Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis

References

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2020. CA Cancer J Clin. 2020;70(1):7–30.
   PubMed Web of Science ®Google Scholar
• Bill-Axelson A, Holmberg L, Filen F, et al. Radical prostatectomy versus watchful waiting in localized prostate cancer: the Scandinavian prostate cancer group-4 randomized trial. J Natl Cancer Inst. 2008;100(16):1144–1154.
   PubMedGoogle Scholar
• Janet L, Stanford PZF,P, Ann S, et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the prostate cancer outcomes study. JAMA. 2000;283(3):354–360.
   PubMed Web of Science ®Google Scholar
• Avila M, Patel L, Lopez S, et al. Patient-reported outcomes after treatment for clinically localized prostate cancer: a systematic review and meta-analysis. Cancer Treat Rev. 2018;66:23–44.
   PubMed Web of Science ®Google Scholar
• Shamloul R, Ghanem H. Erectile dysfunction. Lancet. 2013;381(9861):153–165.
   PubMed Web of Science ®Google Scholar
• Montorsi F, Brock G, Lee J, et al. Effect of nightly versus on-demand vardenafil on recovery of erectile function in men following bilateral nerve-sparing radical prostatectomy. Eur Urol. 2008;54(4):924–931.
   PubMed Web of Science ®Google Scholar
• Montorsi F, Brock G, Stolzenburg JU, et al. Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT). Eur Urol. 2014;65(3):587–596.
   PubMed Web of Science ®Google Scholar
• Kristensen LS, Andersen MS, Stagsted LVW, et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675–691.
   PubMed Web of Science ®Google Scholar
• Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384–388.
   PubMed Web of Science ®Google Scholar
• Memczak S, Jens M, Elefsinioti A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333–338.
   PubMed Web of Science ®Google Scholar
• Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56(1):55–66.
   PubMed Web of Science ®Google Scholar
• Sun Z, Zhang A, Hou M, et al. Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p. Bioengineered. 2020;11(1):949–957.
   PubMed Web of Science ®Google Scholar
• Zhou R, Miao S, Xu J, et al. Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate Bone Morphogenetic Protein BMP2. Bioengineered. 2021;12(1):3824–3836.
   PubMed Web of Science ®Google Scholar
• Zhu K, Hu X, Chen H, et al. Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI. EBioMedicine. 2019;49:341–353.
   PubMed Web of Science ®Google Scholar
• Jiang P, Aimaier M, Maimaitiyiming M, et al. Changes of microRNA profile after Yimusake treatment in ED rat model. Acta Biochim Biophys Sin (Shanghai). 2019;51(8):873–875.
   PubMed Web of Science ®Google Scholar
• Huo W, Li Y, Zhang Y, et al. Mesenchymal stem cells-derived exosomal microRNA-21-5p downregulates PDCD4 and ameliorates erectile dysfunction in a rat model of diabetes mellitus. The FASEB Journal. 2020;34(10):13345–13360.
   PubMed Web of Science ®Google Scholar
• Chen S, Sun X, Wu S, et al. Role of identified noncoding RNA in erectile dysfunction. Andrologia. 2020;52(7):e13596.
   PubMed Web of Science ®Google Scholar
• Chen S, Huang X, Kong X, et al. Hypoxia-induced phenotypic transformation of corpus cavernosum smooth muscle cells after cavernous nerve crush injury by down-regulating P38 mitogen-activated protein kinase expression. Sex Med. 2019;7(4):433–440.
   PubMed Web of Science ®Google Scholar
• Jamil Rehman GC, Melman A, Fleischmann J. Intracavernous pressure responses to physical and electrical stimulation of the cavernous nerve in rats. Urology. 1998;51:640–644.
   PubMed Web of Science ®Google Scholar
• Ravi RK, Walton K, Khosroheidari M. MiSeq: a next generation sequencing platform for genomic analysis. Methods Mol Biol. 2018;1706:223–232.
   PubMedGoogle Scholar
• Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139–140.
