7,358
Views
62
CrossRef citations to date
0
Altmetric
Research Paper

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

, , , , , , & ORCID Icon show all
Pages 5932-5949 | Received 26 Jun 2021, Accepted 20 Aug 2021, Published online: 07 Sep 2021

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249. PubMed PMID: 33538338. Epub 2021/ 02/05.
  • Travis WD. Pathology of lung cancer. Clin Chest Med. 2011;32(4):669–692. Epub 2011/ 11/08. PubMed PMID: 22054879.
  • Hao CC, Xu CY, Zhao XY, et al. Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma. J Exp Clin Cancer Res. 2020;39(1):256. PubMed PMID: 33228740; PubMed Central PMCID: PMCPMC7687693. Epub 2020/ 11/25.
  • Zehendner CM, Valasarajan C, Werner A, et al. Long Noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated Regulation of PDGFRβ. Am J Respir Crit Care Med. 2020;202(10):1445–1457. PubMed PMID: 32634060; PubMed Central PMCID: PMCPMC7786813. Epub 2020/ 07/08.
  • Zhu G, Luo H, Feng Y, et al. HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia. Nat Commun. 2021;12(1):1956. PubMed PMID: 33782403. Epub 2021/ 03/31.
  • Monteiro JP, Rodor J, Caudrillier A, et al. MIR503HG loss promotes endothelial-to-mesenchymal transition in vascular disease. Circ Res. 2021;128(8):1173–1190. PubMed PMID: 33703914; PubMed Central PMCID: PMCPMC7610629. Epub 2021/ 03/12.
  • Zhang Y, Zhang X, Cai B, et al. The long noncoding RNA lncCIRBIL disrupts the nuclear translocation of Bclaf1 alleviating cardiac ischemia–reperfusion injury. Nat Commun. 2021;12(1):522. PubMed PMID: 33483496; PubMed Central PMCID: PMCPMC7822959. Epub 2021/ 01/24.
  • Ruan X, Li P, Ma Y, et al. Identification of human long noncoding RNAs associated with nonalcoholic fatty liver disease and metabolic homeostasis. J Clin Invest. 2021;131(1). Epub 2020/ 10/14. DOI:10.1172/JCI136336. PubMed PMID: 33048844; PubMed Central PMCID: PMCPMC7773374.
  • Trembinski DJ, Bink DI, Theodorou K, et al. Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction. Nat Commun. 2020;11(1):2039. PubMed PMID: 32341350; PubMed Central PMCID: PMCPMC7184724. Epub 2020/ 04/29.
  • Lin RX, Yang SL, Jia Y, et al. Epigenetic regulation of papillary thyroid carcinoma by long non-coding RNAs. Semin Cancer Biol. 2021 PubMed PMID: 33785446. DOI:10.1016/j.semcancer.2021.03.027. Epub 2021/ 04/01.
  • Shi J, Gao W, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci. 2017;42(4):245–254. Epub 2016/ 12/10. PubMed PMID: 27932073.
  • Miao EA, Rajan JV, Aderem A. Caspase-1-induced pyroptotic cell death. Immunol Rev. 2011;243(1):206–214. Epub 2011/ 09/03. PubMed PMID: 21884178; PubMed Central PMCID: PMCPMC3609431.
  • Yang Y, Liu PY, Bao W, et al. Hydrogen inhibits endometrial cancer growth via a ROS/NLRP3/caspase-1/GSDMD-mediated pyroptotic pathway. BMC Cancer. 2020;20(1):28. Epub 2020/ 01/12. PubMed PMID: 31924176; PubMed Central PMCID: PMCPMC6954594.
  • Zhang J, Jiang N, Zhang L, et al. NLRP6 expressed in astrocytes aggravates neurons injury after OGD/R through activating the inflammasome and inducing pyroptosis. Int Immunopharmacol. 2020;80:106183. Epub 2020/ 01/14. PubMed PMID: 31927506.
  • Xu R, Yang J, Qian Y, et al. Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF. Nanoscale Horiz. 2021;6(4):348–356. PubMed PMID: 33687417. Epub 2021/ 03/10.
  • Wang Y, Gao W, Shi X, et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017;547(7661):99–103. PubMed PMID: 28459430. Epub 2017/ 05/02.
  • Woo Y, Lee HJ, Jung YM, et al. Regulated necrotic cell death in alternative tumor therapeutic strategies. Cells. 2020;9(12):2709. Epub 2020/ 12/23. PubMed PMID: 33348858; PubMed Central PMCID: PMCPMC7767016.
