Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury

References

• Betgem R, de Waard G, Nijveldt R, et al. Intramyocardial haemorrhage after acute myocardial infarction. Nature Reviews Cardiology. 2015;12:156–167.
   Google Scholar
• Masoudi F, Ponirakis A, Yeh R, et al. Cardiovascular care facts: a report from the national cardiovascular data registry. Journal of the American College of Cardiology. 2011;2013(62):1931–1947.
   Google Scholar
• Davidson S, Ferdinandy P, Andreadou I, et al. Multitarget strategies to reduce myocardial ischemia/reperfusion injury: JACC review topic of the week. Journal of the American College of Cardiology. 2019;73:89–99.
   Google Scholar
• Sharma P, Wang X, Ming C, et al. Considerations for the bioengineering of advanced cardiac in vitro models of myocardial infarction. Small (Weinheim an der Bergstrasse, Germany). 2021;17:e2003765.
   Google Scholar
• De Villiers C, Riley P. mechanisms. Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion. Disease Models & Mechanisms. 2020;13(11).
   Google Scholar
• Statello L, Guo C, Chen L, et al. Gene regulation by long non-coding RNAs and its biological functions. American Journal of Translational Research. 2021;22:96–118.
   Google Scholar
• Lou Z, Wu W, Chen R, et al. Microarray analysis reveals a potential role of lncRNA expression in remote ischemic preconditioning in myocardial ischemia-reperfusion injury. 2021;13:234–252.
   Google Scholar
• Wu X, Liu Y, Mo S, et al. LncRNA TUG1 competitively binds to miR-340 to accelerate myocardial ischemia-reperfusion injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021;35:e21163.
   Google Scholar
• Liang Y, Liu Q, Xu G, et al. The lncRNA ROR/miR-124-3p/TRAF6 axis regulated the ischaemia reperfusion injury-induced inflammatory response in human cardiac myocytes. Journal of Bioenergetics and Biomembranes. 2019;51:381–392.
   Google Scholar
• Wu G, Li J, Leng R, et al. Identification of long non-coding RNAs GAS5, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus. Oncotarget. 2017;8:23650–23663.
   Google Scholar
• Zhu X, Wang X, Wang Y, et al. Exosomal long non-coding RNA GAS5 suppresses Th1 differentiation and promotes Th2 differentiation via downregulating EZH2 and T-bet in allergic rhinitis. Bioscience Reports. 2020;118:30–39.
   Google Scholar
• Li J, Yang C, Li Y, et al. LncRNA GAS5 suppresses ovarian cancer by inducing inflammasome formation. Molecular Immunology. 2018;38.
   Google Scholar
• Sun H, Wang J, Que J, et al. RNA sequencing revealing the role of AMP-activated protein kinase signaling in mice myocardial ischemia reperfusion injury. Gene. 2019;703:91–101.
   Google Scholar
• Han Y, Wu N, Xia F, et al. Long non‑coding RNA GAS5 regulates myocardial ischemia‑reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR‑532‑5p. International Journal of Molecular Medicine. 2020;45(858–872)
   Google Scholar
• Liu M, Zhang P, Chen M, et al. Aging might increase myocardial ischemia/reperfusion-induced apoptosis in humans and rats. Archives of Physiology and Biochemistry. 2012;34:621–632.
   Google Scholar
• Song Y, Zhao L, Wang B, et al. The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway. Journal of Molecular and Cellular Cardiology. 2020;155:69–80.
   Google Scholar
• Qiu Z, Wang Y, Liu W, et al. CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis. Life sciences. 2021;7:64.
   Google Scholar
• Chen D, Zhang Z, Lu X, et al. Long non-coding RNA SNHG15 regulates cardiomyocyte apoptosis after hypoxia/reperfusion injury via modulating miR-188-5p/PTEN axis. Nature reviews Cardiology. 2020;1–8.
   Google Scholar
• Huang S, Chen B, Su Y, et al. Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart. Biochimica et biophysica acta Molecular basis of disease. 2019;132:84–97.
   Google Scholar
• Yin H, Chao L, Chao J. Nitric oxide mediates cardiac protection of tissue kallikrein by reducing inflammation and ventricular remodeling after myocardial ischemia/reperfusion. PloS one. 2008;82:156–165.
   Google Scholar
• Heusch G. Myocardial stunning and hibernation revisited. Experimental biology and medicine (Maywood, NJ). 2021;18:522–536.
   Google Scholar
• Bugger H, Pfeil K. Mitochondrial ROS in myocardial ischemia reperfusion and remodeling. Cell death and differentiation. 2020;1866:165768.
   Google Scholar
• Maes M, Schlamp C, Nickells R. Live-cell imaging to measure BAX recruitment kinetics to mitochondria during apoptosis. Drug Design, Development and Therapy. 12(e0184434):2017.
   Google Scholar
• Jensen K, WuWong D, Wong S, et al. Pharmacological inhibition of Bax-induced cell death: bax-inhibiting peptides and small compounds inhibiting Bax. European Review for Medical and Pharmacological Sciences. 2019;244:621–629.
   Google Scholar
• Porter A, Jänicke R. differentiation. Emerging roles of caspase-3 in apoptosis. Journal of cellular and molecular medicine. 1999;6:99–104.
   Google Scholar
• Lv X, Lu P, Hu Y, et al. miR-346 inhibited apoptosis against myocardial ischemia-reperfusion injury via targeting bax in rats. BMC cardiovascular disorders. 2020;21(1):121.
   Google Scholar
• Ren G, et al. Research on cardioprotective effect of irbesartan in rats with myocardial ischemia-reperfusion injury through MAPK-ERK signaling pathway. European review for medical and pharmacological sciences. 2019;23:5487–5494.
   Google Scholar
• Yu S, Dong B, Fang Z, et al. Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy. Experimental and therapeutic medicine. 2018;22:4886–4898.
   Google Scholar
• Li Y, Zhang H, Li Z, et al. microRNA-130a-5p suppresses myocardial ischemia reperfusion injury by downregulating the HMGB2/NF-κB axis. Theranostics. 2021;9(26):8277-93.
   Google Scholar
• Hao L, Lu Y, Ma Y, et al. MiR-140 protects against myocardial ischemia-reperfusion injury by regulating NF-κB pathway. Nature reviews Immunology. 2020; 24(11266–11272)
   Google Scholar
• Xu W, Zhang K, Zhang Y, et al. Downregulation of DEC1 by RNA interference attenuates ischemia/reperfusion-induced myocardial inflammation by inhibiting the TLR4/NF-κB signaling pathway. Nature reviews Immunology. 2020;20:343–350.
   Google Scholar
• Wallach D, Kang TB, Dillon CP, et al. Conditional knockout of TGF-βRII /Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation. Science (New York, NY). 2019;9:8277–8293.
   Google Scholar
• Wallach D, Kang T, Kovalenko A. Concepts of tissue injury and cell death in inflammation: a historical perspective. Nature Reviews Immunology. 2014;14:51–59.
   Google Scholar
• Pasparakis M, Vandenabeele PJN. Necroptosis and its role in inflammation. Nature. 2015;517:311–320.
   Google Scholar
• Wallach D, Kang T, Dillon C, et al. Programmed necrosis in inflammation: toward identification of the effector molecules. Science.  2016;352:aaf2154.
   Google Scholar