Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling

References

• Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am. 2020;104(2):293–311.
   PubMed Web of Science ®Google Scholar
• Kan HS, Chan PK, Chiu KY, et al. Non-surgical treatment of knee osteoarthritis. Hong Kong Med J. 2019;25(2):127–133.
   PubMed Web of Science ®Google Scholar
• Blaney Davidson EN, van Caam AP, van der Kraan PM. Osteoarthritis year in review 2016: biology. Osteoarthritis Cartilage. 2017;25(2):175–180.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. 2011;147(4):728–741.
   PubMed Web of Science ®Google Scholar
• Carames B, Taniguchi N, Otsuki S, et al. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum. 2010;62(3):791–801.
   PubMed Web of Science ®Google Scholar
• Sasaki H, Takayama K, Matsushita T, et al. Autophagy modulates osteoarthritis-related gene expression in human chondrocytes. Arthritis Rheum. 2012;64(6):1920–1928.
   PubMed Web of Science ®Google Scholar
• Lopez de Figueroa P, Lotz MK, Blanco FJ, et al. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol. 2015;67(4):966–976.
   PubMed Web of Science ®Google Scholar
• Blanco FJ, Rego I, Ruiz-Romero C. The role of mitochondria in osteoarthritis. Nat Rev Rheumatol. 2011;7(3):161–169.
   PubMed Web of Science ®Google Scholar
• Carames B, Olmer M, Kiosses WB, et al. The relationship of autophagy defects to cartilage damage during joint aging in a mouse model. Arthritis Rheumatol. 2015;67(6):1568–1576.
   PubMed Web of Science ®Google Scholar
• Bitto A, Ito TK, Pineda VV, et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife. 2016;5:5.
   Web of Science ®Google Scholar
• El-Shitany NA, Eid BG. Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. Biomed Pharmacother. 2019;120:109567.
   PubMed Web of Science ®Google Scholar
• Zeng R, Zhou Q, Zhang W, et al. Icariin-mediated activation of autophagy confers protective effect on rotenone induced neurotoxicity in vivo and in vitro. Toxicol Rep. 2019;6:637–644.
   PubMed Web of Science ®Google Scholar
• Mi B, Wang J, Liu Y, et al. Icariin activates autophagy via down-regulation of the NF-kappaB signaling-mediated apoptosis in chondrocytes. Front Pharmacol. 2018;9:605.
   PubMed Web of Science ®Google Scholar
• Luo Y, Zhang Y, Huang Y. Icariin reduces cartilage degeneration in a mouse model of osteoarthritis and is associated with the changes in expression of indian hedgehog and parathyroid hormone-related protein. Med Sci Monit. 2018;24:6695–6706.
   PubMed Web of Science ®Google Scholar
• Zu Y, Mu Y, Li Q, et al. Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis. J Orthop Surg Res. 2019;14(1):307.
   PubMed Web of Science ®Google Scholar
• Wang P, Xiong X, Zhang J, et al. Icariin increases chondrocyte vitality by promoting hypoxia-inducible factor-1alpha expression and anaerobic glycolysis. Knee. 2020;27(1):18–25.
   PubMed Web of Science ®Google Scholar
• XIE B, Fan ZY, Wang WQ, et al. Adjustment of Bushentongluo recipe to the caspase-3 of the chondrocyte in osteoarthritis rats. Chin J Clin Rehabil. 2006;10:67–69.
   Google Scholar
• Liu P, Feng Y, Dong D, et al. Enhanced renoprotective effect of IGF-1 modified human umbilical cord-derived mesenchymal stem cells on gentamicin-induced acute kidney injury. Sci Rep. 2016;6(1):20287.
   PubMed Web of Science ®Google Scholar
• Zhao L, Feng Y, Chen X, et al. Effects of IGF-1 on neural differentiation of human umbilical cord derived mesenchymal stem cells. Life Sci. 2016;151:93–101.
   PubMed Web of Science ®Google Scholar
• Al-Afifi NA, Alabsi AM, Shaghayegh G, et al. The in vitro and in vivo antitumor effects of Dracaena cinnabari resin extract on oral cancer. Arch Oral Biol. 2019;104:77–89.
   PubMed Web of Science ®Google Scholar
• Ding LZ, Teng X, Zhang ZB, et al. Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells. Int J Mol Med. 2018;41(5):2517–2526.
   PubMed Web of Science ®Google Scholar
• Lin X, Bai D, Wei Z, et al. Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant enzymes and activating the Nrf2-Keap1 pathway. PloS One. 2019;14(5):e0216711.
   PubMed Web of Science ®Google Scholar
• Guo Y, Zhu X, Sun X. COTI-2 induces cell apoptosis in pediatric acute lymphoblastic leukemia via upregulation of miR-203. Bioengineered. 2020;11(1):201–208.
