CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt)

References

• Monk TG, Weldon BC, Garvan CW, et al. Predictors of cognitive dysfunction after major noncardiac surgery. Anesthesiology. 2008;108(1):18–30.
   PubMed Web of Science ®Google Scholar
• Rörtgen D, Kloos J, Fries M, et al. Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial. Br J Anaesth. 2010;104(2):167–174.
   PubMed Web of Science ®Google Scholar
• Shu Q, Zhao X, Geng X, et al. CD82 aggravates sevoflurane-induced neurotoxicity by regulating TRPM7 in developing neurons. Signa Vitae. 2020;16(2):142–147.
   Web of Science ®Google Scholar
• Wang Y, Yin CP, Tai YL, et al. Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats. Exp Ther Med. 2021;21(3):203.
   PubMed Web of Science ®Google Scholar
• Cui RS, Wang K, Wang ZL. Sevoflurane anesthesia alters cognitive function by activating inflammation and cell death in rats. Exp Ther Med. 2018;15(5):4127–4130.
   PubMed Web of Science ®Google Scholar
• Wan Y, Xu J, Ma D, et al. Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology. 2007;106(3):436–443.
   PubMed Web of Science ®Google Scholar
• Griffin R, Nally R, Nolan Y, et al. The age-related attenuation in long-term potentiation is associated with microglial activation. J Neurochem. 2006;99(4):1263–1272.
   PubMed Web of Science ®Google Scholar
• Schäffler A, Buechler C. CTRP family: linking immunity to metabolism. Trends Endocrinol Metab. 2012;23(4):194–204.
   PubMed Web of Science ®Google Scholar
• Ohashi K, Shibata R, Murohara T, et al. Role of anti-inflammatory adipokines in obesity-related diseases. Trends Endocrinol Metab. 2014;25(7):348–355.
   PubMed Web of Science ®Google Scholar
• Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, et al. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 2008;416(2):161–177.
   PubMed Web of Science ®Google Scholar
• Kim MJ, Lee W, Park EJ, et al. C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages. Mol Cells. 2010;30(1):59–64.
   PubMed Web of Science ®Google Scholar
• Lei H, Wu D, Wang JY, et al. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Basic Res Cardiol. 2015;110(4):35.
   PubMed Web of Science ®Google Scholar
• Zheng WF, Zhang SY, Ma HF, et al. C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury. J Cell Biochem. 2019;120(6):10748–10755.
   PubMed Web of Science ®Google Scholar
• Murayama MA, Kakuta S, Inoue A, et al. CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 2015;6:8483.
   PubMed Web of Science ®Google Scholar
• Kambara T, Ohashi K, Shibata R, et al. CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism. J Biol Chem. 2012;287(23):18965–18973.
   PubMed Web of Science ®Google Scholar
• Zhao D, Feng P, Sun Y, et al. Cardiac-derived CTRP9 protects against myocardial ischemia/reperfusion injury via calreticulin-dependent inhibition of apoptosis. Cell Death Dis. 2018;9(7):723.
   PubMedGoogle Scholar
• Li Y, Sun J, Gu L, et al. Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells. Mol Med Rep. 2020;22(1):344–352.
   PubMed Web of Science ®Google Scholar
• Dong P, Zhao J, Li N, et al. Sevoflurane exaggerates cognitive decline in a rat model of chronic intermittent hypoxia by aggravating microglia-mediated neuroinflammation via downregulation of PPAR-γ in the hippocampus. Behav Brain Res. 2018;347:325–331.
   PubMed Web of Science ®Google Scholar
• Poole DC, Copp SW, Colburn TD, et al. Guidelines for animal exercise and training protocols for cardiovascular studies. Am J Physiol Heart Circ Physiol. 2020;318(5):H1100–h1138.
   PubMed Web of Science ®Google Scholar
• Rastogi RP, Singh SP, Häder DP, et al. Detection of reactive oxygen species (ROS) by the oxidant-sensing probe 2ʹ,7ʹ-dichlorodihydrofluorescein diacetate in the cyanobacterium Anabaena variabilis PCC 7937. Biochem Biophys Res Commun. 2010;397(3):603–607.
