Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage

References

• Chen S, Feng H, Sherchan P, et al. Controversies and evolving new mechanisms in subarachnoid hemorrhage. Prog Neurobiol. 2014;115:64–91.
   PubMed Web of Science ®Google Scholar
• Macdonald RL, Schweizer TA. Spontaneous subarachnoid haemorrhage. Lancet. 2017 Feb 11;389(10069):655–666.
   PubMed Web of Science ®Google Scholar
• Van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. Lancet. 2007 Jan 27;369(9558):306–318.
   PubMed Web of Science ®Google Scholar
• Yan Z, Zou Y, Deng Y, et al. Analysis of role of rat cerebral pericytes in cerebral vasospasm after subarachnoid hemorrhage and molecular mechanism of neurovascular injury. Bioengineered. 2021 Dec;12(1):3957–3967.
   PubMed Web of Science ®Google Scholar
• Aydin MD, Kanat A, Yolas C, et al. Spinal subarachnoid hemorrhage induced intractable miotic pupil. a reminder of ciliospinal sympathetic center Ischemia based miosis: an experimental study. Turk Neurosurg. 2019;29(3):434–439.
   PubMed Web of Science ®Google Scholar
• Al-Mufti F, Amuluru K, Changa A, et al. Traumatic brain injury and intracranial hemorrhage-induced cerebral vasospasm: a systematic review. Neurosurg Focus. 2017 Nov;43(5):E14.
   PubMed Web of Science ®Google Scholar
• Francoeur CL, Mayer SA. Management of delayed cerebral ischemia after subarachnoid hemorrhage. Crit Care. 2016 Oct 14;20(1):277.
   PubMedGoogle Scholar
• Geraghty JR, Testai FD. Delayed cerebral Ischemia after subarachnoid hemorrhage: beyond vasospasm and towards a multifactorial pathophysiology. Curr Atheroscler Rep. 2017 Oct 23;19(12):50.
   PubMed Web of Science ®Google Scholar
• Li K, Barras CD, Chandra RV, et al. A review of the management of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. World Neurosurg. 2019 Jun;126:513–527.
   PubMed Web of Science ®Google Scholar
• Al-Mufti F, Amuluru K, Smith B, et al. Emerging markers of early brain injury and delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage. World Neurosurg. 2017 Nov;107:148–159.
   PubMed Web of Science ®Google Scholar
• Rass V, Helbok R. Early brain injury after poor-grade subarachnoid hemorrhage. Curr Neurol Neurosci Rep. 2019 Aug 29;19(10):78.
   PubMed Web of Science ®Google Scholar
• Lu LQ, Tian J, Luo XJ, et al. Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury. Cell Mol Life Sci. 2021 Jan;78(1):63–78.
   Web of Science ®Google Scholar
• Hartman ML. Non-Apoptotic cell death signaling pathways in Melanoma. Int J Mol Sci. 2020 Apr 23;21(8):2980.
   Web of Science ®Google Scholar
• Zhou B, Liu J, Kang R, et al. Ferroptosis is a type of autophagy-dependent cell death. Semin Cancer Biol. 2020 Nov;66:89–100.
   PubMed Web of Science ®Google Scholar
• Proneth B, Conrad M. Ferroptosis and necroinflammation, a yet poorly explored link. Cell Death Differ. 2019 Jan;26(1):14–24.
   PubMed Web of Science ®Google Scholar
• Tang D, Kang R, Berghe TV, et al. The molecular machinery of regulated cell death. Cell Res. 2019 May;29(5):347–364.
   PubMed Web of Science ®Google Scholar
• Li Y, Liu Y, Wu P, et al. Inhibition of ferroptosis alleviates early brain injury after subarachnoid hemorrhage in vitro and in vivo via reduction of lipid peroxidation. Cell Mol Neurobiol. 2021 Mar;41(2):263–278.
   Web of Science ®Google Scholar
• Gao SQ, Liu JQ, Han YL, et al. Neuroprotective role of glutathione peroxidase 4 in experimental subarachnoid hemorrhage models. Life Sci. 2020 Sep 15;257:118050.
   PubMed Web of Science ®Google Scholar
• Tu XK, Yang WZ, Shi SS, et al. Neuroprotective effect of baicalin in a rat model of permanent focal cerebral ischemia. Neurochem Res. 2009 Sep;34(9):1626–1634.
   PubMed Web of Science ®Google Scholar
• Chang CP, Huang WT, Cheng BC, et al. The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke. Neuropharmacology. 2007 Mar;52(3):1024–1033.
   PubMed Web of Science ®Google Scholar
• Wan JY, Gong X, Zhang L, et al. Protective effect of baicalin against lipopolysaccharide/D-galactosamine-induced liver injury in mice by up-regulation of heme oxygenase-1. Eur J Pharmacol. 2008 Jun 10;587(1–3):302–308.
   PubMed Web of Science ®Google Scholar
• Tsai P-L, Tsai T-H. Pharmacokinetics of baicalin in rats and its interactions with cyclosporin A, quinidine and SKF-525A: a microdialysis study. Planta Med. 2004 Nov;70(11):1069–1074.
   PubMed Web of Science ®Google Scholar
• Srinivas NR. Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 2010 May;40(5):357–367.
