Identification of the correlations between interleukin-27 (IL-27) and immune-inflammatory imbalance in preterm birth

References

• Vogel JP, Chawanpaiboon S, Moller AB, et al. The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:3–12.
   PubMed Web of Science ®Google Scholar
• Chawanpaiboon S, Vogel JP, Moller A-B, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7:e37–e46.
   PubMed Web of Science ®Google Scholar
• Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the sustainable development goals. Lancet. 2016;388:3027–3035.
   PubMed Web of Science ®Google Scholar
• Antony KM, Levison J, Suter MA, et al. Qualitative assessment of knowledge transfer regarding preterm birth in Malawi following the implementation of targeted health messages over 3 years. Int J Women’s Health. 2019;11:75–95.
   PubMed Web of Science ®Google Scholar
• Glover AV, Manuck TA. Screening for spontaneous preterm birth and resultant therapies to reduce neonatal morbidity and mortality: a review. Semin Fetal Neonatal Med. 2018;23:126–132.
   PubMed Web of Science ®Google Scholar
• The L. The unfinished agenda of preterm births. Lancet. 2016;388:2323.
   PubMed Web of Science ®Google Scholar
• Hall ES, Greenberg JM. Estimating community-level costs of preterm birth. Public Health. 2016;141:222–228.
   PubMed Web of Science ®Google Scholar
• Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010;362:529–535.
   PubMed Web of Science ®Google Scholar
• Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345:760–765.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Tosto V, Giardina I. The biological basis and prevention of preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018;52:13–22.
   PubMed Web of Science ®Google Scholar
• Peterson LS, Stelzer IA, Tsai AS, et al. Multiomic immune clockworks of pregnancy. Semin Immunopathol. 2020;42:397–412.
   PubMed Web of Science ®Google Scholar
• Cappelletti M, Della Bella S, Ferrazzi E, et al. Inflammation and preterm birth. J Leukoc Biol. 2016;99:67–78.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, StLouis D, Lehr MA, et al. Immune cells in term and preterm labor. Cell Mol Immunol. 2014;11:571–581.
   PubMed Web of Science ®Google Scholar
• Pflanz S, Timans JC, Cheung J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity. 2002;16:779–790.
   PubMed Web of Science ®Google Scholar
• Chen X, Deng R, Chi W, et al. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019;74:910–921.
   PubMed Web of Science ®Google Scholar
• Yao G, Qi J, Liang J, et al. Mesenchymal stem cell transplantation alleviates experimental Sjögren’s syndrome through IFN-β/IL-27 signaling axis. Theranostics. 2019;9:8253–8265.
   PubMed Web of Science ®Google Scholar
• Wang Q, Liu J. Regulation and immune function of IL-27. Adv Exp Med Biol. 2016;941:191–211.
   PubMed Web of Science ®Google Scholar
• Fabbi M, Carbotti G, Ferrini S. Dual roles of IL-27 in cancer biology and immunotherapy. Mediators Inflamm. 2017;2017:3958069.
   PubMed Web of Science ®Google Scholar
• Yoshida H, Hunter CA. The immunobiology of interleukin-27. Annu Rev Immunol. 2015;33:417–443.
   PubMed Web of Science ®Google Scholar
• Cox JH, Kljavin NM, Ramamoorthi N, et al. IL-27 promotes T cell-dependent colitis through multiple mechanisms. J Exp Med. 2011;208:115–123.
   PubMed Web of Science ®Google Scholar
• Guzzo C, Che Mat NF, Gee K. Interleukin-27 induces a STAT1/3- and NF-kappaB-dependent proinflammatory cytokine profile in human monocytes. J Biol Chem. 2010;285:24404–24411.
   PubMed Web of Science ®Google Scholar
• Beizavi Z, Zohouri M, Asadipour M, et al. IL-27, a pleiotropic cytokine for fine-tuning the immune response in cancer. Int Rev Immunol. 2020;1–11. DOI:10.1080/08830185.2020.1840565
   Web of Science ®Google Scholar
• Qi J, Zhang Z, Tang X, et al. IL-27 regulated CD4(+)IL-10(+) T cells in experimental sjögren syndrome. Front Immunol. 2020;11:1699.
