1,607
Views
5
CrossRef citations to date
0
Altmetric
Research Paper

Comprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer

, , , , , , , , & show all
Pages 3550-3565 | Received 17 Mar 2021, Accepted 24 Jun 2021, Published online: 07 Jul 2021

References

  • Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
  • Martin-Richard M, Carmona-Bayonas A, Custodio AB, et al. SEOM clinical guideline for the diagnosis and treatment of gastric cancer (GC) and gastroesophageal junction adenocarcinoma (GEJA) (2019). Clin Transl Oncol. 2020;22:236–244.
  • Peixoto RD, Rocha-Filho DR, Weschenfelder RF, et al. Brazilian group of gastrointestinal tumours’ consensus guidelines for the management of gastric cancer. Ecancermedicalscience. 2020;14:1126.
  • Pirzadeh M, Khalili N, Rezaei N. The interplay between aryl hydrocarbon receptor, H. pylori, tryptophan, and arginine in the pathogenesis of gastric cancer. Int Rev Immunol. 2020;25:1–42.
  • Pang ZP, Sudhof TC. Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol. 2010;22:496–505.
  • Fernandez-Chacon R, Konigstorfer A, Gerber SH, et al. Synaptotagmin I functions as a calcium regulator of release probability. Nature. 2001;410:41–49.
  • Wolfes AC, Dean C. The diversity of synaptotagmin isoforms. Curr Opin Neurobiol. 2020;63:198–209.
  • Moghadam PK, Jackson MB. The functional significance of synaptotagmin diversity in neuroendocrine secretion. Front Endocrinol (Lausanne). 2013;4:124.
  • Boo HJ, Min HY, Jang HJ, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961.
  • Zhang L, Fan B, Zheng Y, et al. Identification SYT13 as a novel biomarker in lung adenocarcinoma. J Cell Biochem. 2020;121:963–973.
  • Li D, Yang M, Liao A, et al. Linc00483 as ceRNA regulates proliferation and apoptosis through activating MAPKs in gastric cancer. J Cell Mol Med. 2018;22:3875–3886.
  • Li Q, Zhang S, Hu M, et al. Silencing of synaptotagmin 13 inhibits tumor growth through suppressing proliferation and promoting apoptosis of colorectal cancer cells. Int J Mol Med. 2020;45:234–244.
  • Sung HY, Han J, Ju W, et al. Synaptotagmin-like protein 2 gene promotes the metastatic potential in ovarian cancer. Oncol Rep. 2016;36:535–541.
  • Wang K, Xiao H, Zhang J, et al. Synaptotagmin7 is overexpressed in colorectal cancer and regulates colorectal cancer cell proliferation. J Cancer. 2018;9:2349–2356.
  • Fei Z, Gao W, Xie R, et al. Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells. Biosci Rep. 2019;39:1–29.
  • Xiao B, Li J, Fan Y, et al. Downregulation of SYT7 inhibits glioblastoma growth by promoting cellular apoptosis. Mol Med Rep. 2017;16:9017–9022.
  • Liu XY, Jiang W, Ma D, et al. SYTL4 downregulates microtubule stability and confers paclitaxel resistance in triple-negative breast cancer. Theranostics. 2020;10:10940–10956.
  • Kanda M, Shimizu D, Tanaka H, et al. Significance of SYT8 for the detection, prediction, and treatment of peritoneal metastasis from gastric cancer. Ann Surg. 2018;267:495–503.
  • Kanda M, Tanaka H, Shimizu D, et al. SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells. Oncogene. 2018;37:5355–5366.
  • Shen H, Wu H, Sun F, et al. A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma. Bioengineered. 2021;12:240–251.
  • Boer K, Hesselink DA, Baan CC. Variations in DNA methylation and allograft rejection. Curr Opin Organ Transplant. 2021;26:30–36.
  • Foschini MP, Morandi L, Sanchez AM, et al. Methylation profile of X-chromosome-related genes in male breast cancer. Front Oncol. 2020;10:784.
  • Drake TM, Soreide K. Cancer epigenetics in solid organ tumours: a primer for surgical oncologists. Eur J Surg Oncol. 2019;45:736–746.
  • Lazar DC, Avram MF, Romosan I, et al. Prognostic significance of tumor immune microenvironment and immunotherapy: novel insights and future perspectives in gastric cancer. World J Gastroenterol. 2018;24:3583–3616.
  • Park HS, Kwon WS, Park S, et al. Comprehensive immune profiling and immune-monitoring using body fluid of patients with metastatic gastric cancer. J Immunother Cancer. 2019;7:268.
  • Pernot S, Terme M, Radosevic-Robin N, et al. Infiltrating and peripheral immune cell analysis in advanced gastric cancer according to the Lauren classification and its prognostic significance. Gastric Cancer. 2020;23:73–81.
  • Oya Y, Hayakawa Y, Koike K. Tumor microenvironment in gastric cancers. Cancer Sci. 2020;111:2696–2707.