Sulforaphane ameliorates amyloid-β-induced inflammatory injury by suppressing the PARP1/SIRT1 pathway in retinal pigment epithelial cells

References

• Neely DC, Bray KJ, Huisingh CE, et al. Prevalence of undiagnosed age-related macular degeneration in primary eye care. JAMA Ophthalmology. 2017;135(6):570–575.
   PubMed Web of Science ®Google Scholar
• Yuan J. Role of inflammatory factors in the effects of aflibercept or ranibizumab treatment for alleviating wet age-associated macular degeneration. Exp Ther Med. 2019;17(5):4249–4258.
   PubMed Web of Science ®Google Scholar
• Weng X, Zhang H, Kan M, et al. Leukocyte telomere length is associated with advanced age-related macular degeneration in the Han Chinese population. Exp Gerontol. 2015;69:36–40.
   PubMed Web of Science ®Google Scholar
• Sharma R, Bose D, Maminishkis A, et al. Retinal pigment epithelium replacement therapy for age-related macular degeneration: are we there yet? Annu Rev Pharmacol Toxicol. 2020;60:553–572.
   PubMed Web of Science ®Google Scholar
• Simo R, Villarroel M, Corraliza L, et al. The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier–implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol. 2010;2010:190724.
   PubMedGoogle Scholar
• Holtkamp GM, Kijlstra A, Peek R, et al. Retinal pigment epithelium-immune system interactions: cytokine production and cytokine-induced changes. Prog Retin Eye Res. 2001;20:29–48.
   PubMed Web of Science ®Google Scholar
• Maltais M, De Souto Barreto P, Hooper C, et al. Association between brain beta-amyloid and frailty in older adults. J Gerontol A Biol Sci Med Sci. 2019;74(11):1747–1752.
   PubMed Web of Science ®Google Scholar
• Yoshida K, Moein A, Bittner T, et al. Pharmacokinetics and pharmacodynamic effect of crenezumab on plasma and cerebrospinal fluid beta-amyloid in patients with mild-to-moderate Alzheimer’s disease. Alzheimers Res Ther. 2020;12(1):16.
   PubMed Web of Science ®Google Scholar
• Wang L, Clark ME, Crossman DK, et al. Abundant lipid and protein components of drusen. PLoS ONE. 2010;5:e10329.
   PubMed Web of Science ®Google Scholar
• Egan MF, Kost J, Tariot PN, et al. Randomized trial of verubecestat for mild-to-moderate Alzheimer’s disease. N Engl J Med. 2018;378(18):1691–1703.
   PubMed Web of Science ®Google Scholar
• Liu Y, Pan N, Ma Y, et al. Inhaled sevoflurane may promote progression of amnestic mild cognitive impairment: a prospective, randomized parallel-group study. Am J Med Sci. 2013;345(5):355–360.
   PubMed Web of Science ®Google Scholar
• Chen H, Liu S, Ji L, et al. Folic acid supplementation mitigates Alzheimer’s disease by reducing inflammation: a randomized controlled trial. Mediators Inflamm. 2016;2016:5912146.
   PubMed Web of Science ®Google Scholar
• Maloney SC, Fernandes BF, Castiglione E, et al. Expression of cyclooxygenase-2 in choroidal neovascular membranes from age-related macular degeneration patients. Retina. 2009;29:176–180.
   PubMed Web of Science ®Google Scholar
• Cao S, Ko A, Partanen M, et al. Relationship between systemic cytokines and complement factor H Y402H polymorphism in patients with dry age-related macular degeneration. Am J Ophthalmol. 2013;156:1176–1183.
   PubMed Web of Science ®Google Scholar
• Kauppinen A, Suuronen T, Ojala J, et al. Antagonistic crosstalk between NF-kappaB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal. 2013;25(10):1939–1948.
   PubMed Web of Science ®Google Scholar
• Zhang YJ, Wu Q. Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1ɑ pathway. Bioengineered. 2021;12(1):4349–4360.
   PubMed Web of Science ®Google Scholar
• Sim H, Lee W, Choo S, et al. Sulforaphane alleviates particulate matter-induced oxidative stress in human retinal pigment epithelial cells. Front Med (Lausanne). 2021;8:685032.
   PubMed Web of Science ®Google Scholar
• Yang PM, Cheng KC, Huang JY, et al. Sulforaphane inhibits blue light-induced inflammation and apoptosis by upregulating the SIRT1/PGC-1α/Nrf2 pathway and autophagy in retinal pigment epithelial cells. Toxicol Appl Pharmacol. 2021;421:115545.
   PubMed Web of Science ®Google Scholar
• Wang H, Muiznieks LD, Ghosh P, et al. Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers. Elife. 2017;6:e28401.