   PubMed Web of Science ®Google Scholar
• Chen W, Gong Y, Zhang X, et al. Decreased expression of IL-27 in moderate-to-severe psoriasis and its anti-inflammation role in imiquimod-induced psoriasis-like mouse model. J Dermatol Sci. 2017;85:115–123.
   PubMed Web of Science ®Google Scholar
• Cui B, Lu S, Lai L, et al. Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells. Oncoimmunology. 2017;6:e1268309.
   PubMed Web of Science ®Google Scholar
• Wang L, Cao J, Li C, et al. IL-27/IL-27 receptor signaling provides protection in clostridium difficile-induced colitis. J Infect Dis. 2018;217:198–207.
   PubMed Web of Science ®Google Scholar
• Guo Y, Cao W, Zhu Y. Immunoregulatory functions of the IL-12 family of cytokines in antiviral systems. Viruses. 2019;11. DOI:10.3390/v11090772
   Web of Science ®Google Scholar
• Udhaya Kumar S, Thirumal Kumar D, Bithia R, et al. Analysis of differentially expressed genes and molecular pathways in familial hypercholesterolemia involved in atherosclerosis: a systematic and bioinformatics approach. Front Genet. 2020;11. DOI:10.3389/fgene.2020.00734
   PubMed Web of Science ®Google Scholar
• Rajan B, Abunada T, Younes S, et al. Involvement of essential signaling cascades and analysis of gene networks in diabesity. Genes (Basel). 2020;11:1256.
   PubMed Web of Science ®Google Scholar
• Fu D, Zhang B, Yang L, et al. Development of an immune-related risk signature for predicting prognosis in lung squamous cell carcinoma. Front Genet. 2020;11. DOI:10.3389/fgene.2020.00978
   Web of Science ®Google Scholar
• Pique-Regi R, Romero R, Tarca AL, et al. Single cell transcriptional signatures of the human placenta in term and preterm parturition. eLife. 2019;8. DOI:10.7554/eLife.52004
   PubMed Web of Science ®Google Scholar
• Menon R, Debnath C, Lai A, et al. Circulating exosomal miRNA profile during term and preterm birth pregnancies: a longitudinal study. Endocrinology. 2019;160:249–275.
   PubMed Web of Science ®Google Scholar
• Ran Y, Yin N, Huang D, et al. Identification and characterization of circular RNA as a novel regulator and biomarker in preterm birth. Front Bioeng Biotechnol. 2020;8:566984.
   PubMed Web of Science ®Google Scholar
• Kumar SU, Kumar DT, Siva R, et al. Integrative bioinformatics approaches to map potential novel genes and pathways involved in ovarian cancer. Front Bioeng Biotechnol. 2019;7. DOI:10.3389/fbioe.2019.00391
   Web of Science ®Google Scholar
• Udhaya Kumar S, Thirumal Kumar D, Siva R, et al. Dysregulation of signaling pathways due to differentially expressed genes from the b-cell transcriptomes of systemic lupus erythematosus patients – a bioinformatics approach. Front Bioeng Biotechnol. 2020;8. DOI:10.3389/fbioe.2020.00276
   PubMed Web of Science ®Google Scholar
• Yan H, Zheng G, Qu J, et al. Identification of key candidate genes and pathways in multiple myeloma by integrated bioinformatics analysis. J Cell Physiol. 2019;234:23785–23797.
   PubMed Web of Science ®Google Scholar
• Yin N, Wang H, Zhang H, et al. IL-27 induces a pro-inflammatory response in human fetal membranes mediating preterm birth. Int Immunopharmacol. 2017;50:361–369.
   PubMed Web of Science ®Google Scholar
• Kim D, Paggi JM, Park C, et al. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat Biotechnol. 2019;37:907–915.
   PubMed Web of Science ®Google Scholar
• Pertea M, Pertea GM, Antonescu CM, et al. StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat Biotechnol. 2015;33(3):290–295.
   PubMed Web of Science ®Google Scholar
• Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43:e47.
   PubMed Web of Science ®Google Scholar
• Franz M, Rodriguez H, Lopes C, et al. GeneMANIA update 2018. Nucleic Acids Res. 2018;46:W60–w4.
