MicroRNA -148 alleviates cardiac dysfunction, immune disorders and myocardial apoptosis in myocardial ischemia-reperfusion (MI/R) injury by targeting pyruvate dehydrogenase kinase (PDK4)

References

• McCusker CG, Doherty NN, Molloy B, et al. A randomized controlled trial of interventions to promote adjustment in children with congenital heart disease entering school and their families. J Pediatr Psychol. 2012;37(10):1089–1103.
   PubMed Web of Science ®Google Scholar
• van Rijen EHM, Utens EMWJ. Roos-Hesselink JW et al. Psychosocial functioning of the adult with congenital heart disease: a 20-33 years follow-up. Eur Heart J. 2003;24(7):673–683.
   PubMed Web of Science ®Google Scholar
• Spijkerboer AW, Utens EMWJ, Bogers AJJC, et al. A historical comparison of long-term behavioral and emotional outcomes in children and adolescents after invasive treatment for congenital heart disease. J Pediatr Surg. 2008;43(3):534–539.
   PubMed Web of Science ®Google Scholar
• Rezende PC, Ribas FF, Serrano CV, et al. Clinical significance of chronic myocardial ischemia in coronary artery disease patients. J Thorac Dis. 2019;11(3):1005–1015.
   PubMed Web of Science ®Google Scholar
• Mokhtari-Zaer A, Marefati N, Atkin SL, et al. The protective role of curcumin in myocardial ischemia-reperfusion injury. J Cell Physiol. 2018;234(1):214–222.
   PubMed Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–1207.
   PubMed Web of Science ®Google Scholar
• Vp Y, Lepilina A, Smith A, et al. Regulation of zebrafish heart regeneration by miR-133. Dev Biol. 2012;365(2):319–327. Beauchemin M, Smith A, Yin VP. Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration Development. 2015;142:4026-4037.
   PubMed Web of Science ®Google Scholar
• Crippa S, Nemir M, Ounzain S, et al. Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Cardiovasc Res. 2016;110(1):73–84.
   PubMed Web of Science ®Google Scholar
• Jiang C-K, Gong F. [Regulation and mechanism of miR-148a on cardiomyocyte differentiation induced by 5-aza in mesenchymal stem cells]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2017;33:514–518.
   PubMedGoogle Scholar
• Zhang J, Ying Z-Z, Tang Z-L, et al. MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1 gene. J Biol Chem. 2012;287(25):21093–21101.
   PubMed Web of Science ®Google Scholar
• Klett H, Jürgensen L, Most P, et al. Delineating the dynamic transcriptome response of mRNA and microRNA during zebrafish heart regeneration. Biomolecules. 2018;9(1):11.
   PubMed Web of Science ®Google Scholar
• Toldo S, Mauro AG, Cutter Z, et al. Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2018;315(6):H1553–h1568.
   PubMed Web of Science ®Google Scholar
• Giri BR, Cheng G. Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection. Int J Parasitol. 2019;49(13–14):993–997.
   PubMed Web of Science ®Google Scholar
• Sheeran FL, Angerosa J, Liaw NY, et al. Adaptations in protein expression and regulated activity of pyruvate dehydrogenase multienzyme complex in human systolic heart failure. Oxid Med Cell Longev. 2019;2019:4532592.
   Google Scholar
• Li T, Xu J, Qin X, et al. Glucose oxidation positively regulates glucose uptake and improves cardiac function recovery after myocardial reperfusion. American Journal of Physiology. Endocrinology and Metabolism. 2017;313(5):E577–e585.
   PubMed Web of Science ®Google Scholar
• Xue R, Lei S, Xia ZY, et al. Selective inhibition of PTEN preserves ischaemic post-conditioning cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways. Clin Sci (Lond). 2016;130(5):377–392.
   PubMed Web of Science ®Google Scholar
• Qiu Z, Lei S. NLRP3 inflammasome activation-mediated pyroptosis aggravates myocardial ischemia/reperfusion injury in diabetic rats. Oxid Med Cell Longev. 2017;2017:9743280.
   Google Scholar
• Yu T, Zhao C. Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats. Braz J Med Biol Res. 2019;52:e8735.
   Google Scholar
• Yu SY, Dong B, Fang ZF, et al. Knockdown of lncRNA AK139328 alleviates myocardial ischaemia/reperfusion injury in diabetic mice via modulating miR-204-3p and inhibiting autophagy. J Cell Mol Med. 2018;22:4886–4898.
   Google Scholar
• Wang H, Huo X, Yang XR, et al. STAT3-mediated upregulation of lncRNA HOXD-AS1 as a ceRNA facilitates liver cancer metastasis by regulating SOX4. Mol Cancer. 2017;16(1):136.
   PubMed Web of Science ®Google Scholar
• Sadeghi S, Hojati Z, Tabatabaeian H. Cooverexpression of EpCAM and c-myc genes in malignant breast tumours. J Genet. 2017;96(1):109–118.
   PubMed Web of Science ®Google Scholar
• Zhang B, Shetti D, Fan C, et al. miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3. Biol Res. 2019;52:38.
   Google Scholar
• An X, Ma H, Liu Y, et al. Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1. J Anim Sci Biotechnol. 2020;11:102.
