Resveratrol acts via the mitogen-activated protein kinase (MAPK) pathway to protect retinal ganglion cells from apoptosis induced by hydrogen peroxide

References

• Hu M, Zhu CH, Li XX, et al. Optic cup segmentation from fundus images for glaucoma diagnosis. Bioengineered. 2017 Jan 2;8(1):21–28.
   PubMed Web of Science ®Google Scholar
• Rukmini AV, Milea D, Gooley JJ. Chromatic pupillometry methods for assessing photoreceptor health in retinal and optic nerve diseases. Front Neurol. 2019;10:76.
   PubMed Web of Science ®Google Scholar
• Yadav KS, Rajpurohit R, Sharma S. Glaucoma: current treatment and impact of advanced drug delivery systems. Life Sci. 2019;221:362–376.
   PubMed Web of Science ®Google Scholar
• Radi E, Formichi P, Battisti C, et al. Apoptosis and oxidative stress in neurodegenerative diseases. J Alzheimers Dis. 2014;42(s3):S125–52.
   PubMedGoogle Scholar
• Chen Z, Wang C, Yu N, et al. INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway. Biomed Pharmacother. 2019;111:151–161.
   PubMed Web of Science ®Google Scholar
• Eells JT. Mitochondrial dysfunction in the aging retina. Biology (Basel). 2019;8(2):31–39.
   PubMedGoogle Scholar
• Chi W, Chen H, Li F, et al. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma. J Neuroinflammation. 2015;12(1):137–146.
   PubMedGoogle Scholar
• Phatak NR, Stankowska DL, Krishnamoorthy RR. Bcl-2, Bcl-xL, and p-AKT are involved in neuroprotective effects of transcription factor Brn3b in an ocular hypertension rat model of glaucoma. Mol Vis. 2016;22:1048–1061.
   PubMed Web of Science ®Google Scholar
• Mammone T, Chidlow G, Casson RJ, et al. Expression and activation of mitogen-activated protein kinases in the optic nerve head in a rat model of ocular hypertension. Mol Cell Neurosci. 2018;88:270–291.
   PubMed Web of Science ®Google Scholar
• Rauf A, Imran M, Suleria HAR, et al. A comprehensive review of the health perspectives of resveratrol. Food Funct. 2017;8(12):4284–4305.
   PubMed Web of Science ®Google Scholar
• Jj T, Howe PRC, et al. Does phytoestrogen supplementation improve cognition in humans? A systematic review. Ann N Y Acad Sci. 2017;1403(1):150–163.
   PubMed Web of Science ®Google Scholar
• Xia N, Daiber A, Förstermann U, et al. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 2017;174(12):1633–1646.
   PubMed Web of Science ®Google Scholar
• KK A-A, Kondkar AA, Chalam KV. Resveratrol and ophthalmic diseases. Nutrients. 2016;8(4):200–216.
   PubMed Web of Science ®Google Scholar
• Luo H, Zhuang J, Hu P, et al. Resveratrol delays retinal ganglion cell loss and attenuates gliosis-related inflammation from ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 2018;59(10):3879–3888.
   PubMed Web of Science ®Google Scholar
• Liang B, Wei W, Wang J, et al. Protective effects of Semiaquilegia adoxoides n-butanol extract against hydrogen peroxideinduced oxidative stress in human lens epithelial cells. Pharmaceutical BioL. 2016;54(9):1656–1663.
   PubMed Web of Science ®Google Scholar
• Li X, Wang Q, Ren Y, et al. Tetramethylpyrazine protects retinal ganglion cells against H2O2-induced damage via the microRNA-182/mitochondrial pathway. Int J Mol Med. 2019;44(2):503–512.
   PubMed Web of Science ®Google Scholar
• Ma X, Lin W, Lin Z, et al. Liraglutide alleviates H(2)O(2)-induced retinal ganglion cells injury by inhibiting autophagy through mitochondrial pathways. Peptides. 2017;92:1–8.
   PubMed Web of Science ®Google Scholar
• Seen S, Tong L. Dry eye disease and oxidative stress. Acta Ophthalmol. 2018;96(4):e412–e420.
