Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy

References

• Waugh N, Cummins E, Royle P, et al. Newer agents for blood glucose control in type 2 diabetes: systematic review and economic evaluation. Health Technol Assess. 2010 Jul;14(36):1–248.
   Web of Science ®Google Scholar
• Marshall SM. Natural history and clinical characteristics of CKD in type 1 and type 2 diabetes mellitus. Adv Chronic Kidney Dis. 2014 May;21(3):267–272.
   PubMed Web of Science ®Google Scholar
• Li L, Qian K, Sun Y, et al. Omarigliptin ameliorated high glucose-induced nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation through activating adenosine monophosphate-activated protein kinase α (AMPKα) in renal glomerular endothelial cells. Bioengineered. 2021;Dec;12(1):4805–4815.
   PubMed Web of Science ®Google Scholar
• Barr CC. Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive insulin therapy, by the diabetes control and complications trial/epidemiology of diabetes interventions and complications research group. N. Engl. J. Med 342: 381-9, 2000. Surv Ophthalmol. 2001 Mar-Apr;45(5):459–460.
   PubMedGoogle Scholar
• Yan HD, Li XZ, Xie JM, et al. Effects of advanced glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells. Chin Med J (Engl). 2007 May 5;120(9):787–793.
   PubMed Web of Science ®Google Scholar
• Yamamoto Y, Kato I, Doi T, et al. Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J Clin Invest. 2001 Jul;108(2):261–268.
   PubMed Web of Science ®Google Scholar
• Elsherbiny NM, Al-Gayyar MM. The role of IL-18 in type 1 diabetic nephropathy: the problem and future treatment. Cytokine. 2016 May;81:15–22.
   PubMed Web of Science ®Google Scholar
• Murea M, Ma L, Freedman BI. Genetic and environmental factors associated with type 2 diabetes and diabetic vascular complications. Rev Diabet Stud. 2012;9(1):6–22. Spring.
   PubMedGoogle Scholar
• Brosius FC, Khoury CC, Buller CL, et al. Abnormalities in signaling pathways in diabetic nephropathy. Expert Rev Endocrinol Metab. 2010;5(1):51–64.
   PubMedGoogle Scholar
• Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol. 2010 Sep;12(9):823–830.
   PubMed Web of Science ®Google Scholar
• Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature. 2008 Feb 28;451(7182):1069–1075.
   PubMed Web of Science ®Google Scholar
• Takabatake Y, Kimura T, Takahashi A, et al. Autophagy and the kidney: health and disease. Nephrol Dial Transplant. 2014 Sep;29(9):1639–1647.
   PubMed Web of Science ®Google Scholar
• Ding Y, Choi ME, Ding Y, Choi ME. Autophagy in diabetic nephropathy. J Endocrinol. 2015 Jan;224(1):R15–30.
   PubMed Web of Science ®Google Scholar
• Inoki K. mTOR signaling in autophagy regulation in the kidney. Semin Nephrol. 2014 Jan;34(1):2–8.
   PubMed Web of Science ®Google Scholar
• Kitada M, Kume S, Takeda-Watanabe A, et al. Sirtuins and renal diseases: relationship with aging and diabetic nephropathy. Clin Sci (Lond). 2013 Feb;124(3):153–164.
   PubMed Web of Science ®Google Scholar
• Tang SCW, Yiu WH. Innate immunity in diabetic kidney disease. Nat Rev Nephrol. 2020 Apr;16(4):206–222.
   PubMed Web of Science ®Google Scholar
• Shao A, Wu H, Hong Y, et al. Hydrogen-Rich saline attenuated subarachnoid hemorrhage-induced early brain injury in rats by suppressing inflammatory response: possible involvement of NF-κB pathway and NLRP3 inflammasome. Mol Neurobiol. 2016 Jul;53(5):3462–3476.
   PubMed Web of Science ®Google Scholar
• Chen L, Chen Y, Yun H, et al. Tetramethylpyrazine (TMP) protects rats against acute pancreatitis through NF-κB pathway. Bioengineered. 2019 Dec;10(1):172–181.
   PubMed Web of Science ®Google Scholar
• Li X, Tong J, Liu J, et al. Down-regulation of ROCK2 alleviates ethanol-induced cerebral nerve injury partly by the suppression of the NF-κB signaling pathway. Bioengineered. 2020 Dec;11(1):779–790.
   PubMed Web of Science ®Google Scholar
• Rossanti R, Shono A, Miura K, et al. Molecular assay for an intronic variant in NUP93 that causes steroid resistant nephrotic syndrome. J Hum Genet. 2019 Jul;64(7):673–679.
   PubMed Web of Science ®Google Scholar
• Rosti RO, Sotak BN, Bielas SL, et al. Homozygous mutation in NUP107 leads to microcephaly with steroid-resistant nephrotic condition similar to galloway-Mowat syndrome. J Med Genet. 2017 Jun;54(6):399–403.
   PubMed Web of Science ®Google Scholar
• Braun DA, Sadowski CE, Kohl S, et al. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nat Genet. 2016 Apr;48(4):457–465.
   PubMed Web of Science ®Google Scholar
• Morchoisne-Bolhy S, Geoffroy MC, Bouhlel IB, et al. Intranuclear dynamics of the Nup107-160 complex. Mol Biol Cell. 2015 Jun 15;26(12):2343–2356.
