Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis

References

• Liu CY, Zhang YH, Li RB, et al. LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription. Nat Commun. 2018;9(1):29.
   PubMed Web of Science ®Google Scholar
• Wang K, Liu CY, Zhou LY, et al. APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nat Commun. 2015;6(1):6779.
   PubMedGoogle Scholar
• Adameova AD, Bhullar SK, Elimban V, et al. Activation of β(1)-adrenoceptors may not be involved in arrhythmogenesis in ischemic heart disease. Rev Cardiovasc Med. 2018;19(3):97–101.
   PubMed Web of Science ®Google Scholar
• Mitręga KA, Nożyński J, Porc M, et al. Dihydropyridines’ metabolites-induced early apoptosis after myocardial infarction in rats; new outlook on preclinical study with M-2 and M-3. Apoptosis. 2016;21(2):195–208.
   PubMed Web of Science ®Google Scholar
• Loor G, Kondalpalli J, Dokic D, et al. Cardiomyocyte death in ischemia-reperfusion is mediated by opening of the mitochondrial permeability transition pore: role of oxidant stress during ischemia. J Am Coll Surg. 2007;205(3):S21–S2.
   Web of Science ®Google Scholar
• Tang C, Han H, Liu Z, et al. Activation of BNIP3-mediated mitophagy protects against renal ischemia-reperfusion injury. Cell Death Dis. 2019;10(9):677.
   PubMedGoogle Scholar
• Zhang W, Siraj S, Zhang R, et al. Mitophagy receptor FUNDC1 regulates mitochondrial homeostasis and protects the heart from I/R injury. Autophagy. 2017;13(6):1080–1081.
   PubMed Web of Science ®Google Scholar
• Strebhardt K. Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. Nat Rev Drug Discov. 2010;9(8):643–660.
   PubMed Web of Science ®Google Scholar
• Gao Z, Man X, Li Z, et al. PLK1 promotes proliferation and suppresses apoptosis of renal cell carcinoma cells by phosphorylating MCM3. Cancer Gene Ther. 2020;27(6):412–423.
   PubMed Web of Science ®Google Scholar
• Wu ZY, Wei N. Knockdown of PLK1 inhibits invasion and promotes apoptosis in glioma cells through regulating autophagy. Eur Rev Med Pharmacol Sci. 2018;22(9):2723–2733.
   PubMed Web of Science ®Google Scholar
• Chen LL, Wang YB, Song JX, et al. Phosphoproteome-based kinase activity profiling reveals the critical role of MAP2K2 and PLK1 in neuronal autophagy. Autophagy. 2017;13(11):1969–1980.
   PubMed Web of Science ®Google Scholar
• Liu HJ, Jiang XX, Guo YZ, et al. The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex. Acta Pharmacol Sin. 2017;38(10):1381–1393.
   PubMed Web of Science ®Google Scholar
• Jopling C, Sleep E, Raya M, et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 2010;464(7288):606–609.
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Cufí S, Oliveras-Ferraros C, et al. Polo-like kinase 1 directs the AMPK-mediated activation of myosin regulatory light chain at the cytokinetic cleavage furrow independently of energy balance. Cell Cycle. 2012;11(13):2422–2426.
   PubMed Web of Science ®Google Scholar
• Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, et al. Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus. Cell Cycle. 2011;10(8):1295–1302.
   PubMed Web of Science ®Google Scholar
• Liu D, Ma Z, Di S, et al. AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis. Free Radic Biol Med. 2018;129:59–72.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang Y, Xu J, et al. Melatonin attenuates myocardial ischemia-reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways. J Pineal Res. 2019;66(2):e12542.
   PubMed Web of Science ®Google Scholar
• Gao J, Yu L, Wang Z, et al. Induction of mitophagy in C2C12 cells by electrical pulse stimulation involves increasing the level of the mitochondrial receptor FUNDC1 through the AMPK-ULK1 pathway. Am J Transl Res. 2020;12(10):6879–6894.
   PubMed Web of Science ®Google Scholar
• Zhang W, Ren H, Xu C, et al. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 2016;5.
   Web of Science ®Google Scholar
• Ren J, Sun M, Zhou H, et al. FUNDC1 interacts with FBXL2 to govern mitochondrial integrity and cardiac function through an IP3R3-dependent manner in obesity. Sci Adv. 2020;6(38):38.
   Web of Science ®Google Scholar
• Yu W, Xu M, Zhang T, et al. promotes cardiac ischemia-reperfusion injury by inhibiting the ERK-CREB pathway and repressing FUNDC1-mediated mitophagy. J Physiol Sci. 2019;69(1):113–127.
   PubMed Web of Science ®Google Scholar
• Zhou H, Wang J, Zhu P, et al. NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α. Basic Res Cardiol. 2018;113(4):23.
   PubMed Web of Science ®Google Scholar
• Zhang AP, Zhang YY, Liu AF, et al. Molecular mechanism of long-term neuroprotective effects of gradual flow restoration on cerebral ischemia reperfusion injury in MCAO rats. J Stroke Cerebrovasc Dis. 2020;29(9):105041.
