Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway

References

• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 May;71(3):209-249.
   PubMed Web of Science ®Google Scholar
• Wang H, Lu Z, Zhao X. Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer. J Hematol Oncol. 2019;12:133.
   PubMed Web of Science ®Google Scholar
• Chen X, Sun X, Li X, et al. LncRNA-HEIH is a novel diagnostic and predictive biomarker in gastric cancer. Genet Test Mol Biomarkers. 2021;25:284–292.
   PubMed Web of Science ®Google Scholar
• Chen R, Zhang C, Cheng Y, et al. LncRNA UCC promotes epithelial-mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer. Lab Invest. 2021;101:1153–1165.
   Web of Science ®Google Scholar
• Chen L, Qian X, Wang Z, et al. The HOTAIR lncRNA: a remarkable oncogenic promoter in human cancer metastasis. Oncol Lett. 2021;21:302.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Yan H, Jiang Y, et al. Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2. Exp Biol Med (Maywood). 2021;246:371–379.
   PubMed Web of Science ®Google Scholar
• Yan B, Ren Z, Sun J, et al. IGF2-AS knockdown inhibits glycolysis and accelerates apoptosis of gastric cancer cells through targeting miR-195/CREB1 axis. Biomed Pharmacother. 2020;130:110600.
   PubMed Web of Science ®Google Scholar
• Liu B, Liu Y, Zhou M, et al. Comprehensive ceRNA network analysis and experimental studies identify an IGF2-AS/miR-150/IGF2 regulatory axis in colorectal cancer. Pathol Res Pract. 2020;216:153104.
   PubMed Web of Science ®Google Scholar
• Salmena L, Poliseno L, Tay Y, et al. A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? Cell. 2011;146:353–358.
   PubMed Web of Science ®Google Scholar
• Tay Y, Rinn J, Pandolfi PP. The multilayered complexity of ceRNA crosstalk and competition. Nature. 2014;505:344–352.
   PubMed Web of Science ®Google Scholar
• Zheng S, Guo Y, Dai L, et al. Long intergenic noncoding RNA01134 accelerates hepatocellular carcinoma progression by sponging microRNA-4784 and downregulating structure specific recognition protein 1. Bioengineered. 2020;11:1016–1026.
   PubMed Web of Science ®Google Scholar
• Hu S, Chang J, Ruan H, et al. Cantharidin inhibits osteosarcoma proliferation and metastasis by directly targeting miR-214-3p/DKK3 axis to inactivate beta-catenin nuclear translocation and LEF1 translation. Int J Biol Sci. 2021;17:2504–2522.
   PubMed Web of Science ®Google Scholar
• Gao C, Wen Y, Jiang F, et al. Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA −140-3p. Bioengineered. 2021;12:1890–1901.
   PubMed Web of Science ®Google Scholar
• Zhu Y, Ke KB, Xia ZK, et al. Discovery of vanoxerine dihydrochloride as a CDK2/4/6 triple-inhibitor for the treatment of human hepatocellular carcinoma. Mol Med. 2021;27:15.
   PubMed Web of Science ®Google Scholar
• Xia Y, Tang G, Chen Y, et al. Tumor-targeted delivery of siRNA to silence Sox2 gene expression enhances therapeutic response in hepatocellular carcinoma. Bioact Mater. 2021;6:1330–1340.
   PubMed Web of Science ®Google Scholar
• Cao C, Zhang T, Zhang D, et al. The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma. Oncogene. 2017;36:1112–1122.
   PubMed Web of Science ®Google Scholar
• Qu L, Ding J, Chen C, et al. Exosome-transmitted lncARSR promotes sunitinib resistance in renal cancer by acting as a competing endogenous RNA. Cancer Cell. 2016;29:653–668.
   PubMed Web of Science ®Google Scholar
• Yuan R, Wang K, Hu J, et al. Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying beta-catenin degradation. Cancer Res. 2014;74:5287–5300.
   PubMed Web of Science ®Google Scholar
• Ernst C, Bureau A, Turecki G. Application of microarray outlier detection methodology to psychiatric research. BMC Psychiatry. 2008;8:29.
   PubMed Web of Science ®Google Scholar
• Liang L, Chen V, Zhu K, et al. Integrating data and knowledge to identify functional modules of genes: a multilayer approach. BMC Bioinformatics. 2019;20:225.
   PubMed Web of Science ®Google Scholar
• Sebastiani P, Timofeev N, Dworkis DA, et al. Genome-wide association studies and the genetic dissection of complex traits. Am J Hematol. 2009;84:504–515.
   PubMed Web of Science ®Google Scholar
• Huang J, Chen YX, Zhang B. IGF2-AS affects the prognosis and metastasis of gastric adenocarcinoma via acting as a ceRNA of miR-503 to regulate SHOX2. Gastric Cancer. 2020;23:23–38.
   PubMed Web of Science ®Google Scholar
• Shin Low S, Pan Y, Ji D, et al. Smartphone-based portable electrochemical biosensing system for detection of circulating microRNA-21 in saliva as a proof-of-concept. Sens Actuators B Chem. 2020;308:127718.
   Web of Science ®Google Scholar
• Zhao J, Li H, Zhao S, et al. Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling. Mol Cancer. 2021;20:46.
   PubMed Web of Science ®Google Scholar
• Cesana M, Cacchiarelli D, Legnini I, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 2011;147:358–369.
   PubMed Web of Science ®Google Scholar
• Liang Y, Song X, Li Y, et al. LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis. Mol Cancer. 2020;19:85.
   PubMed Web of Science ®Google Scholar
• Lalevee S, Feil R. Long noncoding RNAs in human disease: emerging mechanisms and therapeutic strategies. Epigenomics. 2015;7:877–879.
   PubMed Web of Science ®Google Scholar
• Su JL, Chen PB, Chen YH, et al. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Res. 2010;70:5096–5108.
   PubMed Web of Science ®Google Scholar
• Geng W, Song H, Zhao Q, et al. miR-520h stimulates drug resistance to paclitaxel by targeting the OTUD3-PTEN axis in breast cancer. Biomed Res Int. 2020;2020:9512793.
   PubMed Web of Science ®Google Scholar
• Yuan X, Ma R, Yang S, et al. miR-520g and miR-520h overcome bortezomib resistance in multiple myeloma via suppressing APE1. Cell Cycle. 2019;18:1660–1669.
   PubMed Web of Science ®Google Scholar
• Sun P, Zhang K, Hassan SH, et al. Endothelium-Targeted Deletion of microRNA-15a/16-1 promotes poststroke angiogenesis and improves long-term neurological recovery. Circ Res. 2020;126:1040–1057.
   PubMed Web of Science ®Google Scholar
• Xue X, Wang X, Zhao Y, et al. Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A. Biochem Biophys Res Commun. 2018;502:515–521.
   PubMed Web of Science ®Google Scholar
• He C, Chen H, Liu Y, et al. miR-106b-5p promotes cell proliferation and cell cycle progression by directly targeting CDKN1A in osteosarcoma. Exp Ther Med. 2020;19:3203–3210.
   PubMed Web of Science ®Google Scholar
• Xia X, Lu H, Li C, et al. miR-106b regulates the proliferation and differentiation of neural stem/progenitor cells through Tp53inp1-Tp53-Cdkn1a axis. Stem Cell Res Ther. 2019;10:282.
   PubMed Web of Science ®Google Scholar
• Wang J, Song C, Cao X, et al. MiR-208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A. J Cell Physiol. 2019;234:3720–3729.
   PubMed Web of Science ®Google Scholar