   PubMed Web of Science ®Google Scholar
• Stefanatos R, Sanz A. The role of mitochondrial ROS in the aging brain. FEBS Lett. 2018;592(5):743–758.
   PubMed Web of Science ®Google Scholar
• Kocyigit A, Guler EM. Curcumin induce DNA damage and apoptosis through generation of reactive oxygen species and reducing mitochondrial membrane potential in melanoma cancer cells. Cell Mol Biol (Noisy-le-grand). 2017;63(11):97–105.
   PubMed Web of Science ®Google Scholar
• TJ F, Han LH, Cong RS, et al. Caspase family proteases and apoptosis. Acta Biochim Biophys Sin (Shanghai). 2005;37(11):719–727.
   PubMed Web of Science ®Google Scholar
• Xu F, Xu J, Xiong X, et al. Salidroside inhibits MAPK, NF-kappaB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation. Redox Rep. 2019;24(1):70–74.
   PubMedGoogle Scholar
• EK K, Choi EJ. Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 2010;1802(4):396–405.
   PubMed Web of Science ®Google Scholar
• Moniruzzaman M, Ghosal I, Das D, et al. Melatonin ameliorates H2O2-induced oxidative stress through modulation of Erk/Akt/NFkB pathway. Biol Res. 2018;51(1):17–22.
   PubMedGoogle Scholar
• Bigeard J, Hirt H. Nuclear signaling of plant MAPKs. Front Plant Sci. 2018;9:469–478.
   PubMed Web of Science ®Google Scholar
• Miloso M, Scuteri A, Foudah D, et al. MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases. Curr Med Chem. 2008;15(6):538–548.
   PubMed Web of Science ®Google Scholar
• Faid I, Al-Hussaini H, Kilarkaje N. Resveratrol alleviates diabetes-induced testicular dysfunction by inhibiting oxidative stress and c-Jun N-terminal kinase signaling in rats. Toxicol Appl Pharmacol. 2015;289(3):482–494.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang J, Li B, et al. Resveratrol ameliorates low shear stress-induced oxidative stress by suppressing ERK/eNOS-Thr495 in endothelial cells. Mol Med Rep. 2014;10(4):1964–1972.
   PubMed Web of Science ®Google Scholar
• Hu W, Yang E, Ye J, et al. Resveratrol protects neuronal cells from isoflurane-induced inflammation and oxidative stress-associated death by attenuating apoptosis via Akt/p38 MAPK signaling. Exp Ther Med. 2018;15(2):1568–1573.
   PubMed Web of Science ®Google Scholar
• Bb A, Bhardwaj A, Aggarwal RS, et al. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004;24(5A):2783–2840.
   PubMed Web of Science ®Google Scholar
• KF C, Pe D, Ht A, et al. Polyphenol effects on cholesterol metabolism via bile acid biosynthesis, CYP7A1: a review. Nutrients. 2019;11(11):2588–2593.
   PubMed Web of Science ®Google Scholar
• Yang X, Jiang T, Wang Y, et al. The role and mechanism of SIRT1 in resveratrol-regulated osteoblast autophagy in osteoporosis rats. Sci Rep. 2019;9(1):184–193.
   PubMedGoogle Scholar
• Wang C, Ren YL, Zhai J, et al. Down-regulated LAMA4 inhibits oxidative stress-induced apoptosis of retinal ganglion cells through the MAPK signaling pathway in rats with glaucoma. Cell Cycle. 2019;18(9):932–948.
   PubMed Web of Science ®Google Scholar
• Nassar K, Tura A, Lüke J, et al. A p38 MAPK inhibitor improves outcome after glaucoma filtration surgery. J Glaucoma. 2015;24(2):165–178.
   PubMed Web of Science ®Google Scholar
• WS L, Pasini S, Collyer JW, et al. Of mice and,monkeys: neuroprotective efficacy of the p38 iInhibitor BIRB 796 depends on model duration in experimental glaucoma. Sci Rep. 2020;10(1):8535.
   PubMed Web of Science ®Google Scholar