Study of calcitriol anti-aging effects on human natural killer cells in vitro

References

• Ovadya Y, Landsberger T, Leins H, et al. Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun. 2018;9(1):5435.
   PubMed Web of Science ®Google Scholar
• López-Otín C, Blasco MA, Partridge L, et al. The hallmarks of aging. Cell. 2013;153:1194–1217.
   PubMed Web of Science ®Google Scholar
• Hodgins JJ, Khan ST, Park MM, et al. Killers 2.0: NK cell therapies at the forefront of cancer control. J Clin Invest. 2019;129(9):3499–3510.
   PubMed Web of Science ®Google Scholar
• Zhu H, Blum RH, Bjordahl R, et al. Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity. Blood. 2020;135(6):399–410.
   PubMed Web of Science ®Google Scholar
• Mandal A, Viswanathan C. Natural killer cells: in health and disease. Hematol Oncol Stem Cell Ther. 2015;8(2):47–55.
   PubMedGoogle Scholar
• Le Garff-Tavernier M, et al. Human NK cells display major phenotypic and functional changes over the life span. Aging Cell. 2010;9(4):527–535.
   PubMed Web of Science ®Google Scholar
• Le Garff-Tavernier M, Béziat V, Decocq J, et al. Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education. Blood. 2010;116(19):3853–3864.
   PubMed Web of Science ®Google Scholar
• Manser AR, Uhrberg M. Age-related changes in natural killer cell repertoires: impact on NK cell function and immune surveillance. Cancer Immunol Immunother. 2016;65(4):417–426.
   PubMed Web of Science ®Google Scholar
• Bi J, Tian Z. NK Cell Exhaustion. Front Immunol. 2017;8:760.
   PubMed Web of Science ®Google Scholar
• Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822–1832.
   PubMed Web of Science ®Google Scholar
• Liu Y, et al. A cytomegalovirus peptide-specific antibody alters natural killer cell homeostasis and is shared in several autoimmune diseases. Cell Host Microbe. 2016;19(3):400–408.
   PubMed Web of Science ®Google Scholar
• Camous X, Pera A, Solana R, et al. NK cells in healthy aging and age-associated diseases. J Biomed Biotechnol. 2012;2012:195956.
   PubMedGoogle Scholar
• Liu Y, Mu R, Gao YP, et al. Effect of aging on nk cell population and their proliferation at ex vivo culture condition. Anal Cell Pathol (Amst). 2018;2018:7871814.
   PubMedGoogle Scholar
• Sintov AC, Yarmolinsky L, Dahan A, et al. Pharmacological effects of vitamin D and its analogs: recent developments. Drug Discov Today. 2014;19(11):1769–1774.
   PubMed Web of Science ®Google Scholar
• Halicka HD, Zhao H, Li J, et al. Attenuation of constitutive DNA damage signaling by 1,25-dihydroxyvitamin D3. Aging (Albany NY), 2区, 4.06. 2012;4:270–278.
   Google Scholar
• Liu W, Zhang L, Xu HJ, et al. The anti-inflammatory effects of vitamin d in tumorigenesis. Int J Mol Sci. 2018;19(9):2736.
   Web of Science ®Google Scholar
• Wu S, Sun J. Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection. Discov Med. 2011;11:325–335.
   PubMed Web of Science ®Google Scholar
• Toniato E, Spinas E, Saggini A, et al. IMMUNOMODULATORY EFFECTS OF VITAMIN D ON SKIN INFLAMMATION. J Biol Regul Homeost Agents. 2015;29:563–567.
   PubMed Web of Science ®Google Scholar
• Suh HW, Kim JK, Kim TS, et al. New insights into vitamin d and autophagy in inflammatory bowel diseases. Curr Med Chem. 2017;24(9):898–910.
   PubMed Web of Science ®Google Scholar
• Gungor S, Köylü AA, Saglam S, et al. Effects of oxidant-antioxidant and vitamin d levels on clinical and laboratory data in children with fatty liver disease. Cureus. 2020;12:e11849.
   PubMed Web of Science ®Google Scholar
• Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech Ageing Dev. 2004;125(10–11):811–826.
   PubMed Web of Science ®Google Scholar
• Kaszubowska L, Foerster J, Kwiatkowski P, et al. NKT-like cells reveal higher than T lymphocytes expression of cellular protective proteins HSP70 and SOD2 and comparably increased expression of SIRT1 in the oldest seniors. Folia Histochem Cytobiol. 2018;56(4):231–240.