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, et al. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16:284–287.
   PubMed Web of Science ®Google Scholar
• Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–2504.
   PubMed Web of Science ®Google Scholar
• Ito K, Murphy D. Application of ggplot2 to pharmacometric graphics. CPT. 2013;2:e79.
   Google Scholar
• Liberzon A, Birger C, Thorvaldsdóttir H, et al. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1:417–425.
   PubMed Web of Science ®Google Scholar
• Miao YR, Zhang Q, Lei Q, et al. ImmuCellAI: a unique method for comprehensive T-cell subsets abundance prediction and its application in cancer immunotherapy. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2020;7:1902880.
   PubMedGoogle Scholar
• Coulomb-L’Herminé A, Larousserie F, Pflanz S, et al. Expression of interleukin-27 by human trophoblast cells. Placenta. 2007;28:1133–1140.
   PubMed Web of Science ®Google Scholar
• Wang WJ, Liu FJ, Qu HM, et al. Regulation of the expression of Th17 cells and regulatory T cells by IL-27 in patients with unexplained early recurrent miscarriage. J Reprod Immunol. 2013;99:39–45.
   PubMed Web of Science ®Google Scholar
• Hu X, Zhu Q, Wang Y, et al. Newly characterized decidual Tim-3+ Treg cells are abundant during early pregnancy and driven by IL-27 coordinately with Gal-9 from trophoblasts. Hum Reprod. 2020;35:2454–2466.
   PubMed Web of Science ®Google Scholar
• Xu F, Yi J, Wang Z, et al. IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations. Immunol Res. 2017;65:903–912.
   PubMed Web of Science ®Google Scholar
• Tagoma A, Haller-Kikkatalo K, Roos K, et al. Interleukin-7, T helper 1, and regulatory T-cell activity-related cytokines are increased during the second trimester of healthy pregnancy compared to non-pregnant women. Am J Reproduct Immunol. 2019;82:e13188.
   PubMed Web of Science ®Google Scholar
• Yin N, Zhang H, Luo X, et al. IL-27 activates human trophoblasts to express IP-10 and IL-6: implications in the immunopathophysiology of preeclampsia. Mediators Inflamm. 2014;2014:926875.
   PubMed Web of Science ®Google Scholar
• Jahantigh D, Mousavi M, Forghani F, et al. Association between maternal circulating IL-27 levels and preeclampsia. Cytokine. 2018;102:163–167.
   PubMed Web of Science ®Google Scholar
• Verbruggen SW, Oyen ML, Phillips AT, et al. Function and failure of the fetal membrane: modelling the mechanics of the chorion and amnion. PloS One. 2017;12:e0171588.
   PubMed Web of Science ®Google Scholar
• Menon R. Human fetal membranes at term: dead tissue or signalers of parturition? Placenta. 2016;44:1–5.
   PubMed Web of Science ®Google Scholar
• Meng J, Wekesa JS, Shi GL, et al. Protein function prediction based on data fusion and functional interrelationship. Math Biosci. 2016;274:25–32.
   PubMed Web of Science ®Google Scholar
• Mishra S, Shah MI, Udhaya Kumar S, et al. Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by bioinformatics approach. Adv Protein Chem Struct Biol. Amsterdam, Netherlands: Elsevier; 2021; 123:241-73.
   Google Scholar
• Udhaya Kumar S, Saleem A, Thirumal Kumar D, et al. A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis. Advances in protein chemistry and structural biology. Academic Press; 2021.
   Google Scholar
• Orozco S, Oberst A. RIPK3 in cell death and inflammation: the good, the bad, and the ugly. Immunol Rev. 2017;277:102–112.
   PubMed Web of Science ®Google Scholar
• Moriwaki K, Chan FK. The Inflammatory Signal Adaptor RIPK3: functions Beyond Necroptosis. Int Rev Cell Mol Biol. 2017;328:253–275.
   PubMed Web of Science ®Google Scholar
• Shlomovitz I, Zargrian S, Gerlic M. Mechanisms of RIPK3-induced inflammation. Immunol Cell Biol. 2017;95:166–172.
