4,958
Views
22
CrossRef citations to date
0
Altmetric
Research Paper

Identification of candidate biomarkers correlated with poor prognosis of breast cancer based on bioinformatics analysis

, , , , , & show all
Pages 5149-5161 | Received 07 Jun 2021, Accepted 22 Jul 2021, Published online: 12 Aug 2021

References

  • Cheng L, Huang YZ, Chen WX, et al. Cell division cycle proteinising prognostic biomarker of breast cancer. Biosci Rep. 2020;40(5):BSR20191227.
  • Niu T, Zhang W, Xiao W. MicroRNA regulation of cancer stem cells in the pathogenesis of breast cancer. Cancer Cell Int. 2021;21(1):31.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70:7–30.
  • Onitilo AA, Engel JM, Greenlee RT, et al. Breast cancer subtypes based on ER/PR and Her2 expression: comparison of clinicopathologic features and survival. Clin Med Res. 2009;7(1–2):4–13.
  • Yang G, Jian L, Chen Q. Comprehensive analysis of expression and prognostic value of the claudin family in human breast cancer. Aging (Albany NY). 2021;13(6):8777–8796.
  • Lin Y, Fu F, Lv J, et al. Identification of potential key genes for HER-2 positive breast cancer based on bioinformatics analysis. Medicine (Baltimore). 2020;99(1):e18445.
  • Liu S, Liu X, Wu J, et al. Identification of candidate biomarkers correlated with the pathogenesis and prognosis of breast cancer via integrated bioinformatics analysis. Medicine (Baltimore). 2020;99(49):e23153.
  • Wei L, Jin Z, Yang S, et al. TCGA-assembler 2: software pipeline for retrieval and processing of TCGA/CPTAC data. Bioinformatics. 2018;34(9):1615–1617.
  • Zhao H, Jiang A, Yu M, et al. Identification of biomarkers correlated with diagnosis and prognosis of endometrial cancer using bioinformatics analysis. J Cell Biochem. 2020;121(12):4908–4921.
  • Gene Ontology Consortium. The Gene Ontology (GO) project in 2006. Nucleic Acids Res. 2006;34(90001):D322–6.
  • Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30.
  • Wang X, Yue J, Ren X, et al. Modularity analysis based on predicted protein-protein interactions provides new insights into pathogenicity and cellular process of Escherichia coli O157:H7. Theor Biol Med Model. 2011;8(1):47.
  • Song W, Ren J, Wang C, et al. Analysis of Circular RNA-related competing endogenous RNA identifies the immune-related risk signature for colorectal cancer. Front Genet. 2020;11:505.
  • Cai Y, Mei J, Xiao Z, et al. Identification of five hub genes as monitoring biomarkers for breast cancer metastasis in silico. Hereditas. 2019;156(1):20.
  • Baade P. Geographical variation in breast cancer outcomes. Int J Environ Res Public Health. 2017;14(5):523.
  • Liang Y, Zhang H, Song X, et al. Metastatic heterogeneity of breast cancer: molecular mechanism and potential therapeutic targets. Semin Cancer Biol. 2020;60:14–27.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.
  • Du R, Huang C, Liu K, et al. Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy. Mol Cancer. 2021;20:15.
  • Carvalhal S, Ribeiro SA, Arocena M, et al. The nucleoporin ALADIN regulates Aurora A localization to ensure robust mitotic spindle formation. Mol Biol Cell. 2015;26(19):3424–3438.
  • de Martino M, Shariat SF, Hofbauer SL, et al. Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer. World J Urol. 2015;33(1):105–110.
  • Lei Y, Yan S, Ming-De L, et al. Prognostic significance of Aurora-A expression in human bladder cancer. Acta Histochem. 2011;113(5):514–518.
  • Matarasso N, Bar-Shira A, Rozovski U, et al. Functional analysis of the Aurora Kinase A Ile31 allelic variant in human prostate. Neoplasia. 2007;9(9):707–IN25.
  • Buschhorn HM, Klein RR, Chambers SM, et al. Aurora-A over-expression in high-grade PIN lesions and prostate cancer. Prostate. 2005;64(4):341–346.
  • Lentini L, Amato A, Schillaci T, et al. Aurora-A transcriptional silencing and vincristine treatment show a synergistic effect in human tumor cells. Oncol Res. 2008;17(3):115–125.
