Mex-3 RNA binding MEX3A promotes the proliferation and migration of breast cancer cells via regulating RhoA/ROCK1/LIMK1 signaling pathway

References

• Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394–424.
   PubMed Web of Science ®Google Scholar
• McAnena PF, McGuire A, Ramli A, et al. Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options. BMC Cancer. 2018 Feb 20;18(1):203.
   PubMedGoogle Scholar
• Wei C, Wang Y, Li X. The role of Hippo signal pathway in breast cancer metastasis. Onco Targets Ther. 2018 Apr;17(11):2185–2193.
   Google Scholar
• Teles RHG, Moralles HF, Cominetti MR. Global trends in nanomedicine research on triple negative breast cancer: a bibliometric analysis. Int J Nanomedicine. 2018 Apr;17(13):2321–2336.
   Google Scholar
• Neophytou C, Boutsikos P, Papageorgis P. Molecular mechanisms and emerging therapeutic targets of triple-negative breast cancer metastasis. Front Oncol. 2018 Feb;22(8):31.
   Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7–34.
   PubMed Web of Science ®Google Scholar
• Mahvi DA, Liu R, Grinstaff MW, et al. Local cancer recurrence: the realities, challenges, and opportunities for new therapies. CA Cancer J Clin. 2018 Nov;68(6):488–505.
   PubMed Web of Science ®Google Scholar
• Hu W, Tan C, He Y, et al. Functional miRNAs in breast cancer drug resistance. Onco Targets Ther. 2018 Mar;19(11):1529–1541.
   Google Scholar
• Buchet-Poyau K, Courchet J, Le Hir H, et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res. 2007;35(4):1289–1300.
   PubMed Web of Science ®Google Scholar
• Valverde R, Edwards L, Regan L. Structure and function of KH domains. FEBS J. 2008 Jun;275(11):2712–2726.
   PubMed Web of Science ®Google Scholar
• Cano F, Bye H, Duncan LM, et al. The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. EMBO J. 2012 Aug 29;31(17):3596–3606.
   PubMed Web of Science ®Google Scholar
• Wang X, Shan YQ, Tan QQ, et al. MEX3A knockdown inhibits the development of pancreatic ductal adenocarcinoma. Cancer Cell Int. 2020 Feb 28;20:63.
   PubMed Web of Science ®Google Scholar
• Liang J, Li H, Han J, et al. Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway. Cell Death Dis. 2020 Aug 13;11(8):614.
   PubMed Web of Science ®Google Scholar
• Jiang S, Meng L, Chen X, et al. MEX3A promotes triple negative breast cancer proliferation and migration via the PI3K/AKT signaling pathway. Exp Cell Res. 2020 Jul;29:112191.
   Google Scholar
• Liang J, Takeuchi H, Jin S, et al. Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway. Brain Res. 2010 Mar;31(1322):8–23.
   Google Scholar
• Sheth U, Parker R. Decapping and decay of messenger RNA occur in cytoplasmic processing bodies. Science. 2003 May 2;300(5620):805–808. PMID: 12730603; PMCID: PMC1876714.
   PubMed Web of Science ®Google Scholar
• Teixeira D, Sheth U, Valencia-Sanchez MA, et al. Processing bodies require RNA for assembly and contain nontranslating mRNAs. RNA. 2005 Apr;11(4):371–382.
   PubMed Web of Science ®Google Scholar
• Yang D, Jiao Y, Li Y, et al. Clinical characteristics and prognostic value of MEX3A mRNA in liver cancer. PeerJ. 2020 Jan 21;8:e8252.
   PubMed Web of Science ®Google Scholar
• Bufalieri F, Caimano M, Lospinoso Severini L, et al. The RNA-binding ubiquitin ligase MEX3A affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of RIG-I. Cancers (Basel). 2020 Jan 30;12(2):321.
   PubMed Web of Science ®Google Scholar
• Jiang H, Zhang X, Luo J, et al. Knockdown of hMex-3A by small RNA interference suppresses cell proliferation and migration in human gastric cancer cells. Mol Med Rep. 2012 Sep;6(3):575–580.
   PubMed Web of Science ®Google Scholar
• Zhou X, Zheng Y. Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting. J Biol Chem. 2013 Dec 20;288(51):36179–36188.
   PubMed Web of Science ®Google Scholar
• Loirand G, Guérin P, Pacaud P. Rho kinases in cardiovascular physiology and pathophysiology. Circ Res. 2006 Feb 17;98(3):322–334.
   PubMed Web of Science ®Google Scholar
• Chen K, Zhang W, Chen J, et al. Rho-associated protein kinase modulates neurite extension by regulating microtubule remodeling and vinculin distribution. Neural Regen Res. 2013 Nov 15;8(32):3027–3035.
   PubMed Web of Science ®Google Scholar
• McBeath R, Pirone DM, Nelson CM, et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell. 2004 Apr;6(4):483–495.
   PubMed Web of Science ®Google Scholar
• Tang J, Liu C, Xu B, et al. ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition. Exp Cell Res. 2019 Jan 1;374(1):46–68.
   PubMed Web of Science ®Google Scholar
• Lin L, Li M, Lin L, et al. FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway. Biochem Biophys Res Commun. 2018 Feb 5;496(2):536–541.
   PubMed Web of Science ®Google Scholar
• Zhang G, Zhu F, Han G, et al. Silencing of URG11 expression inhibits the proliferation and epithelial‑mesenchymal transition in benign prostatic hyperplasia cells via the RhoA/ROCK1 pathway. Mol Med Rep. 2018 Jul;18(1):391–398.
   PubMed Web of Science ®Google Scholar
• Wang W, Goswami S, Lapidus K, et al. Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res. 2004 Dec 1;64(23):8585–8594.
   PubMed Web of Science ®Google Scholar
• Ma L, Liu YP, Geng CZ, et al. Over expression of RhoA is associated with progression in invasive breast duct carcinoma. Breast J. 2010 Jan-Feb;16(1):105–107.
   PubMed Web of Science ®Google Scholar
• Zeng Y, Cao Y, Liu L, et al. SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA/FAK signaling pathway regulation. Cell Death Dis. 2019 Sep 26;10(10):720.
   PubMedGoogle Scholar
• Scott RW, Olson MF. LIM kinases: function, regulation and association with human disease. J Mol Med (Berl). 2007 Jun;85(6):555–568.
   PubMed Web of Science ®Google Scholar
• Lee MH, Kundu JK, Chae JI, et al. Targeting ROCK/LIMK/cofilin signaling pathway in cancer. Arch Pharm Res. 2019 Jun;42(6):481–491.
   PubMed Web of Science ®Google Scholar
• Zhu Q, Wu Y, Yang M, et al. IRX5 promotes colorectal cancer metastasis by negatively regulating the core components of the RHOA pathway. Mol Carcinog. 2019 Nov;58(11):2065–2076.
   PubMed Web of Science ®Google Scholar
• Yu J, Shi W, Zhao R, et al. FHOD3 promotes carcinogenesis by regulating RhoA/ROCK1/LIMK1 signaling pathway in medulloblastoma. Clin Transl Oncol. 2020 May 23(1 Suppl).
   Web of Science ®Google Scholar