An in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats

References

• Ma K, Chen S, Li Z, et al. Mechanisms of endogenous repair failure during intervertebral disc degeneration. Osteoarthritis Cartilage. 2019;27:41–48.
   PubMed Web of Science ®Google Scholar
• Guo W, Zhang B, Mu K, et al. Circular RNA GRB10 as a competitive endogenous RNA regulating nucleus pulposus cells death in degenerative intervertebral disk. Cell Death Dis. 2018;9:319.
   PubMed Web of Science ®Google Scholar
• Teles Filho RV, Abe GDM, Daher MT, et al. Genetic influence in disc degeneration - systematic review of literature. Rev Bras Ortop (Sao Paulo). 2020;55:131–138. .
   Google Scholar
• Wu PH, Hs K, Jang IT Intervertebral disc diseases PART 2: a review of the current diagnostic and treatment strategies for intervertebral disc disease. Int J Mol Sci. 2020;21(6): 2135
   PubMed Web of Science ®Google Scholar
• Hanaei S, Abdollahzade S, Khoshnevisan A, et al. Genetic aspects of intervertebral disc degeneration. Rev Neurosci. 2015;26:581–606.
   PubMed Web of Science ®Google Scholar
• Guo HY, Guo MK, Wan ZY, et al. Emerging evidence on noncoding-RNA regulatory machinery in intervertebral disc degeneration: a narrative review. Arthritis Res Ther. 2020;22:270.
   PubMed Web of Science ®Google Scholar
• Lei M, Wang K, Li S, et al. The c-Jun signaling pathway has a protective effect on nucleus pulposus cells in patients with intervertebral disc degeneration. Exp Ther Med. 2020;20:123.
   PubMed Web of Science ®Google Scholar
• Li H, Li W, Liang B, et al. Role of AP-2α/TGF-β1/Smad3 axis in rats with intervertebral disc degeneration. Life Sci. 2020;263:118567.
   PubMed Web of Science ®Google Scholar
• Xiao L, Ding M, Saadoon O, et al. A novel culture platform for fast proliferation of human annulus fibrosus cells. Cell Tissue Res. 2017;367:339–350.
   PubMed Web of Science ®Google Scholar
• Matta A, Erwin WM. Injectable biologics for the treatment of degenerative disc disease. Curr Rev Musculoskelet Med. 2020;13:680–687.
   PubMed Web of Science ®Google Scholar
• Yurube T, Ito M, Kakiuchi Y, et al. Autophagy and mTOR signaling during intervertebral disc aging and degeneration. JOR Spine. 2020;3:e1082.
   PubMedGoogle Scholar
• Byers NM, Vandergaast RL, Friesen PD, et al. Baculovirus inhibitor-of-apoptosis Op-IAP3 blocks apoptosis by interaction with and stabilization of a host insect cellular IAP. J Virol. 2016;90(1):533–544.
   PubMed Web of Science ®Google Scholar
• Jin H, Shen J, Wang B, et al. TGF-β. signaling plays an essential role in the growth and maintenance of intervertebral disc tissue. FEBS Lett. 2011;585:1209–1215.
   PubMed Web of Science ®Google Scholar
• Khan NM, Diaz-Hernandez ME, Presciutti SM, et al. Network analysis identifies gene regulatory network indicating the role of RUNX1 in human intervertebral disc degeneration. Genes (Basel). 2020;11(7):11.
   Web of Science ®Google Scholar
• Feng C, Liu H, Yang M, et al. Disc cell senescence in intervertebral disc degeneration: causes and molecular pathways. Cell Cycle. 2016;15(13):1674–1684.
   PubMed Web of Science ®Google Scholar
• Angel P, Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1991;1072(2–3):129–157.
   PubMed Web of Science ®Google Scholar
• Papavassiliou AG, Musti AM. The multifaceted output of c-jun biological activity: focus at the junction of CD8 T cell activation and exhaustion. Cells. 2020;9. DOI:10.3390/cells9112470
   PubMed Web of Science ®Google Scholar
• Wisdom R, RS J, Moore C c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. Embo J. 1999;18:188–197.
   PubMed Web of Science ®Google Scholar
• Chuang HC, Tsai CY, Hsueh CH, et al. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401.
   PubMed Web of Science ®Google Scholar
• Behrens A, Sibilia M, David JP, et al. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. Embo J. 2002;21:1782–1790.
   PubMed Web of Science ®Google Scholar
• Behrens A, Haigh J, Mechta-Grigoriou F, et al. Impaired intervertebral disc formation in the absence of Jun. Development. 2003;130:103–109.
   PubMed Web of Science ®Google Scholar
• Sanber KS, Knight SB, Stephen SL, et al. Construction of stable packaging cell lines for clinical lentiviral vector production. Sci Rep. 2015;5:9021.