   PubMed Web of Science ®Google Scholar
• Lynch CJ, Shah ZH, Allison SJ, et al. SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PloS One. 2010;5(10):e13502.
   PubMed Web of Science ®Google Scholar
• Shi W, Nie D, Jin G, et al. BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy. Biomaterials. 2012;33(11):3119–3126.
   PubMed Web of Science ®Google Scholar
• Tuong ZK, Lewandowski A, Bridge JA, et al. Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Sci Rep. 2019;9(1):17754.
   PubMed Web of Science ®Google Scholar
• Mao H, Tao T, Song D, et al. Zedoarondiol inhibits platelet-derived growth factor-induced vascular smooth muscle cells proliferation via regulating amp-activated protein kinase signaling pathway. Cell Physiol Biochem. 2016;40(6):1506–1520.
   PubMedGoogle Scholar
• Kandarian F, Sunga GM, Arango-Saenz D, et al. 2017. Cytotoxicity assay for the assessment of human nk cell activity. J Vis Exp. 126. DOI: 10.3791/56191.
   PubMed Web of Science ®Google Scholar
• Wang YC, Yu SQ, Wang XH, et al. Differences in phenotype and gene expression of prostate stromal cells from patients of varying ages and their influence on tumour formation by prostate epithelial cells. Asian J Androl. 2011;13(5):732–741.
   PubMed Web of Science ®Google Scholar
• Pan L, Nie L, Yao S, et al. Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species‑mediated apoptosis by targeting the electron transport chain. Int J Mol Med. 2020;46(6):2137–2149.
   PubMed Web of Science ®Google Scholar
• Sui X, Zhang C, Zhou J, et al. Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway. J Exp Clin Cancer Res. 2017;36(1):133.
   PubMed Web of Science ®Google Scholar
• Dodig S, Čepelak I, Pavić I. Hallmarks of senescence and aging. Biochem Med (Zagreb). 2019;29(3):030501.
   PubMed Web of Science ®Google Scholar
• El Assar M, Angulo J, Rodríguez-Mañas L. Oxidative stress and vascular inflammation in aging. Free Radic Biol Med. 2013;65:380–401.
   PubMed Web of Science ®Google Scholar
• Campos C, Pera A, Lopez-Fernandez I, et al. Proinflammatory status influences NK cells subsets in the elderly. Immunol Lett. 2014;162(1):298–302.
   PubMed Web of Science ®Google Scholar
• Neves J, Sousa-Victor P. Regulation of inflammation as an anti-aging intervention. FEBS J. 2020;287(1):43–52.
   PubMed Web of Science ®Google Scholar
• Bektas A, Schurman SH, Sen R, et al. Aging, inflammation and the environment. Exp Gerontol. 2018;105:10–18.
   PubMed Web of Science ®Google Scholar
• Ge Z, Wu S, Zhang Z, et al. Mechanism of tumor cells escaping from immune surveillance of NK cells. Immunopharmacol Immunotoxicol. 2020;42(3):187–198.
   PubMed Web of Science ®Google Scholar
• Blagosklonny MV. Rapamycin for longevity: opinion article. Aging (Albany NY). 2019;11(19):8048–8067.
   PubMedGoogle Scholar
• Wang J, Truong T, Ladiges W, et al. Rapamycin increases breast tumor burden in young wheel-running mice. Pathobiol Aging Age Relat Dis. 2019;9(1):1647746.
   PubMedGoogle Scholar
• Han Y, Luo H, Wang H, et al. SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions. Apoptosis. 2017;22(10):1260–1272.
   PubMed Web of Science ®Google Scholar
• Tang BL. Sirt1 and the Mitochondria. Mol Cells. 2016;39:87–95.
   PubMed Web of Science ®Google Scholar
• Chen P, Chen F, Lei J, et al. Activation of the miR-34a-mediated sirt1/mtor signaling pathway by urolithin a attenuates d-galactose-induced brain aging in mice. Neurotherapeutics. 2019;16(4):1269–1282.
   PubMed Web of Science ®Google Scholar
• Bhadra M, Howell P, Dutta S, et al. Alternative splicing in aging and longevity. Hum Genet. 2020;139(3):357–369.
   PubMed Web of Science ®Google Scholar
• Wu A, Ying Z, Gomez-Pinilla F. Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortex. Eur J Neurosci. 2006;23(10):2573–2580.
   PubMed Web of Science ®Google Scholar