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Research Paper

Potential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis

ORCID Icon, , , , , , , , , & show all
Pages 2810-2819 | Received 21 Apr 2021, Accepted 02 Jun 2021, Published online: 27 Jun 2021

References

  • Lipsky PE. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat Immunol. 2001;2:764–766.
  • Cervera R, Khamashta MA, Font J, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003;82(5):299–308.
  • Yazdany J, Marafino BJ, Dean ML, et al. Thirty-day hospital readmissions in systemic lupus erythematosus: predictors and hospital- and state-level variation. Arthritis Rheumatol. 2014;66:2828–2836.
  • Quintero OL, Rojas-Villarraga A, Mantilla RD, et al. Autoimmune diseases in the intensive care unit. An update. Autoimmun Rev. 2013;12:380–395.
  • Mackern-Oberti JP, Llanos C, Riedel CA, et al. Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus. Immunology. 2015;146:497–507.
  • Cunningham M, Gilkeson G. Estrogen receptors in immunity and autoimmunity. Clin Rev Allergy Immunol. 2011;40(1):66–73.
  • Dorgham K, Amoura Z, Parizot C, et al. Ultraviolet light converts propranolol, a nonselective beta-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand. Eur J Immunol. 2015;45(11):3174–3187.
  • Qiu CC, Caricchio R, Gallucci S. Triggers of autoimmunity: the role of bacterial infections in the extracellular exposure of lupus nuclear autoantigens. Front Immunol. 2019;10:2608.
  • Barrett T, Troup DB, Wilhite SE, et al. Ncbi geo: archive for functional genomics data sets—10 years on. Nucleic Acids Res. 2011;39:1005–1010.
  • Wang J, Zhang C. Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer. Bioengineered. 2021;12(1):898–913.
  • Bolstad BM, Irizarry RA, Astrand M, et al. A comparison of normalization methods for high den sity oligonucleotide array data based on variance and bias. Bioinformatics. 2003;19:185–193.
  • Saavedra PHV, Huang L, Ghazavi F, et al. Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis. Nat Commun. 2018;9(1):4846.
  • Ashburner M, Ball CA, Blake JA, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25(1):25–29.
  • Kanehisa M, Goto S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30.
  • Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.
  • Szklarczyk D, Gable AL, Lyon D, et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47(D1):607–613.
  • Zhang M, Gu Y, Huang S, et al. Copy number variations and polymorphisms in HSP90AB1 and risk of systemic lupus erythematosus and efficacy of glucocorticoids. J Cell Mol Med. 2019;23(8):5340–5348.
  • Khare SD, Sarosi I, Xia XZ, et al. Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice. Proc Natl Acad Sci USA. 2000;97(7):3370–3375.
  • Yin Y, Zhao L, Zhang F, et al. Impact of CD200-Fc on dendritic cells in lupus-prone NZB/WF1 mice. Sci Rep. 2016;6:31874.
  • Han T, Zhou Y, Li D. Relationship between hepatocellular carcinoma and depression via online database analysis. Bioengineered. 2021;12(1):1689–1697.
  • Meng Y, Li C, Liu CX. Immune cell infiltration landscape and immune marker molecular typing in preeclampsia. Bioengineered. 2021;12(1):540–554.
  • Luster AD. Chemokines—chemotactic cytokines that mediate inflammation. N Engl J Med. 1998;12:436.
  • Proudfoot AE, Wells TN, Clapham PR. Chemokine receptors—future therapeutic targets for HIV? Biochem Pharmacol. 1999;57(5):451–463.
  • Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature. 1996;382:635–638.
  • Griffith JW, Sokol CL, Luster AD. Chemokines and chemokine receptors: positioning cells for host defense and immunity. Annu Rev Immunol. 2014;32:659–702.
  • Chu XK, Wang Y, Ardeljan D, et al. Controversial view of a genetically altered mouse model of focal retinal degeneration. Bioengineered. 2013;4(3):130–135.
  • Tsou CL, Peters W, Si Y, et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007;117(4):902–909.
  • Dominguez-Gutierrez PR, Ceribelli A, Satoh M, et al. Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Arthritis Res Ther. 2014;16(1):23.
  • Lee HK, Kim HS, Kim JS, et al. CCL2 deficient mesenchymal stem cells fail to establish long-lasting contact with T cells and no longer ameliorate lupus symptoms. Sci Rep. 2017;7:41258.
  • Ramji DP, Davies TS. Cytokines in atherosclerosis: key players in all stages of disease and promising therapeutic targets. Cytokine Growth Factor Rev. 2015;26(6):673–685.
  • Tektonidou MG, Kravvariti E, Konstantonis G, et al. Subclinical atherosclerosis in systemic lupus erythematosus: comparable risk with diabetes mellitus and rheumatoid arthritis. Autoimmun Rev. 2017;16(3):308–312.
  • Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003;92(8):827–839.
  • Opdenakker G, Van Den Steen PE, Dubois B, et al. Gelatinase B functions as regulator and effector in leukocyte biology. J Leukoc Biol. 2001;69(6):851–859.
  • Urowitz MB, Gladman DD, Tozman EC, et al. The lupus activity criteria count (LACC). J Rheumatol. 1984;11(6):783–787.
  • Faber-Elmann A, Sthoeger Z, Tcherniack A, et al. Activity of matrix metalloproteinase-9 is elevated in sera of patients with systemic lupus erythematosus. Clin Exp Immunol. 2002;127(2):393–398.
  • Ainiala H, Hietaharju A, Dastidar P, et al. Increased serum matrix metalloproteinase 9 levels in systemic lupus erythematosus patients with neuropsychiatric manifestations and brain magnetic resonance imaging abnormalities. Arthritis Rheum. 2004;50(3):858–865.
  • Mawrin C, Brunn A, Röcken C, et al. Peripheral neuropathy in systemic lupus erythematosus: pathomorphological features and distribution pattern of matrix metalloproteinases. Acta Neuropathol. 2003;105(4):365–372.
  • Opdenakker G, Van Den Steen PE, Van Damme J. Gelatinase B: a tuner and amplifier of immune functions. Trends Immunol. 2001;22(10):571–579.
  • Fitzgerald KA. The interferon inducible gene: viperin. J Interferon Cytokine Res. 2011;31(1):131–135.
  • Jang JS, Lee JH, Jung NC, et al. Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway. Cell Death Dis. 2018;9(8):823.
  • Lübbers J, Brink M, Van De Stadt LA, et al. The type I IFN signature as a biomarker of preclinical rheumatoid arthritis. Ann Rheum Dis. 2013;72(5):776–780.
  • Sezin T, Vorobyev A, Sadik CD, et al. Gene expression analysis reveals novel shared gene signatures and candidate molecular mechanisms between pemphigus and systemic lupus erythematosus in CD4+ T cells. Front Immunol. 2017;8:1992.
  • Fan H, Zhao G, Ren D, et al. Gender differences of B cell signature related to estrogen-induced IFI44L/BAFF in systemic lupus erythematosus. Immunol Lett. 2017;181:71–78.
  • Doedens JR, Jones WD, Hill K, et al. Blood-borne RNA correlates with disease activity and IFN-stimulated gene expression in systemic lupus erythematosus. J Immunol. 2016;197(7):2854–2863.