References
- Smyth EC, Nilsson M, Grabsch HI, et al. Gastric cancer. Lancet. 2020;396(10251):635–648. .
- Deng Y, Wang M, Zhou L, et al. Global burden of larynx cancer, 1990-2017: estimates from the global burden of disease 2017 study. Aging (Albany NY). 2020;12(3):2545–2583. .
- Bray F, Ferlay J, Soerjomataram I, et al. Erratum: global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2020;70(4):313
- IBM SPSS Statistics. Available from: https://www.ibm.com/products/spss-statistics.
- Latest global cancer data: cancer burden rises to 19.3 million new cases and 10.0 million cancer deaths in 2020. Available from: https://www.iarc.who.int/faq/latest-global-cancer-data-2020-qa/.
- Lee J, Ahmed S, Kozma R, et al. The N-terminal region of n-Chimaerin allows lipid modulation of the C-terminal p21rac-GTPase activating domain. Biochem Soc Trans. 1992;20(3):310s. .
- Guan X, Guan X, Dong C, et al. Rho GTPases and related signaling complexes in cell migration and invasion. Exp Cell Res. 2020;388(1):111824. .
- Lawson CD, Ridley AJ. Rho GTPase signaling complexes in cell migration and invasion. J Cell Biol. 2018;217(2):447–457.
- Lim L. n-Chimaerin and neuronal signal transduction mechanisms. Biochem Soc Trans. 1992;20(3):611–614.
- Volk AE, Fricke J, Strobl J, et al. Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders. Graefes Arch Clin Exp Ophthalmol. 2010;248(9):1351–1357. .
- Rhodes DR, Yu J, Shanker K, et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia. 2004;6(1):1–6. .
- Pan JH, Zhou H, Cooper L, et al. LAYN is a prognostic biomarker and correlated with immune infiltrates in gastric and colon cancers. Front Immunol. 2019;10:6.
- GSE118919. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE118916.
- GSE13861. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE13861.
- GSE29272. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE29272.
- Na Z, Luo Y, Schofield JA, et al. The NBDY microprotein regulates cellular RNA decapping. Biochemistry. 2020;59(42):4131–4142. .
- Zheng J. Immunohistochemistry and immunocytochemistry. Methods Mol Biol. 1998;105:307–314.
- Son HK, Kim D, Lim Y, et al. A novel TGF-β receptor II mutation (I227T/N236D) promotes aggressive phenotype of oral squamous cell carcinoma via enhanced EGFR signaling. BMC Cancer. 2020;20(1):1163. .
- Kurien BT, Scofield RH. Western blotting: an introduction. Methods Mol Biol. 2015;1312:17–30.
- Chen W, Chen X, Li S, et al. Expression, immune infiltration and clinical significance of SPAG5 in hepatocellular carcinoma: a gene expression-based study. J Gene Med. 2020;22(4):e3155. .
- Franz M, Rodriguez H, Lopes C, et al. GeneMANIA update 2018. Nucleic Acids Res. 2018;46(W1):W60–w64. .
- Li T, Kim A, Rosenbluh J, et al. GeNets: a unified web platform for network-based genomic analyses. Nat Methods. 2018;15(7):543–546. .
- Zhou Y, Zhou B, Pache L, et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat Commun. 2019;10(1):1523. .
- Subramanian A, Kuehn H, Gould J, et al. GSEA-P: a desktop application for gene set enrichment analysis. Bioinformatics. 2007;23(23):3251–3253. .
- Liberzon A, Subramanian A, Pinchback R, et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics. 2011;27(12):1739–1740. .
- Chen B, Khodadoust M S , Liu C L , et al. Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol. 2018;1711:243–259.
- Modhukur V, Iljasenko T, Metsalu T, et al. MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data. Epigenomics. 2018;10(3):277–288. .
- Machlowska J, Baj J, Sitarz M , et al. Gastric Cancer: Epidemiology, Risk Factors, Classification, Genomic Characteristics and Treatment Strategies[J]. International Journal of Molecular Sciences, 2020;21(11):4012.
- Silverman EK, Schmidt H , Anastasiadou E , et al. Molecular networks in Network Medicine: Development and applications[J]. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2020;(6951):e1489.
- Conte F, Fiscon G, Licursi V, et al. A paradigm shift in medicine: a comprehensive review of network-based approaches. Biochim Biophys Acta Gene Regul Mech. 2020;1863(6):194416. .
- Fiscon G, Conte F, Farina L, et al. Network-based approaches to explore complex biological systems towards network medicine. Genes (Basel). 2018;9(9):437.
- Liu J, Li Y, Chen X, et al. Upregulation of miR-205 induces CHN1 expression, which is associated with the aggressive behaviour of cervical cancer cells and correlated with lymph node metastasis. BMC Cancer. 2020;20(1):1029. .
- Gerson JN, Skariah S, Denlinger CS, et al. Perspectives of HER2-targeting in gastric and esophageal cancer. Expert Opin Investig Drugs. 2017;26(5):531–540. .
- Meric-Bernstam F, Johnson AM, Dumbrava EEI, et al. Advances in HER2-targeted therapy: novel agents and opportunities beyond breast and gastric cancer. Clin Cancer Res. 2019;25(7):2033–2041. .
- Kozma R, Ahmed S, Best A, et al. The GTPase-activating protein n-chimaerin cooperates with Rac1 and Cdc42Hs to induce the formation of lamellipodia and filopodia. Mol Cell Biol. 1996;16(9):5069–5080. .
- Machesky LM. Lamellipodia and filopodia in metastasis and invasion. FEBS Lett. 2008;582(14):2102–2111.
- De Craene B, Berx G. Regulatory networks defining EMT during cancer initiation and progression. Nat Rev Cancer. 2013;13(2):97–110.
- Pastushenko I, Blanpain C. EMT transition states during tumor progression and metastasis. Trends Cell Biol. 2019;29(3):212–226.
- Geukes Foppen MH, Donia M, Svane IM, et al. Tumor-infiltrating lymphocytes for the treatment of metastatic cancer. Mol Oncol. 2015;9(10):1918–1935. .
- Fridman WH, Pagès F, Sautès-Fridman C, et al. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012;12(4):298–306. .
- Ren Q, Zhu P, Zhang H, et al. Identification and validation of stromal-tumor microenvironment-based subtypes tightly associated with PD-1/PD-L1 immunotherapy and outcomes in patients with gastric cancer. Cancer Cell Int. 2020;20(1):92. .
- Parikh AR, He Y, Hong TS, et al. Analysis of DNA damage response gene alterations and tumor mutational burden across 17,486 tubular gastrointestinal carcinomas: implications for therapy. Oncologist. 2019;24(10):1340–1347. .
- Klutstein M, Nejman D, Greenfield R, et al. DNA methylation in cancer and aging. Cancer Res. 2016;76(12):3446–3450. .
- Das PM, Singal R. DNA methylation and cancer. J Clin Oncol. 2004;22(22):4632–4642.
- Koch A, Joosten SC, Feng Z, et al. Analysis of DNA methylation in cancer: location revisited. Nat Rev Clin Oncol. 2018;15(7):459–466. .
- Kulis M, Esteller M. DNA methylation and cancer. Adv Genet. 2010;70:27–56.