Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis

References

• World Health Organization. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. Geneva (CH): World Health Organization; 2013.
   Google Scholar
• Coustan DR. Gestational diabetes mellitus. Clin Chem. 2013 Sept;59(9):1310–1321.
   PubMed Web of Science ®Google Scholar
• Poola-Kella S, Steinman RA, Mesmar B, et al. Gestational diabetes mellitus: post-partum risk and follow up. Rev Recent Clin Trials. 2018 Jan 31;13(1):5–14.
   PubMed Web of Science ®Google Scholar
• Mack LR, Tomich PG. Gestational diabetes: diagnosis, classification, and clinical care. Obstet Gynecol Clin North Am. 2017 June;44(2):207–217.
   PubMed Web of Science ®Google Scholar
• Kim C, Berger DK, Chamany S. Recurrence of gestational diabetes mellitus: a systematic review. Diabetes Care. 2007 May;30(5):1314–1319.
   PubMed Web of Science ®Google Scholar
• Chiefari E, Arcidiacono B, Foti D, et al. Gestational diabetes mellitus: an updated overview. J Endocrinol Invest. 2017 Sept;40(9):899–909.
   PubMed Web of Science ®Google Scholar
• Kintiraki E, Goulis DG. Gestational diabetes mellitus: multi-disciplinary treatment approaches. Metabolism. 2018 Sept;86:91–101.
   PubMed Web of Science ®Google Scholar
• Schiano C, Grimaldi V, Franzese M, et al. Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694.
   PubMed Web of Science ®Google Scholar
• McElwain CJ, Tuboly E, McCarthy FP, et al. Mechanisms of endothelial dysfunction in pre-eclampsia and gestational diabetes mellitus: windows into future cardiometabolic health? Front Endocrinol (Lausanne). 2020 Sept;11(11):655.
   PubMed Web of Science ®Google Scholar
• Chen LL, Yang L. Regulation of circRNA biogenesis. RNA Biol. 2015;12(4):381–388.
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Andersen MS, Stagsted LVW, et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019 Nov;20(11):675–691.
   PubMed Web of Science ®Google Scholar
• Filardi T, Catanzaro G, Mardente S, et al. Non-coding RNA: role in gestational diabetes pathophysiology and complications. Int J Mol Sci. 2020 June 4;21(11):4020.
   PubMed Web of Science ®Google Scholar
• He C, Zheng S, Luo Y, et al. Exosome theranostics: biology and translational medicine. Theranostics. 2018 Jan 1;8(1):237–255.
   PubMed Web of Science ®Google Scholar
• Mathieu M, Martin-Jaular L, Lavieu G, et al. Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication. Nat Cell Biol. 2019 Jan;21(1):9–17.
   PubMed Web of Science ®Google Scholar
• Ludwig N, Whiteside TL, Reichert TE. Challenges in exosome isolation and analysis in health and disease. Int J Mol Sci. 2019 Sept 21;20(19):4684.
   PubMed Web of Science ®Google Scholar
• Li Y, Zheng Q, Bao C, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015 Aug;25(8):981–984.
   PubMed Web of Science ®Google Scholar
• Cao M, Zhang L, Lin Y, et al. Circular RNA expression profiles in umbilical cord blood exosomes from normal and gestational diabetes mellitus patients. Biosci Rep. 2020 Nov 27;40(11):BSR20201946.
   PubMed Web of Science ®Google Scholar
• American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2013 Jan;36(Suppl1):S67–74.
   PubMed Web of Science ®Google Scholar
• Wang W, Hong G, Wang S, et al. Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX). Bioengineered. 2021 Dec;12(1):821–831.
   PubMed Web of Science ®Google Scholar
• Ma C, Wang X, Yang F, et al. Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit. Mol Cancer. 2020 Nov 10;19(1):157.
   PubMed Web of Science ®Google Scholar
• Tang Q, Chen Z, Zhao L, et al. Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1. Aging (Albany NY). 2019 Nov 26;11(22):9982–9999.
   PubMedGoogle Scholar
• Wang H, She G, Zhou W, et al. Expression profile of circular RNAs in placentas of women with gestational diabetes mellitus. Endocr J. 2019 May 28;66(5):431–441.
   PubMed Web of Science ®Google Scholar
• Wang H, Zhou W, She G, et al. Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the beta-catenin and NF-kappaB pathways. Reprod Biol Endocrinol. 2020 May 20;18(1):51.
   PubMed Web of Science ®Google Scholar
• Chen H, Zhang S, Wu Y, et al. The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts. Biol Res. 2021 Apr 20;54(1):14.
   PubMed Web of Science ®Google Scholar
• Liu Y, Yang Y, Wang Z, et al. Insights into the regulatory role of circRNA in angiogenesis and clinical implications. Atherosclerosis. 2020 Apr;298:14–26.
   PubMed Web of Science ®Google Scholar
• Mairinger FD, Ting S, Werner R, et al. Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study. Mod Pathol. 2014 Dec;27(12):1632–1640.
   PubMed Web of Science ®Google Scholar
• Pan B, Zhao M, Wang N, et al. LncRNA RGMB-AS1 promotes glioma growth and invasion through miR-1200/HOXB2 axis. Onco Targets Ther. 2019 Nov 25;12:10107–10114.
   PubMed Web of Science ®Google Scholar
• Li S, Pei Y, Wang W, et al. Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2. Cell Cycle. 2019 June;18(11):1281–1291.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Yu X, Zhou B, et al. Circular RNA circ_0026359 enhances cisplatin resistance in gastric cancer via targeting miR-1200/POLD4 pathway. Biomed Res Int. 2020 Aug 13;2020:5103272.
   PubMed Web of Science ®Google Scholar
• Liu Y, Wang Y, Wang Y, et al. Gene expression changes in arterial and venous endothelial cells exposed to gestational diabetes mellitus. Gynecol Endocrinol. 2020 Sept;36(9):791–795.
   PubMed Web of Science ®Google Scholar
• Gorski DH, Walsh K. Control of vascular cell differentiation by homeobox transcription factors. Trends Cardiovasc Med. 2003 Aug;13(6):213–220.
   PubMed Web of Science ®Google Scholar
• Gorski DH, Leal AJ. Inhibition of endothelial cell activation by the homeobox gene Gax. J Surg Res. 2003;111:91–99.
   PubMed Web of Science ®Google Scholar
• Douville JM, Cheung DY, Herbert KL, et al. Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells. PLoS One. 2011;6(12):e29099.
   PubMed Web of Science ®Google Scholar
• Gohn CR, Blue EK, Sheehan BM, et al. Mesenchyme homeobox 2 enhances migration of endothelial colony forming cells exposed to intrauterine diabetes mellitus. J Cell Physiol. 2017 July;232(7):1885–1892.
   PubMed Web of Science ®Google Scholar