The up-regulation of miR-21 by gastrodin to promote the angiogenesis ability of human umbilical vein endothelial cells by activating the signaling pathway of PI3K/Akt

References

• Wang ZD, Wei SQ, Wang QY. Targeting oncogenic KRAS in non-small cell lung cancer cells by phenformin inhibits growth and angiogenesis. Am J Cancer Res. 2015;5:3339–3349.
   PubMed Web of Science ®Google Scholar
• Khurana R, Simons M. Insights from angiogenesis trials using fibroblast growth factor for advanced arteriosclerotic disease. Trends Cardiovasc Med. 2003;13(3):116–122.
   PubMed Web of Science ®Google Scholar
• Wei JW, Heeley EL, Wang JG, et al. Comparison of recovery patterns and prognostic indicators for ischemic and hemorrhagic stroke in China: the ChinaQUEST (QUality Evaluation of Stroke Care and Treatment) Registry study. Stroke. 2010;41(9):1877–1883.
   PubMed Web of Science ®Google Scholar
• Ruan L, Wang B, ZhuGe Q, et al. Coupling of neurogenesis and angiogenesis after ischemic stroke. Brain Res. 2015;1623:166–173.
   PubMed Web of Science ®Google Scholar
• Phng LK, Gerhardt H. Angiogenesis: a team effort coordinated by notch. Dev Cell. 2009;16(2):196–208.
   PubMed Web of Science ®Google Scholar
• Mohr T, Haudek-Prinz V, Slany A, et al. Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis. PLoS One. 2017;12:e0179065.
   PubMed Web of Science ®Google Scholar
• Liu Y, Gao J, Peng M, et al. A review on central nervous system effects of gastrodin. Front Pharmacol. 2018;9:24.
   PubMed Web of Science ®Google Scholar
• Wang JS, Bojovic D, Chen Y, et al. Homocysteine sensitizes the mouse neuromuscular junction to oxidative stress by nitric oxide. Neuroreport. 2018;29(12):1030–1035.
   PubMed Web of Science ®Google Scholar
• Shu C, Chen C, Zhang DP, et al. Gastrodin protects against cardiac hypertrophy and fibrosis. Mol Cell Biochem. 2012;359(1–2):9–16.
   PubMed Web of Science ®Google Scholar
• Peng Z, Wang S, Chen G, et al. Gastrodin alleviates cerebral ischemic damage in mice by improving anti-oxidant and anti-inflammation activities and inhibiting apoptosis pathway. Neurochem Res. 2015;40(4):661–673.
   PubMed Web of Science ®Google Scholar
• Lin J, Shi Y, Miao J, et al. Gastrodin Alleviates Oxidative Stress-Induced Apoptosis and Cellular Dysfunction in Human Umbilical Vein Endothelial Cells via the Nuclear Factor-Erythroid 2-Related Factor 2/Heme Oxygenase-1 Pathway and Accelerates Wound Healing In Vivo. Front Pharmacol. 2019;10:1273.
   PubMed Web of Science ®Google Scholar
• Chen J, Huang Y, Hu X, et al. Gastrodin prevents homocysteine-induced human umbilical vein endothelial cells injury via PI3K/Akt/eNOS and Nrf2/ARE pathway. J Cell Mol Med. 2021;25(1):345–357.
   PubMed Web of Science ®Google Scholar
• Boro A, Bauer D, Born W, et al. Plasma levels of miRNA-155 as a powerful diagnostic marker for dedifferentiated liposarcoma. Am J Cancer Res. 2016;6:544–552.
   PubMed Web of Science ®Google Scholar
• Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res. 2008;79(4):581–588.
   PubMed Web of Science ®Google Scholar
• Chang CH, Yen MC, Liao SH, et al. Dual Role of MiR-21-Mediated Signaling in HUVECs and Rat Surgical Flap under Normoxia and Hypoxia Condition. Int J Mol Sci. 2017;18(9):1917.
   PubMed Web of Science ®Google Scholar
• An Y, Zhao J, Nie F, et al. Exosomes from Adipose-Derived Stem Cells (ADSCs) Overexpressing miR-21 Promote Vascularization of Endothelial Cells. Sci Rep. 2019;9(1):12861.
   PubMedGoogle Scholar
• Goto F, Goto K, Weindel K, et al. Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest. 1993;69:508–517.
   PubMed Web of Science ®Google Scholar
• Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003;101(10):3765–3777.
   PubMed Web of Science ®Google Scholar
• Mei Z, Huang B, Qian X, et al. Gastrodin improves preeclampsia-induced cell apoptosis by regulation of TLR4/NF-κB in rats. Food Sci Nutr. 2020;8(2):820–829.
   PubMed Web of Science ®Google Scholar
• Liu S, Zhou L, Yang L, et al. Gastrodin alleviates glucocorticoid induced osteoporosis in rats via activating the Nrf2 signaling pathways. Oncotarget. 2018;9(14):11528–11540.
   PubMedGoogle Scholar
• Xi Z, Qiao Y, Wang J, et al. Retracted: gastrodin relieves inflammation injury induced by lipopolysaccharides in MRC-5 cells by up-regulation of miR-103. J Cell Mol Med. 2020;24(2):1451–1459.
   PubMed Web of Science ®Google Scholar
• Hayes J, Peruzzi PP, Lawler S. MicroRNAs in cancer: biomarkers, functions and therapy. Trends Mol Med. 2014;20(8):460–469.
   PubMed Web of Science ®Google Scholar
• Pfeffer SR, Yang CH, Pfeffer LM. The Role of miR-21 in Cancer. Drug Dev Res. 2015;76(6):3765–3767.
   PubMed Web of Science ®Google Scholar
• Ng R, Song G, Roll GR, et al. A microRNA-21 surge facilitates rapid cyclin D1 translation and cell cycle progression in mouse liver regeneration. J Clin Invest. 2012;122(3):820–829.
   Web of Science ®Google Scholar
• Hu Y, Rao -S-S, Wang Z-X, et al. Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function. Theranostics. 2018;8(1):169–184.
   PubMed Web of Science ®Google Scholar
• Dai J, Lin Y, Duan Y, et al. Andrographolide Inhibits Angiogenesis by Inhibiting the Mir-21-5p/TIMP3 Signaling Pathway. Int J Biol Sci. 2017;13(5):660–668.
   PubMed Web of Science ®Google Scholar
• Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer. 2005;5(12):921–929.
   PubMed Web of Science ®Google Scholar
• Cain RJ, Vanhaesebroeck B, Ridley AJ. The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1. J Cell Biol. 2010;188(6):863–876.
   PubMed Web of Science ®Google Scholar
• Lu JM, Zhang ZZ, Ma X, et al. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Exp Eye Res. 2020;190:107886.
   PubMed Web of Science ®Google Scholar
• Liu Y, Liu J, Xia T, et al. MiR-21 promotes fracture healing by activating the PI3K/Akt signaling pathway. Eur Rev Med Pharmacol Sci. 2019;23:2727–2733.
   PubMedGoogle Scholar