1,394
Views
7
CrossRef citations to date
0
Altmetric
Research Paper

MicroRNA-15a-5p plays a role in osteogenic MC3T3-E1 cells differentiation by targeting PDCD4 (programmed cell death 4) via Wnt/β-catenin dependent signaling pathway

, , , , , , & show all
Pages 8173-8185 | Received 15 Jun 2021, Accepted 03 Sep 2021, Published online: 21 Oct 2021

References

  • Kim MB, Song Y, Hwang JK. Kirenol stimulates osteoblast differentiation through activation of the BMP and Wnt/β-catenin signaling pathways in MC3T3-E1 cells. Fitoterapia. 2014;98:59–65.
  • Das S, Crockett JC. Osteoporosis - a current view of pharmacological prevention and treatment. Drug Des Devel Ther. 2013;7:435–448.
  • Man X, Yang L, Liu S, et al. Arbutin promotes MC3T3‑E1 mouse osteoblast precursor cell proliferation and differentiation via the Wnt/β‑catenin signaling pathway. Mol Med Rep. 2019;19:4637–4644.
  • Hernlund E, Svedbom A, Ivergård M, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos. 2013;8(1–2):136.
  • Lo YC, Chang YH, Wei BL, et al. Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals. J Agric Food Chem. 2010;58(11):6643–6649.
  • Yoon HJ, Seo C-R, Kim M, et al. Dichloromethane extracts of Sophora japonica L. stimulate osteoblast differentiation in mesenchymal stem cells. Nutr Res. 2013;33(12):1053–1062.
  • Vicente R, Noël D, Pers YM, et al. Deregulation and therapeutic potential of microRNAs in arthritic diseases. Nat Rev Rheumatol. 2016;12(4):211–220.
  • Weilner S, Skalicky S, Salzer B, et al. Differentially circulating miRNAs after recent osteoporotic fractures can influence osteogenic differentiation. Bone. 2015;79:43–51.
  • Heilmeier U, Hackl M, Skalicky S, et al. Serum miRNA signatures are indicative of skeletal fractures in postmenopausal women with and without type 2 diabetes and influence osteogenic and adipogenic differentiation of adipose tissue-derived mesenchymal stem cells in vitro. J Bone Miner Res. 2016;31(12):2173–2192.
  • Li CJ, Cheng P, Liang M-K, et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest. 2015;125(4):1509–1522.
  • Lian WS, Ko J-Y, Chen Y-S, et al. MicroRNA-29a represses osteoclast formation and protects against osteoporosis by regulating PCAF-mediated RANKL and CXCL12. Cell Death Dis. 2019;10(10):705.
  • Alderman C, Yang Y. The anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p. RNA & disease (Houston, Tex.). 2016;3.
  • Long J, Jiang C, Liu B, et al. MicroRNA-15a-5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF. Tumour Biol. 2016;37(5):5821–5828.
  • Shang J, He Q, Chen Y, et al. miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA. J Cell Physiol. 2019;234(6):9746–9755.
  • Duan L, Zhao H, Xiong Y, et al. miR-16-2* Interferes with WNT5A to regulate osteogenesis of mesenchymal stem cells. Cell Physiol Biochem. 2018;51(3):1087–1102.
  • Chen H, Tian Y. MiR-15a-5p regulates viability and matrix degradation of human osteoarthritis chondrocytes via targeting VEGFA. Biosci Trends. 2017;10(6):482–488.
  • Wei X, Wang W, Wang L, et al. Micro RNA-21 induces 5-fluorouracil resistance in human pancreatic cancer cells by regulating PTEN and PDCD 4. Cancer Med. 2016;5(4):693–702.
  • Zhen Y, Li D, Li W, et al. Reduced PDCD4 expression promotes cell growth through PI3K/Akt signaling in non-small cell lung cancer. 2016;23:61–68.
