Advanced search
Publication Cover
Bioengineered Volume 12, 2021 - Issue 1
Submit an article Journal homepage
1,462
Views
7
CrossRef citations to date
0
Altmetric
Research Paper

Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression

Chunyan CaiDepartment Of Gynaecology, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaView further author information
,
Xing PengDepartment Of Gynaecology, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaView further author information
&
Yumei ZhangDepartment Of Gynaecology, The Affiliated Huai’an No.1 People’s Hospital of Nanjing Medical University, Huai’an, Jiangsu, ChinaCorrespondence[email protected]
View further author information
Pages 7007-7019 | Received 04 Mar 2021, Accepted 26 Jun 2021, Published online: 23 Sep 2021

References

  • Zhilinskaya NT, Bespalov VG, Semenov AL, et al. Cisplatin effect on digital cytomorphometric and bioinformatic tumor cell characteristics in rat ovarian cancer model-a preliminary study. Pharmacol Rep. 2021;73(2):642–649.
  • Yang XY, Li Y, Cai SQ, et al. Optimization of 7,12-dimethylbenz(a)anthracene-induced rat epithelial ovarian tumors. Oncol Lett. 2021;21(3):206.
  • Matsuo K, Lin YG, Roman LD, et al. Overcoming platinum resistance in ovarian carcinoma. Expert Opin Investig Drugs. 2010;19(11):1339–1354.
  • Roy D, Sheng GY, Herve S, et al. Interplay between cancer cell cycle and metabolism: challenges, targets and therapeutic opportunities. Biomed Pharmacother. 2017;89:288–296.
  • Gill RM, Gabor TV, Couzens AL, et al. The MYC-associated protein CDCA7 is phosphorylated by AKT to regulate MYC-dependent apoptosis and transformation. Mol Cell Biol. 2013;33(3):498–513.
  • Jiménez-P R, Martín-Cortázar C, Kourani O, et al. CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth. Haematologica. 2018;103(10):1669–1678.
  • Osthus RC, Karim B, Prescott JE, et al. The Myc target gene JPO1/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res. 2005;65(13):5620–5627.
  • Li S, Huang J, Qin M, et al. High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer. Mol Med Rep. 2020;22(1):57–66.
  • Cho H, Lim BJ, Kang ES, et al. Molecular characterization of a new ovarian cancer cell line, YDOV-151, established from mucinous cystadenocarcinoma. Tohoku J Exp Med. 2009;218(2):129–139.
  • Irshad R, Husain M. Natural products in the reprogramming of Cancer epigenetics. Toxicol Appl Pharmacol. 2021;417:115467.
  • Gentile C, Kmita M. Polycomb repressive complexes in hox gene regulation: silencing and beyond: the functional dynamics of polycomb repressive complexes in hox gene regulation. Bioessays. 2020;42(10):e1900249.
  • Aoyama K, Shinoda D, Suzuki E, et al. PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome. Leukemia. 2020;35(4):1156-1165.
  • Liang W, Wu J, Qiu X. LINC01116 facilitates colorectal cancer cell proliferation and angiogenesis through targeting EZH2-regulated TPM1. J Transl Med. 2021;19(1):45.
  • Dai ZY, Jin SM, Luo HQ, et al. LncRNA HOTAIR regulates anoikis-resistance capacity and spheroid formation of ovarian cancer cells by recruiting EZH2 and influencing H3K27 methylation. Neoplasma. 2021;68(3):509–518.
  • Santoni M, Miccini F, Cimadamore A, et al. An update on investigational therapies that target STAT3 for the treatment of cancer. Expert Opin Investig Drugs. 2021;30(3):245-251.
  • Stewart C, Ralyea C, Lockwood S. Ovarian cancer: an integrated review. Semin Oncol Nurs. 2019;35(2):151–156.
  • Cabral-Pacheco GA, Garza-Veloz I, Castruita-de La Rosa C, et al. The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci. 2020;21(24):9739.
  • Scheau C, Badarau IA, Costache R, et al. The role of matrix metalloproteinases in the Epithelial-Mesenchymal transition of hepatocellular carcinoma. Anal Cell Pathol (Amst). 2019;2019:9423907.
  • Ntellas P, Mavroeidis L, Gkoura S, et al. Old player-new tricks: non angiogenic effects of the VEGF/VEGFR pathway in cancer. Cancers (Basel). 2020;12(11):3145.
  • Ferrara N, Hillan KJ, Gerber HP, et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov. 2004;3(5):391–400.
  • Rinderknecht M, Villa A, Ballmer-Hofer K, et al. Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS One. 2010;5(8):e11941.
  • Su SG, Li QL, Zhang MF, et al. An E2F1/DDX11/EZH2 positive feedback loop promotes cell proliferation in hepatocellular carcinoma. Front Oncol. 2020;10:593293.
  • Sun XB, Chen YW, Yao QS, et al. MicroRNA-144 suppresses prostate cancer growth and metastasis by targeting EZH2. Technol Cancer Res Treat. 2021;20:1533033821989817.
  • Yang X, Wang J, Li H, et al. Downregulation of hsa_circ_0026123 suppresses ovarian cancer cell metastasis and proliferation through the miR‑124‑3p/EZH2 signaling pathway. Int J Mol Med. 2021;47(2):668–676.
  • Zong X, Wang W, Ozes A, et al. EZH2-Mediated downregulation of the tumor suppressor DAB2IP maintains ovarian cancer stem cells. Cancer Res. 2020;80(20):4371–4385.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.