Overexpression of Notch2 enhances radiosensitivity via inhibition of the AKT/mTOR signaling pathway in nasopharyngeal carcinoma

References

• Yang W. Preclinical advances in nasopharyngeal carcinoma treatment. Cell Cycle. 2017;16:1015–1016.
   PubMed Web of Science ®Google Scholar
• Chen YP, Chan AT, Le QT, et al. Nasopharyngeal carcinoma. Lancet. 2019;394:64–80.
   PubMed Web of Science ®Google Scholar
• Lang J, Hu C, Lu T, et al. Chinese expert consensus on diagnosis and treatment of nasopharyngeal carcinoma: evidence from current practice and future perspectives. Cancer Manag Res. 2019;11:6365–6376.
   PubMed Web of Science ®Google Scholar
• Lee AW, Ma BB, Ng WT, et al. Management of nasopharyngeal carcinoma: current practice and future perspective. J Clin Oncol. 2015;33:3356–3364.
   PubMed Web of Science ®Google Scholar
• Wanigasooriya K, Tyler R, Barros-Silva JD, et al. Radiosensitising cancer using phosphatidylinositol-3-Kinase (PI3K), protein kinase B (AKT) or mammalian target of rapamycin (mTOR) inhibitors. Cancers (Basel). 2020;12. DOI:10.3390/cancers12051278.
   PubMed Web of Science ®Google Scholar
• Wei F, Liu Y, Guo Y, et al. miR-99b-targeted mTOR induction contributes to irradiation resistance in pancreatic cancer. Mol Cancer. 2013;12:81.
   PubMed Web of Science ®Google Scholar
• Freudlsperger C, Burnett JR, Friedman JA, et al. EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy. Expert Opin Ther Tar. 2011;15:63–74.
   PubMed Web of Science ®Google Scholar
• Zhu P, Wang Y, Du Y, et al. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling. Nat Commun. 2015;6:7122.
   PubMed Web of Science ®Google Scholar
• Wang X, Meng Q, Qiao W, et al. miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC. Stem Cell Res Ther. 2018;9:327.
   PubMed Web of Science ®Google Scholar
• Wang WJ, Yao Y, Jiang LL, et al. Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Dis Markers. 2013;35:395–405.
   PubMedGoogle Scholar
• Zou Y, Yang R, Huang ML, et al. NOTCH2 negatively regulates metastasis and epithelial-Mesenchymal transition via TRAF6/AKT in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2019;38:456.
   PubMed Web of Science ®Google Scholar
• Marie-Egyptienne DT, Lohse I, Hill RP. Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: potential role of hypoxia. Cancer Lett. 2013;341:63–72.
   PubMed Web of Science ®Google Scholar
• Wang L, Wu A, Wang Y, et al. Functional genomics reveals linkers critical for influenza virus polymerase. J Virol. 2015;90(6):2938–2947.
   PubMed Web of Science ®Google Scholar
• Wang Z, Mao JW, Liu Y, et al. MicroRNA-372 enhances radiosensitivity while inhibiting cell invasion and metastasis in nasopharyngeal carcinoma through activating the PBK-dependent p53 signaling pathway. Cancer Med. 2019;8(2):712–728.
   PubMed Web of Science ®Google Scholar
• Qu W, Wen X, Su K, et al. MiR-552 promotes the proliferation, migration and EMT of hepatocellular carcinoma cells by inhibiting AJAP1 expression. J Cell Mol Med. 2019;23(2):1541–1552.
   PubMed Web of Science ®Google Scholar
• Tan S, Yi P, Wang H, et al. RAC1 involves in the radioresistance by mediating epithelial-mesenchymal transition in lung cancer. Front Oncol. 2020;10:649.
   PubMed Web of Science ®Google Scholar
• Xu G, Fan L, Zhao S, et al. Neuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway. Bioengineered. 2021;10:455–464.
   Google Scholar
• Zhang X, Wen L, Chen S, et al. The novel long noncoding RNA CRART16 confers cetuximab resistance in colorectal cancer cells by enhancing ERBB3 expression via miR-371a-5p. Cancer Cell Int. 2020;20:68.
   PubMed Web of Science ®Google Scholar
• Yang T, Zhiheng H, Zhanhuai W, et al. Increased RAB31 expression in cancer-associated fibroblasts promotes colon cancer progression through HGF-MET signaling. Front Oncol. 2020;10:1747.