   PubMed Web of Science ®Google Scholar
• Vollmer B, Lorenz M, Moreno-Andrés D, et al. Nup153 Recruits the Nup107-160 Complex to the Inner Nuclear Membrane for Interphasic Nuclear Pore Complex Assembly. Dev Cell. 2015 Jun 22;33(6):717–728.
   PubMed Web of Science ®Google Scholar
• Wang P, Zhao F, Nie X, et al. Knockdown of NUP160 inhibits cell proliferation, induces apoptosis, autophagy and cell migration, and alters the expression and localization of podocyte associated molecules in mouse podocytes. Gene. 2018 Jul 20;664:12–21.
   PubMed Web of Science ®Google Scholar
• Dong WH, Chu QQ, Liu SQ, et al. Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway. J Food Biochem. 2020 Sep;44(9):e13405.
   PubMed Web of Science ®Google Scholar
• Gao YF, Zhang MN, Wang TX, et al. Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway. Mol Cell Endocrinol. 2016 Sep 15;433:26–34.
   PubMed Web of Science ®Google Scholar
• Cui W, Li B, Bai Y, et al. Potential role for Nrf2 activation in the therapeutic effect of MG132 on diabetic nephropathy in OVE26 diabetic mice. Am J Physiol Endocrinol Metab. 2013 Jan 1;304(1):E87–99.
   PubMed Web of Science ®Google Scholar
• Feng J, Lu C, Dai Q, et al. SIRT3 facilitates amniotic fluid stem cells to repair diabetic nephropathy through protecting mitochondrial homeostasis by modulation of mitophagy. Cell Physiol Biochem. 2018;46(4):1508–1524.
   PubMedGoogle Scholar
• Yao J, Liu X, Sun Y, et al. Curcumin-alleviated osteoarthritic progression in rats fed a high-fat diet by inhibiting apoptosis and activating autophagy via modulation of MicroRNA-34a. J Inflamm Res. 2021;14:2317–2331.
   PubMed Web of Science ®Google Scholar
• Wei TT, Yang LT, Guo F, et al. Activation of GPR120 in podocytes ameliorates kidney fibrosis and inflammation in diabetic nephropathy. Acta Pharmacol Sin. 2021 Feb;42(2):252–263.
   PubMed Web of Science ®Google Scholar
• Li J, Chen Y, Qin X, et al. MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability. Nucleic Acids Res. 2014 Jan;42(1):458–474.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001 Dec;25(4):402–408.
   PubMed Web of Science ®Google Scholar
• Chen L, Fang Z, Wang X, et al. G protein-coupled receptor 39 activation alleviates oxidized low-density lipoprotein-induced macrophage inflammatory response, lipid accumulation and apoptosis by inducing A20 expression. Bioengineered. 2021;Dec;12(1):4070–4080.
   PubMed Web of Science ®Google Scholar
• Xing Y, Ding J, Fan Q, et al. Diversities of podocyte molecular changes induced by different antiproteinuria drugs. Exp Biol Med (Maywood). 2006 May;231(5):585–593.
   PubMed Web of Science ®Google Scholar
• Kaushal GP, Chandrashekar K, Juncos LA, et al. Autophagy function and regulation in kidney disease. Biomolecules. 2020 Jan 7;10(1):100.
   PubMed Web of Science ®Google Scholar
• Liu L, Yang L, Chang B, et al. The protective effects of rapamycin on cell autophagy in the renal tissues of rats with diabetic nephropathy via mTOR-S6K1-LC3II signaling pathway. Ren Fail. 2018 Nov;40(1):492–497.
   PubMed Web of Science ®Google Scholar
• Ebrahim N, Ahmed IA, Hussien NI, et al. Mesenchymal stem cell-derived exosomes ameliorated diabetic nephropathy by autophagy induction through the mtor signaling pathway. Cells. 2018 Nov 22;7(12):12.
   PubMed Web of Science ®Google Scholar
• Li H, Peng X, Wang Y, et al. Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosis. Autophagy. 2016 Sep;12(9):1472–1486.
   PubMed Web of Science ®Google Scholar
• Liu N, Xu L, Shi Y, et al. Podocyte autophagy: a potential therapeutic target to prevent the progression of diabetic nephropathy. J Diabetes Res. 2017;2017:3560238.
   PubMed Web of Science ®Google Scholar
• Liu X, Zhang Y, Shi M, et al. Notch1 regulates PTEN expression to exacerbate renal tubulointerstitial fibrosis in diabetic nephropathy by inhibiting autophagy via interactions with Hes1. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1110–1116.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhao S, Wu D, et al. MicroRNA-22 promotes renal tubulointerstitial fibrosis by targeting PTEN and suppressing autophagy in diabetic nephropathy. J Diabetes Res. 2018;2018:4728645.
   PubMed Web of Science ®Google Scholar
• Guo L, Tan K, Luo Q, et al. Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. Bosn J Basic Med Sci. 2020 Aug 3;20(3):372–380.
   PubMed Web of Science ®Google Scholar
• Zhao F, Zhu JY, Richman A, et al. Mutations in NUP160 are implicated in steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 2019 May;30(5):840–853.
   PubMed Web of Science ®Google Scholar