   PubMed Web of Science ®Google Scholar
• Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004;116(2):281–297.
   PubMed Web of Science ®Google Scholar
• Wu W, Ji P, Zhao F. CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes. Genome Biol. 2020;21(1):101.
   PubMed Web of Science ®Google Scholar
• Fode M, Jensen CFS, Ostergren PB. Sildenafil in postprostatectomy erectile dysfunction (perspective). Int J Impot Res. 2019;31(2):433–434.
   Web of Science ®Google Scholar
• Hassanin AM, Abdel-Hamid AZ. Cavernous smooth muscles: innovative potential therapies are promising for an unrevealed clinical diagnosis. Int Urol Nephrol. 2020;52(2):205–217.
   PubMed Web of Science ®Google Scholar
• Gu X, Thakker PU, Matz EL, et al. Dynamic changes in erectile function and histological architecture after intracorporal injection of human placental stem cells in a pelvic neurovascular injury rat model. J Sex Med. 2020;17(3):400–411.
   PubMed Web of Science ®Google Scholar
• Ying CC, Yang M, Wang Y, et al. Neural-like cells from adipose-derived stem cells for cavernous nerve injury in rats. Neural Regen Res. 2019;14(6):1085–1090.
   PubMed Web of Science ®Google Scholar
• Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Mol Cell. 2017;66(1):22–37 e9.
   PubMed Web of Science ®Google Scholar
• Zhang S-B, Lin S-Y, Liu M, Zhang SB, Lin SY, Liu M, Liu CC, Ding HH, Sun Y, et al. CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain. Nat Commun. 2019;10(1):4119.
   PubMedGoogle Scholar
• Hu ZQ, Zhou SL, Li J, et al. Circular RNA sequencing identifies CircASAP1 as a key regulator in hepatocellular carcinoma metastasis. Hepatology. 2020;72(3):906–922.
   PubMed Web of Science ®Google Scholar
• Wang K, Long B, Liu F, et al. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. Eur Heart J. 2016;37(33):2602–2611.
   PubMed Web of Science ®Google Scholar
• Tao SC, Huang JY, Gao Y, et al. Small extracellular vesicles in combination with sleep-related circRNA3503: a targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis. Bioact Mater. 2021;6(12):4455–4469.
   PubMed Web of Science ®Google Scholar
• Zhao Y, Chen M, Lian D, et al. Non-Coding RNA Regulates the myogenesis of skeletal muscle satellite cells, injury repair and diseases. Cells. 2019 Aug 27;8(9):988.
   Google Scholar
• Zhang X, Zhao F, Zhao JF, et al. PDGF-mediated PI3K/AKT/β-catenin signaling regulates gap junctions in corpus cavernosum smooth muscle cells. Exp Cell Res. 2018;362(2):252–259.
   PubMed Web of Science ®Google Scholar
• Singh L, Arora SK, Bakshi DK, et al. Potential role of CXCL10 in the induction of cell injury and mitochondrial dysfunction. Int J Exp Pathol. 2010;91(3):210–223.
   PubMed Web of Science ®Google Scholar
• Liu CH, Jing XN, Liu XL, et al. Tumor-suppressor miRNA-27b-5p regulates the growth and metastatic behaviors of ovarian carcinoma cells by targeting CXCL1. J Ovarian Res. 2020;13(1):92.
   PubMed Web of Science ®Google Scholar
• Shen L, Chen L, Zhang S, et al. MicroRNA-27b regulates mitochondria biogenesis in myocytes. PLoS One. 2016;11(2):e0148532.
   PubMed Web of Science ®Google Scholar
• Zhang P, Chen X, Fan M. Signaling mechanisms involved in disuse muscle atrophy. Med Hypotheses. 2007;69(2):310–321.
   PubMed Web of Science ®Google Scholar
• JDL RJ, Chanon S, Euthine V, et al. Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling. Cell Commun Signal. 2013 Aug 2;11:55.
   Google Scholar