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Research Paper

Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38

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Pages 6529-6537 | Received 09 Jul 2021, Accepted 24 Aug 2021, Published online: 14 Sep 2021

References

  • Liu Z, Ma M, Yan L, et al. miR-370 regulates ISG15 expression and influences IFN-α sensitivity in hepatocellular carcinoma cells. Cancer Biomark. 2018;22(3):453–466.
  • Foo JN, Tan LC, Irwan ID, et al. Genome-wide association study of Parkinson’s disease in East Asians. Hum Mol Genet. 2017;26(1):226–232.
  • Johnston AM, Naselli G, Gonez LJ, et al. SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene. 2000;19(37):4290–4297.
  • Bazot Q, Paschos K, Allday MJ. Epstein-Barr Virus (EBV). Latent Protein EBNA3A Directly Targets and Silences the STK39 Gene in B Cells Infected by EBV. J Virol. 2018;92(7). 10.1128/jvi.01918-17
  • Huang T, Zhou Y, Cao Y, et al. STK39, overexpressed in osteosarcoma, regulates osteosarcoma cell invasion and proliferation. Oncol Lett. 2017;14(4):4599–4604.
  • Li C, Wang A, Chen Y, et al. MicroRNA‑299‑5p inhibits cell metastasis in breast cancer by directly targeting serine/threonine kinase 39. Oncol Rep. 2020;43(4):1221–1233.
  • Ni FD, Hao SL, Yang WX. Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis. Cell Death Dis. 2019;10(8):541.
  • Cuadrado A, Nebreda AR. Mechanisms and functions of p38 MAPK signalling. Biochem J. 2010;429(3):403–417.
  • Wu Z, He D, Zhao S, et al. IL-17A/IL-17RA promotes invasion and activates MMP-2 and MMP-9 expression via p38 MAPK signaling pathway in non-small cell lung cancer. Mol Cell Biochem. 2019;4551: 195–206
  • Kim YW, Jang EJ, Kim CH, et al. Sauchinone exerts anticancer effects by targeting AMPK signaling in hepatocellular carcinoma cells. Chem Biol Interact. 2017;261:108–117.
  • He H, Qiao K, Wang C, et al. Hydrazinocurcumin induces apoptosis of hepatocellular carcinoma cells through the p38 MAPK pathway. Clin Transl Sci. 2020. DOI:10.1111/cts.12765.
  • Zhao Q, Zhu Y, Liu L, et al. STK39 blockage by RNA interference inhibits the proliferation and induces the apoptosis of renal cell carcinoma. Onco Targets Ther. 2018;11:1511–1519.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34.
  • Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108.
  • Zhang S, Yue M, Shu R, et al. Recent advances in the management of hepatocellular carcinoma. J BUON. 2016;21(2):307–311.
  • Budhu A, Jia HL, Forgues M, et al. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology. 2008;47(3):897–907.
  • Choi WT, Kakar S. Immunohistochemistry in the diagnosis of Hepatocellular Carcinoma. Gastroenterol Clin North Am. 2017;46(2):311–325.
  • Guo Y, Pan Q, Zhang J, et al. Functional and clinical evidence that TAZ is a candidate oncogene in hepatocellular carcinoma. J Cell Biochem. 2015;116(11):2465–2475.
  • Sui J, Yang X, Qi W, et al. Long Non-Coding RNA Linc-USP16 functions as a tumour suppressor in hepatocellular carcinoma by regulating PTEN expression. Cell Physiol Biochem. 2017;44(3):1188–1198.
  • Richardson C, Sakamoto K, de los Heros P, et al. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 2011;124(5):789–800.
  • Chiu MH, Liu HS, Wu YH, et al. SPAK mediates KCC3-enhanced cervical cancer tumorigenesis. Febs J. 2014;281(10):2353–2365.
  • Li Z, Zhu W, Xiong L, et al. Role of high expression levels of STK39 in the growth, migration and invasion of non-small cell type lung cancer cells. Oncotarget. 2016;7(38):61366–61377.
  • Yang H, Mao W, Rodriguez-Aguayo C, et al. Paclitaxel sensitivity of ovarian cancer can be enhanced by knocking down pairs of kinases that regulate MAP4 phosphorylation and microtubule stability. Clin Cancer Res. 2018;24(20):5072–5084.
  • Wang J, Fan Z, Li J, et al. Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial-mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-beta1 /Smad2/3 pathway. Bioengineered. 2021;12(1):3566–3577.
  • Ono K, Han J. The p38 signal transduction pathway: activation and function. Cell Signal. 2000;12(1):1–13.
  • Yu L. TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses. Embo J. 2002;21(14):3749–3759.
  • Zheng HY, Shen FJ, Tong YQ, et al. PP2A inhibits cervical cancer cell migration by dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK signaling pathway. Curr Med Sci. 2018;38(1):115–123.
  • Zhu M, Huang C, Ma X, et al. Phthalates promote prostate cancer cell proliferation through activation of ERK5 and p38. Environ Toxicol Pharmacol. 2018;63:29–33.