  • Fang Y, Tian S, Pan Y, et al. Pyroptosis: a new frontier in cancer. Biomed Pharmacother. 2020;121:109595. Epub 2019/ 11/12. PubMed PMID: 31710896.
  • Ruan J, Wang S, Wang J. Mechanism and regulation of pyroptosis-mediated in cancer cell death. Chem Biol Interact. 2020;323:109052. Epub 2020/ 03/15. PubMed PMID: 32169591.
  • Derangere V, Chevriaux A, Courtaut F, et al. Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells. Cell Death Differ. 2014;21(12):1914–1924. PubMed PMID: 25124554; PubMed Central PMCID: PMCPMC4227150. Epub 2014/ 08/16.
  • Dupaul-Chicoine J, Arabzadeh A, Dagenais M, et al. The Nlrp3 inflammasome suppresses colorectal cancer metastatic growth in the liver by promoting natural killer cell tumoricidal activity. Immunity. 2015;43(4):751–763. PubMed PMID: 26384545. Epub 2015/ 09/20.
  • Wang WJ, Chen D, Jiang MZ, et al. Downregulation of gasdermin D promotes gastric cancer proliferation by regulating cell cycle-related proteins. J Dig Dis. 2018;19(2):74–83. PubMed PMID: 29314754. Epub 2018/ 01/10.
  • Wei Q, Mu K, Li T, et al. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression. Lab Invest. 2014;94(1):52–62. PubMed PMID: 24166187. Epub 2013/ 10/30.
  • Chen YF, Qi HY, Wu FL. Euxanthone exhibits anti-proliferative and anti-invasive activities in hepatocellular carcinoma by inducing pyroptosis: preliminary results. Eur Rev Med Pharmacol Sci. 2018;22(23):8186–8196. Epub 2018/ 12/18. PubMed PMID: 30556857.
  • Pizato N, Luzete BC, Kiffer L, et al. Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells. Sci Rep. 2018;8(1):1952. PubMed PMID: 29386662; PubMed Central PMCID: PMCPMC5792438. Epub 2018/ 02/02.
  • Kolb R, Kluz P, Tan ZW, et al. Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4. Oncogene. 2019;38(13):2351–2363. PubMed PMID: 30518876; PubMed Central PMCID: PMCPMC6440811. Epub 2018/ 12/07.
  • Gao J, Qiu X, Xi G, et al. Downregulation of GSDMD attenuates tumor proliferation via the intrinsic mitochondrial apoptotic pathway and inhibition of EGFR/Akt signaling and predicts a good prognosis in nonsmall cell lung cancer. Oncol Rep. 2018;40(4):1971–1984. PubMed PMID: 30106450; PubMed Central PMCID: PMCPMC6111570. Epub 2018/ 08/15.
  • Wang Y, Kong H, Zeng X, et al. Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells. Oncol Rep. 2016;35(4):2053–2064. PubMed PMID: 26782741. Epub 2016/ 01/20.
  • Lin TY, Tsai MC, Tu W, et al. Role of the NLRP3 Inflammasome: insights Into Cancer Hallmarks. Front Immunol. 2020;11:610492. Epub 2021/ 02/23. PubMed PMID: 33613533; PubMed Central PMCID: PMCPMC7886802.
  • Moossavi M, Parsamanesh N, Bahrami A, et al. Role of the NLRP3 inflammasome in cancer. Mol Cancer. 2018;17(1):158. Epub 2018/ 11/19. PubMed PMID: 30447690; PubMed Central PMCID: PMCPMC6240225.
  • Teng JF, Mei QB, Zhou XG, et al. Polyphyllin VI induces caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer. Cancers (Basel). 2020;12(1):193. PubMed PMID: 31941010; PubMed Central PMCID: PMCPMC7017302. Epub 2020/ 01/17.
  • Zhang Z, Zhang Y, Xia S, et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature. 2020;579(7799):415–420. PubMed PMID: 32188940; PubMed Central PMCID: PMCPMC7123794. Epub 2020/ 03/20.
  • Dupaul-Chicoine J, Yeretssian G, Doiron K, et al. Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity. 2010;32(3):367–378. PubMed PMID: 20226691. Epub 2010/ 03/17.
  • Liu J, Yao L, Zhang M, et al. Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. Aging (Albany NY). 2019;11(18):7830–7846. Epub 2019/ 09/26. PubMed PMID: 31553952; PubMed Central PMCID: PMCPMC6781979.
  • Ren N, Jiang T, Wang C, et al. LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis. Aging (Albany NY). 2020;12(11):11025–11041. PubMed PMID: 32516127; PubMed Central PMCID: PMCPMC7346038. Epub 2020/ 06/10.