   PubMed Web of Science ®Google Scholar
• Zhang J, Li Z, Chen F, et al. TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model. Exp Mol Med. 2017;49:e379.
   PubMed Web of Science ®Google Scholar
• Elliott DM, Yerramalli CS, Beckstein JC, et al. The effect of relative needle diameter in puncture and sham injection animal models of degeneration. Spine (Phila Pa 1976). 1976;2008(33):588–596.
   Google Scholar
• Tolonen J, Grönblad M, Virri J, et al. Oncoprotein c-Fos and c-Jun immunopositive cells and cell clusters in herniated intervertebral disc tissue. Eur Spine J. 2002;11:452–458.
   PubMed Web of Science ®Google Scholar
• Brown S, Matta A, Erwin M, et al. Cell clusters are indicative of stem cell activity in the degenerate intervertebral disc: can their properties be manipulated to improve intrinsic repair of the disc? Stem Cells Dev. 2018;27:147–165.
   PubMed Web of Science ®Google Scholar
• Xu L, Chen Y, Li Q, et al. Molecular cloning. Fish Shellfish Immunol. 2020;98:981–987.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Feng XH, Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature. 1998;394:909–913.
   PubMed Web of Science ®Google Scholar
• Qing J, Zhang Y, Derynck R, et al. Structural and functional characterization of the transforming growth factor-beta -induced Smad3/c-Jun transcriptional cooperativity. J Biol Chem. 2000;275:38802–38812.
   PubMed Web of Science ®Google Scholar
• Zheng Q, Bao C, Guo W, et al. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 2016;7:11215.
   PubMed Web of Science ®Google Scholar
• Bian Q, Ma L, Jain A, et al. Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis. Bone Res. 2017;5:17008.
   PubMed Web of Science ®Google Scholar
• Wang WJ, Yu XH, Wang C, et al. MMPs and ADAMTSs in intervertebral disc degeneration. Clin Chim Acta. 2015;448:238–246.
   PubMed Web of Science ®Google Scholar
• Cai F, Zhu L, Wang F, et al. The paracrine effect of degenerated disc cells on healthy human nucleus pulposus cells is mediated by MAPK and NF-κB pathways and can be reduced by TGF-β1. DNA Cell Biol. 2017;36:143–158.
   PubMed Web of Science ®Google Scholar
• Clerk A, Harrison JG, Long CS, et al. Pro-inflammatory cytokines stimulate mitogen-activated protein kinase subfamilies, increase phosphorylation of c-Jun and ATF2 and upregulate c-Jun protein in neonatal rat ventricular myocytes. J Mol Cell Cardiol. 1999;31(12):2087–2099.
   PubMed Web of Science ®Google Scholar
• Riesenberg S, Groetchen A, Siddaway R, et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015;6:8755.
   PubMed Web of Science ®Google Scholar
• Li JK, Nie L, Zhao YP, et al. IL-17 mediates inflammatory reactions via p38/c-Fos and JNK/c-Jun activation in an AP-1-dependent manner in human nucleus pulposus cells. J Transl Med. 2016;14:77.
   PubMed Web of Science ®Google Scholar
• Monchaux M, Forterre S, Spreng D, et al. Inflammatory processes associated with canine intervertebral disc herniation. Front Immunol. 2017;8:1681.
   PubMed Web of Science ®Google Scholar
• Weber KT, Alipui DO, Sison CP, et al. Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. Arthritis Res Ther. 2016;18:3.
   PubMed Web of Science ®Google Scholar
• Liu XG, HOU H-W, LIU Y-L, et al. Expression levels of IL-17 and TNF-α in degenerated lumbar intervertebral discs and their correlation. Exp Ther Med. 2016;11(6):2333–2340.
   PubMed Web of Science ®Google Scholar
• Sampara P, Banala RR, Vemuri SK, et al. Understanding the molecular biology of intervertebral disc degeneration and potential gene therapy strategies for regeneration: a review. Gene Ther. 2018;25:67–82.
   PubMed Web of Science ®Google Scholar
• Liu Y, Yu T, Ma XX, et al. Lentivirus-mediated TGF-β3, CTGF and TIMP1 gene transduction as a gene therapy for intervertebral disc degeneration in an in vivo rabbit model. Exp Ther Med. 2016;11:1399–1404.
   PubMed Web of Science ®Google Scholar
• Zhang YH, Zhao YL, Li B, et al. Lentivirus Is an Efficient and Stable Transduction Vector for Intervertebral Disc Cells. World Neurosurg. 2018;111:e348–e354.
   PubMed Web of Science ®Google Scholar
• Li P, Zhang R, Gan Y, et al. Effects of osteogenic protein-1 on intervertebral disc regeneration: a systematic review of animal studies. Biomed Pharmacother. 2017;88:260–266.
   PubMed Web of Science ®Google Scholar