   PubMed Web of Science ®Google Scholar
• Najjar M, Saleh D, Zelic M, et al. RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by toll-like receptor 4. Immunity. 2016;45:46–59.
   PubMed Web of Science ®Google Scholar
• Shen W, Chang A, Wang J, et al. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis. 2015;4:e173.
   PubMed Web of Science ®Google Scholar
• Ding N, Zhang Y, Loughran PA, et al. TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release. Free Radic Biol Med. 2013;63:361–367.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Plazyo O, et al. Intra-amniotic administration of HMGB1 induces spontaneous preterm labor and birth. Am J Reproduct Immunol. 2016;75:3–7.
   PubMed Web of Science ®Google Scholar
• Karahoda R, Ceckova M, Staud F. The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta. Toxicol Appl Pharmacol. 2019;368:18–25.
   PubMed Web of Science ®Google Scholar
• Jinno N, Furugen A, Kurosawa Y, et al. Effects of single and repetitive valproic acid administration on the gene expression of placental transporters in pregnant rats: an analysis by gestational period. Reprod Toxicol. 2020;96:47–56.
   PubMed Web of Science ®Google Scholar
• Lee YH, Bae SC, Kim JH, et al. Meta-analysis of SLC22A4 and RUNX1 polymorphisms: associations with rheumatoid arthritis susceptibility. Z Rheumatol. 2015;74:351–358.
   PubMed Web of Science ®Google Scholar
• McCann MJ, Johnston S, Reilly K, et al. The effect of turmeric (Curcuma longa) extract on the functionality of the solute carrier protein 22 A4 (SLC22A4) and interleukin-10 (IL-10) variants associated with inflammatory bowel disease. Nutrients. 2014;6(10):4178–4190.
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay S, Heinz E, Porreca I, et al. Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2. J Exp Med. 2020; 217(2):e20180649.
   Google Scholar
• Mobini M, Mortazavi M, Nadi S, et al. Significant roles played by interleukin-10 in outcome of pregnancy. Iran J Basic Med Sci. 2016;19:119–124.
   PubMed Web of Science ®Google Scholar
• Cheng SB, Sharma S. Interleukin-10: a pleiotropic regulator in pregnancy. Am J Reproduct Immunol. 2015;73:487–500.
   PubMed Web of Science ®Google Scholar
• Fisher AL, Nemeth E. Iron homeostasis during pregnancy. Am J Clin Nutr. 2017;106:1567s–74s.
   PubMed Web of Science ®Google Scholar
• Van Boeckel SR, Davidson DJ, Norman JE, et al. Cell-free fetal DNA and spontaneous preterm birth. Reproduction. 2018;155:R137–r45.
   PubMed Web of Science ®Google Scholar
• Chuffa LGA, Lupi LA, Cucielo MS, et al. Melatonin promotes uterine and placental health: potential molecular mechanisms. Int J Mol Sci. 2019;21. DOI:10.3390/ijms21010300
   PubMed Web of Science ®Google Scholar
• Vassiliadis S, Ranella A, Papadimitriou L, et al. Serum levels of pro- and anti-inflammatory cytokines in non-pregnant women, during pregnancy, labour and abortion. Mediators Inflamm. 1998;7:69–72.
   PubMed Web of Science ®Google Scholar
• Makhseed M, Raghupathy R, El-Shazly S, et al. Pro-inflammatory maternal cytokine profile in preterm delivery. Am J Reproduct Immunol. 2003;49:308–318.
   PubMed Web of Science ®Google Scholar
• Curry AE, Vogel I, Drews C, et al. Mid-pregnancy maternal plasma levels of interleukin 2, 6, and 12, tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor and spontaneous preterm delivery. Acta Obstet Gynecol Scand. 2007;86:1103–1110.
   PubMed Web of Science ®Google Scholar
• Frascoli M, Coniglio L, Witt R, et al. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α. Sci Transl Med. 2018;10. DOI:10.1126/scitranslmed.aan2263
   PubMed Web of Science ®Google Scholar
• PrabhuDas M, Bonney E, Caron K, et al. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol. 2015;16:328–334.