   PubMed Web of Science ®Google Scholar
• Kurien BT, Scofield RH. Western blotting. Methods. 2006;38(4):283–293.
   PubMed Web of Science ®Google Scholar
• Yang Y, Ye Y, Kong C, et al. MiR-124 enriched exosomes promoted the M2 polarization of microglia and enhanced hippocampus neurogenesis after traumatic brain injury by inhibiting TLR4 pathway. Neurochem Res. 2019;44(4):811–828.
   PubMed Web of Science ®Google Scholar
• Wan T, Wang Z, Luo Y, et al. FA-97, a new synthetic caffeic acid phenethyl ester derivative, protects against oxidative stress-mediated neuronal cell apoptosis and scopolamine-induced cognitive impairment by activating Nrf2/HO-1 signaling. Oxid Med Cell Longev. 2019;2019:8239642.
   PubMed Web of Science ®Google Scholar
• Evered LA, Silbert BS. Postoperative cognitive dysfunction and noncardiac surgery. Anesth Analg. 2018;127(2):496–505.
   PubMed Web of Science ®Google Scholar
• Xu Z, Qian B. Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor. Neurosci Lett. 2020;721:134785.
   PubMed Web of Science ®Google Scholar
• Jeong H, Chung JY, Ko IG, et al. Effect of polydeoxyribonucleotide on lipopolysaccharide and sevoflurane-induced postoperative cognitive dysfunction in human neuronal SH-SY5Y cells. Int Neurourol J. 2019;23(Suppl 2):S93–101.
   PubMedGoogle Scholar
• Guéniot L, Lepere V, De Medeiros GF, et al. Muscle injury induces postoperative cognitive dysfunction. Sci Rep. 2020;10(1):2768.
   PubMed Web of Science ®Google Scholar
• He Y, Li Z, Zuo YX. Nerve blockage attenuates postoperative inflammation in hippocampus of young rat model with surgical trauma. Mediators Inflamm. 2015;2015:460125.
   PubMed Web of Science ®Google Scholar
• Seldin MM, Tan SY, Wong GW. Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord. 2014;15(2):111–123.
   PubMed Web of Science ®Google Scholar
• Xu E, Yin C, Yi X, et al. Knockdown of CTRP6 inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells through regulating the Akt/NF-κB pathway. Clin Exp Pharmacol Physiol. 2020;47(7):1203–1211.
   PubMed Web of Science ®Google Scholar
• Lei X, Seldin MM, Little HC, et al. C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 2017;292(36):14836–14850.
   PubMed Web of Science ®Google Scholar
• Gong Z, Huang J, Xu B, et al. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice. J Neuroinflammation. 2019;16(1):62.
   PubMedGoogle Scholar
• Duan MX, Zhou H, Wu QQ, et al. Andrographolide protects against HG-induced inflammation, apoptosis, migration, and impairment of angiogenesis via PI3K/AKT-eNOS signalling in HUVECs. Mediators Inflamm. 2019;2019:6168340.
   PubMed Web of Science ®Google Scholar
• Jiang T, Zhang L, Ding M, et al. Protective effect of vasicine against myocardial infarction in rats via modulation of oxidative stress, inflammation, and the PI3K/Akt pathway. Drug Des Devel Ther. 2019;13:3773–3784.
   PubMed Web of Science ®Google Scholar
• Sun G, Qu S, Wang S, et al. Taurine attenuates acrylamide-induced axonal and myelinated damage through the Akt/GSK3β-dependent pathway. Int J Immunopathol Pharmacol. 2018;32:2058738418805322.
   Web of Science ®Google Scholar
• Zu HB, Liu XY, Yao K. DHCR24 overexpression modulates microglia polarization and inflammatory response via Akt/GSK3β signaling in Aβ(25)(-)(35) treated BV-2 cells. Life Sci. 2020;260:118470.
   PubMed Web of Science ®Google Scholar
• Wang J, Wang A, He H, et al. Trametenolic acid B protects against cerebral ischemia and reperfusion injury through modulation of microRNA-10a and PI3K/Akt/mTOR signaling pathways. Biomed Pharmacother. 2019;112:108692.
   PubMed Web of Science ®Google Scholar