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Research Paper

Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation

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Pages 7020-7032 | Received 23 Jul 2021, Accepted 18 Aug 2021, Published online: 23 Sep 2021

References

  • Sacitharan PK. Ageing and Osteoarthritis. Subcell Biochem. 2019;91:123–159. PubMed PMID: 30888652.
  • Tang X, Wang S, Zhan S, et al. The prevalence of symptomatic knee Osteoarthritis in China: results from the China health and retirement longitudinal study. Arthritis Rheumatol. 2016;68(3):648–653. PubMed PMID: 26474054.
  • Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage. 2018;26(3):319–325. PubMed PMID: 29229563; PubMed Central PMCID: PMCPMC5835411.
  • Ren Y, Hu J, Tan J, et al. Incidence and risk factors of symptomatic knee osteoarthritis among the Chinese population: analysis from a nationwide longitudinal study. BMC Public Health. 2020;20(1):1491. PubMed PMID: 33004017; PubMed Central PMCID: PMCPMC7528331.
  • Boer CG, Radjabzadeh D, Medina-Gomez C, et al. Intestinal microbiome composition and its relation to joint pain and inflammation. Nat Commun. 2019;10(1):4881. PubMed PMID: 31653850; PubMed Central PMCID: PMCPMC6814863.
  • Bijlsma JW, Berenbaum F, Lafeber FP. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115–2126. PubMed PMID: 21684382.
  • Wei T, Kulkarni NH, Zeng QQ, et al. Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage. Osteoarthritis Cartilage. 2010;18(7):992–1000. PubMed PMID: 20434574.
  • Bateman JF, Rowley L, Belluoccio D, et al. Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. Arthritis Rheum. 2013;65(6):1547–1560. PubMed PMID: 23436205.
  • Chen S, Wang J, Cai C, et al. Gene 2 (NDRG2) promotes bone morphogenetic protein 2 (BMP2)-induced Osteoblastic differentiation and calcification by Janus Kinase 3 (JAK3)/signal transducer and activator of transcription 3 (STAT3) signaling pathway. Med Sci Monit. 2020;26:e918541. PubMed PMID: 31911574; PubMed Central PMCID: PMCPMC6977618.
  • Zhou J, Jiang Y, Zhao J, et al. Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma. Cell Oncol (Dordr). 2020;43(3):461–475. PubMed PMID: 32207044.
  • Chien SY, Tsai CH, Liu SC, et al. Noggin inhibits IL-1beta and BMP-2 expression, and attenuates cartilage degeneration and subchondral bone destruction in experimental Osteoarthritis. Cells. 2020;9(4):927. PubMed PMID: 32290085; PubMed Central PMCID: PMCPMC7226847.
  • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001;25(4):402–408. PubMed PMID: 11846609.
  • Gao F, Wu H, Wang R, et al. MicroRNA-485-5p suppresses the proliferation, migration and invasion of small cell lung cancer cells by targeting flotillin-2. Bioengineered. 2019;10(1):1–12. PubMed PMID: 30836864; PubMed Central PMCID: PMCPMC6527069.
  • Lee DH, Park JS, Lee YS, et al. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. Autophagy. 2020;16(11):1949–1973. PubMed PMID: 31913745; PubMed Central PMCID: PMCPMC7595589.
  • Pittayapruek P, Meephansan J, Prapapan O, et al. Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis. Int J Mol Sci. 2016;17(6):868. PubMed PMID: 27271600; PubMed Central PMCID: PMCPMC4926402.
  • Fowkes MM, Lim NH. Purification and activity determination of ADAMTS-4 and ADAMTS-5 and their domain deleted mutants. Methods Mol Biol. 2020;2043:75–91. PubMed PMID: 31463904.