   Google Scholar
• Chen D, Zheng X, Kang D, et al. Apoptosis and expression of the Bcl-2 family of proteins and P53 in human pancreatic ductal adenocarcinoma. Med Princ Pract. 2012;21(1):68–73.
   PubMed Web of Science ®Google Scholar
• Marín-Juez R, El-Sammak H, Helker CSM, et al. Coronary revascularization during heart regeneration is regulated by epicardial and endocardial cues and forms a scaffold for cardiomyocyte repopulation. Dev Cell. 2019;51(4):503–515.e4.
   PubMed Web of Science ®Google Scholar
• Bhaskar S, Stanwell P, Cordato D, et al. Reperfusion therapy in acute ischemic stroke: dawn of a new era? BMC Neurol. 2018;18:8.
   PubMed Web of Science ®Google Scholar
• Jahan R, Saver JL, Schwamm LH, et al. Association between time to treatment with endovascular reperfusion therapy and outcomes in patients with acute ischemic stroke treated in clinical practice. JAMA. 2019;322(3):252–263.
   PubMed Web of Science ®Google Scholar
• Jiao H, Chen R, Jiang Z, et al. miR-22 protect PC12 from ischemia/reperfusion-induced injury by targeting p53 upregulated modulator of apoptosis (PUMA). Bioengineered. 2020;11(1):209–218.
   PubMed Web of Science ®Google Scholar
• Babu KR, Muckenthaler MU. miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma. Sci Rep. 2019;9(1):1518.
   PubMedGoogle Scholar
• Chen Y, Song Y-X, Wang Z-N. The microRNA-148/152 family: multi-faceted players. Mol Cancer. 2013;12(43):43.
   Google Scholar
• Serino G, Sallustio F, Cox SN, et al. Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy. J Am Soc Nephrol. 2012;23:814–824.
   PubMed Web of Science ®Google Scholar
• Nunez Lopez YO, Garufi G, Seyhan AA. Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes. Mol Biosyst. 2016;13(1):106–121.
   PubMedGoogle Scholar
• Farid WRR, Pan Q, van der Meer AJP, et al. Hepatocyte-derived microRNAs as serum biomarkers of hepatic injury and rejection after liver transplantation. Liver Transpl. 2012;18(3):290–297.
   PubMed Web of Science ®Google Scholar
• Chavali V, Tyagi SC, Mishra PK. Differential expression of dicer, miRNAs, and inflammatory markers in diabetic Ins2± Akita hearts. Cell Biochem Biophys. 2014;68(1):25–35.
   PubMed Web of Science ®Google Scholar
• Klett H, Jürgensen L. Delineating the dynamic transcriptome response of mRNA and microRNA during zebrafish heart regeneration. Biomolecules. 2018;9 (1):11.
   Google Scholar
• Cosmi L, Maggi L, Santarlasci V, et al. T helper cells plasticity in inflammation. Cytometry A. 2014;85(1):36–42.
   PubMedGoogle Scholar
• Bedke T, Muscate F, Soukou S, et al. Title: IL-10-producing T cells and their dual functions. Semin Immunol. 2019;44:101335.
   PubMed Web of Science ®Google Scholar
• Xue Q, Yan Y, Zhang R, et al. Regulation of iNOS on immune cells and its role in diseases. Int J Mol Sci. 2018;19(12):3805.
   Web of Science ®Google Scholar
• Mishra BB, Rathinam VAK, Martens GW, et al. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nat Immunol. 2013;14(1):52–60.
   PubMed Web of Science ®Google Scholar
• Friedrich M, Pracht K, Mashreghi M-F, et al. The role of the miR-148/-152 family in physiology and disease. Eur J Immunol. 2017;47(12):2026–2038.
   PubMed Web of Science ®Google Scholar
• Haftmann C, Stittrich A-B, Zimmermann J, et al. miR-148a is upregulated by twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene bim. Eur J Immunol. 2015;45(4):1192–1205. Haftmann C, Riedel R, Porstner Met al. Direct uptake of Antagomirs and efficient knockdown of miRNA in primary B and T lymphocytes J Immunol Methods. 2015;426:128-133.
   PubMed Web of Science ®Google Scholar
• Chu Q, Gao Y, Bi D, et al. MicroRNA-148 as a negative regulator of the common TLR adaptor mediates inflammatory response in teleost fish. Sci Rep. 2017;7(1):4124.
   PubMedGoogle Scholar
• Mc S, MJ H. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia. Curr Drug Targets Immune Endocr Metabol Disord. 2002;2(2):151–165.
   PubMedGoogle Scholar
• Ushikai M, Horiuchi M, Kobayashi K, et al. Induction of PDK4 in the heart muscle of JVS mice, an animal model of systemic carnitine deficiency, does not appear to reduce glucose utilization by the heart. Mol Genet Metab. 2011;102(3):349–355.
   PubMed Web of Science ®Google Scholar
• Liu LX, Rowe GC, Yang S, et al. PDK4 inhibits cardiac pyruvate oxidation in late pregnancy. Circ Res. 2017;121(12):1370–1378.
   PubMed Web of Science ®Google Scholar
• Mori J, Alrob OA, Wagg CS, et al. ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4. Am J Physiol Heart Circ Physiol. 2013;304(8):H1103–H1113.
   PubMed Web of Science ®Google Scholar