Google Scholar
• Kanagaratham C, Radzioch D. Allergic Asthma: a summary from genetic basis, mouse studies, to diagnosis and treatment. Curr Pharm Des. 2016;22(41):6261–6272.
   PubMed Web of Science ®Google Scholar
• Barnes PJ. Cellular and molecular mechanisms of asthma and COPD. Clin Sci (Lond). 2017 Jul 1;131(13):1541–1558.
   PubMed Web of Science ®Google Scholar
• Hammad H, Lambrecht BN. Barrier epithelial cells and the control of type 2 immunity. Immunity. 2015 Jul 21;43(1):29–40.
   PubMed Web of Science ®Google Scholar
• Hansbro PM, Scott GV, Essilfie AT, et al. Th2 cytokine antagonists: potential treatments for severe asthma. Expert Opin Investig Drugs. 2013 Jan;22(1):49–69.
   PubMed Web of Science ®Google Scholar
• Hansbro PM, Kaiko GE, Foster PS. Cytokine/anti-cytokine therapy - novel treatments for asthma? Br J Pharmacol. 2011 May;163(1):81–95.
   PubMed Web of Science ®Google Scholar
• Moturu TR, Sinha S, Salava H, et al. Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway. Plants (Basel). 2020 Mar 1;9(3):299.
   PubMedGoogle Scholar
• Zhu QD, Zhou QQ, Dong L, et al. MiR-199a-5p inhibits the growth and metastasis of colorectal cancer cells by targeting ROCK1. Technol Cancer Res Treat. 2018 Jan 1;17:1533034618775509.
   Web of Science ®Google Scholar
• Qu C, Liu X, Guo Y, et al. MiR-128-3p inhibits vascular smooth muscle cell proliferation and migration by repressing FOXO4/MMP9 signaling pathway. Mol Med. 2020 Nov 25;26(1):116.
   PubMed Web of Science ®Google Scholar
• Huo X, Zhang K, Yi L, et al. Decreased epithelial and plasma miR-181b-5p expression associates with airway eosinophilic inflammation in asthma. Clin Exp Allergy. 2016 Oct;46(10):1281–1290.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sun E, Li X, et al. miR-155 contributes to Df1-induced asthma by increasing the proliferative response of Th cells via CTLA-4 downregulation. Cell Immunol. 2017 Apr;314:1–9.
   PubMed Web of Science ®Google Scholar
• Fussbroich D, Kohnle C, Schwenger T, et al. A combination of LCPUFAs regulates the expression of miRNA-146a-5p in a murine asthma model and human alveolar cells. Prostaglandins Other Lipid Mediat. 2020 Apr;147:106378.
   PubMed Web of Science ®Google Scholar
• Ishida T, Mizushima S, Azuma S, et al. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J Biol Chem. 1996 Nov 15;271(46):28745–28748.
   PubMed Web of Science ®Google Scholar
• Cao Z, Xiong J, Takeuchi M, et al. TRAF6 is a signal transducer for interleukin-1. Nature. 1996 Oct 3;383(6599):443–446.
   PubMed Web of Science ®Google Scholar
• Han D, Walsh MC, Kim KS, et al. Dendritic cell expression of the signaling molecule TRAF6 is required for immune tolerance in the lung. Int Immunol. 2017 Feb 1;29(2):71–78.
   PubMed Web of Science ®Google Scholar
• Xu G, Xia Z, Deng F, et al. LGALS3BP/90K activates antiviral innate immune responses by targeting TRAF6 and TRAF3 complex. PLoS Pathog. 2019 Aug 12;15(8):e1008002.
   PubMed Web of Science ®Google Scholar
• Aslani MR, Keyhanmanesh R, Khamaneh AM, et al. Tracheal overexpression of IL-1β, IRAK-1 and TRAF-6 mRNA in obese-asthmatic male Wistar rats. Iran J Basic Med Sci. 2016 Apr;19(4):350–357.
   PubMed Web of Science ®Google Scholar
• Lyu B, Wei Z, Jiang L, et al. MicroRNA-146a negatively regulates IL-33 in activated group 2 innate lymphoid cells by inhibiting IRAK1 and TRAF6. Genes Immun. 2020 Jan;21(1):37–44.
