Identification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy

References

• Wang C, Jing Q. Non-coding RNAs as biomarkers for acute myocardial infarction. Acta Pharmacol Sin. 2018;39(7):1110–1119.
   PubMed Web of Science ®Google Scholar
• Yang EH, Brilakis ES, Reeder GS, Gersh BJ. Modern management of acute myocardial infarction. Curr Probl Cardiol. 2006;31(12):769–817.
   PubMed Web of Science ®Google Scholar
• Reed GW, Rossi JE, Cannon CP. Acute myocardial infarction. Lancet. 2017;389(10065):197–210.
   PubMed Web of Science ®Google Scholar
• Braunwald E. Unstable angina and non-ST elevation myocardial infarction. Am J Respir Crit Care Med. 2012;185(9):924–932.
   PubMed Web of Science ®Google Scholar
• Healy AM, Pickard MD, Pradhan AD, Wang Y, Chen Z, Croce K, et al. Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events. Circulation. 2006;113(19):2278–2284.
   PubMed Web of Science ®Google Scholar
• McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Jr., et al Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013;33(11):2666–2673.
   PubMed Web of Science ®Google Scholar
• Davies MJ, Thomas A. Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med. 1984;310(18):1137–1140.
   PubMed Web of Science ®Google Scholar
• Bonaventura A, Montecucco F, Dallegri F, Carbone F, Luscher TF, Camici GG, et al. Novel findings in neutrophil biology and their impact on cardiovascular disease. Cardiovasc Res. 2019;115(8):1266–1285.
   PubMed Web of Science ®Google Scholar
• Westman PC, Lipinski MJ, Luger D, Waksman R, Bonow RO, Wu E, et al. Inflammation as a driver of adverse left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2016;67(17):2050–2060.
   PubMed Web of Science ®Google Scholar
• Sreejit G, Abdel-Latif A, Athmanathan B, Annabathula R, Dhyani A, Noothi SK, et al. Neutrophil-derived S100A8/A9 amplify granulopoiesis after myocardial infarction. Circulation. 2020;141(13):1080–1094.
   PubMed Web of Science ®Google Scholar
• Ren Z, Yang K, Zhao M, Liu W, Zhang X, Chi J, et al. Calcium-sensing receptor on neutrophil promotes myocardial apoptosis and fibrosis after acute myocardial infarction via NLRP3 inflammasome activation. Can J Cardiol. 2020;36(6):893–905.
   PubMed Web of Science ®Google Scholar
• Eghbalzadeh K, Georgi L, Louis T, Zhao H, Keser U, Weber C, et al.. Compromised anti-inflammatory action of neutrophil extracellular traps in PAD4-deficient mice contributes to aggravated acute inflammation after myocardial infarction. Front Immunol. 2019;10:2313.
   PubMed Web of Science ®Google Scholar
• Horckmans M, Ring L, Duchene J, Santovito D, Schloss MJ, Drechsler M, et al. Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype. Eur Heart J. 2017;38(3):187–197.
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.
   PubMed Web of Science ®Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559.
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16(5):284–287.
   PubMed Web of Science ®Google Scholar
• Hanzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinformatics. 2013;14(1):7.
   PubMed Web of Science ®Google Scholar
• Frossard M, Fuchs I, Leitner JM, Hsieh K, Vlcek M, Losert H, et al. Platelet function predicts myocardial damage in patients with acute myocardial infarction. Circulation. 2004;110(11):1392–1397.
   PubMed Web of Science ®Google Scholar
• Stojkovic S, Nossent AY, Haller P, Jager B, Vargas KG, Wojta J, et al. MicroRNAs as regulators and biomarkers of platelet function and activity in coronary artery disease. Thromb Haemost. 2019;119(10):1563–1572.
   PubMed Web of Science ®Google Scholar
• Capodanno D, Angiolillo DJ. Antithrombotic therapy for atherosclerotic cardiovascular disease risk mitigation in patients with coronary artery disease and diabetes mellitus. Circulation. 2020;142(22):2172–2188.
   PubMed Web of Science ®Google Scholar
• Gadi I, Fatima S, Elwakiel A, Nazir S, Al-Dabet MM, Rana R, et al. Different DOACs control inflammation in cardiac ischemia-reperfusion differently. Circ Res. 2020;128(4):513–529.
   Web of Science ®Google Scholar
• Luscher TF. The sooner, the better: anti-inflammation in acute myocardial infarction. Eur Heart J. 2020;41(42):4100–4102.
   PubMed Web of Science ®Google Scholar
• Dai Y, Chen Y, Wei G, Zha L, Li X. Ivabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K/AKT/mTOR/p70S6K pathway. Bioengineered. 2021;12(1):1826–1837.
   PubMed Web of Science ®Google Scholar
• von Hundelshausen P, Weber C. Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res. 2007;100(1):27–40.
   PubMed Web of Science ®Google Scholar
• Silvestre-Roig C, Braster Q, Ortega-Gomez A, Soehnlein O. Neutrophils as regulators of cardiovascular inflammation. Nat Rev Cardiol. 2020;17(6):327–340.
   PubMed Web of Science ®Google Scholar
• Gobbi G, Carubbi C, Tagliazucchi GM, Masselli E, Mirandola P, Pigazzani F, et al. Sighting acute myocardial infarction through platelet gene expression. Sci Rep. 2019;9(1):19574.
   PubMedGoogle Scholar
• Zhang R, Ji Z, Qu Y, Yang M, Su Y, Zuo W, et al. Clinical value of ARG1 in acute myocardial infarction patients: Bioinformatics-based approach. Biomed Pharmacother. 2020;121:109590.
   PubMed Web of Science ®Google Scholar
• Mezzano V, Sheikh F. Cell-cell junction remodeling in the heart: possible role in cardiac conduction system function and arrhythmias? Life Sci. 2012;90(9–10):313–321.
   PubMed Web of Science ®Google Scholar
• Flaumenhaft R, Dilks JR, Rozenvayn N, Monahan-Earley RA, Feng D, Dvorak AM. The actin cytoskeleton differentially regulates platelet alpha-granule and dense-granule secretion. Blood. 2005;105(10):3879–3887.
   PubMed Web of Science ®Google Scholar
• Brydon L, Magid K, Steptoe A. Platelets, coronary heart disease, and stress. Brain Behav Immun. 2006;20(2):113–119.
   PubMed Web of Science ®Google Scholar
• Silvain J, Collet JP, Nagaswami C, Beygui F, Edmondson KE, Bellemain-Appaix A, et al. Composition of coronary thrombus in acute myocardial infarction. J Am Coll Cardiol. 2011;57(12):1359–1367.
   PubMed Web of Science ®Google Scholar
• Calvieri C, Tanzilli G, Bartimoccia S, Cangemi R, Arrivi A, Dominici M, et al. Interplay between oxidative stress and platelet activation in coronary thrombus of STEMI patients. Antioxidants (Basel). 2018;7(7.
   Google Scholar
• Wahli W, Michalik L. PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab. 2012;23(7):351–363.
   PubMed Web of Science ®Google Scholar
• Zhou H, Li D, Zhu P, Hu S, Hu N, Ma S, et al. Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARgamma/FUNDC1/mitophagy pathways. J Pineal Res. 2017;63.
   Web of Science ®Google Scholar
• Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P. Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion. J Clin Invest. 1992;89(4):1060–1068.
   PubMed Web of Science ®Google Scholar