   PubMed Web of Science ®Google Scholar
• Fang J, Zhu Y, Wang H, et al. Baicalin protects mice brain from apoptosis in traumatic brain injury model through activation of autophagy. Front Neurosci. 2018;12:1006.
   PubMed Web of Science ®Google Scholar
• Nam JE, Jo SY, Ahn CW, et al. Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu. Life Sci. 2020 Aug 1;254:117742.
   PubMed Web of Science ®Google Scholar
• Liu X, Wang S, Zhao G. Baicalin relieves lipopolysaccharide-evoked inflammatory injury through regulation of miR-21 in H9c2 cells. Phytother Res. 2020 May;34(5):1134–1141.
   PubMed Web of Science ®Google Scholar
• Huang X, Wu P, Huang F, et al. Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A(2A) receptor-induced SDF-1/CXCR4/PI3K/AKT signaling. J Biomed Sci. 2017 Aug 3;24(1):52.
   PubMedGoogle Scholar
• Shi X, Fu Y, Zhang S, et al. Baicalin attenuates subarachnoid hemorrhagic brain injury by modulating blood-brain barrier disruption, inflammation, and oxidative damage in mice. Oxid Med Cell Longev. 2017;2017:1401790.
   PubMed Web of Science ®Google Scholar
• Duan L, Zhang Y, Yang Y, et al. Baicalin inhibits ferroptosis in intracerebral hemorrhage. Front Pharmacol. 2021;12:629379.
   PubMed Web of Science ®Google Scholar
• Zhang HB, Tu XK, Song SW, et al. Baicalin reduces early brain injury after subarachnoid hemorrhage in rats. Chin J Integr Med. 2020 Jul;26(7):510–518.
   PubMed Web of Science ®Google Scholar
• Guo J, Xu B, Han Q, et al. Ferroptosis: a novel anti-tumor action for cisplatin. Cancer Res Treat. 2018 Apr;50(2):445–460.
   PubMed Web of Science ®Google Scholar
• Liang Z, Chi YJ, Lin GQ, et al. LncRNA MEG3 participates in neuronal cell injury induced by subarachnoid hemorrhage via inhibiting the Pi3k/Akt pathway. Eur Rev Med Pharmacol Sci. 2018 May;22(9):2824–2831.
   PubMed Web of Science ®Google Scholar
• Sugawara T, Ayer R, Jadhav V, et al. A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model. J Neurosci Methods. 2008 Jan 30;167(2):327–334.
   PubMed Web of Science ®Google Scholar
• Saini N, Akhtar A, Chauhan M, et al. Protective effect of Indole-3-carbinol, an NF-κB inhibitor in experimental paradigm of Parkinson’s disease: in silico and in vivo studies. Brain Behav Immun. 2020 Nov;90:108–137.
   PubMed Web of Science ®Google Scholar
• Xi G, Hua Y, Bhasin RR, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke. 2001 Dec 1;32(12):2932–2938.
   PubMed Web of Science ®Google Scholar
• Kenny EM, Fidan E, Yang Q, et al. Ferroptosis Contributes to neuronal death and functional outcome after traumatic brain injury. Crit Care Med. 2019 Mar;47(3):410–418.
   PubMed Web of Science ®Google Scholar
• Xie BS, Wang YQ, Lin Y, et al. Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice. CNS Neurosci Ther. 2019 Apr;25(4):465–475.
   PubMed Web of Science ®Google Scholar
• Li W, Li W, Leng Y, et al. Ferroptosis is involved in diabetes myocardial ischemia/reperfusion injury through endoplasmic reticulum stress. DNA Cell Biol. 2020 Feb;39(2):210–225.
   PubMed Web of Science ®Google Scholar
• Li Y, Feng D, Wang Z, et al. Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion. Cell Death Differ. 2019 Nov;26(11):2284–2299.
   PubMed Web of Science ®Google Scholar
• Su L, Jiang X, Yang C, et al. Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury. J Biol Chem. 2019 Dec 13;294(50):19395–19404.
   PubMed Web of Science ®Google Scholar
• Chen B, Chen Z, Liu M, et al. Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects. Brain Res Bull. 2019 Nov;153:122–132.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Wu Y, Yuan S, et al. Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage. Brain Res. 2018 Dec 15;1701:112–125.
   PubMed Web of Science ®Google Scholar
• Qu J, Zhao H, Li Q, et al. MST1 suppression reduces early brain injury by inhibiting the NF-κB/MMP-9 pathway after subarachnoid hemorrhage in mice. Behav Neurol. 2018;2018:6470957.
   PubMed Web of Science ®Google Scholar
• Zhou B, Liu J, Kang R, et al. Ferroptosis is a type of autophagy-dependent cell death. Semin Cancer Biol. 2020 Nov;66:89–100
   Web of Science ®Google Scholar
• Liang H, Yoo SE, Na R, et al. Short form glutathione peroxidase 4 is the essential isoform required for survival and somatic mitochondrial functions. J Biol Chem. 2009 Nov 6;284(45):30836–30844.
   PubMed Web of Science ®Google Scholar
• Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014 Jan 16;156(1–2):317–331.
   PubMed Web of Science ®Google Scholar