2,362
Views
23
CrossRef citations to date
0
Altmetric
Research Paper

Inhibin β-A (INHBA) induces epithelial–mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway

, , , &
Pages 4681-4696 | Received 21 Apr 2021, Accepted 15 Jul 2021, Published online: 04 Aug 2021

References

  • Carlson RW, Allred DC, Anderson BO, et al. Breast cancer. J National Compr Cancer Network. 2009;7(2):122–192. .
  • Hortobagyi GN, Wood AJJ. Treatment of breast cancer. N Engl J Med. 1998;339(14):974–984.
  • Bevers TB, Anderson BO, Bonaccio E, et al. Breast cancer screening and diagnosis. J National Compr Cancer Network. 2009;7(10):1060–1096. .
  • Elmore JG, Armstrong K, Cd L, et al. Screening for breast cancer. JAMA. 2005;293:1245–1256.
  • Network CGA. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490: 61.
  • Brown CW, Houston-Hawkins DE, TK W, et al. Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat Genet. 2000;25(4):453–457.
  • Vale W, Rivier C, Hsueh A, et al.: Chemical and biological characterization of the inhibin family of protein hormones. In: Proceedings of the 1987 Laurentian Hormone Conference Elsevier, pp 1–34, 1988.
  • Bashir M, Damineni S, Mukherjee G, et al. Activin-A signaling promotes epithelial–mesenchymal transition, invasion, and metastatic growth of breast cancer. Npj Breast Cancer. 2015;1: 15007.
  • Burdette JE, Jeruss JS, Kurley SJ, et al. Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res. 2005;65(17):7968–7975.
  • Kalli M, Mpekris F, Wong CK, et al.Activin A signaling regulates IL13Rα2 expression to promote breast cancer metastasis. Front Oncol. 2019;9:32.
  • Seder CW, Hartojo W, Lin L, et al. INHBA overexpression promotes cell proliferation and may be epigenetically regulated in esophageal adenocarcinoma. J Thorac Oncol. 2009;4(4):455–462. .
  • Chen ZL, Qin L, Peng XB, et al. INHBA gene silencing inhibits gastric cancer cell migration and invasion by impeding activation of the TGF‐β signaling pathway. J Cell Physiol. 2019;234(10):18065–18074.
  • Okano M, Yamamoto H, Ohkuma H, et al. Significance of INHBA expression in human colorectal cancer. Oncol Rep. 2013;30(6):2903–2908. .
  • Seder CW, Hartojo W, Lin L, et al. Upregulated INHBA expression may promote cell proliferation and is associated with poor survival in lung adenocarcinoma. Neoplasia. 2009;11(4):388–396. .
  • Li X, Yang Z, Xu S, et al. Targeting INHBA in ovarian cancer cells suppresses cancer xenograft growth by attenuating stromal fibroblast activation. Dis Markers. 2019;7275289:2019.
  • Wang Q, Wen Y-G, Li D-P, et al. Upregulated INHBA expression is associated with poor survival in gastric cancer. Med Oncol. 2012;29(1):77–83. .
  • Martin TA, Ye L, Sanders AJ, et al.: Cancer invasion and metastasis: molecular and cellular perspective. Madame Curie Bioscience Database, 2013.
  • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420–1428.
  • Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial–mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15:178–196.
  • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008;14(6):818–829.
  • Bashir M, Damineni S, Mukherjee G, et al. Activin-A signaling promotes epithelial–mesenchymal transition, invasion, and metastatic growth of breast cancer. NPJ Breast Cancer. 2015;1(1):1–13.
  • Katsuno Y, Lamouille S, Derynck R. TGF-β signaling and epithelial–mesenchymal transition in cancer progression. Curr Opin Oncol. 2013;25(1):76–84.
