Low expression of TCP1 (T-Complex 1) and PSMC1 (Proteasome 26S subunit, ATPase 1) in heterotopic ossification during ankylosing spondylitis

References

• Torossian F, Guerton B, Anginot A, et al. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017;2(21). DOI:10.1172/jci.insight.96034
   PubMed Web of Science ®Google Scholar
• Qian BP, Ji ML, Qiu Y, et al. Identification of serum miR-146a and miR-155 as novel noninvasive complementary biomarkers for ankylosing spondylitis. Spine (Phila Pa 1976). 2016;41(9):735–742.
   PubMed Web of Science ®Google Scholar
• Yu T, Zhang J, Zhu W, et al. Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification. Bone Res. 2021;9(1):19.
   PubMed Web of Science ®Google Scholar
• Jacques P, Lambrecht S, Verheugen E, et al. Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells. Ann Rheum Dis. 2014;73(2):437–445.
   PubMed Web of Science ®Google Scholar
• Lories RJ, Luyten FP, de Vlam K. Progress in spondylarthritis. Mechanisms of new bone formation in spondyloarthritis. Arthritis Res Ther. 2009;11(2):221.
   PubMed Web of Science ®Google Scholar
• Baraliakos X, Heldmann F, Callhoff J, et al. Which spinal lesions are associated with new bone formation in patients with ankylosing spondylitis treated with anti-TNF agents? A long-term observational study using MRI and conventional radiography. Ann Rheum Dis. 2014;73(10):1819–1825.
   PubMed Web of Science ®Google Scholar
• Xie Z, Wang P, Li Y, et al. Imbalance between bone morphogenetic protein 2 and noggin induces abnormal osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis. Arthritis Rheumatol. 2016;68:430–440.
   PubMed Web of Science ®Google Scholar
• Li X, Wang J, Zhan Z, et al. Inflammation intensity-dependent expression of osteoinductive Wnt proteins is critical for ectopic new bone formation in ankylosing spondylitis. Arthritis Rheumatol. 2018;70(7):1056–1070.
   PubMed Web of Science ®Google Scholar
• Gracey E, Yao Y, Green B, et al. Sexual dimorphism in the Th17 signature of ankylosing spondylitis. Arthritis Rheumatol. 2016;68(3):679–689.
   PubMed Web of Science ®Google Scholar
• Torossian F, Guerton B, Anginot A, et al. Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight. 2017;2(21). DOI:10.1172/jci.insight.96034
   PubMed Web of Science ®Google Scholar
• Ritchie ME, Phipson B, Wu D, et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7):e47.
   PubMed Web of Science ®Google Scholar
• Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008;9(1):559.
   PubMed Web of Science ®Google Scholar
• Yu G, Wang LG, Han Y, et al. clusterProfiler: an R package for comparing biological themes among gene clusters. Omics. 2012;16(5):284–287.
   PubMed Web of Science ®Google Scholar
• Van Der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27(4):361–368.
   PubMed Web of Science ®Google Scholar
• Osyczka AM, Nöth U, Danielson KG, et al. Different osteochondral potential of clonal cell lines derived from adult human trabecular bone. Ann N Y Acad Sci. 2002;961(1):73–7.16.
   PubMedGoogle Scholar
• Qian BP, Qiu Y, Wang B, et al. Pedicle subtraction osteotomy through pseudarthrosis to correct thoracolumbar kyphotic deformity in advanced ankylosing spondylitis. Eur Spine J. 2012;21(4):711–718.
   PubMed Web of Science ®Google Scholar
• Woo JH, Lee HJ, Sung IH, et al. Changes of clinical response and bone biochemical markers in patients with ankylosing spondylitis taking etanercept. J Rheumatol. 2007;34:1753–1759.
   PubMed Web of Science ®Google Scholar
• van der Heijde D, Landewé R, Einstein S, et al. Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum. 2008;58(5):1324–1331.
   PubMed Web of Science ®Google Scholar
• Wright C, Edelmann M, diGleria K, et al. Ankylosing spondylitis monocytes show upregulation of proteins involved in inflammation and the ubiquitin proteasome pathway. Ann Rheum Dis. 2009;68(10):1626–1632.
   PubMed Web of Science ®Google Scholar
• Ahmed AS, Li J, Ahmed M, et al. Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132. Arthritis Rheum. 2010;62:2160–2169.
   PubMedGoogle Scholar
• Seavey MM, Lu LD, Stump KL, et al. Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE. Int Immunopharmacol. 2012;12(1):257–270.