   PubMed Web of Science ®Google Scholar
• Wu L, Tan X, Liang L, et al. The role of mitochondria-associated reactive oxygen species in the amyloid beta induced production of angiogenic factors by ARPE-19 cells. Curr Mol Med. 2017;17(2):140–148.
   PubMed Web of Science ®Google Scholar
• Masuda N, Tsujinaka H, Hirai H, et al. Effects of concentration of amyloid β (Aβ) on viability of cultured retinal pigment epithelial cells. BMC Ophthalmology. 2019;19(1):70.
   PubMed Web of Science ®Google Scholar
• Feng L, Liao X, Zhang Y, et al. Protective effects on age-related macular degeneration by activated autophagy induced by amyloid-beta in retinal pigment epithelial cells. Discov Med. 2019;27(148):153–160.
   PubMed Web of Science ®Google Scholar
• Alemasova EE, Lavrik OI. Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins. Nucleic Acids Res. 2019;47(8):3811–3827.
   PubMed Web of Science ®Google Scholar
• Wang S, Han L, Han J, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019;15(12):1223–1231.
   PubMed Web of Science ®Google Scholar
• Gibson BA, Kraus WL. New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs. Nature Reviews Molecular Cell Biology. 2012;13(7):411–424.
   PubMed Web of Science ®Google Scholar
• Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25:486–541.
   PubMed Web of Science ®Google Scholar
• Chang HC, Guarente L. SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab. 2014;25(3):138–145.
   PubMed Web of Science ®Google Scholar
• O’Callaghan C, Vassilopoulos A. Sirtuins at the crossroads of stemness, aging, and cancer. Aging Cell. 2017;16(6):1208–1218.
   PubMed Web of Science ®Google Scholar
• Kauppinen A, Suuronen T, Ojala J, et al. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal. 2013;25(10):1939–1948.
   PubMed Web of Science ®Google Scholar
• Singh V, Ubaid S. Role of silent information regulator 1 (SIRT1) in regulating oxidative stress and inflammation. Inflammation. 2020;43(5):1589–1598.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Cai L-J, Xu L-H, et al. The role of sirt1 in the retinal ganglion cells cultured by high glucose. Int Ophthalmol. 2021;41(3):845–852.
   PubMed Web of Science ®Google Scholar
• Mendelsohn AR, Larrick JW. The NAD+/PARP1/SIRT1 axis in aging. Rejuvenation Res. 2017;20(3):244–247.
   PubMed Web of Science ®Google Scholar
• Jang KH, Hwang Y, Kim E. PARP1 impedes SIRT1-mediated autophagy during degeneration of the retinal pigment epithelium under oxidative stress. Mol Cells. 2020;43(7):632–644.
   PubMed Web of Science ®Google Scholar
• Rajamohan SB, Pillai VB, Gupta M, et al. SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1. Molecular and Cellular Biology. 2009;29(15):4116–4129.
   PubMed Web of Science ®Google Scholar
• Al Sabaani N. Kaempferol Protects Against Hydrogen Peroxide-Induced Retinal Pigment Epithelium Cell Inflammation and Apoptosis by Activation of SIRT1 and Inhibition of PARP1. J Ocul Pharmacol Ther. 2020;36(7):563–577.
   PubMed Web of Science ®Google Scholar
• Piberger AL, Keil C, Platz S, et al. Sulforaphane inhibits damage-induced poly (ADP-ribosyl)ation via direct interaction of its cellular metabolites with PARP-1. Mol Nutr Food Res. 2015;59(11):2231–2242.
   PubMed Web of Science ®Google Scholar
• Li Y-P, Wang S-L, Liu B, et al. Sulforaphane prevents rat cardiomyocytes from hypoxia/reoxygenation injury in vitro via activating SIRT1 and subsequently inhibiting ER stress. Acta Pharmacol Sin. 2016;37(3):138–145.
   Web of Science ®Google Scholar
• Ye L, Yu T, Li Y, et al. Sulforaphane enhances the ability of human retinal pigment epithelial cell against oxidative stress, and its effect on gene expression profile evaluated by microarray analysis. Oxid Med Cell Longev. 2013;2013:413024.
   PubMed Web of Science ®Google Scholar
• Sim H, Lee W, Choo S, et al. Sulforaphane alleviates particulate matter-induced oxidative stress in human retinal pigment epithelial cells. Front Med (Lausanne). 2021;8:685032.
   PubMed Web of Science ®Google Scholar
• Cano V, Reyes M, Park CY, et al. Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress. Invest Ophthalmol Vis Sci. 2008;49(6):2606–2612.
   PubMed Web of Science ®Google Scholar