   PubMed Web of Science ®Google Scholar
• Mohan G, Perilli E, Kuliwaba JS, et al. Application of in vivo micro-computed tomography in the temporal characterisation of subchondral bone architecture in a rat model of low-dose monosodium iodoacetate-induced osteoarthritis. Arthritis Res Ther. 2011;13(6):R210.
   PubMed Web of Science ®Google Scholar
• Zhao H, Liu S, Ma C, et al. Estrogen-related receptor gamma induces angiogenesis and extracellular matrix degradation of temporomandibular joint osteoarthritis in rats. Front Pharmacol. 2019;10:1290.
   PubMed Web of Science ®Google Scholar
• Glasson SS, Chambers MG, Van Den Berg WB, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18(Suppl 3):S17–23.
   PubMed Web of Science ®Google Scholar
• Yao H, Xu JK, Zheng NY, et al. Intra-articular injection of magnesium chloride attenuates osteoarthritis progression in rats. Osteoarthritis Cartilage. 2019;27(12):1811–1821.
   PubMed Web of Science ®Google Scholar
• Bo W, Zhou J, Wang K. Sodium butyrate abolishes the degradation of type II collagen in human chondrocytes. Biomed Pharmacothe. 2018;102:1099–1104.
   PubMed Web of Science ®Google Scholar
• Yang H, Wen Y, Zhang M, et al. MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint. Autophagy. 2020;16(2):271–288.
   PubMed Web of Science ®Google Scholar
• Huang H, Zhang ZF, Qin FW, et al. Icariin inhibits chondrocyte apoptosis and angiogenesis by regulating the TDP-43 signaling pathway. Mol Genet Genomic Med. 2019;7(4):e00586.
   PubMed Web of Science ®Google Scholar
• Romeo-Guitart D, Marmolejo-Martinez-Artesero S, Casas C. Is it the time of autophagy fine-tuners for neuroprotection? Autophagy. 2020;16(11):2108–2109.
   PubMed Web of Science ®Google Scholar
• Xue JF, Shi ZM, Zou J, et al. Inhibition of PI3K/AKT/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis. Biomed Pharmacothe. 2017;89:1252–1261.
   PubMed Web of Science ®Google Scholar
• Huang S, Xie T, Liu W. Icariin inhibits the growth of human cervical cancer cells by inducing apoptosis and autophagy by targeting mTOR/PI3K/AKT signalling pathway. J BUON. 2019;24:990–996.
   PubMed Web of Science ®Google Scholar
• Bao J, Chen Z, Xu L, et al. Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis. Aging (Albany NY). 2020;12(6):5152–5167.
   PubMedGoogle Scholar
• Vinatier C, Dominguez E, Guicheux J, et al. Role of the inflammation-autophagy-senescence integrative network in osteoarthritis. Front Physiol. 2018;9:706.
   PubMed Web of Science ®Google Scholar
• Fernandez AF, Sebti S, Wei Y, et al. Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice. Nature. 2018;558(7708):136–140.
   PubMed Web of Science ®Google Scholar
• Kraft LJ, Nguyen TA, Vogel SS, et al. Size, stoichiometry, and organization of soluble LC3-associated complexes. Autophagy. 2014;10(5):861–877.
   PubMed Web of Science ®Google Scholar
• Li YS, Zhang FJ, Zeng C, et al. Autophagy in osteoarthritis. Joint Bone Spine. 2016;83(2):143–148.
   PubMed Web of Science ®Google Scholar
• Ma L, Liu Y, Zhao X, et al. Rapamycin attenuates articular cartilage degeneration by inhibiting beta-catenin in a murine model of osteoarthritis. Connect Tissue Res. 2019;60(5):452–462.
   PubMed Web of Science ®Google Scholar
• Tang Y, Mo Y, Xin D, et al. beta-ecdysterone alleviates osteoarthritis by activating autophagy in chondrocytes through regulating PI3K/AKT/mTOR signal pathway. Am J Transl Res. 2020;12(11):7174–7186.
   PubMed Web of Science ®Google Scholar
• Xu Z, Han X, Ou D, et al. Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy. Appl Microbiol Biotechnol. 2020;104(2):575–587.
   PubMed Web of Science ®Google Scholar
• Lampada A, O’Prey J, Szabadkai G, et al. mTORC1-independent autophagy regulates receptor tyrosine kinase phosphorylation in colorectal cancer cells via an mTORC2-mediated mechanism. Cell Death Differ. 2017;24(6):1045–1062.
   PubMed Web of Science ®Google Scholar
• Zhang M, Mani SB, He Y, et al. Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis. J Clin Invest. 2016;126(8):2893–2902.
   PubMed Web of Science ®Google Scholar