References
- Wu SM, Wu B, Liu M, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 2019;18(4):394–405.
- Wang YJ, Li ZX, Gu HQ, et al. China Stroke Statistics 2019: a Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations. Stroke Vasc Neurol. 2020;5(3):211–239.
- Gabisonia K, Prosdocimo G, Aquaro GD, et al. MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. Nature. 2019;569(7756):418-+.
- Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315–1323.
- Manabe H, Wang Y, Yoshimura R, et al. Metabolic reflow as a therapy for ischemic brain injury. Acta Neurochirurgica Suppl. 2011;110(Pt 2):87–91.
- Han L, Cai W, Mao L, et al. Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia. Stroke. 2015;46(9):2628–2636.
- Veltkamp R, Gill D. Clinical Trials of Immunomodulation in Ischemic Stroke. Neurotherapeutics. 2016;13(4):791–800.
- Amantea D, Micieli G, Tassorelli C, et al. Rational modulation of the innate immune system for neuroprotection in ischemic stroke. Front Neurosci. 2015;9:147.
- Tang Y, Le W. Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases. Mol Neurobiol. 2016;53(2):1181–1194.
- Zhao X, Wang H, Sun G, et al. Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage. J Neurosci. 2015;35(32):11281–11291.
- Mueller CK, Schultze-Mosgau S. Histomorphometric analysis of the phenotypical differentiation of recruited macrophages following subcutaneous implantation of an allogenous acellular dermal matrix. Int J Oral Maxillofac Surg. 2011;40(4):401–407.
- Miro-Mur F, Perez-de-Puig I, Ferrer-Ferrer M, et al. Immature monocytes recruited to the ischemic mouse brain differentiate into macrophages with features of alternative activation. Brain Behav Immun. 2016;53:18–33.
- Frieler RA, Ray JJ, Meng H, et al. Myeloid mineralocorticoid receptor during experimental ischemic stroke: effects of model and sex. J Am Heart Assoc. 2012;1(5):e002584.
- Frieler RA, Meng H, Duan SZ, et al. Myeloid-specific deletion of the mineralocorticoid receptor reduces infarct volume and alters inflammation during cerebral ischemia. Stroke. 2011;42(1):179–185.
- Jin Q, Cheng J, Liu Y, et al. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke. Brain Behav Immun. 2014;40:131–142.
- Liao TV, Forehand CC, Hess DC, et al. Minocycline repurposing in critical illness: focus on stroke. Curr Top Med Chem. 2013;13(18):2283–2290.
- Yang Y, Salayandia VM, Thompson JF, et al. Attenuation of acute stroke injury in rat brain by minocycline promotes blood-brain barrier remodeling and alternative microglia/macrophage activation during recovery. J Neuroinflammation. 2015;12(1):26.
- Amantea D, Certo M, Petrelli F, et al. Neuroprotective Properties of a Macrolide Antibiotic in a Mouse Model of Middle Cerebral Artery Occlusion: characterization of the Immunomodulatory Effects and Validation of the Efficacy of Intravenous Administration. Assay Drug Dev Technol. 2016;14(5):298–307.
- Yang C, Hawkins KE, Dore S, et al. Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. Am J Physiol Cell Physiol. 2019;316(2):C135–C153.
- Chern CM, Wang YH, Liou KT, et al. 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke. Biochem Pharmacol. 2014;87(3):502–514.
- Sun J, Huang Y, Gong J, et al. Transplantation of hPSC-derived pericyte-like cells promotes functional recovery in ischemic stroke mice. Nat Commun. 2020;11(1):5196.
- Ronaldson PT, Davis TP. Regulation of blood-brain barrier integrity by microglia in health and disease: a therapeutic opportunity. J Cereb Blood Flow Metab. 2020;40(1):S6–S24.
- Zhang L, Lu X, Gong L, et al. Tetramethylpyrazine Protects Blood-Spinal Cord Barrier Integrity by Modulating Microglia Polarization Through Activation of STAT3/SOCS3 and Inhibition of NF-small ka, CyrillicB Signaling Pathways in Experimental Autoimmune Encephalomyelitis Mice. Cell Mol Neurobiol. 2021;41(4):717–731.
- Zhao J, Zhou K, Ma L, et al. MicroRNA-145 overexpression inhibits neuroblastoma tumorigenesis in vitro and in vivo. Bioengineered. 2020;11(1):219–228.
- Read SJ, Virley D. Stroke genomics: methods and reviews. Totowa, N.J: Humana Press; 2005.
