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Research Paper

Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35

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Pages 5440-5449 | Received 21 Jun 2021, Accepted 07 Aug 2021, Published online: 23 Aug 2021

References

  • Lawrence E, Vegvari C, Ower A, et al. A systematic review of longitudinal studies which measure Alzheimer’s disease biomarkers. J Alzheimers Dis. 2017;59(4):1359–1379.
  • Crous-Bou M, Minguillon C, Gramunt N, et al. Alzheimer’s disease prevention: from risk factors to early intervention. Alzheimers Res Ther. 2017;9(1):71.
  • Wimo A, Winblad B, Jonsson L. The worldwide societal costs of dementia: estimates for 2009. Alzheimers Dement. 2010;6(2):98–103.
  • Weller J, Budson A. Current understanding of Alzheimer’s disease diagnosis and treatment. F1000Res. 2018;7F1000 Faculty Rev-1161.
  • Virmani A, Pinto L, Bauermann O, et al. The Carnitine Palmitoyl Transferase (CPT) system and possible relevance for neuropsychiatric and neurological conditions. Mol Neurobiol. 2015;52(2):826–836. .
  • Lee J, Wolfgang MJ. Metabolomic profiling reveals a role for CPT1c in neuronal oxidative metabolism. BMC Biochem. 2012;13(1):23.
  • Sierra AY, Gratacós E, Carrasco P, et al. CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity. J Biol Chem. 2008;283(11):6878–6885. .
  • Gao XF, Chen W, Kong XP, et al. Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake. Diabetologia. 2009;52(5):912–920. .
  • Carrasco P, Jacas J, Sahun I, et al. Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity. Behav Brain Res. 2013;256:291–297.
  • Benoit SC, Kemp CJ, Elias CF, et al. Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents. J Clin Invest. 2009;119(9):2577–2589. .
  • Rönnemaa E, Zethelius B, Sundelöf J, et al. Impaired insulin secretion increases the risk of Alzheimer disease. Neurology. 2008;71(14):1065–1071. .
  • Rhein V, Eckert A. Effects of Alzheimer’s amyloid-beta and tau protein on mitochondrial function – role of glucose metabolism and insulin signalling. Arch Physiol Biochem. 2007;113(3):131–141.
  • Chen N, Wang J, He Y, et al. Trilobatin protects against Abeta25-35-Induced Hippocampal HT22 cells apoptosis through mediating ROS/p38/caspase 3-dependent pathway. Front Pharmacol. 2020;11:584.
  • Luo R, Su LY, Li G, et al. Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model. Autophagy. 2020;16(1):52–69. .
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta delta C(T)) method. Methods. 2001;25(4):402–408.
  • Zaugg K, Yao Y, Reilly PT, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 2011;25(10):1041–1051. .
  • Chen Y, Wang Y, Huang Y, et al. PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C. Carcinogenesis. 2017;38(4):474–483. .
  • Kantarci K. Molecular imaging of Alzheimer disease pathology. AJNR Am J Neuroradiol. 2014;35(Supplement 6):S12–17.
  • Song XY, Hu JF, Chu SF, et al. Ginsenoside Rg1 attenuates okadaic acid induced spatial memory impairment by the GSK3beta/tau signaling pathway and the Abeta formation prevention in rats. Eur J Pharmacol. 2013;710(1–3):29–38. .
  • Fu AL, Zhou CY, Chen X. Thyroid hormone prevents cognitive deficit in a mouse model of Alzheimer’s disease. Neuropharmacology. 2010;58(4–5):722–729.
  • Cassidy L, Fernandez F, Johnson JB, et al. Oxidative stress in alzheimer’s disease: a review on emergent natural polyphenolic therapeutics. Complement Ther Med. 2020;49:102294.
  • Tarozzi A. Oxidative stress in neurodegenerative diseases: from preclinical studies to clinical applications. J Clin Med. 2020;Apr 24;9(4):1223.
  • Valko M, Morris H, Cronin MT. Metals, toxicity and oxidative stress. Curr Med Chem. 2005;12(10):1161–1208.
  • Carrasco P, Sahun I, McDonald J, et al. Ceramide levels regulated by carnitine palmitoyltransferase 1C control dendritic spine maturation and cognition. J Biol Chem. 2012;287(25):21224–21232. .
  • Behl C. Apoptosis and Alzheimer’s disease. J Neural Transm (Vienna). 2000;107(11):1325–1344.
  • Sanvicens N, Cotter TG. Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells. J Neurochem. 2006;98(5):1432–1444.
  • Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med. 2002;53(1):409–435.
  • Shang D, Liu Y, Zhang J, et al. Peroxisome proliferator-activated receptor γ (PPARγ) suppresses the proliferation and metastasis of patients with urothelial carcinoma after renal transplantation by inhibiting LEF1/β-catenin signaling. Bioengineered. 2020;11(1):1350–1367.
  • Zhang JQ, Long XY, Xie Y, et al. Relationship between PPARα mRNA expression and mitochondrial respiratory function and ultrastructure of the skeletal muscle of patients with COPD. Bioengineered. 2017;8(6):723–731. .
  • Wojtowicz S, Strosznajder AK, Jezyna M, et al. The novel role of PPAR alpha in the brain: promising target in therapy of Alzheimer’s disease and other neurodegenerative disorders. Neurochem Res. 2020;45(5):972–988.
  • Warden A, Truitt J, Merriman M, et al. Localization of PPAR isotypes in the adult mouse and human brain. Sci Rep. 2016;6(1):27618. .
  • Brune S, Kolsch H, Ptok U, et al. Polymorphism in the peroxisome proliferator-activated receptor alpha gene influences the risk for Alzheimer’s disease. J Neural Transm (Vienna). 2003;110(9):1041–1050. .