  • Aso K, Shahtaheri SM, Hill R, et al. Associations of symptomatic knee Osteoarthritis with histopathologic features in subchondral bone. Arthritis Rheumatol. 2019;71(6):916–924. PubMed PMID: 30663865.
  • Choi MC, Jo J, Park Y, et al. NF-kappaB signaling pathways in osteoarthritic cartilage destruction. Cells. 2019;8(7):734. PubMed PMID: 31319599; PubMed Central PMCID: PMCPMC6678954.
  • Zheng L, Zhang Z, Sheng P, et al. The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev. 2021;66:101249. PubMed PMID: 33383189.
  • Goldring MB, Otero M, Tsuchimochi K, et al. Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Ann Rheum Dis. 2008;67(Suppl 3):iii75–82. PubMed PMID: 19022820; PubMed Central PMCID: PMCPMC3939701.
  • Adair-Kirk TL, Senior RM. Fragments of extracellular matrix as mediators of inflammation. Int J Biochem Cell Biol. 2008;40(6–7):1101–1110. PubMed PMID: 18243041; PubMed Central PMCID: PMCPMC2478752.
  • Pakianathan DR. Extracellular matrix proteins and leukocyte function. J Leukoc Biol. 1995;57(5):699–702. PubMed PMID: 7759947.
  • Liu Q, Li M, Jiang L, et al. METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte. Biochem Biophys Res Commun. 2019;516(1):22–27. PubMed PMID: 31186141.
  • Xu Z, Ke T, Zhang Y, et al. Agonism of GPR120 prevented IL-1beta-induced reduction of extracellular matrix through SOX-9. Aging (Albany NY). 2020;12(12):12074–12085. PubMed PMID: 32580167; PubMed Central PMCID: PMCPMC7343462.
  • Zhang Y, Dong Q, Sun X. Positive feedback loop LINC00511/miR-150-5p/SP1 modulates chondrocyte apoptosis and proliferation in Osteoarthritis. DNA Cell Biol. 2020;39(9):1506–1512. PubMed PMID: 32635763.
  • Gardiner MD, Vincent TL, Driscoll C, et al. Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis. Osteoarthritis Cartilage. 2015;23(4):616–628. PubMed PMID: 25545425; PubMed Central PMCID: PMCPMC4373757.
  • Su X, Zhang H, Wang H, et al. MiR-130a/Ndrg2 axis inhibits the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2020;43(6):2048–2060. PubMed PMID: 32990844.
  • Wei M, Ma Y, Shen L, et al. NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis. EBioMedicine. 2020;61:103068. PubMed PMID: 33099085; PubMed Central PMCID: PMCPMC7581885.
  • Zhang Y, Gao H, Li N, et al. NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation. J Mol Histol. 2021;52(1):101–111. PubMed PMID: 33205345.
  • Takarada-Iemata M, Yoshikawa A, Ta HM, et al. N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia. Glia. 2018;66(7):1432–1446. PubMed PMID: 29476556.
  • Sun X, Huang H, Pan X, et al. EGR1 promotes the cartilage degeneration and hypertrophy by activating the Kruppel-like factor 5 and beta-catenin signaling. Biochim Biophys Acta Mol Basis Dis. 2019;1865(9):2490–2503. PubMed PMID: 31201921.
  • Dang X, Yang L, Guo J, et al. miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5. Chem Biol Interact. 2019;300:82–90. PubMed PMID: 30639269.
  • Xie Z, Jie Z, Wang G, et al. TGF-beta synergizes with ML264 to block IL-1beta-induced matrix degradation mediated by Kruppel-like factor 5 in the nucleus pulposus. Biochim Biophys Acta Mol Basis Dis. 2018;1864(2):579–589. PubMed PMID: 29196238.
  • Li H, Miao SB, Dong LH, et al. Clinicopathological correlation of Kruppel-like factor 5 and matrix metalloproteinase-9 expression and cartilage degeneration in human osteoarthritis. Pathol Res Pract. 2012;208(1):9–14. PubMed PMID: 22094285.