  • Hao Y, Baker D, ten Dijke P. TGF-β-mediated epithelial-mesenchymal transition and cancer metastasis. Int J Mol Sci. 2019;20:2767.
  • Chandrashekar DS, Bashel B, Balasubramanya SAH, et al. UALCAN: a portal for facilitating tumor subgroup gene expression and survival analyses. Neoplasia. 2017;19(8):649–658. .
  • Rodenhiser DI, Andrews JD, Vandenberg TA, et al. Gene signatures of breast cancer progression and metastasis. Breast Cancer Res. 2011;13(1):1–8.
  • Simpson PT, Reis‐Filho JS, Gale T, et al. Molecular evolution of breast cancer. J Pathol. 2005;205(2):248–254.
  • Eroles P, Bosch A, Pérez-Fidalgo JA, et al. Molecular biology in breast cancer: intrinsic subtypes and signaling pathways. Cancer Treat Rev. 2012;38(6):698–707.
  • Bombonati A, Sgroi DC. The molecular pathology of breast cancer progression. J Pathol. 2011;223(2):308–318.
  • Drasin DJ, Robin TP, Ford HL. Breast cancer epithelial-to-mesenchymal transition: examining the functional consequences of plasticity. Breast Cancer Res. 2011;13(6):1–13.
  • Guarino M. Epithelial–mesenchymal transition and tumour invasion. Int J Biochem Cell Biol. 2007;39(12):2153–2160.
  • Zhang X, Yang -J-J, Kim YS, et al. An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer. Int J Oncol. 2010;36:405–414.
  • Shimizu S, Seki N, Sugimoto T, et al. Identification of molecular targets in head and neck squamous cell carcinomas based on genome-wide gene expression profiling. Oncol Rep. 2007;18:1489–1497.
  • Peng S, Wang J, Hu P, et al. INHBA knockdown inhibits proliferation and invasion of nasopharyngeal carcinoma SUNE1 cells in vitro. Int J Clin Exp Pathol. 2020;13:854.
  • Kim H, Watkinson J, Varadan V, et al. Multi-cancer computational analysis reveals invasion-associated variant of desmoplastic reaction involving INHBA, THBS2 and COL11A1. BMC Med Genomics. 2010;3(1):51.
  • Hay ED, Zuk A. Transformations between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am J Kidney Diseases. 1995;26(4):678–690.
  • Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol. 2010;11(9):633–643.
  • Gonzalez DM, Medici D. Signaling mechanisms of the epithelial-mesenchymal transition. Sci Signal. 2014;7:re8–re8.
  • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007;7(415–428). DOI:10.1038/nrc2131
  • Nicoletti F, Di Marco R, Patti F, et al. Blood levels of transforming growth factor‐beta 1 (TGF‐β1) are elevated in both relapsing remitting and chronic progressive multiple sclerosis (MS) patients and are further augmented by treatment with interferon‐beta 1b (IFN‐β1b). Clin Exp Immunol. 1998;113(1):96–99. .
  • Fagone P, Mangano K, Mammana S, et al. Identification of novel targets for the diagnosis and treatment of liver fibrosis. Int J Mol Med. 2015;36(3):747–752. .
  • Fagone P, Mangano K, Pesce A, et al. Emerging therapeutic targets for the treatment of hepatic fibrosis. Drug Discov Today. 2016;21(2):369–375.
  • Wei C-J, Li Y-L, Zhu Z-L, et al. Inhibition of activator protein 1 attenuates neuroinflammation and brain injury after experimental intracerebral hemorrhage. CNS Neurosci Ther. 2019;25(10):1182–1188. .
  • Yu Y, Xiao C, Tan L, et al. Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling. Br J Cancer. 2014;110(3):724–732.
  • Imamura T, Hikita A, Inoue Y. The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis. Breast Cancer. 2012;19(2):118–124.
  • Moustakas A, Heldin C-H: Induction of epithelial–mesenchymal transition by transforming growth factor β. In: Seminars in cancer biology. Academic Press: Elsevier, pp 446-454, 2012.