  • Walter BA, Gómez-Macias G, Valera VA, et al. miR-21 expression in pregnancy-associated breast cancer: a possible marker of poor prognosis. J Cancer. 2011;2:67–75.
  • Liu Y, Su D, Song T. Programmed cell death 4 inhibits proliferation and differentiation and induces apoptosis of human mesenchymal stem cells through suppressing the Wnt/β-catenin pathway. RSC Adv. 2017;7(43):26566–26573.
  • Zhang R, Oyajobi BO, Harris SE, et al. Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone. 2013;52(1):145–156.
  • Wrobel E, Leszczynska J, Brzoska E. The characteristics of Human Bone-Derived Cells (HBDCS) during osteogenesis in vitro. Cell Mol Biol Lett. 2016;21(1):26.
  • Fu C, Bai H, Hu Q, et al. Enhanced proliferation and osteogenic differentiation of MC3T3-E1 pre-osteoblasts on graphene oxide-impregnated PLGA–gelatin nanocomposite fibrous membranes. RSC Adv. 2017;7:8886–8897.
  • Hou X, Tang Z, Liu H, et al. Discovery of MicroRNAs associated with myogenesis by deep sequencing of serial developmental skeletal muscles in pigs. PLoS One. 2012;7(12):e52123.
  • Hupkes M, Sotoca AM, Hendriks JM, et al. MicroRNA miR-378 promotes BMP2-induced osteogenic differentiation of mesenchymal progenitor cells. BMC Mol Biol. 2014;15(1):1.
  • Nishimura I, Hisanaga R, Sato T, et al. Effect of osteogenic differentiation medium on proliferation and differentiation of human mesenchymal stem cells in three-dimensional culture with radial flow bioreactor. Regen Ther. 2015;2:24–31.
  • Yang XM, Song YQ, Li L, et al. miR-1249-5p regulates the osteogenic differentiation of ADSCs by targeting PDX1. J Orthop Surg Res. 2021;16(1):10.
  • Duan Z-X, Huang P, Tu C, et al. MicroRNA-15a-5p regulates the development of osteoarthritis by targeting PTHrP in chondrocytes. Biomed Res Int. 2019;2019:3904923.
  • Lu X, Lin J, Jin J, et al. hsa-miR-15a exerts protective effects against osteoarthritis by targeting aggrecanase-2 (ADAMTS5) in human chondrocytes. Int J Mol Med. 2016;37(2):509–516.
  • Liu Y, Liu LY, Jia Y, et al. Role of microRNA-15a-5p in the atherosclerotic inflammatory response and arterial injury improvement of diabetic by targeting FASN. Biosci Rep. 2019;39. DOI:10.1042/bsr20181852.
  • Nakasa T, Yoshizuka M, Andry Usman M, et al. MicroRNAs and bone regeneration. Current Genomics. 2015;16:441–452.
  • Chen J, He G, Wang Y, et al. MicroRNA‑223 promotes osteoblast differentiation of MC3T3‑E1 cells by targeting histone deacetylase 2. Int J Mol Med. 2019;43:1513–1521.
  • Onyido EK, Sweeney E, Nateri AS. Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches. Mol Cancer. 2016;15(1):56.
  • Park KH, Kang JW, Lee E-M, et al. Melatonin promotes osteoblastic differentiation through the BMP/ERK/Wnt signaling pathways. J Pineal Res. 2011;51(2):187–194.
  • Gaur T, Lengner CJ, Hovhannisyan H, et al. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem. 2005;280(39):33132–33140.
  • Liu Y, Su D, Song TJRA. Programmed cell death 4 inhibits proliferation and differentiation and induces apoptosis of human mesenchymal stem cells through suppressing the Wnt/β-catenin pathway. PLoS One. 2017;7:26566–26573.
  • Sugatani T, Vacher J, Hruska KA. A microRNA expression signature of osteoclastogenesis. Blood. 2011;117(13):3648–3657.
  • Ell B, Kang Y. MicroRNAs as regulators of bone homeostasis and bone metastasis. Bonekey Rep. 2014;3:549.