  • Koyuncu D, Sharma U, Goka ET, et al. Spindle assembly checkpoint gene BUB1B is essential in breast cancer cell survival. Breast Cancer Res Treat. 2021;185(2):331–341.
  • Brynychova V, Ehrlichova M, Hlavac V, et al. Genetic and functional analyses do not explain the association of high PRC1 expression with poor survival of breast carcinoma patients. Biomed Pharmacother. 2016;83:857–864.
  • Zhang B, Shi X, Xu G, et al. Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner. J Cell Mol Med. 2017;21(7):1329–1341.
  • Luo HW, Chen QB, Wan YP, et al. Protein regulator of cytokinesis 1 overexpression predicts biochemical recurrence in men with prostate cancer. Biomed Pharmacother. 2016;78:116–120.
  • Yun HJ, Cho YH, Moon Y, et al. Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2. Exp Mol Med. 2008;40(3):345–353.
  • Liu J, Wen Y, Liu Z, et al. VPS33B modulates c-Myc/p53/miR-192-3p to target CCNB1 suppressing the growth of non-small cell lung cancer. Mol Ther Nucleic Acids. 2021;23:324–335.
  • Fei F, Qu J, Liu K, et al. The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance. Lab Invest. 2019;99(4):483–498.
  • Wang L, Xia Y, Chen T, et al. Sanyang Xuedai enhances the radiosensitivity of human non-small cell lung cancer cells via increasing iNOS/NO production. Biomed Pharmacother. 2018;102:618–625.
  • Monteiro LS, Diniz-Freitas M, Warnakulasuriya S, et al. Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 numerical aberrations in oral squamous cell carcinomas. Anal Cell Pathol (Amst). 2018;2018:7253510.
  • Wang W, Shen XB, Jia W, et al. The p53/miR-193a/EGFR feedback loop function as a driving force for non-small cell lung carcinoma tumorigenesis. Ther Adv Med Oncol. 2019;11:1758835919850665.
  • Egloff AM, Weissfeld J, Land SR, et al. Evaluation of anticyclin B1 serum antibody as a diagnostic and prognostic biomarker for lung cancer. Ann N Y Acad Sci. 2005;1062(1):29–40.
  • Gao ZY, Yu F, Jia HX, et al. ASPM predicts poor prognosis and regulates cell proliferation in bladder cancer. Kaohsiung J Med Sci. 2020;36(12):1021–1029.
  • Wang WY, Hsu CC, Wang TY, et al. A gene expression signature of epithelial tubulogenesis and a role for ASPM in pancreatic tumor progression. Gastroenterology. 2013;145(5):1110–1120.
  • Hsu CC, Liao WY, Chan TS, et al. The differential distributions of ASPM isoforms and their roles in Wnt signaling, cell cycle progression, and pancreatic cancer prognosis. J Pathol. 2019;249(4):498–508.
  • Lin SY, Pan HW, Liu SH, et al. ASPM is a novel marker for vascular invasion, early recurrence, and poor prognosis of hepatocellular carcinoma. Clin Cancer Res. 2008;14(15):4814–4820.
  • Alsiary R, Bruning-Richardson A, Bond J, et al. Deregulation of microcephalin and ASPM expression are correlated with epithelial ovarian cancer progression. PLoS One. 2014;9(5):e97059.
  • Bikeye SN, Colin C, Marie Y, et al. ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int. 2010;10(1):1.
  • Xie JJ, Zhuo YJ, Zheng Y, et al. High expression of ASPM correlates with tumor progression and predicts poor outcome in patients with prostate cancer. Int Urol Nephrol. 2017;49(5):817–823.
  • Turnbull AK, Arthur LM, Renshaw L, et al. Accurate prediction and validation of response to endocrine therapy in breast cancer. J Clin Oncol. 2015;33(20):2270–2278.
  • McHugh T, Zou J, Volkov VA, et al. The depolymerase activity of MCAK shows a graded response to Aurora B kinase phosphorylation through allosteric regulation. J Cell Sci. 2019;132(4):jcs228353.
  • Andrews PD, Ovechkina Y, Morrice N, et al. Aurora B regulates MCAK at the mitotic centromere. Dev Cell. 2004;6(2):253–268.
