Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma

References

• Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2021. CA Cancer J Clin. 2021;71(1):7–33.
   PubMed Web of Science ®Google Scholar
• Chang K, Yuan C, Liu X. A new RBPs-related signature predicts the prognosis of colon adenocarcinoma patients. Front Oncol. 2021;11:627504.
   PubMedGoogle Scholar
• Punt CJ, Koopman M, Vermeulen L. From tumour heterogeneity to advances in precision treatment of colorectal cancer. Nat Rev Clin Oncol. 2017;14(4):235–246.
   PubMed Web of Science ®Google Scholar
• Brown KGM, Solomon MJ. Progress and future direction in the management of advanced colorectal cancer. Br J Surg. 2018;105(6):615–617.
   PubMed Web of Science ®Google Scholar
• Bresalier RS, Kopetz S, Brenner DE. Blood-based tests for colorectal cancer screening: do they threaten the survival of the FIT test? Dig Dis Sci. 2015;60(3):664–671.
   PubMed Web of Science ®Google Scholar
• Siegel R, DeSantis C, Virgo K, et al. Cancer treatment and survivorship statistics, 2012. CA Cancer J Clin. 2012;62(4):220–241.
   PubMed Web of Science ®Google Scholar
• Liang Y, Su Q, Wu X. Identification and validation of a novel six-gene prognostic signature of stem cell characteristic in colon cancer. Front Oncol. 2020;10:571655.
   PubMed Web of Science ®Google Scholar
• Schürmann A, Brauers A, Maßmann S, et al. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases. J Biol Chem. 1995;270(48):28982–28988.
   PubMed Web of Science ®Google Scholar
• Sancak Y, Peterson TR, Shaul YD, et al. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 2008;320(5882):1496–1501.
   PubMed Web of Science ®Google Scholar
• Liu S, Wang Y, Miao C, et al. High expression of CDCA7 predicts poor prognosis for clear cell renal cell carcinoma and explores its associations with immunity. Cancer Cell Int. 2021;21(1):140.
   PubMed Web of Science ®Google Scholar
• Shuai Y, Fan E, Zhong Q, et al. CDCA8 as an independent predictor for a poor prognosis in liver cancer. Cancer Cell Int. 2021;21(1):159.
   PubMed Web of Science ®Google Scholar
• Chen Q, Qiu B, Zeng X, et al. Identification of a tumor microenvironment-related gene signature to improve the prediction of cervical cancer prognosis. Cancer Cell Int. 2021;21(1):182.
   PubMed Web of Science ®Google Scholar
• Shi H, Zhong F, Yi X, et al. Application of an autophagy-related gene prognostic risk model based on TCGA database in cervical cancer. Front Genet. 2020;11:616998.
   PubMed Web of Science ®Google Scholar
• Xie H, Xie C. A six-gene signature predicts survival of adenocarcinoma type of non-small-cell lung cancer patients: a comprehensive study based on integrated analysis and weighted gene coexpression network. Biomed Res Int. 2019;2019:4250613.
   PubMed Web of Science ®Google Scholar
• Liu J, Xu F, Cheng W, et al. Identification and verification of a ten-gene signature predicting overall survival for ovarian cancer. Exp Cell Res. 2020;395(2):112235.
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.
   PubMed Web of Science ®Google Scholar
• Liberzon A, Birger C, Thorvaldsdóttir H, et al. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1(6):417–425.
   PubMed Web of Science ®Google Scholar
• Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550.
   PubMed Web of Science ®Google Scholar
• Szklarczyk D, Franceschini A, Kuhn M, et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res. 2011;39:D561–8.
   PubMed Web of Science ®Google Scholar
• Uhlén M, Fagerberg L, Hallstrom BM, et al. Proteomics. Tissue-based map of the human proteome. Science. 2015;347(6220):1260419.
   PubMed Web of Science ®Google Scholar
• Hu J, Qiu D, Yu A, et al. YTHDF1 Is a potential pan-cancer biomarker for prognosis and immunotherapy. Front Oncol. 2021;11:607224.
   PubMed Web of Science ®Google Scholar
• Zhang L, Liu Z, Dong Y, et al. E2F2 drives glioma progression via PI3K/AKT in a PFKFB4-dependent manner. Life Sci. 2021;276:119412.
   PubMed Web of Science ®Google Scholar
• Hundal J, Carreno BM, Petti AA, et al. pVAC-Seq: a genome-guided in silico approach to identifying tumor neoantigens. Genome Med. 2016;8(1):11.
   PubMed Web of Science ®Google Scholar
• Yoshihara K, Shahmoradgoli M, Martínez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4(1):2612.
   PubMed Web of Science ®Google Scholar
• Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–457.
   PubMed Web of Science ®Google Scholar
• Gauvreau K, Pagano M. Student’s t test. Nutrition. 1993;9(4):386.
   PubMed Web of Science ®Google Scholar
• Crichton N. Information point: wilcoxon signed rank test. J Clin Nurs. 2000;9(4):584.
