1,861
Views
14
CrossRef citations to date
0
Altmetric
Research Paper

Pinocembrin suppresses proliferation and enhances apoptosis in lung cancer cells in vitro by restraining autophagy

Pages 6035-6044 | Received 07 Jun 2021, Accepted 21 Aug 2021, Published online: 04 Sep 2021

References

  • Zhao Y, Feng C, Li Y, et al. H19 promotes lung cancer proliferation and metastasis by inhibiting miR-200a function. Mol Cell Biochem. 2019;460(1–2):1–8.
  • Spiro SG, Gould MK. Colice GL and American college of chest p. initial evaluation of the patient with lung cancer: symptoms, signs, laboratory tests, and paraneoplastic syndromes: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest. 2007;132(3 suppl): 149S–160S.
  • Didkowska J, Wojciechowska U, Mańczuk M. Manczuk M and Lobaszewski J. Lung cancer epidemiology: contemporary and future challenges worldwide. Ann Transl Med. 2016;4(8):150.
  • Diaz Napal GN, Carpinella MC, Palacios SM. Antifeedant activity of ethanolic extract from flourensia oolepis and isolation of pinocembrin as its active principle compound. Bioresour Technol. 2009;100(14):3669–3673.
  • Jaganathan SK, Mandal M. Antiproliferative effects of honey and of its polyphenols: a review. J Biomed Biotechnol. 2009;2009:830616.
  • Jiang H, Morgan JA. Optimization of an in vivo plant P450 monooxygenase system in saccharomyces cerevisiae. Biotechnol Bioeng. 2004;85(2):130–137.
  • Tao J, Shen C, Sun Y. Chen W and Yan G. Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy. Biomed Pharmacother. 2018;106:1003–1010.
  • Lan X, Wang W, Li Q, et al. The natural flavonoid pinocembrin: molecular targets and potential therapeutic applications. Mol Neurobiol. 2016;53(3):1794–1801.
  • Hanieh H, Hairul Islam VI, Saravanan S, et al. Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro. Eur J Pharmacol. 2017;814:178–186.
  • Gao J, Lin S, Gao Y, et al. Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor. Biomed Pharmacother. 2019;120:109505.
  • Zheng Y, Wang K, Wu Y, et al. Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells. Cancer Lett. 2018;431:31–42.
  • Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal. 2014;20(3):460–473.
  • Onorati AV, Dyczynski M, Ojha R. and Amaravadi RK. Targeting autophagy in cancer. Cancer. 2018;124(16):3307–3318.
  • Chen M, Hong MJ, Sun H, et al. Essential role for autophagy in the maintenance of immunological memory against influenza infection. Nat Med. 2014;20(5):503–510.
  • Sarparanta J, Garcia-Macia M, Autophagy SR. Mitochondria in obesity and type 2 diabetes. Curr Diabetes Rev. 2017;13(4):352–369.
  • Sforcin JM, Bankova V. Propolis: is there a potential for the development of new drugs? J Ethnopharmacol. 2011;133(2):253–260.
  • Geng N, Shi BJ, Li SL, et al. Knockdown of ferroportin accelerates erastin-induced ferroptosis in neuroblastoma cells. Eur Rev Med Pharmacol Sci. 2018;22:3826–3836.
  • Denton D, Kumar S. Autophagy-dependent cell death. Cell Death Differ. 2019;26(4):605–616.
  • Santana-Codina N, Mancias JD, Kimmelman AC. The role of autophagy in cancer. Annu Rev Cancer Biol. 2017;1(1):19–39.
  • Cao J, Wu L, Lei X. Shi K and Shi L. A signature of 13 autophagy‑related gene pairs predicts prognosis in hepatocellular carcinoma. Bioengineered. 2021;12(1):697–707.
  • Li C, Liu S, Zheng J. and Xue Y. Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway. Bioengineered. 2021;12(1):3516–3524.
  • Liu B, Yan X, Hou Z. Zhang L and Zhang D. Impact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path. Bioengineered. 2021;12(1):2723–2733.
  • Liu K, Xue B, Bai G. and Zhang W. Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest. Bioengineered. 2021;12(1):1517–1529.
  • Mizushima N. Autophagy: process and function. Genes Dev. 2007;21(22):2861–2873.
  • Tanida I. Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal. 2011;14(11):2201–2214.
  • White E, Karp C, Strohecker AM. Guo Y and Mathew R. Role of autophagy in suppression of inflammation and cancer. Curr Opin Cell Biol. 2010;22(2):212–217.
  • Mantovani A, Allavena P, Sica A. and Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–444.
  • Strohecker AM, White E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF -Driven cancers. Cancer Discov. 2014;4(7):766–772.
  • Wang XY, Gong LJ, Huang JM. Pinocembrin alleviates glucocorticoid-induced apoptosis by activating autophagy via suppressing the PI3K/Akt/mTOR pathway in osteocytes. Eur J Pharmacol. 2020;880:173212.
  • Kim KY, Park KI, Kim SH, et al. Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells. Int J Mol Sci. 2017;18(5):1088.