Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65(1):5–29.
   PubMed Web of Science ®Google Scholar
• Boire A, Brastianos PK, Garzia L, et al. Brain metastasis. Nat Rev Cancer. 2020;20(1):4–11.
   PubMed Web of Science ®Google Scholar
• Korn EL, Liu PY, Lee SJ, et al. Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials. J Clin Oncol. 2008;26(4):527–534.
   PubMed Web of Science ®Google Scholar
• Eggermont AM, Spatz A, Robert C. Cutaneous melanoma. Lancet. 2014;383(9919):816–827.
   PubMed Web of Science ®Google Scholar
• Luís R, Brito C. Pojo M.Melanoma metabolism: cell survival and resistance to therapy. Adv Exp Med Biol. 2020;1219:203–223.
   PubMed Web of Science ®Google Scholar
• Strickley JD, Jenson AB, Jung JY. Cutaneous metastasis. Hematol Oncol Clin North Am. 2019;33(1):173–197.
   PubMed Web of Science ®Google Scholar
• Haradwaj U, Kasembeli MM, Robinson P, et al. Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution. Pharmacol Rev. 2020;72(2):486–526.
   PubMed Web of Science ®Google Scholar
• Johnson DE, O’Keefe RA, Grandis JR. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15(4):234–248.
   PubMed Web of Science ®Google Scholar
• Ding C, Tang W, Fan X, et al. Overexpression of PEAK1 contributes to epithelial-mesenchymal transition and tumor metastasis in lung cancer through modulating ERK1/2 and JAK2 signaling. Cell Death Dis. 2018;9(8):802.
   PubMedGoogle Scholar
• Tan HX, Cao ZB, He TT, et al. TGFβ1 is essential for MSCs-CAFs differentiation and promotes HCT116 cells migration and invasion via JAK/STAT3 signaling. Onco Targets Ther. 2019;12:5323–5334.
   PubMed Web of Science ®Google Scholar
• Liu L, Nam S, Tian Y. 6-Bromoindirubin-3ʹ-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells. Cancer Res. 2011;71(11):3972–3979.
   PubMed Web of Science ®Google Scholar
• Wang Y, Kelber JA, Tran Cao HS, et al. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. Proc Natl Acad Sci U S A. 2010;107(24):10920–10925.
   PubMed Web of Science ®Google Scholar
• Kelber JA, Klemke RL. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 2010;1(3):219–223.
   PubMedGoogle Scholar
• Huang L, Wen C, Yang X, et al. PEAK1, acting as a tumor promoter in colorectal cancer, is regulated by the EGFR/KRas signaling axis and miR-181d. Cell Death Dis. 2018;9(3):271.
   PubMedGoogle Scholar
• Agajanian M, Campeau A, Hoover M, et al. PEAK1 acts as a molecular switch to regulate context-dependent TGF-beta responses in breast cancer. PLoS One. 2015;10(8):e0135748.
   PubMed Web of Science ®Google Scholar
• Croucher DR, Hochgräfe F, Zhang L, et al. Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway. Cancer Res. 2013;73(6):1969–1980.
   PubMed Web of Science ®Google Scholar
• Tactacan CM, Phua YW, Liu L, et al. The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling. Mol Cancer. 2015 Jul 29;14:139.
   PubMed Web of Science ®Google Scholar
• Kelber JA, Reno T, Kaushal S, et al. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res. 2012;72(10):2554–2564.
   PubMed Web of Science ®Google Scholar
• Runa F, Adamian Y, Kelber JA. Ascending the PEAK1 toward targeting TGFβ during cancer progression: recent advances and future perspectives. Cancer Cell Microenviron. 2016;3(1):e1162.
   PubMedGoogle Scholar
• Fu JJ, Lin P, Lv XY, et al. Low molecular mass polypeptide-2 in human trophoblast: over-expression in hydatidiform moles and possible role in trophoblast cell invasion. Placenta. 2009;30(4):305–312.
   PubMed Web of Science ®Google Scholar
• Zheng H, Kang Y. Multilayer control of the EMT master regulators. Oncogene. 2014;33:1755–1763.
   PubMed Web of Science ®Google Scholar
• Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15:178–196.
   PubMed Web of Science ®Google Scholar
• Teng Y, Ross JL, Cowell JK. The involvement of JAK-STAT3 in cell motility, invasion, and metastasis. JAKSTAT. 2014;3(1):e28086.
   PubMedGoogle Scholar
• Strnadel J, Choi S, Fujimura K, et al. eIF5A-PEAK1 signaling regulates YAP1/TAZ protein expression and pancreatic cancer cell growth. Cancer Res. 2017;77(8):1997–2007.
   PubMed Web of Science ®Google Scholar
• Smith A, Teknos TN, Pan Q. Epithelial to mesenchymal transition in head and neck squamous cell carcinoma. Oral Oncol. 2013;49(4):287–292.
   PubMed Web of Science ®Google Scholar
• Bai Y, Sha J, Kanno T. The role of carcinogenesis-related biomarkers in the wnt pathway and their effects on epithelial-mesenchymal transition (EMT) in oral squamous cell carcinoma. Cancers (Basel). 2020;12(3):229–234.
   PubMed Web of Science ®Google Scholar
• TMM R-F, Brisson BK, Durham AC, et al. Characteristics of the epithelial-mesenchymal transition in primary and paired metastatic canine mammary carcinomas. Vet Pathol. 2018;55(5):622–633.
   PubMed Web of Science ®Google Scholar
• Serrano-Gomez SJ, Maziveyi M, Alahari SK. Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications. Mol Cancer. 2016;15:18.
   PubMed Web of Science ®Google Scholar
• Agajanian M, Runa F, Kelber JA. We recently reported that Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer. Biochem Biophys Res Commun. 2015;465(3):606–612.
   PubMed Web of Science ®Google Scholar
• Gao Q, Liu Q, Chen H. Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis. Bioengineered. 2021;12(1):1381–1390.
   PubMed Web of Science ®Google Scholar
• Cui N, Sun Q, Liu H, et al. Long non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer. Bioengineered. 2021;12(1):2915–2927.
   Google Scholar
• Jin W. Role of JAK/STAT3 signaling in the regulation of metastasis, the transition of cancer stem cells, and chemoresistance of cancer by epithelial-mesenchymal transition. Cells. 2020;15;9(1):217.
   Web of Science ®Google Scholar
• Li R, Huang Y, Lin J. Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models. Nat Commun. 2020;11(1):642.
   PubMed Web of Science ®Google Scholar
• Gupta P, Sharma Y, Viswanathan P, et al. Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair. Cytokine. 2020;127:154946.
   PubMed Web of Science ®Google Scholar
• Tan Q, Liu Z, Li H, et al. Hormesis of mercuric chloride-human serum albumin adduct on N9 microglial cells via the ERK/MAPKs and JAK/STAT3 signaling pathways. Toxicology. 2018;408:62–69.
   PubMed Web of Science ®Google Scholar
• Liang Q, Ma D, Zhu X, et al. RING-finger protein 6 amplification activates JAK/ STAT3 pathway by modifying SHP-1 ubiquitylation and associates with poor outcome in colorectal cancer. Clin Cancer Res. 2018;24(6):1473–1485.
   PubMed Web of Science ®Google Scholar
• Lee IO, Kim JH, Choi YJ, et al. Helicobacter pylori CagA phosphorylation status determines the gp130-activated SHP2/ERK and JAK/STAT signal transduction pathways in gastric epithelial cells. J Biol Chem. 2010;285(21):16042–16050.
   PubMed Web of Science ®Google Scholar