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Research Paper

The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro

The protective mechanism of rhein in preventing obesity

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Pages 5797-5813 | Received 16 Jul 2021, Accepted 12 Aug 2021, Published online: 13 Sep 2021

References

  • Tabrizi R, Moosazadeh M, Lankarani KB, et al. The effects of synbiotic supplementation on glucose metabolism and lipid profiles in patients with diabetes: a systematic review and meta-analysis of randomized controlled trials. Probiotics Antimicrob Proteins. 2018;10(2):329–342.
  • Yang L, Yang J, Liang X, et al. Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication. Bioengineered. 2021;12(1):4757–4767.
  • Ferrières J, Lautsch D, Bramlage P, et al. Lipid-lowering treatment and low-density lipoprotein cholesterol target achievement in patients with type 2 diabetes and acute coronary syndrome. Arch Cardiovasc Dis. 2020;113(10):617–629.
  • Jia ZH, Liu ZH, Zheng JM, et al. Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db Mice. Exp Clin Endocrinol Diabetes. 2007;115(9):571–576.
  • Wang QW, Su Y, Sheng JT, et al. Anti-influenza A virus activity of rhein through regulating oxidative stress, TLR4, Akt, MAPK, and NF-κB signal pathways. PLoS One. 2018;13(1):e0191793.
  • Wu C, Cao H, Zhou H, et al. Research progress on the antitumor effects of rhein: literature review. Anticancer Agents Med Chem. 2017;17:1624–1632.
  • Yu C, Qi D, Sun JF, et al. Rhein prevents endotoxin-induced acute kidney injury by inhibiting NF-κB activities. Sci Rep. 2015;5(1):11822.
  • Zhao Q, Wang X, Chen A, et al. Rhein protects against cerebral ischemic‑/reperfusion‑induced oxidative stress and apoptosis in rats. Int J Mol Med. 2018;41:2802–2812.
  • Zhuang S, Yu R, Zhong J, et al. Rhein from rheum rhabarbarum inhibits hydrogen-peroxide-induced oxidative stress in intestinal epithelial cells partly through PI3K/Akt-mediated Nrf2/HO-1 pathways. J Agric Food Chem. 2019;67(9):2519–2529.
  • Hsia TC, Yang JS, Chen GW, et al. The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells. Anticancer Res. 2009;29:309–318.
  • Wang J, Liu S, Yin Y, et al. FOXO3-mediated up-regulation of Bim contributes to rhein-induced cancer cell apoptosis. Apoptosis. 2015;20(3):399–409.
  • Hsu YA, Kuo YH, Chen CS, et al. Galectin-12 is involved in corn silk-induced anti-adipogenesis and anti-obesity effects. Am J Chin Med. 2018;46(5):1045–1063.
  • Liu Q, Zhang XL, Tao RY, et al. Rhein, an inhibitor of adipocyte differentiation and adipogenesis. J Asian Nat Prod Res. 2011;13(8):714–723.
  • Avgerinos KI, Spyrou N. Mantzoros CS and Dalamaga M. Obesity and cancer risk: emerging biological mechanisms and perspectives. Metabolism. 2019;92:121–135.
  • Russo L, Lumeng CN. Properties and functions of adipose tissue macrophages in obesity. Immunology. 2018;155(4):407–417.
  • Zhao H, Shang Q, Pan Z, et al. Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing m2 macrophages and beiging in white adipose tissue. Diabetes. 2018;67(2):235–247.
  • Kowalczuk A, Bourebaba N, Kornicka-Garbowska K, et al. Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and hyperinsulinemia induced in HepG2 cells through the regulation of SIRT1/NF-kB/JNK pathway. Cell Commun Signal. 2021;19(1):61.
  • Ren CJ, Zhang Y, Wz C, et al. [Progress in the role of oxidative stress in the pathogenesis of type 2 diabetes]. Sheng Li Xue Bao. 2013;65:664–673.
  • Long Q, Chen H, Yang W, et al. Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells. Bioengineered. 2021;12(1):3837–3849.