  • Lan W, Zhang X, Kline-Smith SL, et al. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol. 2004;14(4):273–286.
  • Bie L, Zhao G, Wang YP, et al. Kinesin family member 2C (KIF2C/MCAK) is a novel marker for prognosis in human gliomas. Clin Neurol Neurosurg. 2012;114(4):356–360.
  • Ishikawa K, Kamohara Y, Tanaka F, et al. Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer. Br J Cancer. 2008;98(11):1824–1829.
  • Nakamura Y, Tanaka F, Haraguchi N, et al. Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer. Br J Cancer. 2007;97(4):543–549.
  • Heidebrecht HJ, Buck F, Steinmann J, et al. p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. Blood. 1997;90(1):226–233.
  • Hsu CW, Chen YC, Su HH, et al. Targeting TPX2 suppresses the tumorigenesis of hepatocellular carcinoma cells resulting in arrested mitotic phase progression and increased genomic instability. J Cancer. 2017;8(8):1378–1394.
  • Liang B, Jia C, Huang Y, et al. TPX2 level correlates with hepatocellular carcinoma cell proliferation, apoptosis, and EMT. Dig Dis Sci. 2015;60(8):2360–2372.
  • Liu HC, Zhang Y, Wang XL, et al. Upregulation of the TPX2 gene is associated with enhanced tumor malignance of esophageal squamous cell carcinoma. Biomed Pharmacother. 2013;67(8):751–755.
  • Mills CA, Suzuki A, Arceci A, et al. Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation. J Biol Chem. 2017;292(42):17178–17189.
  • Tang Y, Zhang Y, Hu X. Identification of potential hub genes related to diagnosis and prognosis of hepatitis b virus-related hepatocellular carcinoma via integrated bioinformatics analysis. Biomed Res Int. 2020;2020:4251761.
  • Deng JL, Xu YH, Wang G. Identification of potential crucial genes and key pathways in breast cancer using bioinformatic analysis. Front Genet. 2019;10:695.
  • Zhang R, Xu J, Zhao J, et al. Proliferation and invasion of colon cancer cells are suppressed by knockdown of TOP2A. J Cell Biochem. 2018;119(9):7256–7263.
  • Liu HQ, Zhang SL, Song S. HER-2/neu and TOPIIa expression in gastric cancer reflect disease severity. Hepatogastroenterology. 2012;59:1290–1293.
  • Shen J, Yu S, Sun X, et al. Identification of key biomarkers associated with development and prognosis in patients with ovarian carcinoma: evidence from bioinformatic analysis. J Ovarian Res. 2019;12(1):110.
  • Yu H, Xu Z, Guo M, et al. FOXM1 modulates docetaxel resistance in prostate cancer by regulating KIF20A. Cancer Cell Int. 2020;20(1):545.
  • He Q, Meng J, Liu S, et al. Long non-coding RNA UCA1 upregulates KIF20A expression to promote cell proliferation and invasion via sponging miR-204 in cervical cancer. Cell Cycle. 2020;19(19):2486–2495.
  • Song Z, Huang Y, Zhao Y, et al. The identification of potential biomarkers and biological pathways in prostate cancer. J Cancer. 2019;10(6):1398–1408.
  • Shi C, Huang D, Lu N, et al. Aberrantly activated Gli2-KIF20A axis is crucial for growth of hepatocellular carcinoma and predicts poor prognosis. Oncotarget. 2016;7(18):26206–26219.
  • Khongkow P, Gomes AR, Gong C, et al. Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance. Oncogene. 2016;35(8):990–1002.
  • Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75(1):681–706.
  • Jin CY, Du L, Nuerlan AH, et al. High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma. Aging (Albany NY). 2020;13(3):3518–3535.
  • Grolmusz VK, Karaszi K, Micsik T, et al. Cell cycle dependent RRM2 may serve as proliferation marker and pharmaceutical target in adrenocortical cancer. Am J Cancer Res. 2016;6:2041–2053.
  • Grossi F, Dal Bello MG, Salvi S, et al. Expression of ribonucleotide reductase subunit-2 and thymidylate synthase correlates with poor prognosis in patients with resected stages I-III non-small cell lung cancer. Dis Markers. 2015;2015:302649.