   PubMed Web of Science ®Google Scholar
• Van Dam LS, Osmani Z, Kamerling SWA, et al. A reverse translational study on the effect of rituximab, rituximab plus belimumab, or bortezomib on the humoral autoimmune response in SLE. Rheumatol (Oxford). 2020;59(10):2734–2745.
   PubMed Web of Science ®Google Scholar
• Ma M, Yang W, Cai Z, et al. SMAD-specific E3 ubiquitin ligase 2 promotes angiogenesis by facilitating PTX3 degradation in MSCs from patients with ankylosing spondylitis. Stem Cells. 2021;39:581–599.
   PubMed Web of Science ®Google Scholar
• Macsai CE, Foster BK, Xian CJ. Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair. J Cell Physiol. 2008;215(3):578–587.
   PubMed Web of Science ®Google Scholar
• Yang Y, Topol L, Lee H, et al. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development. 2003;130(5):1003–1015.
   PubMed Web of Science ®Google Scholar
• Tang N, Cai X, Peng L, et al. TCP1 regulates Wnt7b/beta-catenin pathway through P53 to influence the proliferation and migration of hepatocellular carcinoma cells. Signal Transduct Target Ther. 2020;5(1):169.
   PubMed Web of Science ®Google Scholar
• Qian T, Cui L, Liu Y, et al. High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma. Pharmacogenomics J. 2020;20(4):563–573.
   PubMed Web of Science ®Google Scholar
• Qu H, Zhu F, Dong H, et al. Upregulation of CCT-3 induces breast cancer cell proliferation through miR-223 competition and Wnt/beta-catenin signaling pathway activation. Front Oncol. 2020;10:533176.
   PubMed Web of Science ®Google Scholar
• Gómez-Garre P, Jesús S, Carrillo F, et al. PSMC1 gene in Parkinsons disease. Eur Neurol. 2012;68(4):193–198.
   PubMed Web of Science ®Google Scholar
• Shi CX, Kortum KM, Zhu YX, et al. CRISPR genome-wide screening identifies dependence on the proteasome subunit PSMC6 for bortezomib sensitivity in multiple myeloma. Mol Cancer Ther. 2017;16(12):2862–2870.
   PubMed Web of Science ®Google Scholar
• Zhang JY, Shi KZ, Liao XY, et al. The silence of PSMC6 inhibits cell growth and metastasis in lung adenocarcinoma. BioMed Res Int. 2021;2021:9922185.
   PubMed Web of Science ®Google Scholar
• Amano M, Nakayama M, Kaibuchi K. Rho-kinase/ROCK: a key regulator of the cytoskeleton and cell polarity. Cytoskeleton (Hoboken). 2010;67(9):545–554.
   PubMed Web of Science ®Google Scholar
• Liu Y, Dou Y, Yan L, et al. The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study. Biosci Rep. 2020;40(7). DOI:10.1042/BSR20200407
   Google Scholar
• Hu X, Ji X, Yang M, et al. Cdc42 is essential for both articular cartilage degeneration and subchondral bone deterioration in experimental osteoarthritis. J Bone Miner Res. 2018;33(5):945–958.
   PubMed Web of Science ®Google Scholar
• Cao J, Zhang C, Jiang GQ, et al. Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses. Bioengineered. 2021;12(1):296–309.
   PubMed Web of Science ®Google Scholar
• Park SJ, Lee JY, Lee SH, et al. SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity. Biochem Biophys Res Commun. 2019;514(3):868–874.
   PubMed Web of Science ®Google Scholar
• Han B, Zhao JY, Wang WT, et al. Cdc42 promotes Schwann cell proliferation and migration through Wnt/beta-catenin and p38 MAPK signaling pathway after sciatic nerve injury. Neurochem Res. 2017;42(5):1317–1324.
   PubMed Web of Science ®Google Scholar
• Bocelli-Tyndall C, Bracci L, Spagnoli G, et al. Bone marrow mesenchymal stromal cells (BM-MSCs) from healthy donors and auto-immune disease patients reduce the proliferation of autologous- and allogeneic-stimulated lymphocytes in vitro. Rheumatol (Oxford). 2007;46(3):403–408.
   PubMed Web of Science ®Google Scholar
• Sun LY, Zhang HY, Feng XB, et al. Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus. 2007;16(2):121–128.
   PubMed Web of Science ®Google Scholar
• Li F, Wu H, Zou G, et al. Circular RNA_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via regulation of microRNA-145/CBFB axis. Bioengineered. 2021;12(1):1952–1963.
   PubMed Web of Science ®Google Scholar
• Liu CH, Raj S, Chen CH, et al. HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis. J Clin Invest. 2019;129(12):5357–5373.
   PubMed Web of Science ®Google Scholar