1,821
Views
5
CrossRef citations to date
0
Altmetric
Research Paper

Azilsartan protects against hyperglycemia-induced hyperpermeability of the blood-brain barrier

, , , , & ORCID Icon
Pages 3621-3633 | Received 06 Apr 2021, Accepted 23 Jun 2021, Published online: 16 Jul 2021

References

  • Juan J, Yang H. Prevalence, Prevention, and Lifestyle Intervention of Gestational Diabetes Mellitus in China. Int J Environ Res Public Health. 2020;17(24):9517.
  • Tumminia A, Vinciguerra F, Parisi M, et al. Type 2 Diabetes Mellitus and Alzheimer’s Disease: Role of Insulin Signalling and Therapeutic Implications. Int J Mol Sci. 2018 Oct 24;19(11):3306.
  • Umegaki H, Hayashi T, Nomura H, et al. Cognitive dysfunction: an emerging concept of a new diabetic complication in the elderly. Geriatr Gerontol Int. 2013;13(1):28–34. DOI:10.1111/j.1447-0594.2012.00922.x.
  • Cukierman-Yaffee T. The relationship between dysglycemia and cognitive dysfunction. Curr Opin Invest Drugs. 2009;10:70–74.
  • Biessels GJ. Sweet memories: 20 years of progress in research on cognitive functioning in diabetes. Eur J Pharmacol. 2013;719(1–3):153–160.
  • Prasad S, Sajja RK, Naik P, et al. Diabetes mellitus and blood-brain barrier dysfunction: an overview. J Pharmacovigil. 2014;2:125.
  • Daneman R, Prat A. The blood-brain barrier.Cold Spring Harb Perspect Biol. 2015;7:a020412.
  • Chehade JM, Haas MJ, Mooradian AD. Diabetes-related changes in rat cerebral occludin and zonula occludens-1 (ZO-1) expression. Neurochem Res. 2002;27(3):249–252.
  • VanGilder RL, Kelly KA, Chua MD, et al. Administration of sesamol improved blood-brain barrier function in streptozotocin-induced diabetic rats. Exp Brain Res. 2009;197(1):23–34.
  • Kook SY, Seok Hong H, Moon M, et al. Disruption of blood-brain barrier in Alzheimer disease pathogenesis. Tissue Barriers. 2013;1:e23993. DOI:10.4161/tisb.23993
  • Chiplunkar AR, Curtis BC, Eades GL, et al. The Kruppel-like factor 2 and Kruppel-like factor 4 genes interact to maintain endothelial integrity in mouse embryonic vasculogenesis. BMC Dev Biol. 2013;13(1):40. DOI:10.1186/1471-213X-13-40.
  • Hjermitslev M, Grimm DG, Wehland M, et al. Azilsartan medoxomil, an angiotensin ii receptor antagonist for the treatment of hypertension. Basic Clin Pharmacol Toxicol. 2017;121(4):225–233.
  • Pradhan A, Tiwari A, Sethi R. Azilsartan: current evidence and perspectives in management of hypertension. Int J Hypertens. 2019;2019:1824621.
  • Liu H, Mao P, Wang J, et al. Azilsartan, an angiotensin II type 1 receptor blocker, attenuates tert-butyl hydroperoxide-induced endothelial cell injury through inhibition of mitochondrial dysfunction and anti-inflammatory activity. Neurochem Int. 2016;94:48–56.
  • Gupta V, Dhull DK, Joshi J, et al. Neuroprotective potential of azilsartan against cerebral ischemic injury: possible involvement of mitochondrial mechanisms. Neurochem Int. 2020;132:104604.
  • Nong A, Li QF, Huang ZJ, et al. MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway. Bioengineered. 2021;12(1):2639–2648.
  • Chen LQ, Zhu QL, Lu LW, et al. MiR-132 inhibits migration and invasion and increases chemosensitivity of cisplatin-resistant oral squamous cell carcinoma cells via targeting TGF-β1. Bioengineered. 2020;11(1):91–102.
  • Liu WY, Miao YQ, Zhang L, et al. MiR-211 protects cerebral ischemia/reperfusion injury by inhibiting cell apoptosis. Bioengineered. 2020;11(1):189–200.
  • Yamagishi S, Imaizumi T. Diabetic vascular complications: pathophysiology, biochemical basis and potential therapeutic strategy. Curr Pharm Des. 2005;11(18):2279–2299.
  • Calderon-Garciduenas L, Villarreal-Calderon R, Valencia-Salazar G, et al. Systemic inflammation, endothelial dysfunction, and activation in clinically healthy children exposed to air pollutants. Inhal Toxicol. 2008;20(5):499–506. DOI:10.1080/08958370701864797.
  • Stauber WT, Ong SH, McCuskey RS. Selective extravascular escape of albumin into the cerebral cortex of the diabetic rat. Diabetes. 1981;30(6):500–503.
  • Kumar TP, Antony S, Gireesh G, et al. Curcumin modulates dopaminergic receptor, CREB and phospholipase C gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. J Biomed Sci. 2010;17(1):43.
  • Zhao Z, Hu J, Gao X, et al. Hyperglycemia via activation of thromboxane A2 receptor impairs the integrity and function of blood-brain barrier in microvascular endothelial cells. Oncotarget. 2017;8(18):30030–30038. DOI:10.18632/oncotarget.16273.
  • Rom S, Zuluaga-Ramirez V, Gajghate S, et al. Hyperglycemia-driven neuroinflammation compromises bbb leading to memory loss in both diabetes mellitus (DM) Type 1 and Type 2 mouse models. Mol Neurobiol. 2019;56(3):1883–1896. DOI:10.1007/s12035-018-1195-5.
  • Muriach M, Flores-Bellver M, Romero FJ, et al. Diabetes and the brain: oxidative stress, inflammation, and autophagy. Oxid Med Cell Longev. 2014;102158. DOI:10.1155/2014/102158
  • Deli MA, Descamps L, Dehouck MP, et al. Exposure of tumor necrosis factor-alpha to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin. J Neurosci Res. 1995;41(6):717–726. DOI:10.1002/jnr.490410602.
  • Didier N, Romero IA, Creminon C, et al. Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability. J Neurochem. 2003;86(1):246–254.
  • Engelhardt B, Sorokin L. The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol. 2009;31(4):497–511.
  • Karam BS, Chavez-Moreno A, Koh W, et al. Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes. Cardiovasc Diabetol. 2017;16(1):120.
  • Price TO, Eranki V, Banks WA, et al. Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice. Endocrinology. 2012;153(1):362–372.
  • Jha P, Das H. KLF2 in regulation of NF-kappaB-mediated immune cell function and inflammation. Int J Mol Sci. 2017;18.
  • Atkins GB, Jain MK. Role of Kruppel-like transcription factors in endothelial biology. Circ Res. 2007;100(12):1686–1695.
  • Shi H, Sheng B, Zhang F, et al. Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function. Am J Physiol Heart Circ Physiol. 2013;304(6):H796–805. DOI:10.1152/ajpheart.00712.2012.
  • Wang B, Chandrasekera PC, Pippin JJ. Leptin- and leptin receptor-deficient rodent models: relevance for human type 2 diabetes. Curr Diabetes Rev. 2014;10(2):131–145.
  • Alonso-Galicia M, Brands MW, Zappe DH, et al. Hypertension in obese Zucker rats Role of angiotensin II and adrenergic activity. Hypertension. 1996 Dec;28(6):1047–1054.