  • Karki R, Kanneganti TD. Diverging inflammasome signals in tumorigenesis and potential targeting. Nat Rev Cancer. 2019;19(4):197–214. Epub 2019/ 03/08. PubMed PMID: 30842595; PubMed Central PMCID: PMCPMC6953422.
  • Man SM, Kanneganti TD. Regulation of inflammasome activation. Immunol Rev. 2015;265(1):6–21. Epub 2015/ 04/17. PubMed PMID: 25879280; PubMed Central PMCID: PMCPMC4400844.
  • Wallach D, Kang TB, Dillon CP, et al. Programmed necrosis in inflammation: toward identification of the effector molecules. Science. 2016;352(6281):aaf2154. Epub 2016/ 04/02. PubMed PMID: 27034377.
  • Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47. PubMed PMID: 25605792; PubMed Central PMCID: PMCPMC4402510. Epub 2015/ 01/22.
  • Iasonos A, Schrag D, Raj GV, et al. How to build and interpret a nomogram for cancer prognosis. J Clin Oncol. 2008;26(8):1364–1370. Epub 2008/ 03/08. PubMed PMID: 18323559.
  • Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545–15550. PubMed PMID: 16199517; PubMed Central PMCID: PMCPMC1239896. Epub 2005/ 10/04.
  • Li T, Fan J, Wang B, et al. TIMER: a web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77(21):e108–e10. PubMed PMID: 29092952; PubMed Central PMCID: PMCPMC6042652. Epub 2017/ 11/03.
  • Mayakonda A, Lin DC, Assenov Y, et al. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018;28(11):1747–1756. Epub 2018/ 10/21. PubMed PMID: 30341162; PubMed Central PMCID: PMCPMC6211645.
  • Robinson DR, Wu YM, Lonigro RJ, et al. Integrative clinical genomics of metastatic cancer. Nature. 2017;548(7667):297–303. PubMed PMID: 28783718; PubMed Central PMCID: PMCPMC5995337. Epub 2017/ 08/08.
  • Geeleher P, Cox N, Huang RS. pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 2014;9(9):e107468. Epub 2014/ 09/18. PubMed PMID: 25229481; PubMed Central PMCID: PMCPMC4167990.
  • Samstein RM, Lee CH, Shoushtari AN, et al. Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nat Genet. 2019;51(2):202–206. PubMed PMID: 30643254; PubMed Central PMCID: PMCPMC6365097. Epub 2019/ 01/16.
  • Tan C, Liu W, Zheng ZH, et al. LncRNA HOTTIP inhibits cell pyroptosis by targeting miR-148a-3p/AKT2 axis in ovarian cancer. Cell Biol Int. 2021;45(7):1487–1497. Epub 2021/ 03/13. PubMed PMID: 33710684.
  • Chen Z, He M, Chen J, et al. Long non‑coding RNA SNHG7 inhibits NLRP3‑dependent pyroptosis by targeting the miR‑34a/SIRT1 axis in liver cancer. Oncol Lett. 2020;20(1):893–901. Epub 2020/ 06/23. PubMed PMID: 32566017; PubMed Central PMCID: PMCPMC7285900.
  • Yan H, Luo B, Wu X, et al. Cisplatin induces pyroptosis via activation of MEG3/NLRP3/caspase-1/GSDMD pathway in triple-negative breast cancer. Int J Biol Sci. 2021;17(10):2606–2621. PubMed PMID: 34326697; PubMed Central PMCID: PMCPMC8315016. Epub 2021/ 07/31.
  • Lin W, Chen Y, Wu B, et al. Identification of the pyroptosis‑related prognostic gene signature and the associated regulation axis in lung adenocarcinoma. Cell Death Discov. 2021;7(1):161. Epub 2021/ 07/07. PubMed PMID: 34226539; PubMed Central PMCID: PMCPMC8257680.
  • Liu R, Ju C, Zhang F, et al. LncRNA GSEC promotes the proliferation, migration and invasion by sponging miR-588/ EIF5A2 axis in osteosarcoma. Biochem Biophys Res Commun. 2020;532(2):300–307. PubMed PMID: 32868080. Epub 2020/ 09/02.
  • Matsumura K, Kawasaki Y, Miyamoto M, et al. The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration. Oncogene. 2017;36(9):1191–1199. PubMed PMID: 27797375. Epub 2016/ 11/01.