   PubMed Web of Science ®Google Scholar
• Erle DJ, Sheppard D. The cell biology of asthma. J Cell Biol. 2014 Jun 9;205(5):621–631.
   PubMed Web of Science ®Google Scholar
• Fireman P. Understanding asthma pathophysiology. Allergy Asthma Proc. 2003 Mar-Apr;24(2):79–83.
   PubMed Web of Science ®Google Scholar
• Liu C, Zhang X, Xiang Y, et al. Role of epithelial chemokines in the pathogenesis of airway inflammation in asthma (Review). Mol Med Rep. 2018 May;17(5):6935–6941.
   PubMed Web of Science ®Google Scholar
• Muñoz-Cano RM, Casas-Saucedo R, Valero Santiago A, et al. Platelet-Activating Factor (PAF) in Allergic Rhinitis: clinical and therapeutic implications. J Clin Med. 2019 Aug 29;8(9):1338.
   PubMed Web of Science ®Google Scholar
• Kasperska-Zajac A, Brzoza Z, Rogala B. Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. Inflammation. 2008 Apr;31(2):112–120.
   PubMed Web of Science ®Google Scholar
• Lou YP, Takeyama K, Grattan KM, et al. Platelet-activating factor induces goblet cell hyperplasia and mucin gene expression in airways. Am J Respir Crit Care Med. 1998 Jun;157(6 Pt 1):1927–1934.
   PubMed Web of Science ®Google Scholar
• Guo X, Zheng M, Pan R, et al. Hydroxysafflor yellow a suppresses platelet activating factor-induced activation of human small airway epithelial cells. Front Pharmacol. 2018 Aug;3(9):859.
   Google Scholar
• Yuan J, Xiao G, Peng G, et al. MiRNA-125a-5p inhibits glioblastoma cell proliferation and promotes cell differentiation by targeting TAZ. Biochem Biophys Res Commun. 2015 Feb 6;457(2):171–176.
   PubMed Web of Science ®Google Scholar
• Su WZ, Ren LF. MiRNA-199 inhibits malignant progression of lung cancer through mediating RGS17. Eur Rev Med Pharmacol Sci. 2019 Apr;23(8):3390–3400.
   PubMed Web of Science ®Google Scholar
• Li Y, Yin Z, Fan J, et al. The roles of exosomal miRNAs and lncRNAs in lung diseases. Signal Transduct Target Ther. 2019 Nov;13(4):47.
   Google Scholar
• Simpson LJ, Patel S, Bhakta NR, et al. A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production. Nat Immunol. 2014 Dec;15(12):1162–1170.
   PubMed Web of Science ®Google Scholar
• Bartel S, Carraro G, Alessandrini F, et al. miR-142-3p is associated with aberrant WNT signaling during airway remodeling in asthma. Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L328–L333.
   PubMed Web of Science ®Google Scholar
• Ma L, Zhang Q, Hao J, et al. LncRNA PVT1 exacerbates the inflammation and cell-barrier injury during asthma by regulating miR-149. J Biochem Mol Toxicol. 2020 Aug;24:e22563.
   Google Scholar
• Zapata JM, Martínez-García V, Lefebvre S. Phylogeny of the TRAF/MATH domain. Adv Exp Med Biol. 2007;597:1–24.
   PubMed Web of Science ®Google Scholar
• Arcipowski KM, Stunz LL, Bishop GA. TRAF6 is a critical regulator of LMP1 functions in vivo. Int Immunol. 2014 Mar;26(3):149–158.
   PubMed Web of Science ®Google Scholar
• Wu H, Arron JR. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays. 2003 Nov;25(11):1096–1105.
   PubMed Web of Science ®Google Scholar
• Pan J, Du M, Cao Z, et al. miR-146a-5p attenuates IL-1β-induced IL-6 and IL-1β expression in a cementoblast-derived cell line. Oral Dis. 2020 Mar;26(6):1308–1317..
   Web of Science ®Google Scholar
• Ge YT, Zhong AQ, Xu GF, et al. Resveratrol protects BV2 mouse microglial cells against LPS-induced inflammatory injury by altering the miR-146a-5p/TRAF6/NF-κB axis. Immunopharmacol Immunotoxicol. 2019 Oct;41(5):549–557.
   PubMed Web of Science ®Google Scholar