   PubMed Web of Science ®Google Scholar
• Yang F, Zheng Q, Jin L. Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface. Front Immunol. 2019;10:2317.
   PubMed Web of Science ®Google Scholar
• Zhao S, Liang T, Zhang C, et al. IL-27 Rα(+) cells promoted allorejection via enhancing STAT1/3/5 phosphorylation. J Cell Mol Med. 2020;24:10756–10767.
   PubMed Web of Science ®Google Scholar
• Amadi-Obi A, Yu CR, Dambuza I, et al. Interleukin 27 induces the expression of complement factor H (CFH) in the retina. PloS One. 2012;7:e45801.
   PubMed Web of Science ®Google Scholar
• Hu X, Goswami S, Qiu J, et al. Profiles of long non-coding RNAs and mRNA expression in human macrophages regulated by interleukin-27. Int J Mol Sci. 2019;20. DOI:10.3390/ijms20246207
   Web of Science ®Google Scholar
• Galindo-Sevilla N, Reyes-Arroyo F, Mancilla-Ramírez J. The role of complement in preterm birth and prematurity. J Perinat Med. 2019;47:793–803.
   PubMed Web of Science ®Google Scholar
• Girardi G. Complement activation, a threat to pregnancy. Semin Immunopathol. 2018;40:103–111.
   PubMed Web of Science ®Google Scholar
• Erlebacher A. Immunology of the maternal-fetal interface. Annu Rev Immunol. 2013;31:387–411.
   PubMed Web of Science ®Google Scholar
• Peshkova IO, Aghayev T, Fatkhullina AR, et al. IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm development. Nat Commun. 2019;10:5046.
   PubMed Web of Science ®Google Scholar
• Tang MX, Hu XH, Liu ZZ, et al. What are the roles of macrophages and monocytes in human pregnancy? J Reprod Immunol. 2015;112:73–80.
   PubMed Web of Science ®Google Scholar
• Guzzo C, Ayer A, Basta S, et al. IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. J Immunol. 2012;188:864–873.
   PubMed Web of Science ®Google Scholar
• Gregersen I, Sandanger Ø, Askevold ET, et al. Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation. PloS One. 2017;12:e0188387.
   PubMed Web of Science ®Google Scholar
• Petes C, Wynick C, Guzzo C, et al. IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages. J Leukoc Biol. 2017;102:83–94.
   PubMed Web of Science ®Google Scholar
• Tong M, Abrahams VM. Neutrophils in preterm birth: friend or foe? Placenta. 2020;102:17–20.
   PubMed Web of Science ®Google Scholar
• Povroznik JM, Robinson CM. IL-27 regulation of innate immunity and control of microbial growth. Future Sci OA. 2020;6:Fso588.
   PubMed Web of Science ®Google Scholar
• Gwyer Findlay E, Villegas-Mendez A, de Souza JB, et al. IL-27 receptor signaling regulates CD4+ T cell chemotactic responses during infection. J Immunol. 2013;190:4553–4561.
   PubMed Web of Science ®Google Scholar
• Wang S, Sun F, Li M, et al. The appropriate frequency and function of decidual Tim-3(+)CTLA-4(+)CD8(+) T cells are important in maintaining normal pregnancy. Cell Death Dis. 2019;10:407.
   PubMed Web of Science ®Google Scholar
• Wang SC, Li YH, Piao HL, et al. PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy. Cell Death Dis. 2015;6:e1738.
   PubMed Web of Science ®Google Scholar
• Papúchová H, Meer TB, Li Q, et al. The Dual Role of HLA-C in Tolerance and Immunity at the Maternal-Fetal Interface. Front Immunol. 2019;10:2730.
   PubMed Web of Science ®Google Scholar
• Blois SM, Joachim R, Kandil J, et al. Depletion of CD8+ cells abolishes the pregnancy protective effect of progesterone substitution with dydrogesterone in mice by altering the Th1/Th2 cytokine profile. J Immunol. 2004;172:5893–5899.
   PubMed Web of Science ®Google Scholar
• Liu S, Diao L, Huang C, et al. The role of decidual immune cells on human pregnancy. J Reprod Immunol. 2017;124:44–53.
   PubMed Web of Science ®Google Scholar