   PubMed Web of Science ®Google Scholar
• Schober P, Vetter TR. Logistic regression in medical research. Anesth Analg. 2021;132(2):365–366.
   PubMed Web of Science ®Google Scholar
• Schober P, Vetter TR. Kaplan-meier curves, log-rank tests, and cox regression for time-to-event data. Anesth Analg. 2021;132(4):969–970.
   PubMed Web of Science ®Google Scholar
• Bunte K, Kuhn C, Walther C, et al. Clinical significance of ragA, ragB, and PG0982 genes in Porphyromonas gingivalis isolates from periodontitis patients. Eur J Oral Sci. 2021; 129(3):e12776.
   PubMed Web of Science ®Google Scholar
• Ma Y, Sun S, Shang X, et al. Integrative differential expression and gene set enrichment analysis using summary statistics for scRNA-seq studies. Nat Commun. 2020;11(1):1585.
   PubMed Web of Science ®Google Scholar
• Liu Z, Liu J, Liu R, et al. Downregulated ZNF132 predicts unfavorable outcomes in breast Cancer via Hypermethylation modification. BMC Cancer. 2021;21(1):367.
   PubMed Web of Science ®Google Scholar
• Szmida E, Karpiński P, Leszczynski P, et al. Aberrant methylation of ERBB pathway genes in sporadic colorectal cancer. J Appl Genet. 2015;56(2):185–192.
   PubMed Web of Science ®Google Scholar
• Liu S, Shi Y, Liu Z, et al. Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552. Cell Cycle. 2021:1–13. DOI:10.1080/15384101.2021.1949840.
   PubMed Web of Science ®Google Scholar
• Keku TO, Vidal A, Oliver S, et al. Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites. Cancer Causes Control. 2012;23(7):1127–1138.
   PubMed Web of Science ®Google Scholar
• Feng L, Huang S, An G, et al. Identification of new cancer stem cell markers and signaling pathways in HER-2-positive breast cancer by transcriptome sequencing. Int J Oncol. 2019;55(5):1003–1018.
   PubMed Web of Science ®Google Scholar
• Wang Y, Cong R, Liu S, et al. Decreased expression of METTL14 predicts poor prognosis and construction of a prognostic signature for clear cell renal cell carcinoma. Cancer Cell Int. 2021;21(1):46.
   PubMed Web of Science ®Google Scholar
• Yan D, Liu W, Liu Y, et al. LINC00261 suppresses human colon cancer progression via sponging miR-324-3p and inactivating the Wnt/β-catenin pathway. J Cell Physiol. 2019;234(12):22648–22656.
   PubMed Web of Science ®Google Scholar
• Wu X, LUO F, Li J, et al. Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. Int J Oncol. 2016;48(4):1333–1340.
   PubMed Web of Science ®Google Scholar
• He C, Lv X, Hua G, et al. YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression. Oncogene. 2015;34(50):6040–6054.
   PubMed Web of Science ®Google Scholar
• Grimont A, Pinho AV, Cowley MJ, et al. SOX9 regulates ERBB signalling in pancreatic cancer development. Gut. 2015;64(11):1790–1799.
   PubMed Web of Science ®Google Scholar
• Iasonos A, Schrag D, Raj GV, et al. How to build and interpret a nomogram for cancer prognosis. J Clin Oncol. 2008;26(8):1364–1370.
   PubMed Web of Science ®Google Scholar
• Wang RR, He M, Gui X, et al. A nomogram based on serum cystatin C for predicting acute kidney injury in patients with traumatic brain injury. Ren Fail. 2021;43(1):206–215.
   PubMed Web of Science ®Google Scholar
• Liu X, Chen B, Chen J, et al. A novel tp53-associated nomogram to predict the overall survival in patients with pancreatic cancer. BMC Cancer. 2021;21(1):335.
   PubMed Web of Science ®Google Scholar
• Wang B, Zhong J-L, Li H-Z, et al. Diagnostic and therapeutic values of PMEPA1 and its correlation with tumor immunity in pan-cancer. Life Sci. 2021;277:119452.
   PubMed Web of Science ®Google Scholar
• Zeng D, Ye Z, Wu J, et al. Macrophage correlates with immunophenotype and predicts anti-PD-L1 response of urothelial cancer. Theranostics. 2020;10(15):7002–7014.
   PubMed Web of Science ®Google Scholar
• Jiao S, Subudhi SK, Aparicio A, et al. Differences in tumor microenvironment dictate T helper lineage polarization and response to immune checkpoint therapy. Cell. 2019;179(5):1177–1190.e13.
   PubMed Web of Science ®Google Scholar
• Neal JT, Li X, Zhu J, et al. Organoid modeling of the tumor immune microenvironment. Cell. 2018;175(7):1972–1988.e16.
   PubMed Web of Science ®Google Scholar
• Kaderbhaï C, Tharin Z, Ghiringhelli F. The role of molecular profiling to predict the response to immune checkpoint inhibitors in lung cancer. Cancers (Basel). 2019;11(2):201.
   PubMed Web of Science ®Google Scholar