Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma

References

• McGlynn KA, Petrick JL, London WT. Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability. Clin Liver Dis. 2015;19(223–238):223–238.
   PubMedGoogle Scholar
• Couri T, Pillai A. Goals and targets for personalized therapy for HCC. Hepatol Int. 2019;13(2):125–137.
   PubMed Web of Science ®Google Scholar
• Orcutt ST, Anaya DA. Liver resection and surgical strategies for management of primary liver cancer. Cancer Control. 2018;25(1):107327481774462.
   Web of Science ®Google Scholar
• Ikeda M, Morizane C, Ueno M, et al. Chemotherapy for hepatocellular carcinoma: current status and future perspectives. Jpn J Clin Oncol. 2018;48(2):103–114. .
   PubMed Web of Science ®Google Scholar
• Johnston MP, Khakoo SI. Immunotherapy for hepatocellular carcinoma: current and future. OncoImmunology. 2013;2(11):e26468.
   PubMedGoogle Scholar
• Prieto J, Melero I, Sangro B. Immunological landscape and immunotherapy of hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2015;12(12):681–700.
   PubMed Web of Science ®Google Scholar
• Jiang Y, Han QJ, Zhang J. Hepatocellular carcinoma: mechanisms of progression and immunotherapy. World J Gastroenterol. 2019;25(25):3151–3167.
   PubMed Web of Science ®Google Scholar
• Chen Y, Chen H-N, Wang K, et al. Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma. J Hepatol. 2019;70(1):66–77. .
   PubMed Web of Science ®Google Scholar
• Liu Y, Lou G, Norton JT, et al. 6-Methoxyethylamino-numonafide inhibits hepatocellular carcinoma xenograft growth as a single agent and in combination with sorafenib. FASEB J. 2017;31(12):5453–5465. .
   PubMed Web of Science ®Google Scholar
• Boege Y, Malehmir M, Healy ME, et al. A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development. Cancer Cell. 2017;32(3):342–359.e10. .
   PubMed Web of Science ®Google Scholar
• Mouw KW, Goldberg MS, Konstantinopoulos PA, et al. DNA damage and repair biomarkers of immunotherapy response. Cancer Discov. 2017;7(7):675–693.
   PubMed Web of Science ®Google Scholar
• Zhang T, Zhang X, Shi W, et al. The DNA damage repair protein Ku70 regulates tumor cell and hepatic carcinogenesis by interacting with FOXO4. Pathol Res Pract. 2016;212(3):153–161.
   PubMed Web of Science ®Google Scholar
• Fujimoto A, Furuta M, Totoki Y, et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer.Nat Genet. 2016;48(5):500–509.
   PubMed Web of Science ®Google Scholar
• Tang Z, Li C, Kang B, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–W102. .
   PubMed Web of Science ®Google Scholar
• Menyhárt -OA-O, Nagy Á, Győrffy B. Determining consistent prognostic biomarkers of overall survival and vascular invasion in hepatocellular carcinoma. R Soc Open Sci. 2018;5(12):181006.
   PubMed Web of Science ®Google Scholar
• Uhlén M, Björling E, Agaton C, et al. A human protein atlas for normal and cancer tissues based on antibody proteomics. Mol Amp Cell Proteomics. 2005;4(12):1920–1932.
   PubMed Web of Science ®Google Scholar
• Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77(21):e108–e110. .
   PubMed Web of Science ®Google Scholar
• Parnell LD, Lindenbaum P, Shameer K, et al. BioStar: an online question & answer resource for the bioinformatics community. PLoS Comput Biol. 2011;7(10):e1002216. .
   PubMed Web of Science ®Google Scholar
• Song D, Wang Y, Zhu K, et al. DCK is a promising prognostic biomarker and correlated with immune infiltrates in hepatocellular carcinoma. World J Surg Oncol. 2020; 18(1):176.
   PubMed Web of Science ®Google Scholar
• Rohr-Udilova N, Klinglmüller F, Schulte-Hermann R, et al. Deviations of the immune cell landscape between healthy liver and hepatocellular carcinoma. Sci Rep. 2018;8(1)..
   Google Scholar
• Ma CJ, Kwon Y, Sung P, et al. Human RAD52 interactions with replication protein A and the RAD51 presynaptic complex. J Biol Chem. 2017;292(28):11702–11713.
   PubMed Web of Science ®Google Scholar
• Xie DY, Ren ZG, Zhou J, et al. 2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights. Hepatobiliary Surg Nutr. 2020;9(4):452–463.
   PubMed Web of Science ®Google Scholar
• Akamatsu N, Cillo U, Cucchetti A, et al. Surgery and hepatocellular carcinoma. Liver Cancer. 2017;6(1):44–50. .
   Web of Science ®Google Scholar
• Xu X-F, Xing H, Han J, et al. Risk factors, patterns, and outcomes of late recurrence after liver resection for hepatocellular carcinoma: a multicenter study from China. JAMA Surg. 2019;154(3):209. .
   PubMed Web of Science ®Google Scholar
• Zheng S, Liu L, Xue T, et al. Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma. Front Genet. 2021;18(12):648156.
   Google Scholar
• Zhao S, Devega R, Francois A, et al. Human alkbh6 is required for maintenance of genomic stability and promoting cell survival during exposure of alkylating agents in pancreatic cancer. Front Genet. 2021;7(12):635808.
   Google Scholar
• Satyananda V, Oshi M, Endo I, et al. High BRCA2 gene expression is associated with aggressive and highly proliferative breast cancer. LID. Ann Surg Oncol. 2021;8
   Google Scholar
• Yoshida K, Miki Y. Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage. Cancer Sci. 2004;95(11):866–871.
   PubMed Web of Science ®Google Scholar
• Nagathihalli NS, Nagaraju G. RAD51 as a potential biomarker and therapeutic target for pancreatic cancer. Biochim Biophys Acta Rev Cancer. 2011;1816(2):209–218.
   Web of Science ®Google Scholar
• Sriramulu S, Ramachandran M, Subramanian S, et al. A review on role of ATM gene in hereditary transfer of colorectal cancer. Acta Biomed. 2019;89(4):463–469.
   PubMedGoogle Scholar
• Zeng X, Zhang Y, Yang L, et al. Association between RAD51 135 G/C polymorphism and risk of 3 common gynecological cancers: a meta-analysis. Medicine (Baltimore). 2018;97(26):e11251. .
   PubMed Web of Science ®Google Scholar
• Leonardi GC, Candido S, Cervello M, et al. The tumor microenvironment in hepatocellular carcinoma (review). Int J Oncol. 2012;40(6):1733–1747.
   PubMed Web of Science ®Google Scholar
• Mossanen JC, Tacke F. Role of lymphocytes in liver cancer. OncoImmunology. 2013;2(11):e26468.
   PubMed Web of Science ®Google Scholar
• Kim SY, Kyaw YY, Cheong J. Functional interaction of endoplasmic reticulum stress and hepatitis B virus in the pathogenesis of liver diseases. World J Gastroenterol. 2017;23(43):7657–7665.
   PubMed Web of Science ®Google Scholar
• Chen YR, Ouyang -S-S, Chen Y-L, et al. BRD4/8/9 are prognostic biomarkers and associated with immune infiltrates in hepatocellular carcinoma. Aging (Albany NY). 2020;12(17541–17567):17541–17567.
   PubMedGoogle Scholar
• Mohammed A, Shoemaker RA-O, Sei S. Cancer immunoprevention: challenges and potential opportunities for use of immune checkpoint inhibitors. Cancer Prev Res (Phila). 2020;13(11):897–900.
   Google Scholar