  • Lu AG, Feng H, Wang PX, et al. Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair. World J Gastroenterol. 2012;18(34):4704–4713.
  • Hsu NY, Wu JY, Liu X, et al. Expression status of ribonucleotide reductase small subunits hRRM2/p53R2 as prognostic biomarkers in stage I and II non-small cell lung cancer. Anticancer Res. 2011;31:3475–3481.
  • Fatkhutdinov N, Sproesser K, Krepler C, et al. Targeting RRM2 and Mutant BRAF is a novel combinatorial strategy for melanoma. Mol Cancer Res. 2016;14(9):767–775.
  • Huang R, Zhang J, Li M, et al. The Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Pan-Cancer. PPAR Res. 2020;2020:6527564.
  • Bandera Merchan B, Tinahones FJ, Macias-Gonzalez M. Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis. PPAR Res. 2016;2016:2308249.
  • Fujita M, Yagami T, Fujio M, et al. Cytotoxicity of troglitazone through PPARgamma-independent pathway and p38 MAPK pathway in renal cell carcinoma. Cancer Lett. 2011;312(2):219–227.
  • Plissonnier ML, Fauconnet S, Bittard H, et al. Insights on distinct pathways of thiazolidinediones (PPARgamma ligand)-promoted apoptosis in TRAIL-sensitive or -resistant malignant urothelial cells. Int J Cancer. 2010;127(8):1769–1784.
  • Vallee A, Lecarpentier Y, Vallee JN. Curcumin: a therapeutic strategy in cancers by inhibiting the canonical WNT/beta-catenin pathway. J Exp Clin Cancer Res. 2019;38(1):323.
  • Galbraith LCA, Mui E, Nixon C, et al. PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene. 2021;40(13):2355–2366.
  • Shen D, Fang Y, Zhou F, et al. The inhibitory effect of silencing CDCA3 on migration and proliferation in bladder urothelial carcinoma. Cancer Cell Int. 2021;21(1):257.
  • Adams MN, Burgess JT, He Y, et al. Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non-small cell lung cancer. J Thorac Oncol. 2017;12(7):1071–1084.
  • Perez-Pena J, Alcaraz-Sanabria A, Nieto-Jimenez C, et al. Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors. Oncotarget. 2017;8(13):21733–21740.
  • Endo H, Ikeda K, Urano T, et al. Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation. J Biochem. 2012;151(2):139–144.
  • Yuan W, Xie S, Wang M, et al. Bioinformatic analysis of prognostic value of ZW10 interacting protein in lung cancer. Onco Targets Ther. 2018;11:1683–1695.
  • Ying H, Xu Z, Chen M, et al. Overexpression of Zwint predicts poor prognosis and promotes the proliferation of hepatocellular carcinoma by regulating cell-cycle-related proteins. Onco Targets Ther. 2018;11:689–702.
  • Zhou G, Shen M, Zhang Z. ZW10 Binding Factor (ZWINT), a direct target of mir-204, predicts poor survival and promotes proliferation in breast cancer. Med Sci Monit. 2020;26:e921659.
  • Williamson A, Wickliffe KE, Mellone BG, et al. Identification of a physiological E2 module for the human anaphase-promoting complex. Proc Natl Acad Sci U S A. 2009;106(43):18213–18218.
  • Brown NG, Watson ER, Weissmann F, et al. Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Mol Cell. 2014;56(2):246–260.
  • Li Z, Wang Y, Li Y, et al. Ube2s stabilizes beta-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development. Cell Death Dis. 2018;9(5):456.
  • Yoshimura S, Kasamatsu A, Nakashima D, et al. UBE2S associated with OSCC proliferation by promotion of P21 degradation via the ubiquitin-proteasome system. Biochem Biophys Res Commun. 2017;485(4):483–498.
  • Ma Y, Li K, Li S, et al. Prognostic value of ubiquitin-conjugating enzyme E2 S overexpression in hepatocellular carcinoma. Int J Biol Macromol. 2018;119:225–231.
  • Pan YH, Yang M, Liu LP, et al. UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma. Biochem Biophys Res Commun. 2018;503(2):895–902.
  • Lin TH, Hsu WH, Tsai PH, et al. Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling. Food Funct. 2017;8(4):1558–1568.