  • Xiao G, Wang P, Zheng X, et al. FAM83A-AS1 promotes lung adenocarcinoma cell migration and invasion by targeting miR-150-5p and modifying MMP14. Cell Cycle. 2019;18(21):2972–2985. Epub 2019/ 09/17. PubMed PMID: 31522616; PubMed Central PMCID: PMCPMC6791711.
  • Wang W, Zhao Z, Xu C, et al. LncRNA FAM83A-AS1 promotes lung adenocarcinoma progression by enhancing the pre-mRNA stability of FAM83A. Thorac Cancer. 2021. Epub 2021/ 03/10. PubMed PMID: 33687144. DOI:10.1111/1759-7714.13928
  • Jia J, Li H, Chu J, et al. LncRNA FAM83A-AS1 promotes ESCC progression by regulating miR-214/CDC25B axis. J Cancer. 2021;12(4):1200–1211. PubMed PMID: 33442418; PubMed Central PMCID: PMCPMC7797654. Epub 2021/ 01/15.
  • He J, Yu J. Long noncoding RNA FAM83A-AS1 facilitates hepatocellular carcinoma progression by binding with NOP58 to enhance the mRNA stability of FAM83A. Biosci Rep. 2019;39(11). Epub 2019/ 11/07. DOI:10.1042/BSR20192550 PubMed PMID: 31696213; PubMed Central PMCID: PMCPMC6851519.
  • You J, Fang W, Zhao Q, et al. Identification of a RNA-Seq based prognostic signature with seven immune-related lncRNAs for lung adenocarcinoma. Clin Lab. 2021;67(3). Epub 2021/ 03/20. DOI:10.7754/Clin.Lab.2020.200663 PubMed PMID: 33739047.
  • Wu L, Wen Z, Song Y, et al. A novel autophagy-related lncRNA survival model for lung adenocarcinoma. J Cell Mol Med. 2021;25(12):5681–5690. Epub 2021/ 05/15. PubMed PMID: 33987935; PubMed Central PMCID: PMCPMC8184679.
  • Guo Y, Qu Z, Li D, et al. Identification of a prognostic ferroptosis-related lncRNA signature in the tumor microenvironment of lung adenocarcinoma. Cell Death Discov. 2021;7(1):190. PubMed PMID: 34312372; PubMed Central PMCID: PMCPMC8313561. Epub 2021/ 07/28.
  • Jin D, Song Y, Chen Y, et al. Identification of a Seven-lncRNA immune risk signature and construction of a predictive nomogram for lung adenocarcinoma. Biomed Res Int. 2020;2020:7929132. Epub 2020/ 07/01. PubMed PMID: 32596372; PubMed Central PMCID: PMCPMC7273488.
  • Porporato PE, Filigheddu N, Pedro JMB, et al. Mitochondrial metabolism and cancer. Cell Res. 2018;28(3):265–280. Epub 2017/ 12/09. PubMed PMID: 29219147; PubMed Central PMCID: PMCPMC5835768.
  • Sobanski T, Rose M, Suraweera A, et al. Cell metabolism and DNA repair pathways: implications for cancer therapy. Front Cell Dev Biol. 2021;9:633305. Epub 2021/ 04/10. PubMed PMID: 33834022; PubMed Central PMCID: PMCPMC8021863.
  • Ashton TM, McKenna WG, Kunz-Schughart LA, et al. Oxidative Phosphorylation as an Emerging Target in Cancer Therapy. Clin Cancer Res. 2018;24(11):2482–2490. Epub 2018/ 02/09. PubMed PMID: 29420223.
  • Madan E, Parker TM, Pelham CJ, et al. HIF-transcribed p53 chaperones HIF-1α. Nucleic Acids Res. 2019;47(19):10212–10234. PubMed PMID: 31538203; PubMed Central PMCID: PMCPMC6821315. Epub 2019/ 09/21.
  • Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell. 2017;169(2):361–371. Epub 2017/ 04/08. PubMed PMID: 28388417.
  • Tan AC. Targeting the PI3K/Akt/mTOR pathway in non-small cell lung cancer (NSCLC). Thorac Cancer. 2020;11(3):511–518. Epub 2020/ 01/29. PubMed PMID: 31989769; PubMed Central PMCID: PMCPMC7049515.
  • Bremnes RM, Al-Shibli K, Donnem T, et al. The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer. J Thorac Oncol. 2011;6(4):824–833. PubMed PMID: 21173711. Epub 2010/ 12/22.
  • Remark R, Becker C, Gomez JE, et al. The Non–small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome. Am J Respir Crit Care Med. 2015;191(4):377–390. PubMed PMID: 25369536; PubMed Central PMCID: PMCPMC5447326. Epub 2014/ 11/05.