  • Xue LJ, Han JQ, Zhou YC, et al. Untargeted metabolomics characteristics of nonobese nonalcoholic fatty liver disease induced by high-temperature-processed feed in Sprague-Dawley rats. World J Gastroenterol. 2020;26(46):7299–7311.
  • Guilherme A, Virbasius JV, Puri V, et al. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 2008;9(5):367–377.
  • Shi H, Kokoeva MV, Inouye K, et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116(11):3015–3025.
  • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112(12):1821–1830.
  • Hotamisligil GS, Ns S, Bm S. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87–91.
  • An H, Du X, Huang X, et al. Obesity, altered oxidative stress, and clinical correlates in chronic schizophrenia patients. Transl Psychiatry. 2018;8(1):258.
  • Filgueiras MS, Rocha NP, Novaes JF, et al. Vitamin D status, oxidative stress, and inflammation in children and adolescents: a systematic review. Crit Rev Food Sci Nutr. 2020;60(4):660–669.
  • Park S, Aintablian A. Coupe B and Bouret SG. The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates. Nat Commun. 2020;11(1):1914.
  • Cakir I, Nillni EA. Endoplasmic reticulum stress, the hypothalamus, and energy balance. Trends Endocrinol Metab. 2019;30(3):163–176.
  • Cnop M, Toivonen S, Igoillo-Esteve M, et al. Endoplasmic reticulum stress and eIF2α phosphorylation: the Achilles heel of pancreatic β cells. Mol Metab. 2017;6(9):1024–1039.
  • Yazıcı D, Sezer H. Insulin Resistance, Obesity and Lipotoxicity. Adv Exp Med Biol. 2017;960:277–304.
  • Yilmaz E. Endoplasmic reticulum stress and obesity. Adv Exp Med Biol. 2017;960:261–276.
  • Cao W, Zhang T, Feng R, et al. Hoxa5 alleviates obesity-induced chronic inflammation by reducing ER stress and promoting M2 macrophage polarization in mouse adipose tissue. J Cell Mol Med. 2019;23(10):7029–7042.
  • Ge CX, Xu MX, Qin YT, et al. Endoplasmic reticulum stress-induced iRhom2 up-regulation promotes macrophage-regulated cardiac inflammation and lipid deposition in high fat diet (HFD)-challenged mice: intervention of fisetin and metformin. Free Radic Biol Med. 2019;141:67–83.
  • Yi X, Cai X, Wang S, et al. Mechanisms of impaired pancreatic β‑cell function in high‑fat diet‑induced obese mice: the role of endoplasmic reticulum stress. Mol Med Rep. 2020;21:2041–2050.
  • Amen OM, Sarker SD, Ghildyal R, et al. Endoplasmic reticulum stress activates unfolded protein response signaling and mediates inflammation, obesity, and cardiac dysfunction: therapeutic and molecular approach. Front Pharmacol. 2019;10:977.
  • Senkal CE, Ponnusamy S, Bielawski J, et al. Antiapoptotic roles of ceramide-synthase-6-generated C 16 –ceramide via selective regulation of the ATF6/ CHOP arm of ER-stress-response pathways. Faseb J. 2010;24(1):296–308.
  • Yin J, Wang Y, Gu L, et al. Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: implications for apoptosis and inflammation. Int J Mol Med. 2015;35(4):932–940.
  • Cao M, Pan Q, Dong H, et al. Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice. Stem Cell Res Ther. 2015;6(1):208.
  • Amor S, González-Hedström D, Martín-Carro B, et al. Beneficial effects of an aged black garlic extract in the metabolic and vascular alterations induced by a high fat/sucrose diet in male rats. Nutrients. 2019;11(1):153.
  • Belani M, Deo A, Shah P, et al. Differential insulin and steroidogenic signaling in insulin resistant and non-insulin resistant human luteinized granulosa cells-A study in PCOS patients. J Steroid Biochem Mol Biol. 2018;178:283–292.
  • Khalilpourfarshbafi M, Devi Murugan D, Abdul Sattar MZ, et al. Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice. PLoS One. 2019;14(6):e0218792.