   PubMed Web of Science ®Google Scholar
• Jin Y, Xu K, Chen Q, et al. Simvastatin inhibits the development of radioresistant esophageal cancer cells by increasing the radiosensitivity and reversing EMT process via the PTEN-PI3K/AKT pathway. Exp. Cell. Res 2018;362:362–369.
   PubMed Web of Science ®Google Scholar
• Zhang J, Jin X, Zhou C, et al. Resveratrol suppresses human nasopharyngeal carcinoma cell growth via inhibiting differentiation antagonizing non-protein coding RNA (DANCR) expression. Med Sci Monit. 2020;26:e923622.
   PubMed Web of Science ®Google Scholar
• Yang R, Tao ZZ, Huang ML, et al. Knockout of the placenta specific 8 gene radiosensitizes nasopharyngeal carcinoma cells by activating the PI3K/AKT/GSK3beta pathway. Am J Transl Res. 2018;10:455–464.
   PubMed Web of Science ®Google Scholar
• Nie X, Guo E, Wu C, et al. SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway. Cancer Med. 2019;8:1779–1792.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Huo H, Liao K, et al. RPA1 downregulation enhances nasopharyngeal cancer radiosensitivity via blocking RAD51 to the DNA damage site. Exp Cell Res.2018. DOI: 10.1016/j.yexcr.2018.08.025.
   Web of Science ®Google Scholar
• Eriksson D, Stigbrand T. Radiation-induced cell death mechanisms. Tumour Biol. 2010;31:363–372.
   PubMed Web of Science ®Google Scholar
• Chen J, Li P, Song L, et al. 53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice. Cell Death Differ. 2020;27:2552–2567.
   PubMed Web of Science ®Google Scholar
• Wilson GD. Radiation and the cell cycle, revisited. Cancer Metastasis Rev. 2004;23:209–225.
   PubMed Web of Science ®Google Scholar
• Tchakarska G, Sola B. The double dealing of cyclin D1. Cell Cycle. 2020;19:163–178.
   PubMed Web of Science ®Google Scholar
• Zhao S, Wang L, Zhang C, et al. Inhibitor of growth 3 induces cell death by regulating cell proliferation, apoptosis and cell cycle arrest by blocking the PI3K/AKT pathway. Cancer Gene Ther. 2018;25:240–247.
   PubMed Web of Science ®Google Scholar
• Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993;74:609–619.
   PubMed Web of Science ®Google Scholar
• Griffiths GS, Doe J, Jijiwa M, et al. Bit-1 is an essential regulator of myogenic differentiation. J Cell Sci. 2015;128:1707–1717.
   PubMed Web of Science ®Google Scholar
• Huang F, Liang X, Min X, et al. Simultaneous inhibition of EGFR and HER2 via afatinib augments the radiosensitivity of nasopharyngeal carcinoma cells. J Cancer. 2019;10:2063–2073.
   PubMed Web of Science ®Google Scholar
• Bai M, Ma X, Li X, et al. The accomplices of NF-kappaB lead to radioresistance. Curr. Protein. Pept. Sci. 2015;16:279–294.
   PubMed Web of Science ®Google Scholar
• Chang L, Huang Z, Li S. et al. A low dose of AZD8055 enhances radiosensitivity of nasopharyngeal carcinoma cells by activating autophagy and apoptosis. Am J Cancer Res. 2019;9(9):1922–1937.
   PubMed Web of Science ®Google Scholar
• Horn D, Hess J, Freier K, et al. Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma. Expert Opin Ther Targets. 2015;19:795–805.
   PubMed Web of Science ®Google Scholar
• Zhang CC, Li Y, Feng XZ, et al. Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression. Bioengineered. 2021;12(1):414–425.
   PubMed Web of Science ®Google Scholar
• Zhou J, Guo X, Chen W, et al. Targeting survivin sensitizes cervical cancer cells to radiation treatment. Bioengineered. 2020;11(1):130–140.
   PubMed Web of Science ®Google Scholar
• Huang TQ, Bi YN, Cui Z, et al. MUC1 confers radioresistance in head and neck squamous cell carcinoma (HNSCC) cells. Bioengineered. 2020;11(1):769–778.
   PubMed Web of Science ®Google Scholar