- Nong A, Li Q, Huang Z, et al. MicroRNA miR-126 attenuates brain injury in septic rats via NF-kappaB signaling pathway. Bioengineered. 2021;12(1):2639–2648.
- Han J, Tang H, Yao L, et al. Azilsartan protects against hyperglycemia-induced hyperpermeability of the blood-brain barrier. Bioengineered. 2021;12(1):3621–3633.
- Di Virgilio F, Dal Ben D, Sarti AC, et al. The P2X7 Receptor in Infection and Inflammation. Immunity. 2017;47(1):15–31.
- Grygorowicz T, Struzynska L. Early P2X7R-dependent activation of microglia during the asymptomatic phase of autoimmune encephalomyelitis. Inflammopharmacology. 2019;27(1):129–137.
- Volonte C, Amadio S, Cavaliere F, et al. Extracellular ATP and Neurodegeneration. CNS Neurol Disord-Dr. 2003;2(6):403–412
- Melani A, Corti F, Stephan H, et al. Ecto-ATPase inhibition: ATP and adenosine release under physiological and ischemic in vivo conditions in the rat striatum. Exp Neurol. 2012;233(1):193–204.
- Gelderblom M, Leypoldt F, Steinbach K, et al. Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke. Stroke. 2009;40(5):1849–1857.
- Ritzel RM, Patel AR, Grenier JM, et al. Functional differences between microglia and monocytes after ischemic stroke. J Neuroinflamm. 2015;12:106.
- Naidech AM, Lawlor PN, Xu H, et al. Probing the Effective Treatment Thresholds for Alteplase in Acute Ischemic Stroke With Regression Discontinuity Designs. Front Neurol. 2020;11:961.
- de Ridder IR, Fransen PS, Beumer D, et al. Is Intra-Arterial Treatment for Acute Ischemic Stroke Less Effective in Women than in Men? Interv Neurol. 2016;5(3–4):174–178.
- Gottlieb M, Update HB. Is Endovascular Therapy Effective in the Treatment of Acute Ischemic Stroke? Ann Emerg Med. 2015;66(6):613–615.
- Chen H, Zhu G, Liu N, et al. Low-dose tissue plasminogen activator is as effective as standard tissue plasminogen activator administration for the treatment of acute ischemic stroke. Curr Neurovasc Res. 2014;11(1):62–67.
- Thijs V. Imaging techniques for acute ischemic stroke: nice gadgets or essential tools for effective treatment? Neuroradiology. 2010;52(3):169–171.
- GAN H, LI L, Zhuge YANGY, et al. Buyang Huanwu Decoction Inhibits Inflammation via Regulating Microglia/Macrophage Polarization after Cerebral Ischemia in Rats. JOURNAL OF ZHEJIANG CHINESE MEDICAL UNIVERSITY. 2019;43(1):1–6.
- SHOU D. Curative Effect Observation of Buyang Huanwu Tang with Different Dose of Astragalus for Elderly Cerebral Apoplectic. JOURNAL OF NEW CHINESE MEDICINE. 2016;48(5):48–50.
- JS W, Sluyter R, BJ G, et al. The human P2X7 receptor and its role in innate immunity. Tissue Antigens. 2011;78:5.
- Morad G, Daisy CC, Otu HH, et al. Cdc42-Dependent Transfer of mir301 from Breast Cancer-Derived Extracellular Vesicles Regulates the Matrix Modulating Ability of Astrocytes at the Blood-Brain Barrier. Int J Mol Sci. 2020;21(11):11.
- Reed MJ, Damodarasamy M, Banks WA. The extracellular matrix of the blood-brain barrier: structural and functional roles in health, aging, and Alzheimer’s disease. Tissue Barriers. 2019;7(4):1651157.
- Kanda H, Shimamura R, Koizumi-Kitajima M, et al. Degradation of Extracellular Matrix by Matrix Metalloproteinase 2 Is Essential for the Establishment of the Blood-Brain Barrier in Drosophila. iScience. 2019;16:218–229.
- Henrich-Noack P, Nikitovic D, Neagu M, et al. The blood-brain barrier and beyond: nano-based neuropharmacology and the role of extracellular matrix. Nanomed. 2019;17:359–379.
- Edwards DN, Bix GJ. Roles of blood-brain barrier integrins and extracellular matrix in stroke. Am J Physiol Cell Physiol. 2019;316(2):C252–C263.
- Roberts JM, Maniskas ME, Bix GJ. Bilateral carotid artery stenosis causes unexpected early changes in brain extracellular matrix and blood-brain barrier integrity in mice. PloS One. 2018;13(4):e0195765.