   PubMed Web of Science ®Google Scholar
• Lequin RM. Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin Chem. 2005;51(12):2415–2418.
   PubMed Web of Science ®Google Scholar
• Irwin N, Frizelle P, O’Harte FP, et al. (pGlu-Gln)-CCK-8[mPEG]: a novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes. Biochim Biophys Acta. 2013;1830(8):4009–4016.
   PubMed Web of Science ®Google Scholar
• Majtnerová P, Roušar T. An overview of apoptosis assays detecting DNA fragmentation. Mol Biol Rep. 2018;45(5):1469–1478.
   PubMed Web of Science ®Google Scholar
• Bachman J. Reverse-transcription PCR (RT-PCR). Methods Enzymol. 2013;530:67–74.
   PubMed Web of Science ®Google Scholar
• Kurien BT, Scofield RH. Western blotting: an introduction. Methods Mol Biol. 2015;1312:17–30.
   PubMedGoogle Scholar
• Im K, Mareninov S, Diaz MFP, et al. An Introduction to performing immunofluorescence staining. Methods Mol Biol. 2019;1897:299–311.
   PubMedGoogle Scholar
• Thiele H, Ohman EM, de Waha-Thiele S, et al. Management of cardiogenic shock complicating myocardial infarction: an update 2019. Eur Heart J. 2019;40(32):2671–2683.
   PubMed Web of Science ®Google Scholar
• Liu K, Zhao D, Wang D. LINC00528 regulates myocardial infarction by targeting the miR-143-3p/COX-2 axis. Bioengineered. 2020;11(1):11–18.
   PubMed Web of Science ®Google Scholar
• Liu W, Miao Y, Zhang L, et al. MiR-211 protects cerebral ischemia/reperfusion injury by inhibiting cell apoptosis. Bioengineered. 2020;11(1):189–200.
   PubMed Web of Science ®Google Scholar
• Shah M, Patil S, Patel B, et al. Causes and predictors of 30-day readmission in patients with acute myocardial infarction and cardiogenic shock. Circ Heart Fail. 2018;11(4):e004310.
   PubMed Web of Science ®Google Scholar
• El Hadi H, Vettor R, Rossato M. Cardiomyocyte mitochondrial dysfunction in diabetes and its contribution in cardiac arrhythmogenesis. Mitochondrion. 2019;46:6–14.
   PubMed Web of Science ®Google Scholar
• Yang M, Linn BS, Zhang Y, et al. Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury. Biochim Biophys Acta Mol Basis Dis. 2019;1865(9):2293–2302.
   PubMed Web of Science ®Google Scholar
• Zhou H, Li D, Zhu P, et al. Melatonin suppresses platelet activation and function against cardiac ischemia/reperfusion injury via PPARγ/FUNDC1/mitophagy pathways. J Pineal Res. 2017;63(4):4.
   Web of Science ®Google Scholar
• Wang H, Tao Z, Feng M, et al. Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. Biochem Biophys Res Commun. 2020;533(3):368–375.
   PubMed Web of Science ®Google Scholar
• Li W, Wang HY, Zhao X, et al. A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair. Sci Adv. 2019;5(3):eaau7566.
   PubMed Web of Science ®Google Scholar
• Lu B, Mahmud H, Maass AH, et al. The Plk1 inhibitor BI 2536 temporarily arrests primary cardiac fibroblasts in mitosis and generates aneuploidy in vitro. PLoS One. 2010;5(9):e12963.
   PubMed Web of Science ®Google Scholar
• Liu L, Jin X, Hu CF, et al. Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy Via AMPK and Akt pathways. Cell Physiol Biochem. 2017;43(1):52–68.
   PubMedGoogle Scholar
• Tian L, Cao W, Yue R, et al. Pretreatment with tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway. J Pharmacol Sci. 2019;139(4):352–360.
   PubMed Web of Science ®Google Scholar
• Pan Y, Liu L, Zhang Q, et al. Activation of AMPK suppresses S1P-induced airway smooth muscle cells proliferation and its potential mechanisms. Mol Immunol. 2020;128:106–115.
   PubMed Web of Science ®Google Scholar
• Li W, Li Y, Siraj S, et al. FUN14 domain-containing 1-mediated mitophagy suppresses hepatocarcinogenesis by inhibition of inflammasome activation in mice. Hepatology. 2019;69(2):604–621.
   PubMed Web of Science ®Google Scholar
• Wu S, Lu Q, Ding Y, et al. Hyperglycemia-driven inhibition of AMP-activated protein kinase α2 induces diabetic cardiomyopathy by promoting mitochondria-associated endoplasmic reticulum membranes in vivo. Circulation. 2019;139(16):1913–1936.
   PubMed Web of Science ®Google Scholar
• Lampert MA, Orogo AM, Najor RH, et al. BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation. Autophagy. 2019;15(7):1182–1198.
   PubMed Web of Science ®Google Scholar